Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

E9AHZ4_LEIIN

TriTrypDb:

LINF_360077900

Length:

408

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9AHZ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHZ4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	327	329	PF00675	0.445
CLV_NRD_NRD_1	388	390	PF00675	0.470
CLV_NRD_NRD_1	74	76	PF00675	0.378
CLV_PCSK_KEX2_1	327	329	PF00082	0.445
CLV_PCSK_KEX2_1	388	390	PF00082	0.470
CLV_PCSK_KEX2_1	74	76	PF00082	0.400
DOC_CDC14_PxL_1	359	367	PF14671	0.562
DOC_CYCLIN_yCln2_LP_2	148	154	PF00134	0.424
DOC_MAPK_gen_1	191	198	PF00069	0.679
DOC_MAPK_gen_1	74	82	PF00069	0.645
DOC_MAPK_HePTP_8	72	84	PF00069	0.521
DOC_MAPK_MEF2A_6	341	348	PF00069	0.346
DOC_MAPK_MEF2A_6	74	82	PF00069	0.686
DOC_MAPK_RevD_3	374	389	PF00069	0.501
DOC_PP4_FxxP_1	142	145	PF00568	0.451
DOC_WW_Pin1_4	228	233	PF00397	0.572
LIG_14-3-3_CanoR_1	191	196	PF00244	0.638
LIG_14-3-3_CanoR_1	23	29	PF00244	0.620
LIG_14-3-3_CanoR_1	327	336	PF00244	0.694
LIG_14-3-3_CanoR_1	341	347	PF00244	0.332
LIG_14-3-3_CanoR_1	54	64	PF00244	0.351
LIG_14-3-3_CanoR_1	91	97	PF00244	0.657
LIG_Actin_WH2_2	283	298	PF00022	0.556
LIG_Actin_WH2_2	58	76	PF00022	0.440
LIG_BRCT_BRCA1_1	198	202	PF00533	0.501
LIG_EH_1	180	184	PF12763	0.697
LIG_EH1_1	107	115	PF00400	0.287
LIG_EH1_1	211	219	PF00400	0.424
LIG_FHA_1	110	116	PF00498	0.320
LIG_FHA_1	203	209	PF00498	0.320
LIG_FHA_1	300	306	PF00498	0.429
LIG_FHA_1	312	318	PF00498	0.355
LIG_FHA_1	341	347	PF00498	0.386
LIG_FHA_1	400	406	PF00498	0.723
LIG_FHA_1	57	63	PF00498	0.445
LIG_FHA_1	9	15	PF00498	0.718
LIG_FHA_1	95	101	PF00498	0.679
LIG_GBD_Chelix_1	365	373	PF00786	0.542
LIG_LIR_Gen_1	194	203	PF02991	0.535
LIG_LIR_Gen_1	255	263	PF02991	0.447
LIG_LIR_Gen_1	284	295	PF02991	0.607
LIG_LIR_Gen_1	3	12	PF02991	0.709
LIG_LIR_Gen_1	354	364	PF02991	0.458
LIG_LIR_LC3C_4	112	115	PF02991	0.397
LIG_LIR_Nem_3	106	110	PF02991	0.406
LIG_LIR_Nem_3	194	198	PF02991	0.641
LIG_LIR_Nem_3	199	204	PF02991	0.305
LIG_LIR_Nem_3	20	25	PF02991	0.512
LIG_LIR_Nem_3	255	259	PF02991	0.462
LIG_LIR_Nem_3	273	279	PF02991	0.595
LIG_LIR_Nem_3	284	290	PF02991	0.508
LIG_LIR_Nem_3	3	7	PF02991	0.708
LIG_LIR_Nem_3	354	359	PF02991	0.458
LIG_NRBOX	368	374	PF00104	0.490
LIG_PDZ_Class_2	403	408	PF00595	0.691
LIG_Pex14_2	243	247	PF04695	0.404
LIG_SH2_NCK_1	89	93	PF00017	0.702
LIG_SH2_PTP2	41	44	PF00017	0.501
LIG_SH2_SRC	41	44	PF00017	0.445
LIG_SH2_STAP1	137	141	PF00017	0.497
LIG_SH2_STAT5	125	128	PF00017	0.428
LIG_SH2_STAT5	130	133	PF00017	0.489
LIG_SH2_STAT5	234	237	PF00017	0.534
LIG_SH2_STAT5	24	27	PF00017	0.647
LIG_SH2_STAT5	311	314	PF00017	0.440
LIG_SH2_STAT5	41	44	PF00017	0.504
LIG_SH3_3	115	121	PF00018	0.430
LIG_SH3_3	170	176	PF00018	0.372
LIG_SH3_3	182	188	PF00018	0.596
LIG_SUMO_SIM_anti_2	112	117	PF11976	0.399
LIG_SUMO_SIM_anti_2	205	210	PF11976	0.406
LIG_SUMO_SIM_anti_2	345	350	PF11976	0.377
LIG_SUMO_SIM_par_1	301	307	PF11976	0.414
LIG_SUMO_SIM_par_1	343	350	PF11976	0.466
LIG_TRFH_1	277	281	PF08558	0.658
LIG_TYR_ITIM	274	279	PF00017	0.687
LIG_TYR_ITIM	39	44	PF00017	0.482
LIG_WRC_WIRS_1	1	6	PF05994	0.725
MOD_CK1_1	255	261	PF00069	0.424
MOD_CK1_1	3	9	PF00069	0.706
MOD_CK1_1	358	364	PF00069	0.530
MOD_CK1_1	399	405	PF00069	0.718
MOD_GlcNHglycan	19	22	PF01048	0.415
MOD_GlcNHglycan	237	240	PF01048	0.729
MOD_GlcNHglycan	396	399	PF01048	0.551
MOD_GlcNHglycan	92	95	PF01048	0.430
MOD_GSK3_1	223	230	PF00069	0.471
MOD_GSK3_1	24	31	PF00069	0.534
MOD_GSK3_1	295	302	PF00069	0.408
MOD_GSK3_1	347	354	PF00069	0.368
MOD_GSK3_1	8	15	PF00069	0.690
MOD_GSK3_1	90	97	PF00069	0.683
MOD_N-GLC_1	56	61	PF02516	0.424
MOD_NEK2_1	295	300	PF00069	0.397
MOD_NEK2_1	304	309	PF00069	0.372
MOD_NEK2_1	322	327	PF00069	0.233
MOD_NEK2_1	394	399	PF00069	0.667
MOD_NEK2_1	68	73	PF00069	0.387
MOD_NEK2_2	351	356	PF00069	0.419
MOD_PKA_1	327	333	PF00069	0.625
MOD_PKA_2	327	333	PF00069	0.688
MOD_PKA_2	340	346	PF00069	0.526
MOD_PKA_2	90	96	PF00069	0.682
MOD_Plk_1	56	62	PF00069	0.424
MOD_Plk_4	103	109	PF00069	0.590
MOD_Plk_4	144	150	PF00069	0.378
MOD_Plk_4	197	203	PF00069	0.397
MOD_Plk_4	252	258	PF00069	0.430
MOD_Plk_4	28	34	PF00069	0.411
MOD_Plk_4	299	305	PF00069	0.426
MOD_Plk_4	342	348	PF00069	0.303
MOD_Plk_4	68	74	PF00069	0.397
MOD_ProDKin_1	228	234	PF00069	0.573
TRG_DiLeu_BaLyEn_6	213	218	PF01217	0.485
TRG_DiLeu_BaLyEn_6	264	269	PF01217	0.653
TRG_DiLeu_BaLyEn_6	95	100	PF01217	0.752
TRG_ENDOCYTIC_2	180	183	PF00928	0.702
TRG_ENDOCYTIC_2	276	279	PF00928	0.720
TRG_ENDOCYTIC_2	41	44	PF00928	0.482
TRG_ENDOCYTIC_2	89	92	PF00928	0.697
TRG_ER_diArg_1	326	328	PF00400	0.637
TRG_ER_diArg_1	388	390	PF00400	0.672
TRG_ER_diArg_1	73	75	PF00400	0.494
TRG_Pf-PMV_PEXEL_1	216	221	PF00026	0.659

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I240	Leptomonas seymouri	49%	100%
A0A1X0NN35	Trypanosomatidae	23%	100%
A0A3S7XCE6	Leishmania donovani	100%	100%
A4HQI5	Leishmania braziliensis	74%	100%
E9AU98	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q093	Leishmania major	91%	100%