LeishMANIAdb
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Glucose transporter, lmgt3

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Glucose transporter, lmgt3
Gene product:
glucose transporter 2
Species:
Leishmania infantum
UniProt:
E9AHY8_LEIIN
TriTrypDb:
LINF_360073200
Length:
367

Annotations

LeishMANIAdb annotations

Publication identifier(s): 30068561 23766511
These proteins are related to other Eukaryotic proton-coupled hexose transporters, but the family has extremely expanded in parazitic species.. Subcellular localization depends on the actual paralogue. In L. mexicana, the GT2 protein (E9AU63) is found on the cell membrane, GT3 (E9AU62) is largely located at the ER while GT1 (E9AU64) is flagellar.. Localization: ER (experimental) / Cell surface (experimental) / Flagellar (experimental)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 21
NetGPI no yes: 0, no: 21
Cellular components
Term Name Level Count
GO:0016020 membrane 2 22
GO:0110165 cellular anatomical entity 1 22

Expansion

Sequence features

E9AHY8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHY8

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 10
GO:0008643 carbohydrate transport 5 10
GO:0051179 localization 1 10
GO:0051234 establishment of localization 2 10
GO:0071702 organic substance transport 4 10
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 22
GO:0015144 carbohydrate transmembrane transporter activity 3 2
GO:0022857 transmembrane transporter activity 2 22

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 339 343 PF00656 0.594
CLV_PCSK_KEX2_1 340 342 PF00082 0.350
CLV_PCSK_KEX2_1 345 347 PF00082 0.392
CLV_PCSK_KEX2_1 45 47 PF00082 0.524
CLV_PCSK_PC1ET2_1 340 342 PF00082 0.310
CLV_PCSK_PC1ET2_1 345 347 PF00082 0.366
CLV_PCSK_PC1ET2_1 45 47 PF00082 0.524
CLV_PCSK_PC7_1 341 347 PF00082 0.342
CLV_PCSK_SKI1_1 202 206 PF00082 0.207
DEG_Nend_UBRbox_4 1 3 PF02207 0.299
DEG_ODPH_VHL_1 172 183 PF01847 0.256
DOC_CYCLIN_RxL_1 199 209 PF00134 0.492
DOC_MAPK_gen_1 43 52 PF00069 0.236
DOC_MAPK_HePTP_8 15 27 PF00069 0.416
DOC_MAPK_MEF2A_6 18 27 PF00069 0.291
DOC_MAPK_MEF2A_6 43 52 PF00069 0.255
DOC_MAPK_NFAT4_5 18 26 PF00069 0.354
DOC_PP4_FxxP_1 333 336 PF00568 0.279
DOC_SPAK_OSR1_1 18 22 PF12202 0.321
DOC_USP7_MATH_1 158 162 PF00917 0.126
DOC_USP7_MATH_1 226 230 PF00917 0.316
DOC_USP7_UBL2_3 231 235 PF12436 0.256
DOC_USP7_UBL2_3 340 344 PF12436 0.508
LIG_14-3-3_CanoR_1 273 278 PF00244 0.450
LIG_BRCT_BRCA1_1 195 199 PF00533 0.376
LIG_BRCT_BRCA1_1 357 361 PF00533 0.511
LIG_BRCT_BRCA1_1 72 76 PF00533 0.459
LIG_BRCT_BRCA1_1 94 98 PF00533 0.524
LIG_deltaCOP1_diTrp_1 10 19 PF00928 0.525
LIG_FHA_1 100 106 PF00498 0.500
LIG_FHA_1 148 154 PF00498 0.299
LIG_FHA_1 239 245 PF00498 0.336
LIG_FHA_1 279 285 PF00498 0.319
LIG_FHA_1 295 301 PF00498 0.219
LIG_FHA_1 45 51 PF00498 0.261
LIG_FHA_1 55 61 PF00498 0.214
LIG_LIR_Gen_1 10 20 PF02991 0.492
LIG_LIR_Gen_1 131 142 PF02991 0.446
LIG_LIR_Gen_1 276 285 PF02991 0.230
LIG_LIR_Gen_1 95 105 PF02991 0.451
LIG_LIR_Nem_3 131 135 PF02991 0.535
LIG_LIR_Nem_3 276 280 PF02991 0.324
LIG_LIR_Nem_3 8 14 PF02991 0.422
LIG_LIR_Nem_3 95 101 PF02991 0.437
LIG_LYPXL_S_1 224 228 PF13949 0.274
LIG_LYPXL_yS_3 225 228 PF13949 0.217
LIG_NRBOX 96 102 PF00104 0.498
LIG_Pex14_2 207 211 PF04695 0.321
LIG_Pex14_2 246 250 PF04695 0.241
LIG_Pex14_2 266 270 PF04695 0.293
LIG_Pex14_2 333 337 PF04695 0.323
LIG_Pex14_2 94 98 PF04695 0.515
LIG_PTB_Apo_2 287 294 PF02174 0.259
LIG_PTB_Phospho_1 287 293 PF10480 0.312
LIG_SH2_STAT3 35 38 PF00017 0.250
LIG_SH2_STAT5 134 137 PF00017 0.560
LIG_SH2_STAT5 197 200 PF00017 0.486
LIG_SH2_STAT5 259 262 PF00017 0.339
LIG_SH2_STAT5 35 38 PF00017 0.192
LIG_SH3_3 220 226 PF00018 0.247
LIG_SH3_3 27 33 PF00018 0.291
LIG_SH3_3 288 294 PF00018 0.282
LIG_SUMO_SIM_anti_2 99 105 PF11976 0.417
LIG_TRFH_1 332 336 PF08558 0.279
MOD_CK1_1 209 215 PF00069 0.352
MOD_CK1_1 229 235 PF00069 0.293
MOD_CK1_1 99 105 PF00069 0.480
MOD_CK2_1 2 8 PF00069 0.528
MOD_Cter_Amidation 342 345 PF01082 0.351
MOD_Cter_Amidation 352 355 PF01082 0.318
MOD_GlcNHglycan 300 303 PF01048 0.396
MOD_GlcNHglycan 304 307 PF01048 0.396
MOD_GlcNHglycan 356 360 PF01048 0.313
MOD_GSK3_1 147 154 PF00069 0.295
MOD_GSK3_1 158 165 PF00069 0.300
MOD_GSK3_1 185 192 PF00069 0.280
MOD_GSK3_1 193 200 PF00069 0.239
MOD_GSK3_1 206 213 PF00069 0.179
MOD_GSK3_1 294 301 PF00069 0.248
MOD_GSK3_1 92 99 PF00069 0.434
MOD_N-GLC_2 290 292 PF02516 0.338
MOD_NEK2_1 109 114 PF00069 0.430
MOD_NEK2_1 147 152 PF00069 0.299
MOD_NEK2_1 186 191 PF00069 0.311
MOD_NEK2_1 206 211 PF00069 0.168
MOD_NEK2_1 70 75 PF00069 0.444
MOD_NEK2_2 197 202 PF00069 0.472
MOD_NEK2_2 93 98 PF00069 0.492
MOD_PIKK_1 259 265 PF00454 0.312
MOD_PIKK_1 275 281 PF00454 0.272
MOD_PKB_1 271 279 PF00069 0.450
MOD_Plk_4 162 168 PF00069 0.235
MOD_Plk_4 193 199 PF00069 0.290
MOD_Plk_4 206 212 PF00069 0.233
MOD_Plk_4 70 76 PF00069 0.511
MOD_Plk_4 93 99 PF00069 0.405
TRG_AP2beta_CARGO_1 8 18 PF09066 0.508
TRG_DiLeu_BaEn_1 10 15 PF01217 0.524
TRG_DiLeu_BaLyEn_6 137 142 PF01217 0.507
TRG_ENDOCYTIC_2 132 135 PF00928 0.522
TRG_ENDOCYTIC_2 225 228 PF00928 0.217
TRG_ENDOCYTIC_2 258 261 PF00928 0.416
TRG_ER_diArg_1 270 273 PF00400 0.459
TRG_ER_diLys_1 364 367 PF00400 0.503
TRG_NLS_MonoExtN_4 341 348 PF00514 0.580

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0H2VG78 Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200) 24% 82%
A0A0N0P2E1 Leptomonas seymouri 58% 69%
A0A0N1P9H5 Leptomonas seymouri 47% 79%
A0A0S4JDF9 Bodo saltans 42% 71%
A0A0S4JEY7 Bodo saltans 43% 71%
A0A0S4JH90 Bodo saltans 37% 71%
A0A0S4JS00 Bodo saltans 35% 67%
A0A1X0NKQ5 Trypanosomatidae 60% 100%
A0A1X0NLE0 Trypanosomatidae 64% 67%
A0A1X0NM05 Trypanosomatidae 61% 67%
A0A1X0NN62 Trypanosomatidae 57% 67%
A0A1X0P9L7 Trypanosomatidae 40% 66%
A0A3R7KPU3 Trypanosoma rangeli 39% 66%
A0A3S7WY58 Leishmania donovani 23% 67%
A0A422MNQ4 Trypanosoma rangeli 61% 67%
A0A422MRN5 Trypanosoma rangeli 63% 94%
A4HQD7 Leishmania braziliensis 91% 100%
A4HQE7 Leishmania braziliensis 91% 100%
A4I0Q6 Leishmania infantum 23% 100%
C0SPB2 Bacillus subtilis (strain 168) 24% 80%
C9ZMM0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 66%
D0A3U1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 53% 70%
D0A3U2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 53% 70%
D0A3U3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 54% 69%
E9AWQ8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 23% 100%
K0E3U9 Aspergillus rugulosus 22% 68%
O04249 Arabidopsis thaliana 26% 72%
O52733 Levilactobacillus brevis 23% 80%
O62786 Sus scrofa 23% 70%
O65413 Arabidopsis thaliana 24% 72%
P0AEP1 Escherichia coli (strain K12) 22% 79%
P0AEP2 Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) 22% 79%
P11168 Homo sapiens 23% 70%
P12336 Rattus norvegicus 23% 70%
P14246 Mus musculus 22% 70%
P15686 Parachlorella kessleri 26% 69%
P15729 Synechocystis sp. (strain PCC 6803 / Kazusa) 23% 78%
P23585 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 22% 68%
P23586 Arabidopsis thaliana 26% 70%
P43581 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 20% 67%
P46333 Bacillus subtilis (strain 168) 26% 80%
P49374 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 24% 67%
P58351 Bos taurus 24% 72%
P96710 Bacillus subtilis (strain 168) 23% 79%
Q06221 Trypanosoma brucei brucei 52% 70%
Q06222 Trypanosoma brucei brucei 53% 69%
Q07423 Ricinus communis 24% 72%
Q09037 Trypanosoma brucei brucei 51% 70%
Q10PW9 Oryza sativa subsp. japonica 24% 71%
Q27115 Trypanosoma vivax 53% 68%
Q39524 Parachlorella kessleri 23% 68%
Q39525 Parachlorella kessleri 25% 69%
Q41144 Ricinus communis 22% 70%
Q4QAR5 Leishmania major 23% 100%
Q6Z401 Oryza sativa subsp. japonica 23% 69%
Q6ZKF0 Oryza sativa subsp. japonica 24% 71%
Q7EZD7 Oryza sativa subsp. japonica 26% 71%
Q851G4 Oryza sativa subsp. japonica 27% 70%
Q8GW61 Arabidopsis thaliana 22% 73%
Q93Y91 Arabidopsis thaliana 25% 73%
Q94AZ2 Arabidopsis thaliana 24% 70%
Q94EC3 Oryza sativa subsp. japonica 24% 72%
Q94EC4 Oryza sativa subsp. japonica 24% 72%
Q9FYG3 Arabidopsis thaliana 22% 74%
Q9LT15 Arabidopsis thaliana 22% 71%
Q9SX48 Arabidopsis thaliana 24% 71%
Q9XSC2 Oryctolagus cuniculus 22% 74%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS