LeishMANIAdb
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NYD-SP28_assoc domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
NYD-SP28_assoc domain-containing protein
Gene product:
Sperm tail/Sperm tail C-terminal domain containing protein - putative
Species:
Leishmania infantum
UniProt:
E9AHZ1_LEIIN
TriTrypDb:
LINF_360077600
Length:
648

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005858 axonemal dynein complex 4 12
GO:0005875 microtubule associated complex 2 12
GO:0030286 dynein complex 3 12
GO:0032991 protein-containing complex 1 12
GO:1902494 catalytic complex 2 12
GO:0005930 axoneme 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9AHZ1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHZ1

Function

Biological processes
Term Name Level Count
GO:0009987 cellular process 1 12
GO:0016043 cellular component organization 3 12
GO:0022607 cellular component assembly 4 12
GO:0043933 protein-containing complex organization 4 12
GO:0065003 protein-containing complex assembly 5 12
GO:0070286 axonemal dynein complex assembly 6 12
GO:0071840 cellular component organization or biogenesis 2 12
GO:0001539 cilium or flagellum-dependent cell motility 3 1
GO:0003352 regulation of cilium movement 6 1
GO:0032886 regulation of microtubule-based process 4 1
GO:0048870 cell motility 2 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0060285 cilium-dependent cell motility 4 1
GO:0060632 regulation of microtubule-based movement 5 1
GO:0065007 biological regulation 1 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 100 104 PF00656 0.461
CLV_NRD_NRD_1 132 134 PF00675 0.261
CLV_NRD_NRD_1 205 207 PF00675 0.402
CLV_NRD_NRD_1 223 225 PF00675 0.297
CLV_NRD_NRD_1 230 232 PF00675 0.416
CLV_NRD_NRD_1 260 262 PF00675 0.588
CLV_NRD_NRD_1 557 559 PF00675 0.456
CLV_NRD_NRD_1 596 598 PF00675 0.221
CLV_NRD_NRD_1 82 84 PF00675 0.228
CLV_PCSK_KEX2_1 205 207 PF00082 0.460
CLV_PCSK_KEX2_1 223 225 PF00082 0.335
CLV_PCSK_KEX2_1 260 262 PF00082 0.407
CLV_PCSK_KEX2_1 332 334 PF00082 0.456
CLV_PCSK_KEX2_1 556 558 PF00082 0.507
CLV_PCSK_KEX2_1 82 84 PF00082 0.228
CLV_PCSK_PC1ET2_1 260 262 PF00082 0.407
CLV_PCSK_PC1ET2_1 332 334 PF00082 0.456
CLV_PCSK_PC1ET2_1 556 558 PF00082 0.601
CLV_PCSK_PC7_1 552 558 PF00082 0.517
CLV_PCSK_SKI1_1 145 149 PF00082 0.223
CLV_PCSK_SKI1_1 358 362 PF00082 0.557
CLV_PCSK_SKI1_1 48 52 PF00082 0.399
CLV_PCSK_SKI1_1 612 616 PF00082 0.265
CLV_PCSK_SKI1_1 635 639 PF00082 0.565
DEG_APCC_KENBOX_2 299 303 PF00400 0.423
DOC_CYCLIN_yCln2_LP_2 400 406 PF00134 0.379
DOC_MAPK_gen_1 143 150 PF00069 0.420
DOC_MAPK_gen_1 364 373 PF00069 0.498
DOC_MAPK_MEF2A_6 143 150 PF00069 0.420
DOC_MAPK_NFAT4_5 143 151 PF00069 0.370
DOC_PP1_SILK_1 446 451 PF00149 0.499
DOC_PP2B_LxvP_1 119 122 PF13499 0.477
DOC_PP2B_LxvP_1 400 403 PF13499 0.378
DOC_PP2B_LxvP_1 630 633 PF13499 0.441
DOC_USP7_MATH_1 430 434 PF00917 0.567
DOC_USP7_MATH_1 464 468 PF00917 0.506
DOC_USP7_MATH_1 63 67 PF00917 0.395
DOC_USP7_UBL2_3 217 221 PF12436 0.470
DOC_USP7_UBL2_3 365 369 PF12436 0.451
DOC_WW_Pin1_4 2 7 PF00397 0.613
DOC_WW_Pin1_4 642 647 PF00397 0.553
LIG_14-3-3_CanoR_1 180 187 PF00244 0.398
LIG_14-3-3_CanoR_1 261 270 PF00244 0.417
LIG_14-3-3_CanoR_1 287 291 PF00244 0.431
LIG_14-3-3_CanoR_1 489 497 PF00244 0.527
LIG_14-3-3_CanoR_1 635 643 PF00244 0.485
LIG_APCC_ABBA_1 109 114 PF00400 0.513
LIG_BIR_II_1 1 5 PF00653 0.576
LIG_BIR_III_2 3 7 PF00653 0.492
LIG_BIR_III_3 1 5 PF00653 0.576
LIG_CaM_IQ_9 191 207 PF13499 0.387
LIG_eIF4E_1 631 637 PF01652 0.487
LIG_FHA_1 189 195 PF00498 0.417
LIG_FHA_1 287 293 PF00498 0.595
LIG_FHA_1 340 346 PF00498 0.410
LIG_FHA_1 366 372 PF00498 0.556
LIG_FHA_1 482 488 PF00498 0.454
LIG_FHA_1 506 512 PF00498 0.453
LIG_FHA_1 602 608 PF00498 0.382
LIG_FHA_2 335 341 PF00498 0.489
LIG_FHA_2 469 475 PF00498 0.540
LIG_FHA_2 51 57 PF00498 0.539
LIG_FHA_2 536 542 PF00498 0.619
LIG_LIR_Apic_2 629 634 PF02991 0.496
LIG_LIR_Apic_2 642 646 PF02991 0.448
LIG_LIR_Gen_1 250 259 PF02991 0.420
LIG_LIR_Gen_1 368 376 PF02991 0.419
LIG_LIR_Nem_3 158 164 PF02991 0.513
LIG_LIR_Nem_3 250 256 PF02991 0.424
LIG_LIR_Nem_3 368 373 PF02991 0.390
LIG_LIR_Nem_3 498 502 PF02991 0.464
LIG_NRBOX 319 325 PF00104 0.519
LIG_PCNA_yPIPBox_3 310 324 PF02747 0.423
LIG_PCNA_yPIPBox_3 608 618 PF02747 0.421
LIG_SH2_CRK 631 635 PF00017 0.499
LIG_SH2_GRB2like 621 624 PF00017 0.484
LIG_SH2_NCK_1 643 647 PF00017 0.518
LIG_SH2_PTP2 161 164 PF00017 0.513
LIG_SH2_SRC 327 330 PF00017 0.372
LIG_SH2_SRC 631 634 PF00017 0.497
LIG_SH2_STAP1 190 194 PF00017 0.360
LIG_SH2_STAP1 396 400 PF00017 0.481
LIG_SH2_STAP1 55 59 PF00017 0.496
LIG_SH2_STAP1 628 632 PF00017 0.542
LIG_SH2_STAT3 186 189 PF00017 0.443
LIG_SH2_STAT3 230 233 PF00017 0.470
LIG_SH2_STAT3 290 293 PF00017 0.403
LIG_SH2_STAT3 590 593 PF00017 0.421
LIG_SH2_STAT5 161 164 PF00017 0.477
LIG_SH2_STAT5 186 189 PF00017 0.379
LIG_SH2_STAT5 190 193 PF00017 0.368
LIG_SH2_STAT5 208 211 PF00017 0.455
LIG_SH2_STAT5 281 284 PF00017 0.539
LIG_SH2_STAT5 352 355 PF00017 0.522
LIG_SH2_STAT5 370 373 PF00017 0.515
LIG_SH2_STAT5 499 502 PF00017 0.427
LIG_SH2_STAT5 524 527 PF00017 0.456
LIG_SH2_STAT5 590 593 PF00017 0.452
LIG_SH3_3 400 406 PF00018 0.379
LIG_SUMO_SIM_anti_2 505 513 PF11976 0.588
LIG_SUMO_SIM_par_1 146 152 PF11976 0.435
LIG_TRAF2_1 128 131 PF00917 0.488
LIG_TRAF2_1 413 416 PF00917 0.582
LIG_TRAF2_1 530 533 PF00917 0.485
LIG_TRAF2_1 6 9 PF00917 0.522
LIG_TYR_ITIM 394 399 PF00017 0.473
LIG_TYR_ITIM 497 502 PF00017 0.428
LIG_UBA3_1 444 450 PF00899 0.417
LIG_WRC_WIRS_1 359 364 PF05994 0.409
LIG_WW_3 632 636 PF00397 0.565
MOD_CK1_1 451 457 PF00069 0.460
MOD_CK1_1 642 648 PF00069 0.592
MOD_CK1_1 66 72 PF00069 0.333
MOD_CK2_1 248 254 PF00069 0.467
MOD_CK2_1 39 45 PF00069 0.592
MOD_CK2_1 468 474 PF00069 0.543
MOD_CK2_1 488 494 PF00069 0.267
MOD_CK2_1 50 56 PF00069 0.409
MOD_CK2_1 535 541 PF00069 0.564
MOD_CK2_1 641 647 PF00069 0.656
MOD_GlcNHglycan 250 253 PF01048 0.534
MOD_GlcNHglycan 623 626 PF01048 0.335
MOD_GlcNHglycan 65 68 PF01048 0.335
MOD_GlcNHglycan 98 102 PF01048 0.228
MOD_GSK3_1 175 182 PF00069 0.590
MOD_GSK3_1 444 451 PF00069 0.430
MOD_GSK3_1 464 471 PF00069 0.323
MOD_GSK3_1 535 542 PF00069 0.575
MOD_GSK3_1 599 606 PF00069 0.513
MOD_GSK3_1 635 642 PF00069 0.495
MOD_N-GLC_1 29 34 PF02516 0.592
MOD_N-GLC_1 487 492 PF02516 0.535
MOD_N-GLC_1 548 553 PF02516 0.590
MOD_N-GLC_1 63 68 PF02516 0.522
MOD_NEK2_1 175 180 PF00069 0.503
MOD_NEK2_1 219 224 PF00069 0.522
MOD_NEK2_1 274 279 PF00069 0.601
MOD_NEK2_1 316 321 PF00069 0.395
MOD_NEK2_1 334 339 PF00069 0.351
MOD_NEK2_1 444 449 PF00069 0.422
MOD_NEK2_1 456 461 PF00069 0.340
MOD_NEK2_1 568 573 PF00069 0.444
MOD_NEK2_1 641 646 PF00069 0.492
MOD_NEK2_1 96 101 PF00069 0.428
MOD_PIKK_1 352 358 PF00454 0.569
MOD_PIKK_1 448 454 PF00454 0.494
MOD_PIKK_1 585 591 PF00454 0.486
MOD_PIKK_1 635 641 PF00454 0.665
MOD_PIKK_1 77 83 PF00454 0.461
MOD_PKA_2 179 185 PF00069 0.453
MOD_PKA_2 222 228 PF00069 0.360
MOD_PKA_2 286 292 PF00069 0.431
MOD_PKA_2 488 494 PF00069 0.541
MOD_PKB_1 16 24 PF00069 0.495
MOD_Plk_1 170 176 PF00069 0.516
MOD_Plk_1 197 203 PF00069 0.415
MOD_Plk_1 505 511 PF00069 0.494
MOD_Plk_4 319 325 PF00069 0.377
MOD_Plk_4 451 457 PF00069 0.385
MOD_ProDKin_1 2 8 PF00069 0.607
MOD_ProDKin_1 642 648 PF00069 0.562
MOD_SUMO_rev_2 210 219 PF00179 0.451
MOD_SUMO_rev_2 229 239 PF00179 0.295
MOD_SUMO_rev_2 42 51 PF00179 0.557
MOD_SUMO_rev_2 526 536 PF00179 0.517
TRG_DiLeu_BaEn_1 135 140 PF01217 0.428
TRG_DiLeu_BaEn_1 160 165 PF01217 0.513
TRG_DiLeu_BaEn_1 171 176 PF01217 0.601
TRG_DiLeu_BaEn_1 215 220 PF01217 0.384
TRG_DiLeu_BaEn_1 507 512 PF01217 0.551
TRG_DiLeu_BaEn_1 613 618 PF01217 0.421
TRG_ENDOCYTIC_2 161 164 PF00928 0.513
TRG_ENDOCYTIC_2 253 256 PF00928 0.426
TRG_ENDOCYTIC_2 370 373 PF00928 0.487
TRG_ENDOCYTIC_2 396 399 PF00928 0.483
TRG_ENDOCYTIC_2 499 502 PF00928 0.427
TRG_ER_diArg_1 16 19 PF00400 0.472
TRG_NES_CRM1_1 137 152 PF08389 0.370

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IAH6 Leptomonas seymouri 69% 100%
A0A0S4J8E8 Bodo saltans 40% 100%
A0A1X0NL92 Trypanosomatidae 48% 100%
A0A3R7KG47 Trypanosoma rangeli 44% 99%
A0A3S7XCE4 Leishmania donovani 100% 100%
A4HQI2 Leishmania braziliensis 82% 100%
D0A3N0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 45% 100%
E9AU95 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
F1QRC1 Danio rerio 25% 97%
P0DL09 Chlamydomonas reinhardtii 27% 93%
Q32KY1 Bos taurus 25% 91%
Q3USS3 Mus musculus 26% 86%
Q4Q096 Leishmania major 95% 100%
Q5XI65 Rattus norvegicus 26% 86%
Q7T0Y4 Xenopus laevis 28% 94%
V5BD07 Trypanosoma cruzi 51% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS