Putative cAMP-specific phosphodiesterase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cAMP-specific phosphodiesterase, putative

Species:

Leishmania braziliensis

UniProt:

E9AI20_LEIBR

TriTrypDb:

LbrM.04.0070 , LBRM2903_040005400

Length:

744

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

E9AI20

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AI20

Function

Biological processes
Term	Name	Level	Count
GO:0007165	signal transduction	2	12
GO:0009987	cellular process	1	12
GO:0050789	regulation of biological process	2	12
GO:0050794	regulation of cellular process	3	12
GO:0065007	biological regulation	1	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004112	cyclic-nucleotide phosphodiesterase activity	6	12
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	7	12
GO:0008081	phosphoric diester hydrolase activity	5	12
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0042578	phosphoric ester hydrolase activity	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	361	365	PF00656	0.416
CLV_C14_Caspase3-7	459	463	PF00656	0.561
CLV_C14_Caspase3-7	673	677	PF00656	0.452
CLV_NRD_NRD_1	210	212	PF00675	0.494
CLV_NRD_NRD_1	505	507	PF00675	0.583
CLV_NRD_NRD_1	622	624	PF00675	0.524
CLV_PCSK_SKI1_1	137	141	PF00082	0.486
CLV_PCSK_SKI1_1	180	184	PF00082	0.319
CLV_PCSK_SKI1_1	211	215	PF00082	0.463
CLV_PCSK_SKI1_1	329	333	PF00082	0.313
CLV_PCSK_SKI1_1	436	440	PF00082	0.477
CLV_PCSK_SKI1_1	496	500	PF00082	0.493
CLV_PCSK_SKI1_1	600	604	PF00082	0.426
DEG_APCC_DBOX_1	411	419	PF00400	0.415
DEG_Nend_Nbox_1	1	3	PF02207	0.583
DEG_ODPH_VHL_1	480	493	PF01847	0.321
DOC_MAPK_gen_1	178	185	PF00069	0.392
DOC_MAPK_MEF2A_6	178	185	PF00069	0.424
DOC_MAPK_NFAT4_5	178	186	PF00069	0.460
DOC_PP1_RVXF_1	203	210	PF00149	0.345
DOC_PP1_RVXF_1	451	457	PF00149	0.496
DOC_PP2B_LxvP_1	2	5	PF13499	0.574
DOC_PP4_FxxP_1	240	243	PF00568	0.433
DOC_USP7_MATH_1	269	273	PF00917	0.348
DOC_USP7_MATH_1	282	286	PF00917	0.299
DOC_USP7_MATH_1	376	380	PF00917	0.446
DOC_USP7_MATH_1	381	385	PF00917	0.417
DOC_USP7_MATH_1	416	420	PF00917	0.208
DOC_USP7_MATH_1	516	520	PF00917	0.670
DOC_USP7_MATH_1	574	578	PF00917	0.629
DOC_USP7_MATH_1	6	10	PF00917	0.602
DOC_USP7_MATH_1	660	664	PF00917	0.653
DOC_USP7_MATH_1	700	704	PF00917	0.453
DOC_WW_Pin1_4	127	132	PF00397	0.483
DOC_WW_Pin1_4	14	19	PF00397	0.685
DOC_WW_Pin1_4	37	42	PF00397	0.563
DOC_WW_Pin1_4	514	519	PF00397	0.570
DOC_WW_Pin1_4	554	559	PF00397	0.668
DOC_WW_Pin1_4	568	573	PF00397	0.708
DOC_WW_Pin1_4	66	71	PF00397	0.609
DOC_WW_Pin1_4	706	711	PF00397	0.724
DOC_WW_Pin1_4	724	729	PF00397	0.451
LIG_14-3-3_CanoR_1	180	186	PF00244	0.328
LIG_14-3-3_CanoR_1	211	219	PF00244	0.462
LIG_14-3-3_CanoR_1	412	416	PF00244	0.458
LIG_14-3-3_CanoR_1	470	475	PF00244	0.536
LIG_14-3-3_CanoR_1	616	622	PF00244	0.397
LIG_14-3-3_CanoR_1	90	98	PF00244	0.555
LIG_Actin_WH2_2	136	154	PF00022	0.388
LIG_Actin_WH2_2	40	57	PF00022	0.581
LIG_Actin_WH2_2	481	497	PF00022	0.530
LIG_BRCT_BRCA1_1	236	240	PF00533	0.433
LIG_BRCT_BRCA1_1	376	380	PF00533	0.434
LIG_Clathr_ClatBox_1	276	280	PF01394	0.433
LIG_Clathr_ClatBox_1	680	684	PF01394	0.488
LIG_DCNL_PONY_1	1	4	PF03556	0.585
LIG_DLG_GKlike_1	556	564	PF00625	0.494
LIG_FHA_1	128	134	PF00498	0.476
LIG_FHA_1	261	267	PF00498	0.349
LIG_FHA_1	300	306	PF00498	0.325
LIG_FHA_1	391	397	PF00498	0.259
LIG_FHA_1	422	428	PF00498	0.427
LIG_FHA_1	440	446	PF00498	0.341
LIG_FHA_1	483	489	PF00498	0.540
LIG_FHA_1	560	566	PF00498	0.491
LIG_FHA_2	313	319	PF00498	0.336
LIG_FHA_2	359	365	PF00498	0.416
LIG_FHA_2	545	551	PF00498	0.623
LIG_LIR_Apic_2	237	243	PF02991	0.433
LIG_LIR_Gen_1	179	190	PF02991	0.358
LIG_LIR_Gen_1	204	214	PF02991	0.245
LIG_LIR_Gen_1	330	341	PF02991	0.386
LIG_LIR_Gen_1	428	438	PF02991	0.335
LIG_LIR_Gen_1	580	589	PF02991	0.392
LIG_LIR_Gen_1	675	686	PF02991	0.486
LIG_LIR_Nem_3	179	185	PF02991	0.383
LIG_LIR_Nem_3	188	193	PF02991	0.341
LIG_LIR_Nem_3	204	209	PF02991	0.308
LIG_LIR_Nem_3	285	290	PF02991	0.375
LIG_LIR_Nem_3	330	336	PF02991	0.376
LIG_LIR_Nem_3	428	433	PF02991	0.341
LIG_LIR_Nem_3	579	585	PF02991	0.413
LIG_LIR_Nem_3	675	681	PF02991	0.490
LIG_MLH1_MIPbox_1	236	240	PF16413	0.433
LIG_PTB_Apo_2	189	196	PF02174	0.332
LIG_REV1ctd_RIR_1	237	242	PF16727	0.433
LIG_SH2_CRK	333	337	PF00017	0.411
LIG_SH2_GRB2like	223	226	PF00017	0.313
LIG_SH2_GRB2like	430	433	PF00017	0.409
LIG_SH2_PTP2	430	433	PF00017	0.433
LIG_SH2_SRC	430	433	PF00017	0.377
LIG_SH2_STAP1	333	337	PF00017	0.403
LIG_SH2_STAT5	153	156	PF00017	0.375
LIG_SH2_STAT5	194	197	PF00017	0.288
LIG_SH2_STAT5	430	433	PF00017	0.316
LIG_SH2_STAT5	566	569	PF00017	0.638
LIG_SH2_STAT5	582	585	PF00017	0.373
LIG_SH2_STAT5	617	620	PF00017	0.360
LIG_SH2_STAT5	686	689	PF00017	0.447
LIG_SH2_STAT5	78	81	PF00017	0.620
LIG_SH3_1	12	18	PF00018	0.538
LIG_SH3_3	12	18	PF00018	0.538
LIG_SH3_3	263	269	PF00018	0.439
LIG_SH3_3	431	437	PF00018	0.393
LIG_SH3_3	708	714	PF00018	0.775
LIG_Sin3_3	678	685	PF02671	0.344
LIG_SUMO_SIM_anti_2	297	303	PF11976	0.433
LIG_SUMO_SIM_anti_2	442	449	PF11976	0.415
LIG_SUMO_SIM_par_1	275	280	PF11976	0.424
LIG_SUMO_SIM_par_1	297	303	PF11976	0.441
LIG_SUMO_SIM_par_1	678	684	PF11976	0.330
LIG_SUMO_SIM_par_1	713	718	PF11976	0.537
LIG_TRAF2_1	250	253	PF00917	0.389
LIG_TRAF2_1	547	550	PF00917	0.521
LIG_WRC_WIRS_1	582	587	PF05994	0.418
LIG_WW_3	69	73	PF00397	0.540
MOD_CDC14_SPxK_1	517	520	PF00782	0.667
MOD_CDC14_SPxK_1	727	730	PF00782	0.710
MOD_CDK_SPK_2	132	137	PF00069	0.510
MOD_CDK_SPxK_1	514	520	PF00069	0.606
MOD_CDK_SPxK_1	66	72	PF00069	0.620
MOD_CDK_SPxK_1	724	730	PF00069	0.714
MOD_CDK_SPxxK_3	37	44	PF00069	0.542
MOD_CK1_1	121	127	PF00069	0.531
MOD_CK1_1	19	25	PF00069	0.678
MOD_CK1_1	321	327	PF00069	0.441
MOD_CK1_1	346	352	PF00069	0.413
MOD_CK1_1	37	43	PF00069	0.498
MOD_CK1_1	533	539	PF00069	0.624
MOD_CK1_1	559	565	PF00069	0.732
MOD_CK1_1	698	704	PF00069	0.491
MOD_CK1_1	737	743	PF00069	0.735
MOD_CK2_1	247	253	PF00069	0.297
MOD_CK2_1	312	318	PF00069	0.336
MOD_CK2_1	544	550	PF00069	0.570
MOD_CK2_1	574	580	PF00069	0.381
MOD_CK2_1	647	653	PF00069	0.428
MOD_GlcNHglycan	18	21	PF01048	0.607
MOD_GlcNHglycan	302	305	PF01048	0.254
MOD_GlcNHglycan	320	323	PF01048	0.306
MOD_GlcNHglycan	348	351	PF01048	0.411
MOD_GlcNHglycan	355	359	PF01048	0.381
MOD_GlcNHglycan	418	421	PF01048	0.350
MOD_GlcNHglycan	540	543	PF01048	0.770
MOD_GlcNHglycan	650	653	PF01048	0.541
MOD_GlcNHglycan	697	700	PF01048	0.612
MOD_GlcNHglycan	83	86	PF01048	0.573
MOD_GlcNHglycan	95	98	PF01048	0.585
MOD_GSK3_1	113	120	PF00069	0.596
MOD_GSK3_1	181	188	PF00069	0.316
MOD_GSK3_1	354	361	PF00069	0.438
MOD_GSK3_1	390	397	PF00069	0.315
MOD_GSK3_1	421	428	PF00069	0.315
MOD_GSK3_1	496	503	PF00069	0.486
MOD_GSK3_1	530	537	PF00069	0.612
MOD_GSK3_1	540	547	PF00069	0.720
MOD_GSK3_1	550	557	PF00069	0.583
MOD_GSK3_1	62	69	PF00069	0.655
MOD_GSK3_1	737	744	PF00069	0.621
MOD_GSK3_1	89	96	PF00069	0.654
MOD_N-GLC_1	224	229	PF02516	0.423
MOD_N-GLC_1	514	519	PF02516	0.523
MOD_N-GLC_1	544	549	PF02516	0.715
MOD_NEK2_1	126	131	PF00069	0.599
MOD_NEK2_1	162	167	PF00069	0.456
MOD_NEK2_1	181	186	PF00069	0.372
MOD_NEK2_1	195	200	PF00069	0.328
MOD_NEK2_1	219	224	PF00069	0.542
MOD_NEK2_1	299	304	PF00069	0.401
MOD_NEK2_1	311	316	PF00069	0.278
MOD_NEK2_1	476	481	PF00069	0.567
MOD_NEK2_1	484	489	PF00069	0.524
MOD_NEK2_1	534	539	PF00069	0.613
MOD_NEK2_1	54	59	PF00069	0.452
MOD_NEK2_1	540	545	PF00069	0.572
MOD_NEK2_1	560	565	PF00069	0.427
MOD_NEK2_1	89	94	PF00069	0.623
MOD_NEK2_1	98	103	PF00069	0.521
MOD_NEK2_2	147	152	PF00069	0.516
MOD_NEK2_2	282	287	PF00069	0.433
MOD_PIKK_1	381	387	PF00454	0.407
MOD_PIKK_1	560	566	PF00454	0.591
MOD_PK_1	470	476	PF00069	0.364
MOD_PKA_1	506	512	PF00069	0.560
MOD_PKA_2	343	349	PF00069	0.357
MOD_PKA_2	411	417	PF00069	0.443
MOD_PKA_2	54	60	PF00069	0.546
MOD_PKA_2	89	95	PF00069	0.682
MOD_Plk_1	219	225	PF00069	0.472
MOD_Plk_1	34	40	PF00069	0.366
MOD_Plk_1	421	427	PF00069	0.208
MOD_Plk_1	476	482	PF00069	0.634
MOD_Plk_2-3	713	719	PF00069	0.642
MOD_Plk_4	113	119	PF00069	0.553
MOD_Plk_4	121	127	PF00069	0.550
MOD_Plk_4	170	176	PF00069	0.542
MOD_Plk_4	185	191	PF00069	0.320
MOD_Plk_4	234	240	PF00069	0.372
MOD_Plk_4	282	288	PF00069	0.380
MOD_Plk_4	294	300	PF00069	0.368
MOD_Plk_4	343	349	PF00069	0.397
MOD_Plk_4	390	396	PF00069	0.332
MOD_Plk_4	422	428	PF00069	0.342
MOD_Plk_4	470	476	PF00069	0.605
MOD_Plk_4	556	562	PF00069	0.644
MOD_ProDKin_1	127	133	PF00069	0.477
MOD_ProDKin_1	14	20	PF00069	0.680
MOD_ProDKin_1	37	43	PF00069	0.562
MOD_ProDKin_1	514	520	PF00069	0.576
MOD_ProDKin_1	554	560	PF00069	0.666
MOD_ProDKin_1	568	574	PF00069	0.703
MOD_ProDKin_1	66	72	PF00069	0.598
MOD_ProDKin_1	706	712	PF00069	0.726
MOD_ProDKin_1	724	730	PF00069	0.457
MOD_SUMO_rev_2	503	509	PF00179	0.521
MOD_SUMO_rev_2	9	14	PF00179	0.746
TRG_DiLeu_BaEn_1	294	299	PF01217	0.433
TRG_DiLeu_BaEn_1	637	642	PF01217	0.437
TRG_ENDOCYTIC_2	333	336	PF00928	0.411
TRG_ENDOCYTIC_2	430	433	PF00928	0.333
TRG_ENDOCYTIC_2	582	585	PF00928	0.390
TRG_ER_diArg_1	341	344	PF00400	0.313
TRG_NES_CRM1_1	252	265	PF08389	0.433
TRG_NES_CRM1_1	601	614	PF08389	0.292
TRG_NLS_MonoExtC_3	622	628	PF00514	0.318
TRG_Pf-PMV_PEXEL_1	152	156	PF00026	0.492

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3J8	Leptomonas seymouri	62%	100%
A0A0S4J2W3	Bodo saltans	28%	100%
A0A1X0NMW5	Trypanosomatidae	38%	100%
A0A3R7NEI4	Trypanosoma rangeli	36%	100%
A0A3S5H571	Leishmania donovani	84%	100%
A4HRZ8	Leishmania infantum	84%	100%
C9ZXZ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AJY5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q95Z92	Leishmania major	82%	100%
V5BDS9	Trypanosoma cruzi	37%	100%