LeishMANIAdb
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MIF4G domain-containing protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
MIF4G domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
E9AHY2_LEIIN
TriTrypDb:
LINF_360060300
Length:
620

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Could not find GO cellular_component term for this entry.

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

E9AHY2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHY2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 130 134 PF00656 0.311
CLV_C14_Caspase3-7 556 560 PF00656 0.366
CLV_C14_Caspase3-7 59 63 PF00656 0.504
CLV_NRD_NRD_1 216 218 PF00675 0.406
CLV_NRD_NRD_1 350 352 PF00675 0.345
CLV_NRD_NRD_1 38 40 PF00675 0.639
CLV_NRD_NRD_1 424 426 PF00675 0.582
CLV_NRD_NRD_1 585 587 PF00675 0.363
CLV_NRD_NRD_1 74 76 PF00675 0.573
CLV_PCSK_FUR_1 72 76 PF00082 0.554
CLV_PCSK_KEX2_1 112 114 PF00082 0.523
CLV_PCSK_KEX2_1 350 352 PF00082 0.345
CLV_PCSK_KEX2_1 38 40 PF00082 0.703
CLV_PCSK_KEX2_1 424 426 PF00082 0.581
CLV_PCSK_KEX2_1 563 565 PF00082 0.424
CLV_PCSK_KEX2_1 585 587 PF00082 0.352
CLV_PCSK_KEX2_1 74 76 PF00082 0.571
CLV_PCSK_PC1ET2_1 112 114 PF00082 0.541
CLV_PCSK_PC1ET2_1 563 565 PF00082 0.424
CLV_PCSK_PC7_1 70 76 PF00082 0.572
CLV_PCSK_SKI1_1 109 113 PF00082 0.588
CLV_PCSK_SKI1_1 116 120 PF00082 0.555
CLV_PCSK_SKI1_1 151 155 PF00082 0.391
CLV_PCSK_SKI1_1 26 30 PF00082 0.583
CLV_PCSK_SKI1_1 273 277 PF00082 0.348
CLV_PCSK_SKI1_1 306 310 PF00082 0.433
CLV_PCSK_SKI1_1 476 480 PF00082 0.450
CLV_PCSK_SKI1_1 485 489 PF00082 0.378
CLV_PCSK_SKI1_1 512 516 PF00082 0.382
CLV_PCSK_SKI1_1 585 589 PF00082 0.381
DEG_APCC_DBOX_1 272 280 PF00400 0.359
DEG_APCC_DBOX_1 584 592 PF00400 0.359
DEG_Nend_UBRbox_2 1 3 PF02207 0.606
DEG_SCF_FBW7_1 514 519 PF00400 0.285
DEG_SCF_FBW7_2 324 331 PF00400 0.594
DOC_CKS1_1 325 330 PF01111 0.600
DOC_CYCLIN_RxL_1 473 483 PF00134 0.393
DOC_CYCLIN_RxL_1 583 594 PF00134 0.354
DOC_MAPK_gen_1 166 174 PF00069 0.271
DOC_MAPK_gen_1 277 284 PF00069 0.328
DOC_MAPK_MEF2A_6 166 174 PF00069 0.271
DOC_PP1_RVXF_1 466 473 PF00149 0.412
DOC_PP1_RVXF_1 584 591 PF00149 0.358
DOC_PP2B_LxvP_1 248 251 PF13499 0.470
DOC_PP4_FxxP_1 357 360 PF00568 0.522
DOC_PP4_MxPP_1 200 203 PF00568 0.396
DOC_USP7_MATH_1 15 19 PF00917 0.543
DOC_USP7_MATH_1 326 330 PF00917 0.580
DOC_USP7_MATH_1 4 8 PF00917 0.713
DOC_USP7_MATH_1 404 408 PF00917 0.740
DOC_USP7_UBL2_3 112 116 PF12436 0.543
DOC_USP7_UBL2_3 344 348 PF12436 0.321
DOC_WW_Pin1_4 100 105 PF00397 0.669
DOC_WW_Pin1_4 195 200 PF00397 0.505
DOC_WW_Pin1_4 268 273 PF00397 0.374
DOC_WW_Pin1_4 324 329 PF00397 0.614
DOC_WW_Pin1_4 512 517 PF00397 0.300
DOC_WW_Pin1_4 536 541 PF00397 0.444
LIG_14-3-3_CanoR_1 128 132 PF00244 0.420
LIG_14-3-3_CanoR_1 217 225 PF00244 0.470
LIG_14-3-3_CanoR_1 383 389 PF00244 0.542
LIG_14-3-3_CanoR_1 425 433 PF00244 0.519
LIG_14-3-3_CanoR_1 485 490 PF00244 0.445
LIG_14-3-3_CanoR_1 569 577 PF00244 0.346
LIG_14-3-3_CanoR_1 91 96 PF00244 0.642
LIG_Actin_WH2_2 507 525 PF00022 0.413
LIG_Actin_WH2_2 574 591 PF00022 0.473
LIG_BIR_III_4 62 66 PF00653 0.514
LIG_BRCT_BRCA1_1 146 150 PF00533 0.459
LIG_BRCT_BRCA1_1 440 444 PF00533 0.363
LIG_CaM_IQ_9 336 352 PF13499 0.422
LIG_FHA_1 225 231 PF00498 0.522
LIG_FHA_1 307 313 PF00498 0.492
LIG_FHA_1 517 523 PF00498 0.380
LIG_FHA_1 578 584 PF00498 0.444
LIG_FHA_2 128 134 PF00498 0.476
LIG_FHA_2 182 188 PF00498 0.389
LIG_FHA_2 369 375 PF00498 0.676
LIG_FHA_2 398 404 PF00498 0.623
LIG_FHA_2 410 416 PF00498 0.553
LIG_FHA_2 427 433 PF00498 0.337
LIG_FHA_2 447 453 PF00498 0.445
LIG_FHA_2 486 492 PF00498 0.540
LIG_FHA_2 513 519 PF00498 0.401
LIG_Integrin_RGD_1 66 68 PF01839 0.547
LIG_LIR_Apic_2 354 360 PF02991 0.498
LIG_LIR_Gen_1 122 131 PF02991 0.368
LIG_LIR_Gen_1 180 191 PF02991 0.399
LIG_LIR_Gen_1 441 451 PF02991 0.386
LIG_LIR_Gen_1 464 470 PF02991 0.438
LIG_LIR_Gen_1 483 494 PF02991 0.247
LIG_LIR_Nem_3 122 127 PF02991 0.378
LIG_LIR_Nem_3 147 153 PF02991 0.353
LIG_LIR_Nem_3 180 186 PF02991 0.349
LIG_LIR_Nem_3 187 193 PF02991 0.334
LIG_LIR_Nem_3 441 447 PF02991 0.374
LIG_LIR_Nem_3 464 469 PF02991 0.393
LIG_LIR_Nem_3 483 489 PF02991 0.303
LIG_SH2_PTP2 171 174 PF00017 0.256
LIG_SH2_STAT5 140 143 PF00017 0.364
LIG_SH2_STAT5 171 174 PF00017 0.371
LIG_SH3_3 196 202 PF00018 0.421
LIG_SH3_3 248 254 PF00018 0.662
LIG_SH3_3 255 261 PF00018 0.603
LIG_SH3_3 370 376 PF00018 0.678
LIG_SH3_3 578 584 PF00018 0.472
LIG_SUMO_SIM_anti_2 281 286 PF11976 0.325
LIG_SUMO_SIM_par_1 506 513 PF11976 0.366
LIG_TRAF2_1 376 379 PF00917 0.682
LIG_UBA3_1 189 197 PF00899 0.442
LIG_UBA3_1 341 348 PF00899 0.350
LIG_WRC_WIRS_1 156 161 PF05994 0.409
LIG_WW_3 359 363 PF00397 0.429
MOD_CDK_SPK_2 268 273 PF00069 0.385
MOD_CK1_1 155 161 PF00069 0.423
MOD_CK1_1 268 274 PF00069 0.527
MOD_CK1_1 406 412 PF00069 0.590
MOD_CK1_1 510 516 PF00069 0.562
MOD_CK1_1 539 545 PF00069 0.391
MOD_CK1_1 6 12 PF00069 0.657
MOD_CK2_1 133 139 PF00069 0.461
MOD_CK2_1 181 187 PF00069 0.385
MOD_CK2_1 268 274 PF00069 0.423
MOD_CK2_1 368 374 PF00069 0.525
MOD_CK2_1 397 403 PF00069 0.623
MOD_CK2_1 426 432 PF00069 0.479
MOD_CK2_1 446 452 PF00069 0.369
MOD_CK2_1 485 491 PF00069 0.421
MOD_Cter_Amidation 72 75 PF01082 0.504
MOD_GlcNHglycan 17 20 PF01048 0.508
MOD_GlcNHglycan 218 221 PF01048 0.501
MOD_GlcNHglycan 328 331 PF01048 0.612
MOD_GlcNHglycan 406 409 PF01048 0.604
MOD_GlcNHglycan 440 443 PF01048 0.460
MOD_GlcNHglycan 546 549 PF01048 0.298
MOD_GlcNHglycan 553 556 PF01048 0.354
MOD_GlcNHglycan 6 9 PF01048 0.615
MOD_GlcNHglycan 95 98 PF01048 0.642
MOD_GSK3_1 306 313 PF00069 0.545
MOD_GSK3_1 320 327 PF00069 0.542
MOD_GSK3_1 340 347 PF00069 0.318
MOD_GSK3_1 378 385 PF00069 0.561
MOD_GSK3_1 403 410 PF00069 0.591
MOD_GSK3_1 512 519 PF00069 0.395
MOD_GSK3_1 532 539 PF00069 0.251
MOD_GSK3_1 609 616 PF00069 0.470
MOD_N-GLC_1 13 18 PF02516 0.502
MOD_N-GLC_1 456 461 PF02516 0.336
MOD_NEK2_1 126 131 PF00069 0.356
MOD_NEK2_1 294 299 PF00069 0.384
MOD_NEK2_1 419 424 PF00069 0.663
MOD_NEK2_1 570 575 PF00069 0.341
MOD_NEK2_1 577 582 PF00069 0.392
MOD_PIKK_1 161 167 PF00454 0.441
MOD_PIKK_1 173 179 PF00454 0.343
MOD_PIKK_1 419 425 PF00454 0.571
MOD_PIKK_1 456 462 PF00454 0.471
MOD_PIKK_1 570 576 PF00454 0.350
MOD_PKA_1 306 312 PF00069 0.342
MOD_PKA_2 127 133 PF00069 0.387
MOD_PKA_2 216 222 PF00069 0.480
MOD_PKA_2 32 38 PF00069 0.566
MOD_PKA_2 382 388 PF00069 0.538
MOD_PKB_1 41 49 PF00069 0.565
MOD_PKB_1 64 72 PF00069 0.540
MOD_PKB_1 91 99 PF00069 0.645
MOD_Plk_1 378 384 PF00069 0.605
MOD_Plk_2-3 133 139 PF00069 0.393
MOD_Plk_4 155 161 PF00069 0.391
MOD_Plk_4 265 271 PF00069 0.558
MOD_Plk_4 320 326 PF00069 0.521
MOD_Plk_4 446 452 PF00069 0.430
MOD_Plk_4 485 491 PF00069 0.384
MOD_Plk_4 504 510 PF00069 0.341
MOD_ProDKin_1 100 106 PF00069 0.667
MOD_ProDKin_1 195 201 PF00069 0.498
MOD_ProDKin_1 268 274 PF00069 0.372
MOD_ProDKin_1 324 330 PF00069 0.607
MOD_ProDKin_1 512 518 PF00069 0.297
MOD_ProDKin_1 536 542 PF00069 0.443
MOD_SUMO_rev_2 147 156 PF00179 0.417
MOD_SUMO_rev_2 556 565 PF00179 0.403
TRG_DiLeu_BaEn_1 265 270 PF01217 0.511
TRG_DiLeu_BaEn_2 79 85 PF01217 0.540
TRG_DiLeu_BaLyEn_6 287 292 PF01217 0.406
TRG_DiLeu_BaLyEn_6 561 566 PF01217 0.352
TRG_ENDOCYTIC_2 171 174 PF00928 0.373
TRG_ER_diArg_1 350 352 PF00400 0.369
TRG_ER_diArg_1 38 41 PF00400 0.567
TRG_ER_diArg_1 424 426 PF00400 0.566
TRG_ER_diArg_1 584 586 PF00400 0.356
TRG_ER_diArg_1 72 75 PF00400 0.536
TRG_ER_diArg_1 90 93 PF00400 0.552
TRG_NLS_MonoExtC_3 111 116 PF00514 0.508
TRG_NLS_MonoExtN_4 109 116 PF00514 0.458
TRG_Pf-PMV_PEXEL_1 350 354 PF00026 0.367
TRG_Pf-PMV_PEXEL_1 575 579 PF00026 0.545

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IHF8 Leptomonas seymouri 61% 98%
A0A0S4JKM1 Bodo saltans 29% 100%
A0A3R7LPT3 Trypanosoma rangeli 35% 100%
A0A3S7XBM9 Leishmania donovani 98% 100%
A4HQ24 Leishmania braziliensis 70% 100%
D0A8U5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 100%
E9ATU2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
Q4Q0Q4 Leishmania major 88% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS