LeishMANIAdb
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ZZ-type domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
ZZ-type domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
E9AHZ2_LEIIN
TriTrypDb:
LINF_360077700
Length:
751

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AHZ2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHZ2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 109 113 PF00656 0.480
CLV_C14_Caspase3-7 506 510 PF00656 0.671
CLV_NRD_NRD_1 155 157 PF00675 0.523
CLV_PCSK_SKI1_1 336 340 PF00082 0.488
CLV_PCSK_SKI1_1 451 455 PF00082 0.467
CLV_PCSK_SKI1_1 619 623 PF00082 0.452
CLV_Separin_Metazoa 637 641 PF03568 0.536
DEG_APCC_DBOX_1 330 338 PF00400 0.532
DEG_APCC_DBOX_1 356 364 PF00400 0.513
DEG_SCF_FBW7_1 693 700 PF00400 0.731
DEG_SCF_SKP2-CKS1_1 692 699 PF00560 0.664
DOC_CDC14_PxL_1 196 204 PF14671 0.457
DOC_CDC14_PxL_1 638 646 PF14671 0.554
DOC_CKS1_1 685 690 PF01111 0.638
DOC_CYCLIN_RxL_1 296 307 PF00134 0.484
DOC_CYCLIN_RxL_1 596 606 PF00134 0.466
DOC_MAPK_DCC_7 213 221 PF00069 0.517
DOC_MAPK_gen_1 331 339 PF00069 0.500
DOC_MAPK_gen_1 354 362 PF00069 0.475
DOC_MAPK_gen_1 396 404 PF00069 0.469
DOC_MAPK_MEF2A_6 333 341 PF00069 0.495
DOC_MAPK_MEF2A_6 354 362 PF00069 0.493
DOC_PP2B_LxvP_1 315 318 PF13499 0.448
DOC_PP2B_LxvP_1 608 611 PF13499 0.542
DOC_PP2B_LxvP_1 622 625 PF13499 0.433
DOC_PP4_FxxP_1 477 480 PF00568 0.524
DOC_USP7_MATH_1 141 145 PF00917 0.586
DOC_USP7_MATH_1 535 539 PF00917 0.522
DOC_USP7_MATH_1 697 701 PF00917 0.726
DOC_USP7_MATH_1 745 749 PF00917 0.744
DOC_WW_Pin1_4 139 144 PF00397 0.563
DOC_WW_Pin1_4 42 47 PF00397 0.557
DOC_WW_Pin1_4 458 463 PF00397 0.510
DOC_WW_Pin1_4 489 494 PF00397 0.741
DOC_WW_Pin1_4 514 519 PF00397 0.575
DOC_WW_Pin1_4 684 689 PF00397 0.544
DOC_WW_Pin1_4 693 698 PF00397 0.577
DOC_WW_Pin1_4 708 713 PF00397 0.605
DOC_WW_Pin1_4 93 98 PF00397 0.536
LIG_14-3-3_CanoR_1 23 28 PF00244 0.523
LIG_14-3-3_CanoR_1 281 287 PF00244 0.497
LIG_14-3-3_CanoR_1 336 342 PF00244 0.463
LIG_14-3-3_CanoR_1 396 402 PF00244 0.534
LIG_14-3-3_CanoR_1 669 679 PF00244 0.518
LIG_APCC_ABBAyCdc20_2 399 405 PF00400 0.577
LIG_BIR_II_1 1 5 PF00653 0.662
LIG_BRCT_BRCA1_1 378 382 PF00533 0.477
LIG_FAT_LD_1 449 457 PF03623 0.535
LIG_FHA_1 202 208 PF00498 0.475
LIG_FHA_1 232 238 PF00498 0.488
LIG_FHA_1 275 281 PF00498 0.514
LIG_FHA_1 585 591 PF00498 0.435
LIG_FHA_2 107 113 PF00498 0.548
LIG_FHA_2 180 186 PF00498 0.514
LIG_FHA_2 212 218 PF00498 0.557
LIG_FHA_2 338 344 PF00498 0.533
LIG_FHA_2 354 360 PF00498 0.412
LIG_FHA_2 386 392 PF00498 0.486
LIG_FHA_2 504 510 PF00498 0.658
LIG_LIR_Apic_2 474 480 PF02991 0.410
LIG_LIR_Gen_1 223 232 PF02991 0.455
LIG_LIR_Gen_1 284 294 PF02991 0.478
LIG_LIR_Gen_1 400 409 PF02991 0.551
LIG_LIR_Gen_1 516 527 PF02991 0.438
LIG_LIR_Gen_1 605 614 PF02991 0.531
LIG_LIR_Gen_1 646 656 PF02991 0.516
LIG_LIR_Nem_3 117 123 PF02991 0.402
LIG_LIR_Nem_3 187 192 PF02991 0.377
LIG_LIR_Nem_3 223 227 PF02991 0.385
LIG_LIR_Nem_3 284 289 PF02991 0.487
LIG_LIR_Nem_3 400 404 PF02991 0.577
LIG_LIR_Nem_3 516 522 PF02991 0.519
LIG_LIR_Nem_3 605 610 PF02991 0.538
LIG_LIR_Nem_3 646 652 PF02991 0.470
LIG_LYPXL_S_1 198 202 PF13949 0.456
LIG_LYPXL_SIV_4 188 196 PF13949 0.383
LIG_LYPXL_yS_3 199 202 PF13949 0.417
LIG_LYPXL_yS_3 641 644 PF13949 0.552
LIG_NRBOX 171 177 PF00104 0.457
LIG_NRBOX 448 454 PF00104 0.533
LIG_NRBOX 616 622 PF00104 0.520
LIG_PCNA_yPIPBox_3 669 679 PF02747 0.518
LIG_Pex14_2 227 231 PF04695 0.475
LIG_Rb_pABgroove_1 167 175 PF01858 0.531
LIG_SH2_CRK 173 177 PF00017 0.494
LIG_SH2_CRK 189 193 PF00017 0.243
LIG_SH2_CRK 519 523 PF00017 0.494
LIG_SH2_CRK 525 529 PF00017 0.530
LIG_SH2_CRK 649 653 PF00017 0.468
LIG_SH2_GRB2like 713 716 PF00017 0.754
LIG_SH2_NCK_1 473 477 PF00017 0.475
LIG_SH2_SRC 465 468 PF00017 0.505
LIG_SH2_SRC 678 681 PF00017 0.566
LIG_SH2_SRC 77 80 PF00017 0.616
LIG_SH2_STAP1 473 477 PF00017 0.475
LIG_SH2_STAP1 649 653 PF00017 0.393
LIG_SH2_STAT5 224 227 PF00017 0.370
LIG_SH2_STAT5 288 291 PF00017 0.469
LIG_SH2_STAT5 401 404 PF00017 0.613
LIG_SH2_STAT5 432 435 PF00017 0.521
LIG_SH2_STAT5 465 468 PF00017 0.473
LIG_SH2_STAT5 539 542 PF00017 0.486
LIG_SH2_STAT5 559 562 PF00017 0.196
LIG_SH2_STAT5 607 610 PF00017 0.536
LIG_SH2_STAT5 678 681 PF00017 0.404
LIG_SH2_STAT5 692 695 PF00017 0.607
LIG_SH2_STAT5 713 716 PF00017 0.724
LIG_SH3_3 194 200 PF00018 0.437
LIG_SH3_3 277 283 PF00018 0.508
LIG_SH3_3 359 365 PF00018 0.509
LIG_SH3_3 40 46 PF00018 0.543
LIG_SH3_3 529 535 PF00018 0.505
LIG_SH3_3 549 555 PF00018 0.264
LIG_SH3_3 576 582 PF00018 0.602
LIG_SH3_3 636 642 PF00018 0.518
LIG_SH3_3 682 688 PF00018 0.586
LIG_SH3_5 73 77 PF00018 0.555
LIG_SUMO_SIM_anti_2 359 364 PF11976 0.503
LIG_SUMO_SIM_anti_2 391 396 PF11976 0.488
LIG_SUMO_SIM_anti_2 405 411 PF11976 0.309
LIG_SUMO_SIM_anti_2 587 595 PF11976 0.491
LIG_SUMO_SIM_par_1 599 606 PF11976 0.503
LIG_TRAF2_1 57 60 PF00917 0.558
LIG_TRAF2_1 748 751 PF00917 0.711
LIG_TRFH_1 93 97 PF08558 0.577
LIG_TYR_ITIM 171 176 PF00017 0.517
LIG_TYR_ITIM 197 202 PF00017 0.419
LIG_TYR_ITIM 639 644 PF00017 0.518
LIG_TYR_ITIM 647 652 PF00017 0.480
LIG_UBA3_1 448 454 PF00899 0.474
LIG_WW_2 579 582 PF00397 0.614
MOD_CDK_SPxK_1 684 690 PF00069 0.573
MOD_CDK_SPxK_1 693 699 PF00069 0.599
MOD_CK1_1 114 120 PF00069 0.557
MOD_CK1_1 32 38 PF00069 0.533
MOD_CK1_1 538 544 PF00069 0.550
MOD_CK1_1 643 649 PF00069 0.540
MOD_CK1_1 711 717 PF00069 0.746
MOD_CK2_1 179 185 PF00069 0.540
MOD_CK2_1 200 206 PF00069 0.434
MOD_CK2_1 385 391 PF00069 0.437
MOD_CK2_1 42 48 PF00069 0.475
MOD_CK2_1 54 60 PF00069 0.442
MOD_CK2_1 544 550 PF00069 0.375
MOD_CK2_1 588 594 PF00069 0.475
MOD_CK2_1 745 751 PF00069 0.712
MOD_GlcNHglycan 124 127 PF01048 0.497
MOD_GlcNHglycan 14 19 PF01048 0.466
MOD_GlcNHglycan 163 166 PF01048 0.559
MOD_GlcNHglycan 193 196 PF01048 0.466
MOD_GlcNHglycan 444 447 PF01048 0.545
MOD_GlcNHglycan 529 532 PF01048 0.572
MOD_GlcNHglycan 540 543 PF01048 0.521
MOD_GlcNHglycan 546 549 PF01048 0.491
MOD_GlcNHglycan 573 576 PF01048 0.734
MOD_GlcNHglycan 708 711 PF01048 0.721
MOD_GlcNHglycan 719 722 PF01048 0.677
MOD_GSK3_1 339 346 PF00069 0.431
MOD_GSK3_1 454 461 PF00069 0.463
MOD_GSK3_1 584 591 PF00069 0.526
MOD_GSK3_1 693 700 PF00069 0.722
MOD_GSK3_1 713 720 PF00069 0.643
MOD_GSK3_1 89 96 PF00069 0.526
MOD_N-GLC_1 129 134 PF02516 0.516
MOD_N-GLC_1 714 719 PF02516 0.756
MOD_N-GLC_2 416 418 PF02516 0.582
MOD_NEK2_1 231 236 PF00069 0.460
MOD_NEK2_1 274 279 PF00069 0.485
MOD_NEK2_1 337 342 PF00069 0.461
MOD_NEK2_1 419 424 PF00069 0.500
MOD_NEK2_1 456 461 PF00069 0.495
MOD_NEK2_1 602 607 PF00069 0.543
MOD_NEK2_1 706 711 PF00069 0.714
MOD_PIKK_1 419 425 PF00454 0.384
MOD_PIKK_1 456 462 PF00454 0.487
MOD_PK_1 23 29 PF00069 0.526
MOD_PK_1 54 60 PF00069 0.476
MOD_PKA_1 513 519 PF00069 0.547
MOD_PKA_2 353 359 PF00069 0.553
MOD_PKB_1 87 95 PF00069 0.522
MOD_Plk_1 129 135 PF00069 0.521
MOD_Plk_1 673 679 PF00069 0.514
MOD_Plk_1 714 720 PF00069 0.728
MOD_Plk_1 89 95 PF00069 0.596
MOD_Plk_4 318 324 PF00069 0.529
MOD_Plk_4 588 594 PF00069 0.540
MOD_Plk_4 603 609 PF00069 0.398
MOD_Plk_4 719 725 PF00069 0.687
MOD_ProDKin_1 139 145 PF00069 0.555
MOD_ProDKin_1 42 48 PF00069 0.559
MOD_ProDKin_1 458 464 PF00069 0.501
MOD_ProDKin_1 489 495 PF00069 0.736
MOD_ProDKin_1 514 520 PF00069 0.565
MOD_ProDKin_1 684 690 PF00069 0.558
MOD_ProDKin_1 693 699 PF00069 0.577
MOD_ProDKin_1 708 714 PF00069 0.606
MOD_ProDKin_1 93 99 PF00069 0.531
TRG_DiLeu_BaEn_2 222 228 PF01217 0.474
TRG_DiLeu_BaEn_2 242 248 PF01217 0.248
TRG_DiLeu_BaLyEn_6 197 202 PF01217 0.344
TRG_DiLeu_BaLyEn_6 296 301 PF01217 0.464
TRG_DiLeu_BaLyEn_6 448 453 PF01217 0.336
TRG_DiLeu_BaLyEn_6 616 621 PF01217 0.519
TRG_DiLeu_BaLyEn_6 99 104 PF01217 0.495
TRG_ENDOCYTIC_2 120 123 PF00928 0.377
TRG_ENDOCYTIC_2 173 176 PF00928 0.485
TRG_ENDOCYTIC_2 189 192 PF00928 0.243
TRG_ENDOCYTIC_2 199 202 PF00928 0.344
TRG_ENDOCYTIC_2 224 227 PF00928 0.448
TRG_ENDOCYTIC_2 401 404 PF00928 0.580
TRG_ENDOCYTIC_2 519 522 PF00928 0.406
TRG_ENDOCYTIC_2 557 560 PF00928 0.479
TRG_ENDOCYTIC_2 607 610 PF00928 0.533
TRG_ENDOCYTIC_2 641 644 PF00928 0.411
TRG_ENDOCYTIC_2 649 652 PF00928 0.385
TRG_ER_diArg_1 331 334 PF00400 0.541
TRG_ER_diArg_1 480 483 PF00400 0.617
TRG_NES_CRM1_1 384 398 PF08389 0.495
TRG_Pf-PMV_PEXEL_1 156 161 PF00026 0.483
TRG_Pf-PMV_PEXEL_1 302 306 PF00026 0.531
TRG_Pf-PMV_PEXEL_1 454 458 PF00026 0.509
TRG_Pf-PMV_PEXEL_1 633 637 PF00026 0.412

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P7Z3 Leptomonas seymouri 68% 100%
A0A1X0NLV7 Trypanosomatidae 30% 100%
A0A3Q8IJH5 Leishmania donovani 100% 100%
A0A422NKF8 Trypanosoma rangeli 29% 100%
A4HQI3 Leishmania braziliensis 89% 100%
D0A3N2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
E9AU96 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
Q4Q095 Leishmania major 97% 100%
V5AXM1 Trypanosoma cruzi 31% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS