Integral membrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

E9AI06_LEIIN

TriTrypDb:

LINF_360079200

Length:

273

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

E9AI06

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AI06

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	165	167	PF00675	0.311
CLV_NRD_NRD_1	254	256	PF00675	0.415
CLV_PCSK_FUR_1	131	135	PF00082	0.396
CLV_PCSK_KEX2_1	111	113	PF00082	0.414
CLV_PCSK_KEX2_1	125	127	PF00082	0.245
CLV_PCSK_KEX2_1	133	135	PF00082	0.369
CLV_PCSK_KEX2_1	216	218	PF00082	0.309
CLV_PCSK_KEX2_1	254	256	PF00082	0.412
CLV_PCSK_PC1ET2_1	111	113	PF00082	0.461
CLV_PCSK_PC1ET2_1	125	127	PF00082	0.240
CLV_PCSK_PC1ET2_1	133	135	PF00082	0.378
CLV_PCSK_PC1ET2_1	216	218	PF00082	0.389
CLV_PCSK_SKI1_1	133	137	PF00082	0.391
CLV_PCSK_SKI1_1	177	181	PF00082	0.394
CLV_PCSK_SKI1_1	200	204	PF00082	0.311
CLV_PCSK_SKI1_1	216	220	PF00082	0.370
CLV_PCSK_SKI1_1	74	78	PF00082	0.465
DEG_APCC_DBOX_1	57	65	PF00400	0.370
DEG_APCC_DBOX_1	73	81	PF00400	0.266
DOC_CKS1_1	201	206	PF01111	0.522
DOC_MAPK_gen_1	216	224	PF00069	0.495
DOC_MAPK_gen_1	233	242	PF00069	0.532
DOC_MAPK_gen_1	58	66	PF00069	0.379
DOC_MAPK_HePTP_8	230	242	PF00069	0.539
DOC_MAPK_MEF2A_6	216	224	PF00069	0.501
DOC_MAPK_MEF2A_6	233	242	PF00069	0.615
DOC_PP1_RVXF_1	227	233	PF00149	0.561
DOC_USP7_MATH_1	28	32	PF00917	0.379
DOC_USP7_MATH_1	6	10	PF00917	0.516
DOC_USP7_UBL2_3	260	264	PF12436	0.591
DOC_WW_Pin1_4	2	7	PF00397	0.467
DOC_WW_Pin1_4	200	205	PF00397	0.499
LIG_14-3-3_CanoR_1	112	121	PF00244	0.521
LIG_14-3-3_CanoR_1	217	221	PF00244	0.545
LIG_14-3-3_CanoR_1	27	36	PF00244	0.494
LIG_14-3-3_CanoR_1	99	105	PF00244	0.523
LIG_Actin_RPEL_3	51	70	PF02755	0.389
LIG_BIR_II_1	1	5	PF00653	0.540
LIG_deltaCOP1_diTrp_1	188	194	PF00928	0.514
LIG_eIF4E_1	201	207	PF01652	0.584
LIG_FHA_1	201	207	PF00498	0.521
LIG_FHA_1	217	223	PF00498	0.549
LIG_FHA_1	33	39	PF00498	0.493
LIG_FHA_1	5	11	PF00498	0.382
LIG_FHA_2	243	249	PF00498	0.633
LIG_LIR_Apic_2	198	204	PF02991	0.497
LIG_LIR_Apic_2	44	50	PF02991	0.323
LIG_LIR_Nem_3	103	109	PF02991	0.619
LIG_LIR_Nem_3	169	174	PF02991	0.576
LIG_LIR_Nem_3	245	249	PF02991	0.538
LIG_LIR_Nem_3	65	69	PF02991	0.358
LIG_NRBOX	37	43	PF00104	0.431
LIG_Pex14_1	190	194	PF04695	0.507
LIG_Pex14_2	207	211	PF04695	0.587
LIG_REV1ctd_RIR_1	240	248	PF16727	0.562
LIG_SH2_CRK	78	82	PF00017	0.379
LIG_SH2_PTP2	201	204	PF00017	0.574
LIG_SH2_STAP1	115	119	PF00017	0.543
LIG_SH2_STAP1	78	82	PF00017	0.362
LIG_SH2_STAT3	110	113	PF00017	0.588
LIG_SH2_STAT3	121	124	PF00017	0.478
LIG_SH2_STAT5	171	174	PF00017	0.493
LIG_SH2_STAT5	201	204	PF00017	0.507
LIG_SH2_STAT5	209	212	PF00017	0.501
LIG_SH2_STAT5	63	66	PF00017	0.418
LIG_SH3_3	158	164	PF00018	0.517
LIG_SH3_3	255	261	PF00018	0.595
LIG_SH3_3	66	72	PF00018	0.339
LIG_SH3_4	260	267	PF00018	0.602
LIG_TYR_ITSM	167	174	PF00017	0.483
MOD_CK1_1	31	37	PF00069	0.629
MOD_CK1_1	4	10	PF00069	0.654
MOD_CK2_1	242	248	PF00069	0.503
MOD_GlcNHglycan	30	33	PF01048	0.655
MOD_GSK3_1	1	8	PF00069	0.692
MOD_GSK3_1	28	35	PF00069	0.652
MOD_GSK3_1	50	57	PF00069	0.519
MOD_LATS_1	52	58	PF00433	0.431
MOD_N-GLC_1	256	261	PF02516	0.533
MOD_NEK2_1	1	6	PF00069	0.616
MOD_NEK2_1	242	247	PF00069	0.424
MOD_NEK2_1	76	81	PF00069	0.424
MOD_PIKK_1	135	141	PF00454	0.527
MOD_PKA_1	166	172	PF00069	0.329
MOD_PKA_1	216	222	PF00069	0.430
MOD_PKA_2	113	119	PF00069	0.442
MOD_PKA_2	216	222	PF00069	0.430
MOD_PKA_2	98	104	PF00069	0.553
MOD_Plk_1	32	38	PF00069	0.609
MOD_Plk_4	76	82	PF00069	0.416
MOD_ProDKin_1	2	8	PF00069	0.592
MOD_ProDKin_1	200	206	PF00069	0.364
MOD_SUMO_for_1	179	182	PF00179	0.482
TRG_ENDOCYTIC_2	171	174	PF00928	0.336
TRG_ENDOCYTIC_2	63	66	PF00928	0.526
TRG_ENDOCYTIC_2	78	81	PF00928	0.281
TRG_ER_diArg_1	112	115	PF00400	0.528
TRG_ER_diArg_1	253	255	PF00400	0.528
TRG_NLS_MonoExtN_4	108	115	PF00514	0.518
TRG_Pf-PMV_PEXEL_1	134	139	PF00026	0.441

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFV7	Leptomonas seymouri	78%	100%
A0A0S4JY76	Bodo saltans	51%	100%
A0A1X0NLD5	Trypanosomatidae	70%	100%
A0A3Q8II78	Leishmania donovani	100%	100%
A4HQJ6	Leishmania braziliensis	90%	100%
D0A3P5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	100%
E9AUA9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q081	Leishmania major	95%	100%
V5BHN0	Trypanosoma cruzi	66%	100%