LeishMANIAdb
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Putative delta-6 fatty acid desaturase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative delta-6 fatty acid desaturase
Gene product:
delta-6 fatty acid desaturase
Species:
Leishmania infantum
UniProt:
E9AI08_LEIIN
TriTrypDb:
LINF_360081600
Length:
394

Annotations

Annotations by Jardim et al.

Lipid Metabolism, delta-6 fatty acid desaturase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0016020 membrane 2 7
GO:0110165 cellular anatomical entity 1 7

Expansion

Sequence features

E9AI08
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AI08

Function

Biological processes
Term Name Level Count
GO:0006629 lipid metabolic process 3 9
GO:0008152 metabolic process 1 9
GO:0044238 primary metabolic process 2 9
GO:0071704 organic substance metabolic process 2 9
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 9
GO:0016491 oxidoreductase activity 2 9
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 3 1
GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 50 54 PF00656 0.453
CLV_NRD_NRD_1 104 106 PF00675 0.354
CLV_NRD_NRD_1 192 194 PF00675 0.261
CLV_NRD_NRD_1 352 354 PF00675 0.256
CLV_NRD_NRD_1 355 357 PF00675 0.249
CLV_PCSK_KEX2_1 104 106 PF00082 0.370
CLV_PCSK_KEX2_1 352 354 PF00082 0.288
CLV_PCSK_KEX2_1 68 70 PF00082 0.336
CLV_PCSK_PC1ET2_1 68 70 PF00082 0.336
CLV_PCSK_SKI1_1 131 135 PF00082 0.493
CLV_PCSK_SKI1_1 244 248 PF00082 0.488
CLV_PCSK_SKI1_1 352 356 PF00082 0.295
CLV_PCSK_SKI1_1 49 53 PF00082 0.284
CLV_PCSK_SKI1_1 68 72 PF00082 0.248
DEG_APCC_DBOX_1 251 259 PF00400 0.275
DOC_CYCLIN_RxL_1 66 79 PF00134 0.538
DOC_CYCLIN_yCln2_LP_2 5 11 PF00134 0.569
DOC_MAPK_gen_1 104 110 PF00069 0.503
DOC_MAPK_gen_1 66 75 PF00069 0.532
DOC_MAPK_MEF2A_6 112 120 PF00069 0.297
DOC_MAPK_MEF2A_6 82 89 PF00069 0.503
DOC_PP2B_LxvP_1 208 211 PF13499 0.495
DOC_PP2B_LxvP_1 5 8 PF13499 0.557
DOC_USP7_MATH_1 211 215 PF00917 0.495
DOC_USP7_MATH_1 246 250 PF00917 0.325
DOC_USP7_MATH_1 390 394 PF00917 0.552
DOC_WW_Pin1_4 3 8 PF00397 0.565
DOC_WW_Pin1_4 385 390 PF00397 0.488
LIG_14-3-3_CanoR_1 12 16 PF00244 0.522
LIG_14-3-3_CanoR_1 239 244 PF00244 0.325
LIG_14-3-3_CanoR_1 33 37 PF00244 0.453
LIG_14-3-3_CanoR_1 356 365 PF00244 0.479
LIG_14-3-3_CanoR_1 384 389 PF00244 0.454
LIG_14-3-3_CanoR_1 95 102 PF00244 0.424
LIG_Actin_WH2_2 229 246 PF00022 0.400
LIG_Actin_WH2_2 60 78 PF00022 0.528
LIG_AP2alpha_2 321 323 PF02296 0.479
LIG_BRCT_BRCA1_1 129 133 PF00533 0.333
LIG_BRCT_BRCA1_1 241 245 PF00533 0.297
LIG_BRCT_BRCA1_1 319 323 PF00533 0.459
LIG_BRCT_BRCA1_1 85 89 PF00533 0.467
LIG_BRCT_BRCA1_2 85 91 PF00533 0.496
LIG_CSL_BTD_1 208 211 PF09270 0.453
LIG_deltaCOP1_diTrp_1 23 32 PF00928 0.428
LIG_deltaCOP1_diTrp_1 325 328 PF00928 0.453
LIG_deltaCOP1_diTrp_1 369 379 PF00928 0.515
LIG_deltaCOP1_diTrp_1 99 106 PF00928 0.493
LIG_DLG_GKlike_1 239 247 PF00625 0.357
LIG_eIF4E_1 262 268 PF01652 0.295
LIG_FHA_1 134 140 PF00498 0.274
LIG_FHA_1 223 229 PF00498 0.537
LIG_FHA_1 312 318 PF00498 0.453
LIG_FHA_1 386 392 PF00498 0.537
LIG_LIR_Apic_2 128 132 PF02991 0.274
LIG_LIR_Gen_1 301 308 PF02991 0.429
LIG_LIR_Gen_1 321 331 PF02991 0.342
LIG_LIR_Gen_1 86 96 PF02991 0.467
LIG_LIR_Nem_3 125 129 PF02991 0.383
LIG_LIR_Nem_3 301 307 PF02991 0.429
LIG_LIR_Nem_3 321 327 PF02991 0.342
LIG_LIR_Nem_3 52 58 PF02991 0.428
LIG_LIR_Nem_3 86 92 PF02991 0.476
LIG_LYPXL_yS_3 348 351 PF13949 0.495
LIG_PCNA_PIPBox_1 332 341 PF02747 0.428
LIG_Pex14_1 106 110 PF04695 0.428
LIG_Pex14_2 102 106 PF04695 0.493
LIG_Pex14_2 133 137 PF04695 0.207
LIG_Pex14_2 175 179 PF04695 0.442
LIG_Pex14_2 323 327 PF04695 0.428
LIG_SH2_CRK 129 133 PF00017 0.287
LIG_SH2_CRK 231 235 PF00017 0.281
LIG_SH2_CRK 304 308 PF00017 0.428
LIG_SH2_NCK_1 129 133 PF00017 0.333
LIG_SH2_STAP1 224 228 PF00017 0.364
LIG_SH2_STAP1 231 235 PF00017 0.206
LIG_SH2_STAT5 126 129 PF00017 0.404
LIG_SH2_STAT5 224 227 PF00017 0.342
LIG_SH2_STAT5 235 238 PF00017 0.174
LIG_SH2_STAT5 262 265 PF00017 0.248
LIG_SH2_STAT5 306 309 PF00017 0.442
LIG_SH3_3 338 344 PF00018 0.428
LIG_SUMO_SIM_anti_2 254 259 PF11976 0.253
LIG_TRFH_1 3 7 PF08558 0.575
LIG_TYR_ITIM 260 265 PF00017 0.253
LIG_WRC_WIRS_1 134 139 PF05994 0.363
MOD_CDK_SPxxK_3 3 10 PF00069 0.533
MOD_CK1_1 214 220 PF00069 0.479
MOD_CK1_1 273 279 PF00069 0.312
MOD_CK1_1 57 63 PF00069 0.453
MOD_GlcNHglycan 248 251 PF01048 0.495
MOD_GSK3_1 28 35 PF00069 0.453
MOD_LATS_1 47 53 PF00433 0.495
MOD_NEK2_1 127 132 PF00069 0.268
MOD_NEK2_1 133 138 PF00069 0.263
MOD_NEK2_1 234 239 PF00069 0.278
MOD_NEK2_1 253 258 PF00069 0.289
MOD_NEK2_2 222 227 PF00069 0.475
MOD_NEK2_2 54 59 PF00069 0.495
MOD_PKA_1 356 362 PF00069 0.436
MOD_PKA_2 11 17 PF00069 0.517
MOD_PKA_2 311 317 PF00069 0.428
MOD_PKA_2 32 38 PF00069 0.428
MOD_PKA_2 383 389 PF00069 0.503
MOD_Plk_1 253 259 PF00069 0.295
MOD_Plk_1 27 33 PF00069 0.433
MOD_Plk_4 122 128 PF00069 0.289
MOD_Plk_4 133 139 PF00069 0.263
MOD_Plk_4 222 228 PF00069 0.515
MOD_Plk_4 253 259 PF00069 0.352
MOD_Plk_4 273 279 PF00069 0.142
MOD_ProDKin_1 3 9 PF00069 0.564
MOD_ProDKin_1 385 391 PF00069 0.491
TRG_DiLeu_BaEn_2 202 208 PF01217 0.495
TRG_ENDOCYTIC_2 231 234 PF00928 0.396
TRG_ENDOCYTIC_2 262 265 PF00928 0.228
TRG_ENDOCYTIC_2 304 307 PF00928 0.428
TRG_ENDOCYTIC_2 348 351 PF00928 0.495
TRG_ER_diArg_1 104 106 PF00400 0.608
TRG_ER_diArg_1 351 353 PF00400 0.491
TRG_NES_CRM1_1 65 79 PF08389 0.578
TRG_NLS_MonoExtN_4 66 72 PF00514 0.531
TRG_Pf-PMV_PEXEL_1 105 109 PF00026 0.352

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0C5PRW9 Tachysurus fulvidraco 26% 89%
A0A0N1HZP4 Leptomonas seymouri 25% 95%
A0A0N1IMB2 Leptomonas seymouri 82% 98%
A0A0N1PAQ6 Leptomonas seymouri 25% 94%
A0A0S4IVF3 Bodo saltans 24% 92%
A0A0S4KLP1 Bodo saltans 55% 100%
A0A1X0NMZ1 Trypanosomatidae 66% 100%
A0A1X0NPK3 Trypanosomatidae 22% 94%
A0A3Q8I9Z6 Leishmania donovani 25% 95%
A0A3Q8IK71 Leishmania donovani 99% 100%
A0A3S5H618 Leishmania donovani 24% 94%
A0A422NCE1 Trypanosoma rangeli 22% 92%
A0PJ29 Rebecca salina 22% 88%
A4FV48 Bos taurus 25% 89%
A4H558 Leishmania braziliensis 23% 100%
A4H7V4 Leishmania braziliensis 21% 100%
A4HQL7 Leishmania braziliensis 90% 100%
A4HTD5 Leishmania infantum 24% 100%
A4HW80 Leishmania infantum 25% 100%
A4IFP3 Bos taurus 25% 89%
A4KDP0 Rebecca salina 26% 93%
A4KDP1 Rebecca salina 26% 92%
A4UVI1 Papio anubis 26% 89%
A8MWK0 Homo sapiens 23% 82%
A9SIZ6 Physcomitrium patens 22% 82%
B2KKL4 Siganus canaliculatus 25% 89%
B8R1K0 Papio anubis 24% 89%
C4QVU3 Komagataella phaffii (strain GS115 / ATCC 20864) 21% 73%
D8X2C5 Siganus canaliculatus 26% 89%
E9ALC8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
E9APY2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 100%
E9AUD2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
G5EG11 Caenorhabditis elegans 29% 88%
I2CYZ4 Chlamydomonas reinhardtii 24% 76%
O04353 Borago officinalis 25% 88%
O60427 Homo sapiens 27% 89%
O95864 Homo sapiens 24% 89%
P19967 Drosophila melanogaster 24% 90%
Q08871 Synechocystis sp. (strain PCC 6803 / Kazusa) 25% 100%
Q0VAX3 Mus musculus 25% 81%
Q23221 Caenorhabditis elegans 27% 89%
Q3EBF7 Arabidopsis thaliana 25% 88%
Q43469 Helianthus annuus 27% 86%
Q4Q058 Leishmania major 97% 100%
Q4QFK0 Leishmania major 24% 100%
Q4QIH7 Leishmania major 24% 100%
Q4R749 Macaca fascicularis 24% 89%
Q5REA7 Pongo abelii 23% 89%
Q6CMK7 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 20% 69%
Q6DDK2 Xenopus laevis 25% 88%
Q8K1P9 Rattus norvegicus 26% 88%
Q8NKG9 Lachancea kluyveri (strain ATCC 58438 / CBS 3082 / BCRC 21498 / NBRC 1685 / JCM 7257 / NCYC 543 / NRRL Y-12651) 21% 69%
Q8S3C1 Thraustochytrium sp. 21% 90%
Q920L1 Mus musculus 26% 88%
Q920R3 Rattus norvegicus 25% 88%
Q9DEX7 Danio rerio 23% 89%
Q9FR82 Borago officinalis 27% 88%
Q9JJE7 Mus musculus 26% 88%
Q9LEM9 Ceratodon purpureus 29% 76%
Q9LEN0 Ceratodon purpureus 27% 82%
Q9SWQ9 Euglena gracilis 30% 94%
Q9Y1W0 Dictyostelium discoideum 21% 85%
Q9Y5Q0 Homo sapiens 26% 89%
Q9Z0R9 Mus musculus 24% 89%
Q9Z122 Rattus norvegicus 24% 89%
Q9ZNW2 Physcomitrium patens 27% 75%
Q9ZRP7 Arabidopsis thaliana 24% 88%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS