Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Acyl CoA binding protein - putative

Species:

Leishmania infantum

UniProt:

E9AHY9_LEIIN

TriTrypDb:

LINF_360077300

Length:

324

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AHY9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHY9

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006629	lipid metabolic process	3	1
GO:0006631	fatty acid metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0032787	monocarboxylic acid metabolic process	6	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0000062	fatty-acyl-CoA binding	4	11
GO:0000166	nucleotide binding	3	11
GO:0005488	binding	1	11
GO:0008289	lipid binding	2	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0033218	amide binding	2	11
GO:0036094	small molecule binding	2	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0120227	acyl-CoA binding	3	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11
GO:1901567	fatty acid derivative binding	3	11
GO:1901681	sulfur compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	121	125	PF00082	0.656
CLV_PCSK_SKI1_1	211	215	PF00082	0.587
CLV_PCSK_SKI1_1	286	290	PF00082	0.727
CLV_PCSK_SKI1_1	34	38	PF00082	0.335
CLV_Separin_Metazoa	206	210	PF03568	0.526
DEG_Nend_UBRbox_2	1	3	PF02207	0.540
DOC_CYCLIN_RxL_1	209	221	PF00134	0.558
DOC_PP1_RVXF_1	32	38	PF00149	0.355
DOC_USP7_MATH_1	135	139	PF00917	0.723
DOC_USP7_MATH_1	140	144	PF00917	0.724
DOC_USP7_MATH_1	52	56	PF00917	0.378
DOC_WW_Pin1_4	131	136	PF00397	0.685
DOC_WW_Pin1_4	157	162	PF00397	0.737
DOC_WW_Pin1_4	169	174	PF00397	0.749
DOC_WW_Pin1_4	23	28	PF00397	0.535
DOC_WW_Pin1_4	245	250	PF00397	0.659
DOC_WW_Pin1_4	311	316	PF00397	0.709
LIG_14-3-3_CanoR_1	241	249	PF00244	0.597
LIG_14-3-3_CanoR_1	286	293	PF00244	0.735
LIG_BRCT_BRCA1_1	318	322	PF00533	0.647
LIG_eIF4E_1	202	208	PF01652	0.562
LIG_FHA_2	161	167	PF00498	0.680
LIG_FHA_2	90	96	PF00498	0.482
LIG_LIR_Gen_1	75	84	PF02991	0.335
LIG_LIR_Nem_3	7	12	PF02991	0.340
LIG_MYND_1	259	263	PF01753	0.698
LIG_Pex14_2	83	87	PF04695	0.408
LIG_PTB_Apo_2	196	203	PF02174	0.532
LIG_PTB_Phospho_1	196	202	PF10480	0.533
LIG_SH2_STAT5	15	18	PF00017	0.415
LIG_SH2_STAT5	19	22	PF00017	0.437
LIG_SH2_STAT5	202	205	PF00017	0.453
LIG_SH3_2	257	262	PF14604	0.540
LIG_SH3_3	111	117	PF00018	0.659
LIG_SH3_3	251	257	PF00018	0.600
LIG_SH3_3	272	278	PF00018	0.604
LIG_SH3_3	309	315	PF00018	0.744
LIG_TRAF2_1	164	167	PF00917	0.771
LIG_Vh1_VBS_1	189	207	PF01044	0.528
MOD_CDK_SPxxK_3	169	176	PF00069	0.542
MOD_CK1_1	134	140	PF00069	0.610
MOD_CK1_1	160	166	PF00069	0.711
MOD_CK1_1	172	178	PF00069	0.572
MOD_CK1_1	193	199	PF00069	0.578
MOD_CK1_1	221	227	PF00069	0.710
MOD_CK1_1	267	273	PF00069	0.733
MOD_CK1_1	284	290	PF00069	0.601
MOD_CK1_1	316	322	PF00069	0.709
MOD_CK2_1	160	166	PF00069	0.781
MOD_CK2_1	175	181	PF00069	0.549
MOD_CK2_1	221	227	PF00069	0.620
MOD_CK2_1	284	290	PF00069	0.722
MOD_CK2_1	72	78	PF00069	0.335
MOD_CK2_1	89	95	PF00069	0.442
MOD_CMANNOS	321	324	PF00535	0.580
MOD_DYRK1A_RPxSP_1	311	315	PF00069	0.657
MOD_GlcNHglycan	104	107	PF01048	0.694
MOD_GlcNHglycan	142	145	PF01048	0.765
MOD_GlcNHglycan	177	180	PF01048	0.621
MOD_GlcNHglycan	192	195	PF01048	0.583
MOD_GlcNHglycan	219	223	PF01048	0.592
MOD_GlcNHglycan	249	252	PF01048	0.767
MOD_GlcNHglycan	269	272	PF01048	0.575
MOD_GlcNHglycan	283	286	PF01048	0.585
MOD_GlcNHglycan	315	318	PF01048	0.737
MOD_GSK3_1	131	138	PF00069	0.600
MOD_GSK3_1	171	178	PF00069	0.629
MOD_GSK3_1	228	235	PF00069	0.721
MOD_GSK3_1	23	30	PF00069	0.529
MOD_GSK3_1	313	320	PF00069	0.715
MOD_GSK3_1	48	55	PF00069	0.369
MOD_N-GLC_1	228	233	PF02516	0.748
MOD_N-GLC_1	267	272	PF02516	0.670
MOD_N-GLC_1	95	100	PF02516	0.622
MOD_NEK2_1	1	6	PF00069	0.599
MOD_NEK2_1	218	223	PF00069	0.557
MOD_NEK2_1	94	99	PF00069	0.634
MOD_PIKK_1	89	95	PF00454	0.532
MOD_PKA_2	281	287	PF00069	0.685
MOD_PKA_2	293	299	PF00069	0.680
MOD_PKA_2	72	78	PF00069	0.434
MOD_Plk_1	1	7	PF00069	0.512
MOD_Plk_4	317	323	PF00069	0.684
MOD_Plk_4	52	58	PF00069	0.330
MOD_ProDKin_1	131	137	PF00069	0.684
MOD_ProDKin_1	157	163	PF00069	0.740
MOD_ProDKin_1	169	175	PF00069	0.742
MOD_ProDKin_1	23	29	PF00069	0.528
MOD_ProDKin_1	245	251	PF00069	0.658
MOD_ProDKin_1	311	317	PF00069	0.710
MOD_SUMO_rev_2	118	125	PF00179	0.619
TRG_DiLeu_BaEn_4	24	30	PF01217	0.480
TRG_DiLeu_LyEn_5	24	29	PF01217	0.533
TRG_ENDOCYTIC_2	9	12	PF00928	0.368
TRG_ER_diArg_1	208	211	PF00400	0.463
TRG_Pf-PMV_PEXEL_1	201	206	PF00026	0.497
TRG_Pf-PMV_PEXEL_1	215	219	PF00026	0.545

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMA6	Leptomonas seymouri	47%	100%
A0A1X0NL99	Trypanosomatidae	35%	100%
A0A3S7XC89	Leishmania donovani	98%	100%
A0A422P468	Trypanosoma rangeli	32%	100%
A4HQH9	Leishmania braziliensis	67%	100%
E9AU92	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q099	Leishmania major	91%	100%
V5A2D1	Trypanosoma cruzi	36%	100%
V5B4W0	Trypanosoma cruzi	37%	100%