Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nitroreductase family - putative

Species:

Leishmania infantum

UniProt:

E9AHY5_LEIIN

TriTrypDb:

LINF_360068100

Length:

231

Annotations

Annotations by Jardim et al.

Oxidoreductase, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AHY5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHY5

Function

Biological processes
Term	Name	Level	Count
GO:0006950	response to stress	2	8
GO:0006979	response to oxidative stress	3	8
GO:0009987	cellular process	1	8
GO:0033554	cellular response to stress	3	8
GO:0034599	cellular response to oxidative stress	4	8
GO:0042221	response to chemical	2	8
GO:0050896	response to stimulus	1	8
GO:0051716	cellular response to stimulus	2	8
GO:0062197	cellular response to chemical stress	4	8
GO:0070887	cellular response to chemical stimulus	3	8

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0016491	oxidoreductase activity	2	8
GO:0016651	oxidoreductase activity, acting on NAD(P)H	3	8
GO:0016657	oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor	4	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	42	44	PF00675	0.295
CLV_PCSK_KEX2_1	41	43	PF00082	0.297
CLV_PCSK_PC1ET2_1	41	43	PF00082	0.371
CLV_PCSK_SKI1_1	190	194	PF00082	0.379
CLV_PCSK_SKI1_1	97	101	PF00082	0.355
DEG_Nend_UBRbox_1	1	4	PF02207	0.579
DOC_MAPK_MEF2A_6	77	85	PF00069	0.323
DOC_PP4_FxxP_1	193	196	PF00568	0.332
DOC_USP7_MATH_1	206	210	PF00917	0.355
DOC_USP7_MATH_1	218	222	PF00917	0.521
DOC_USP7_MATH_1	28	32	PF00917	0.576
DOC_USP7_UBL2_3	137	141	PF12436	0.323
DOC_USP7_UBL2_3	97	101	PF12436	0.295
LIG_14-3-3_CanoR_1	219	227	PF00244	0.465
LIG_14-3-3_CanoR_1	22	28	PF00244	0.407
LIG_Actin_WH2_2	88	103	PF00022	0.295
LIG_BRCT_BRCA1_1	31	35	PF00533	0.433
LIG_FHA_1	78	84	PF00498	0.323
LIG_FHA_2	102	108	PF00498	0.355
LIG_FHA_2	64	70	PF00498	0.396
LIG_LIR_Gen_1	197	207	PF02991	0.371
LIG_LIR_Nem_3	197	202	PF02991	0.355
LIG_SH2_SRC	130	133	PF00017	0.371
LIG_SH2_STAP1	146	150	PF00017	0.389
LIG_SUMO_SIM_anti_2	58	64	PF11976	0.284
LIG_SUMO_SIM_anti_2	78	85	PF11976	0.279
LIG_SUMO_SIM_par_1	58	64	PF11976	0.284
LIG_TRAF2_1	104	107	PF00917	0.355
LIG_WRC_WIRS_1	150	155	PF05994	0.371
MOD_CK1_1	154	160	PF00069	0.355
MOD_CK1_1	5	11	PF00069	0.607
MOD_CK2_1	101	107	PF00069	0.317
MOD_CK2_1	52	58	PF00069	0.355
MOD_CK2_1	63	69	PF00069	0.355
MOD_GlcNHglycan	157	160	PF01048	0.297
MOD_GlcNHglycan	166	169	PF01048	0.299
MOD_GlcNHglycan	17	20	PF01048	0.600
MOD_GlcNHglycan	31	34	PF01048	0.418
MOD_GSK3_1	151	158	PF00069	0.314
MOD_GSK3_1	17	24	PF00069	0.590
MOD_GSK3_1	2	9	PF00069	0.580
MOD_GSK3_1	37	44	PF00069	0.245
MOD_N-GLC_1	116	121	PF02516	0.299
MOD_NEK2_1	15	20	PF00069	0.516
MOD_NEK2_1	52	57	PF00069	0.415
MOD_PIKK_1	151	157	PF00454	0.371
MOD_PIKK_1	50	56	PF00454	0.299
MOD_PKA_1	101	107	PF00069	0.355
MOD_PKA_1	41	47	PF00069	0.355
MOD_PKA_2	21	27	PF00069	0.424
MOD_PKA_2	218	224	PF00069	0.482
MOD_PKA_2	41	47	PF00069	0.308
MOD_Plk_1	116	122	PF00069	0.429
MOD_Plk_4	123	129	PF00069	0.295
MOD_Plk_4	77	83	PF00069	0.323
MOD_SUMO_rev_2	107	116	PF00179	0.355
MOD_SUMO_rev_2	209	218	PF00179	0.478
TRG_DiLeu_BaEn_1	197	202	PF01217	0.355
TRG_ENDOCYTIC_2	181	184	PF00928	0.295
TRG_NES_CRM1_1	183	198	PF08389	0.355

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAF5	Leptomonas seymouri	64%	100%
A0A3Q8IWH0	Leishmania donovani	99%	100%
A4HQ99	Leishmania braziliensis	74%	100%
C9ZSG5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AU17	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
P37261	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	100%
Q4Q0H8	Leishmania major	94%	100%
Q96VH4	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	100%