LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
E9AHY3_LEIIN
TriTrypDb:
LINF_360061500
Length:
987

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AHY3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHY3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 485 489 PF00656 0.399
CLV_C14_Caspase3-7 899 903 PF00656 0.528
CLV_NRD_NRD_1 371 373 PF00675 0.418
CLV_NRD_NRD_1 482 484 PF00675 0.499
CLV_NRD_NRD_1 752 754 PF00675 0.498
CLV_NRD_NRD_1 955 957 PF00675 0.434
CLV_PCSK_KEX2_1 185 187 PF00082 0.421
CLV_PCSK_KEX2_1 206 208 PF00082 0.408
CLV_PCSK_KEX2_1 309 311 PF00082 0.469
CLV_PCSK_KEX2_1 371 373 PF00082 0.418
CLV_PCSK_KEX2_1 481 483 PF00082 0.478
CLV_PCSK_KEX2_1 510 512 PF00082 0.386
CLV_PCSK_KEX2_1 752 754 PF00082 0.498
CLV_PCSK_KEX2_1 87 89 PF00082 0.349
CLV_PCSK_KEX2_1 954 956 PF00082 0.536
CLV_PCSK_PC1ET2_1 185 187 PF00082 0.421
CLV_PCSK_PC1ET2_1 206 208 PF00082 0.408
CLV_PCSK_PC1ET2_1 309 311 PF00082 0.518
CLV_PCSK_PC1ET2_1 510 512 PF00082 0.386
CLV_PCSK_PC1ET2_1 87 89 PF00082 0.349
CLV_PCSK_PC7_1 748 754 PF00082 0.395
CLV_PCSK_PC7_1 83 89 PF00082 0.404
CLV_PCSK_SKI1_1 119 123 PF00082 0.345
CLV_PCSK_SKI1_1 83 87 PF00082 0.371
CLV_PCSK_SKI1_1 955 959 PF00082 0.391
CLV_Separin_Metazoa 745 749 PF03568 0.384
CLV_Separin_Metazoa 758 762 PF03568 0.415
DEG_APCC_DBOX_1 954 962 PF00400 0.331
DEG_SCF_FBW7_1 104 109 PF00400 0.569
DEG_SPOP_SBC_1 698 702 PF00917 0.418
DOC_CDC14_PxL_1 456 464 PF14671 0.380
DOC_CDC14_PxL_1 619 627 PF14671 0.464
DOC_CKS1_1 103 108 PF01111 0.571
DOC_CKS1_1 289 294 PF01111 0.359
DOC_CKS1_1 546 551 PF01111 0.586
DOC_CKS1_1 723 728 PF01111 0.408
DOC_CYCLIN_yCln2_LP_2 801 807 PF00134 0.358
DOC_MAPK_gen_1 34 42 PF00069 0.452
DOC_MAPK_gen_1 371 378 PF00069 0.364
DOC_MAPK_gen_1 765 773 PF00069 0.419
DOC_MAPK_gen_1 954 960 PF00069 0.394
DOC_MAPK_MEF2A_6 34 42 PF00069 0.431
DOC_MAPK_MEF2A_6 371 378 PF00069 0.364
DOC_MAPK_MEF2A_6 639 648 PF00069 0.536
DOC_MAPK_MEF2A_6 765 773 PF00069 0.412
DOC_PP1_RVXF_1 191 198 PF00149 0.405
DOC_PP1_RVXF_1 759 765 PF00149 0.416
DOC_PP2B_LxvP_1 221 224 PF13499 0.381
DOC_PP2B_LxvP_1 504 507 PF13499 0.362
DOC_SPAK_OSR1_1 411 415 PF12202 0.396
DOC_USP7_MATH_1 106 110 PF00917 0.570
DOC_USP7_MATH_1 17 21 PF00917 0.326
DOC_USP7_MATH_1 230 234 PF00917 0.573
DOC_USP7_MATH_1 29 33 PF00917 0.453
DOC_USP7_MATH_1 3 7 PF00917 0.430
DOC_USP7_MATH_1 334 338 PF00917 0.617
DOC_USP7_MATH_1 353 357 PF00917 0.567
DOC_USP7_MATH_1 533 537 PF00917 0.593
DOC_USP7_MATH_1 697 701 PF00917 0.436
DOC_USP7_MATH_1 873 877 PF00917 0.542
DOC_USP7_MATH_1 895 899 PF00917 0.317
DOC_USP7_MATH_1 913 917 PF00917 0.651
DOC_WW_Pin1_4 102 107 PF00397 0.570
DOC_WW_Pin1_4 288 293 PF00397 0.376
DOC_WW_Pin1_4 405 410 PF00397 0.434
DOC_WW_Pin1_4 440 445 PF00397 0.615
DOC_WW_Pin1_4 463 468 PF00397 0.436
DOC_WW_Pin1_4 51 56 PF00397 0.348
DOC_WW_Pin1_4 545 550 PF00397 0.603
DOC_WW_Pin1_4 574 579 PF00397 0.645
DOC_WW_Pin1_4 640 645 PF00397 0.619
DOC_WW_Pin1_4 722 727 PF00397 0.450
LIG_14-3-3_CanoR_1 142 148 PF00244 0.435
LIG_14-3-3_CanoR_1 16 26 PF00244 0.425
LIG_14-3-3_CanoR_1 170 178 PF00244 0.396
LIG_14-3-3_CanoR_1 186 192 PF00244 0.306
LIG_14-3-3_CanoR_1 28 34 PF00244 0.338
LIG_14-3-3_CanoR_1 336 341 PF00244 0.530
LIG_14-3-3_CanoR_1 360 365 PF00244 0.422
LIG_14-3-3_CanoR_1 436 446 PF00244 0.497
LIG_14-3-3_CanoR_1 475 481 PF00244 0.401
LIG_14-3-3_CanoR_1 511 521 PF00244 0.334
LIG_14-3-3_CanoR_1 537 546 PF00244 0.730
LIG_14-3-3_CanoR_1 686 693 PF00244 0.505
LIG_14-3-3_CanoR_1 69 74 PF00244 0.413
LIG_14-3-3_CanoR_1 831 838 PF00244 0.569
LIG_14-3-3_CanoR_1 847 851 PF00244 0.363
LIG_Actin_WH2_2 191 208 PF00022 0.394
LIG_Actin_WH2_2 20 36 PF00022 0.424
LIG_Actin_WH2_2 377 395 PF00022 0.388
LIG_Actin_WH2_2 559 577 PF00022 0.352
LIG_Actin_WH2_2 817 833 PF00022 0.335
LIG_Actin_WH2_2 890 908 PF00022 0.399
LIG_APCC_ABBA_1 960 965 PF00400 0.400
LIG_BIR_II_1 1 5 PF00653 0.376
LIG_BRCT_BRCA1_1 193 197 PF00533 0.362
LIG_BRCT_BRCA1_1 336 340 PF00533 0.503
LIG_BRCT_BRCA1_1 442 446 PF00533 0.402
LIG_BRCT_BRCA1_1 494 498 PF00533 0.394
LIG_BRCT_BRCA1_1 667 671 PF00533 0.446
LIG_BRCT_BRCA1_1 934 938 PF00533 0.344
LIG_CSL_BTD_1 801 804 PF09270 0.404
LIG_DLG_GKlike_1 336 343 PF00625 0.526
LIG_EH1_1 411 419 PF00400 0.332
LIG_EH1_1 659 667 PF00400 0.427
LIG_eIF4E_1 521 527 PF01652 0.355
LIG_EVH1_1 722 726 PF00568 0.434
LIG_EVH1_2 723 727 PF00568 0.480
LIG_FHA_1 105 111 PF00498 0.548
LIG_FHA_1 135 141 PF00498 0.476
LIG_FHA_1 170 176 PF00498 0.454
LIG_FHA_1 179 185 PF00498 0.423
LIG_FHA_1 284 290 PF00498 0.381
LIG_FHA_1 541 547 PF00498 0.765
LIG_FHA_1 616 622 PF00498 0.679
LIG_FHA_1 641 647 PF00498 0.593
LIG_FHA_1 686 692 PF00498 0.516
LIG_FHA_1 862 868 PF00498 0.345
LIG_FHA_1 870 876 PF00498 0.395
LIG_FHA_2 144 150 PF00498 0.390
LIG_FHA_2 723 729 PF00498 0.519
LIG_FHA_2 847 853 PF00498 0.403
LIG_FHA_2 897 903 PF00498 0.352
LIG_FHA_2 906 912 PF00498 0.485
LIG_GBD_Chelix_1 212 220 PF00786 0.325
LIG_GBD_Chelix_1 566 574 PF00786 0.413
LIG_GBD_Chelix_1 842 850 PF00786 0.318
LIG_LIR_Gen_1 337 346 PF02991 0.564
LIG_LIR_Gen_1 849 858 PF02991 0.421
LIG_LIR_Gen_1 935 945 PF02991 0.364
LIG_LIR_Nem_3 247 252 PF02991 0.442
LIG_LIR_Nem_3 337 343 PF02991 0.553
LIG_LIR_Nem_3 443 448 PF02991 0.595
LIG_LIR_Nem_3 849 854 PF02991 0.398
LIG_LIR_Nem_3 935 941 PF02991 0.348
LIG_NRBOX 143 149 PF00104 0.364
LIG_NRBOX 215 221 PF00104 0.319
LIG_NRBOX 593 599 PF00104 0.407
LIG_PCNA_PIPBox_1 629 638 PF02747 0.431
LIG_PCNA_yPIPBox_3 629 639 PF02747 0.435
LIG_Pex14_2 249 253 PF04695 0.421
LIG_Pex14_2 270 274 PF04695 0.336
LIG_SH2_CRK 523 527 PF00017 0.368
LIG_SH2_GRB2like 165 168 PF00017 0.369
LIG_SH2_GRB2like 742 745 PF00017 0.431
LIG_SH2_PTP2 161 164 PF00017 0.317
LIG_SH2_SRC 165 168 PF00017 0.369
LIG_SH2_SRC 521 524 PF00017 0.391
LIG_SH2_SRC 809 812 PF00017 0.383
LIG_SH2_STAP1 171 175 PF00017 0.431
LIG_SH2_STAP1 523 527 PF00017 0.379
LIG_SH2_STAT3 171 174 PF00017 0.403
LIG_SH2_STAT3 18 21 PF00017 0.367
LIG_SH2_STAT5 161 164 PF00017 0.317
LIG_SH2_STAT5 165 168 PF00017 0.319
LIG_SH2_STAT5 171 174 PF00017 0.403
LIG_SH2_STAT5 252 255 PF00017 0.438
LIG_SH2_STAT5 267 270 PF00017 0.263
LIG_SH2_STAT5 503 506 PF00017 0.407
LIG_SH2_STAT5 539 542 PF00017 0.684
LIG_SH2_STAT5 636 639 PF00017 0.464
LIG_SH2_STAT5 809 812 PF00017 0.383
LIG_SH3_3 219 225 PF00018 0.331
LIG_SH3_3 403 409 PF00018 0.518
LIG_SH3_3 543 549 PF00018 0.598
LIG_SH3_3 720 726 PF00018 0.446
LIG_SH3_3 875 881 PF00018 0.454
LIG_SH3_3 98 104 PF00018 0.571
LIG_SUMO_SIM_anti_2 22 28 PF11976 0.356
LIG_SUMO_SIM_anti_2 286 291 PF11976 0.337
LIG_SUMO_SIM_anti_2 728 734 PF11976 0.367
LIG_SUMO_SIM_anti_2 852 859 PF11976 0.369
LIG_SUMO_SIM_anti_2 972 978 PF11976 0.371
LIG_SUMO_SIM_par_1 285 291 PF11976 0.335
LIG_TYR_ITIM 159 164 PF00017 0.368
LIG_UBA3_1 289 298 PF00899 0.474
LIG_UBA3_1 593 602 PF00899 0.412
LIG_Vh1_VBS_1 886 904 PF01044 0.407
LIG_WRC_WIRS_1 271 276 PF05994 0.338
MOD_CDC14_SPxK_1 408 411 PF00782 0.427
MOD_CDK_SPxK_1 405 411 PF00069 0.469
MOD_CDK_SPxK_1 545 551 PF00069 0.584
MOD_CDK_SPxxK_3 288 295 PF00069 0.367
MOD_CK1_1 169 175 PF00069 0.445
MOD_CK1_1 187 193 PF00069 0.272
MOD_CK1_1 226 232 PF00069 0.468
MOD_CK1_1 233 239 PF00069 0.511
MOD_CK1_1 273 279 PF00069 0.379
MOD_CK1_1 356 362 PF00069 0.535
MOD_CK1_1 440 446 PF00069 0.457
MOD_CK1_1 463 469 PF00069 0.425
MOD_CK1_1 476 482 PF00069 0.372
MOD_CK1_1 50 56 PF00069 0.367
MOD_CK1_1 538 544 PF00069 0.629
MOD_CK1_1 615 621 PF00069 0.528
MOD_CK1_1 669 675 PF00069 0.484
MOD_CK1_1 869 875 PF00069 0.454
MOD_CK1_1 94 100 PF00069 0.460
MOD_CK2_1 143 149 PF00069 0.381
MOD_CK2_1 33 39 PF00069 0.590
MOD_CK2_1 51 57 PF00069 0.293
MOD_CK2_1 512 518 PF00069 0.350
MOD_CK2_1 846 852 PF00069 0.401
MOD_CK2_1 943 949 PF00069 0.454
MOD_CK2_1 964 970 PF00069 0.437
MOD_Cter_Amidation 750 753 PF01082 0.485
MOD_GlcNHglycan 1 4 PF01048 0.425
MOD_GlcNHglycan 208 211 PF01048 0.378
MOD_GlcNHglycan 228 231 PF01048 0.379
MOD_GlcNHglycan 236 239 PF01048 0.488
MOD_GlcNHglycan 254 257 PF01048 0.304
MOD_GlcNHglycan 262 265 PF01048 0.333
MOD_GlcNHglycan 320 323 PF01048 0.420
MOD_GlcNHglycan 336 339 PF01048 0.508
MOD_GlcNHglycan 430 433 PF01048 0.587
MOD_GlcNHglycan 448 451 PF01048 0.418
MOD_GlcNHglycan 452 455 PF01048 0.384
MOD_GlcNHglycan 493 497 PF01048 0.343
MOD_GlcNHglycan 553 556 PF01048 0.501
MOD_GlcNHglycan 560 563 PF01048 0.433
MOD_GlcNHglycan 605 608 PF01048 0.472
MOD_GlcNHglycan 675 678 PF01048 0.468
MOD_GlcNHglycan 74 77 PF01048 0.375
MOD_GlcNHglycan 786 790 PF01048 0.489
MOD_GlcNHglycan 832 835 PF01048 0.423
MOD_GlcNHglycan 902 905 PF01048 0.430
MOD_GlcNHglycan 946 949 PF01048 0.485
MOD_GlcNHglycan 96 99 PF01048 0.464
MOD_GlcNHglycan 965 969 PF01048 0.357
MOD_GSK3_1 102 109 PF00069 0.585
MOD_GSK3_1 165 172 PF00069 0.401
MOD_GSK3_1 187 194 PF00069 0.360
MOD_GSK3_1 226 233 PF00069 0.489
MOD_GSK3_1 248 255 PF00069 0.333
MOD_GSK3_1 29 36 PF00069 0.520
MOD_GSK3_1 314 321 PF00069 0.475
MOD_GSK3_1 325 332 PF00069 0.363
MOD_GSK3_1 356 363 PF00069 0.502
MOD_GSK3_1 446 453 PF00069 0.429
MOD_GSK3_1 47 54 PF00069 0.323
MOD_GSK3_1 512 519 PF00069 0.347
MOD_GSK3_1 533 540 PF00069 0.613
MOD_GSK3_1 601 608 PF00069 0.412
MOD_GSK3_1 665 672 PF00069 0.571
MOD_GSK3_1 685 692 PF00069 0.432
MOD_GSK3_1 718 725 PF00069 0.536
MOD_GSK3_1 825 832 PF00069 0.462
MOD_GSK3_1 869 876 PF00069 0.459
MOD_GSK3_1 896 903 PF00069 0.407
MOD_N-GLC_1 166 171 PF02516 0.333
MOD_N-GLC_1 794 799 PF02516 0.515
MOD_N-GLC_1 869 874 PF02516 0.455
MOD_NEK2_1 127 132 PF00069 0.436
MOD_NEK2_1 143 148 PF00069 0.275
MOD_NEK2_1 184 189 PF00069 0.395
MOD_NEK2_1 191 196 PF00069 0.328
MOD_NEK2_1 270 275 PF00069 0.333
MOD_NEK2_1 283 288 PF00069 0.348
MOD_NEK2_1 302 307 PF00069 0.634
MOD_NEK2_1 33 38 PF00069 0.523
MOD_NEK2_1 376 381 PF00069 0.315
MOD_NEK2_1 392 397 PF00069 0.458
MOD_NEK2_1 402 407 PF00069 0.512
MOD_NEK2_1 417 422 PF00069 0.269
MOD_NEK2_1 438 443 PF00069 0.637
MOD_NEK2_1 446 451 PF00069 0.535
MOD_NEK2_1 462 467 PF00069 0.415
MOD_NEK2_1 473 478 PF00069 0.319
MOD_NEK2_1 492 497 PF00069 0.344
MOD_NEK2_1 593 598 PF00069 0.421
MOD_NEK2_1 628 633 PF00069 0.406
MOD_NEK2_1 665 670 PF00069 0.370
MOD_NEK2_1 731 736 PF00069 0.393
MOD_NEK2_1 785 790 PF00069 0.556
MOD_NEK2_1 830 835 PF00069 0.539
MOD_NEK2_1 846 851 PF00069 0.416
MOD_NEK2_1 866 871 PF00069 0.371
MOD_NEK2_1 900 905 PF00069 0.437
MOD_NEK2_1 92 97 PF00069 0.390
MOD_NEK2_1 932 937 PF00069 0.399
MOD_NEK2_1 964 969 PF00069 0.466
MOD_NEK2_2 29 34 PF00069 0.337
MOD_OFUCOSY 808 815 PF10250 0.438
MOD_OFUCOSY 90 96 PF10250 0.361
MOD_PIKK_1 17 23 PF00454 0.421
MOD_PIKK_1 170 176 PF00454 0.454
MOD_PIKK_1 224 230 PF00454 0.480
MOD_PIKK_1 302 308 PF00454 0.587
MOD_PIKK_1 353 359 PF00454 0.542
MOD_PIKK_1 666 672 PF00454 0.379
MOD_PIKK_1 777 783 PF00454 0.447
MOD_PIKK_1 794 800 PF00454 0.449
MOD_PIKK_1 825 831 PF00454 0.499
MOD_PIKK_1 873 879 PF00454 0.420
MOD_PIKK_1 932 938 PF00454 0.333
MOD_PK_1 360 366 PF00069 0.418
MOD_PKA_1 206 212 PF00069 0.406
MOD_PKA_1 481 487 PF00069 0.394
MOD_PKA_2 169 175 PF00069 0.353
MOD_PKA_2 206 212 PF00069 0.376
MOD_PKA_2 33 39 PF00069 0.462
MOD_PKA_2 392 398 PF00069 0.486
MOD_PKA_2 438 444 PF00069 0.595
MOD_PKA_2 481 487 PF00069 0.407
MOD_PKA_2 685 691 PF00069 0.407
MOD_PKA_2 830 836 PF00069 0.422
MOD_PKA_2 846 852 PF00069 0.351
MOD_Plk_1 166 172 PF00069 0.343
MOD_Plk_4 143 149 PF00069 0.502
MOD_Plk_4 248 254 PF00069 0.400
MOD_Plk_4 3 9 PF00069 0.389
MOD_Plk_4 402 408 PF00069 0.543
MOD_Plk_4 465 471 PF00069 0.478
MOD_Plk_4 516 522 PF00069 0.330
MOD_Plk_4 593 599 PF00069 0.343
MOD_Plk_4 699 705 PF00069 0.435
MOD_Plk_4 846 852 PF00069 0.482
MOD_Plk_4 896 902 PF00069 0.354
MOD_ProDKin_1 102 108 PF00069 0.569
MOD_ProDKin_1 288 294 PF00069 0.377
MOD_ProDKin_1 405 411 PF00069 0.427
MOD_ProDKin_1 440 446 PF00069 0.610
MOD_ProDKin_1 463 469 PF00069 0.430
MOD_ProDKin_1 51 57 PF00069 0.353
MOD_ProDKin_1 545 551 PF00069 0.604
MOD_ProDKin_1 574 580 PF00069 0.655
MOD_ProDKin_1 640 646 PF00069 0.620
MOD_ProDKin_1 722 728 PF00069 0.442
MOD_SUMO_for_1 296 299 PF00179 0.539
TRG_DiLeu_BaLyEn_6 139 144 PF01217 0.360
TRG_DiLeu_BaLyEn_6 236 241 PF01217 0.427
TRG_DiLeu_BaLyEn_6 38 43 PF01217 0.425
TRG_DiLeu_BaLyEn_6 522 527 PF01217 0.342
TRG_DiLeu_BaLyEn_6 862 867 PF01217 0.351
TRG_DiLeu_LyEn_5 620 625 PF01217 0.505
TRG_ENDOCYTIC_2 161 164 PF00928 0.317
TRG_ENDOCYTIC_2 267 270 PF00928 0.332
TRG_ENDOCYTIC_2 503 506 PF00928 0.524
TRG_ENDOCYTIC_2 523 526 PF00928 0.272
TRG_ER_diArg_1 370 372 PF00400 0.428
TRG_ER_diArg_1 480 483 PF00400 0.427
TRG_ER_diArg_1 764 767 PF00400 0.368
TRG_ER_diArg_1 953 956 PF00400 0.438
TRG_NES_CRM1_1 837 852 PF08389 0.338
TRG_NLS_MonoExtN_4 507 513 PF00514 0.441
TRG_Pf-PMV_PEXEL_1 41 45 PF00026 0.414
TRG_Pf-PMV_PEXEL_1 511 516 PF00026 0.473
TRG_Pf-PMV_PEXEL_1 767 772 PF00026 0.329

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P493 Leptomonas seymouri 36% 98%
A0A3S7XBS3 Leishmania donovani 100% 100%
E9ATV4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 100%
Q4Q0P2 Leishmania major 88% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS