LeishMANIAdb
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Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Transmembrane protein
Gene product:
hypothetical protein
Species:
Leishmania braziliensis
UniProt:
E9AI21_LEIBR
TriTrypDb:
LbrM.04.0071 , LBRM2903_040005500
Length:
73

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 3
GO:0110165 cellular anatomical entity 1 3

Expansion

Sequence features

E9AI21
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AI21

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 28 30 PF00675 0.391
CLV_NRD_NRD_1 35 37 PF00675 0.441
DOC_MAPK_gen_1 36 43 PF00069 0.595
DOC_SPAK_OSR1_1 51 55 PF12202 0.547
DOC_USP7_MATH_1 16 20 PF00917 0.357
LIG_14-3-3_CanoR_1 36 43 PF00244 0.634
LIG_14-3-3_CanoR_1 60 69 PF00244 0.545
LIG_FHA_2 59 65 PF00498 0.620
LIG_SH2_CRK 25 29 PF00017 0.584
LIG_TYR_ITIM 23 28 PF00017 0.621
MOD_CK2_1 58 64 PF00069 0.577
MOD_GlcNHglycan 18 21 PF01048 0.321
MOD_GlcNHglycan 70 73 PF01048 0.464
MOD_GSK3_1 12 19 PF00069 0.323
MOD_GSK3_1 31 38 PF00069 0.600
MOD_PKA_2 35 41 PF00069 0.639
TRG_ENDOCYTIC_2 25 28 PF00928 0.619
TRG_Pf-PMV_PEXEL_1 60 64 PF00026 0.419

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P4C0 Leptomonas seymouri 69% 88%
A0A3S5H572 Leishmania donovani 88% 100%
E9ACP4 Leishmania major 88% 100%
E9AG59 Leishmania infantum 88% 100%
E9AJY6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS