HECT domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Download

Quick info

Protein:

Gene product:

ubiquitin protein ligase - putative

Species:

Leishmania infantum

UniProt:

E9AHX9_LEIIN

TriTrypDb:

LINF_360053000

Length:

619

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AHX9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHX9

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	2
GO:0006511	ubiquitin-dependent protein catabolic process	7	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009057	macromolecule catabolic process	4	2
GO:0009987	cellular process	1	2
GO:0019538	protein metabolic process	3	2
GO:0019941	modification-dependent protein catabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043632	modification-dependent macromolecule catabolic process	5	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0044265	obsolete cellular macromolecule catabolic process	4	2
GO:0051603	proteolysis involved in protein catabolic process	5	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901575	organic substance catabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0004842	ubiquitin-protein transferase activity	4	2
GO:0016740	transferase activity	2	2
GO:0019787	ubiquitin-like protein transferase activity	3	2
GO:0061630	ubiquitin protein ligase activity	5	2
GO:0061659	ubiquitin-like protein ligase activity	4	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	328	330	PF00675	0.349
CLV_NRD_NRD_1	431	433	PF00675	0.338
CLV_NRD_NRD_1	509	511	PF00675	0.491
CLV_NRD_NRD_1	552	554	PF00675	0.428
CLV_NRD_NRD_1	588	590	PF00675	0.404
CLV_NRD_NRD_1	600	602	PF00675	0.443
CLV_PCSK_KEX2_1	431	433	PF00082	0.338
CLV_PCSK_KEX2_1	509	511	PF00082	0.491
CLV_PCSK_KEX2_1	552	554	PF00082	0.428
CLV_PCSK_KEX2_1	588	590	PF00082	0.404
CLV_PCSK_SKI1_1	210	214	PF00082	0.233
CLV_PCSK_SKI1_1	325	329	PF00082	0.342
CLV_PCSK_SKI1_1	330	334	PF00082	0.286
CLV_PCSK_SKI1_1	360	364	PF00082	0.258
CLV_PCSK_SKI1_1	561	565	PF00082	0.414
DEG_SPOP_SBC_1	469	473	PF00917	0.489
DEG_SPOP_SBC_1	476	480	PF00917	0.486
DOC_CDC14_PxL_1	535	543	PF14671	0.271
DOC_CKS1_1	318	323	PF01111	0.445
DOC_CYCLIN_RxL_1	157	167	PF00134	0.228
DOC_CYCLIN_RxL_1	357	364	PF00134	0.266
DOC_MAPK_gen_1	51	60	PF00069	0.278
DOC_MAPK_MEF2A_6	210	217	PF00069	0.233
DOC_MAPK_MEF2A_6	231	239	PF00069	0.254
DOC_MAPK_MEF2A_6	536	543	PF00069	0.270
DOC_PIKK_1	201	208	PF02985	0.241
DOC_PP2B_LxvP_1	290	293	PF13499	0.442
DOC_PP2B_LxvP_1	80	83	PF13499	0.249
DOC_PP4_FxxP_1	318	321	PF00568	0.447
DOC_PP4_FxxP_1	407	410	PF00568	0.266
DOC_USP7_MATH_1	105	109	PF00917	0.373
DOC_USP7_MATH_1	132	136	PF00917	0.449
DOC_USP7_MATH_1	170	174	PF00917	0.279
DOC_USP7_MATH_1	178	182	PF00917	0.306
DOC_USP7_MATH_1	23	27	PF00917	0.362
DOC_USP7_MATH_1	259	263	PF00917	0.276
DOC_USP7_MATH_1	323	327	PF00917	0.366
DOC_USP7_MATH_1	447	451	PF00917	0.479
DOC_USP7_MATH_1	457	461	PF00917	0.499
DOC_USP7_MATH_1	475	479	PF00917	0.489
DOC_USP7_MATH_1	502	506	PF00917	0.482
DOC_USP7_MATH_1	95	99	PF00917	0.371
DOC_USP7_UBL2_3	357	361	PF12436	0.287
DOC_WW_Pin1_4	149	154	PF00397	0.273
DOC_WW_Pin1_4	29	34	PF00397	0.414
DOC_WW_Pin1_4	293	298	PF00397	0.482
DOC_WW_Pin1_4	303	308	PF00397	0.490
DOC_WW_Pin1_4	317	322	PF00397	0.451
DOC_WW_Pin1_4	392	397	PF00397	0.245
LIG_14-3-3_CanoR_1	289	293	PF00244	0.440
LIG_14-3-3_CanoR_1	504	512	PF00244	0.487
LIG_14-3-3_CanoR_1	552	560	PF00244	0.440
LIG_14-3-3_CanoR_1	561	566	PF00244	0.412
LIG_14-3-3_CanoR_1	59	67	PF00244	0.271
LIG_14-3-3_CterR_2	614	619	PF00244	0.450
LIG_Actin_WH2_2	374	392	PF00022	0.279
LIG_BRCT_BRCA1_1	170	174	PF00533	0.279
LIG_Clathr_ClatBox_1	236	240	PF01394	0.278
LIG_FHA_1	185	191	PF00498	0.241
LIG_FHA_1	294	300	PF00498	0.488
LIG_FHA_1	41	47	PF00498	0.365
LIG_FHA_1	515	521	PF00498	0.446
LIG_FHA_1	62	68	PF00498	0.274
LIG_FHA_1	84	90	PF00498	0.244
LIG_FHA_2	309	315	PF00498	0.483
LIG_FHA_2	326	332	PF00498	0.323
LIG_FHA_2	382	388	PF00498	0.313
LIG_FHA_2	425	431	PF00498	0.291
LIG_FHA_2	444	450	PF00498	0.472
LIG_FHA_2	478	484	PF00498	0.486
LIG_FHA_2	569	575	PF00498	0.416
LIG_LIR_Apic_2	315	321	PF02991	0.459
LIG_LIR_Gen_1	194	205	PF02991	0.263
LIG_LIR_Gen_1	277	284	PF02991	0.258
LIG_LIR_Gen_1	542	551	PF02991	0.321
LIG_LIR_LC3C_4	196	200	PF02991	0.269
LIG_LIR_Nem_3	117	121	PF02991	0.465
LIG_LIR_Nem_3	194	200	PF02991	0.272
LIG_LIR_Nem_3	265	271	PF02991	0.267
LIG_LIR_Nem_3	277	282	PF02991	0.248
LIG_LIR_Nem_3	347	353	PF02991	0.268
LIG_LIR_Nem_3	542	546	PF02991	0.283
LIG_MYND_3	538	542	PF01753	0.271
LIG_NRBOX	540	546	PF00104	0.276
LIG_Pex14_1	572	576	PF04695	0.420
LIG_Pex14_2	568	572	PF04695	0.401
LIG_PTB_Apo_2	401	408	PF02174	0.276
LIG_SH2_NCK_1	20	24	PF00017	0.322
LIG_SH2_PTP2	81	84	PF00017	0.232
LIG_SH2_STAP1	220	224	PF00017	0.237
LIG_SH2_STAT5	101	104	PF00017	0.412
LIG_SH2_STAT5	118	121	PF00017	0.466
LIG_SH2_STAT5	16	19	PF00017	0.270
LIG_SH2_STAT5	191	194	PF00017	0.252
LIG_SH2_STAT5	214	217	PF00017	0.240
LIG_SH2_STAT5	401	404	PF00017	0.281
LIG_SH2_STAT5	567	570	PF00017	0.394
LIG_SH2_STAT5	72	75	PF00017	0.288
LIG_SH2_STAT5	81	84	PF00017	0.232
LIG_SH3_3	264	270	PF00018	0.268
LIG_SH3_3	543	549	PF00018	0.303
LIG_SH3_3	99	105	PF00018	0.412
LIG_Sin3_3	161	168	PF02671	0.229
LIG_SUMO_SIM_anti_2	5	11	PF11976	0.265
LIG_SUMO_SIM_anti_2	542	548	PF11976	0.291
LIG_SUMO_SIM_par_1	234	240	PF11976	0.274
LIG_SUMO_SIM_par_1	424	430	PF11976	0.278
LIG_TRAF2_1	68	71	PF00917	0.306
LIG_UBA3_1	605	612	PF00899	0.436
LIG_WRC_WIRS_1	276	281	PF05994	0.244
MOD_CDC14_SPxK_1	32	35	PF00782	0.404
MOD_CDK_SPxK_1	29	35	PF00069	0.413
MOD_CK1_1	117	123	PF00069	0.460
MOD_CK1_1	181	187	PF00069	0.261
MOD_CK1_1	216	222	PF00069	0.246
MOD_CK1_1	278	284	PF00069	0.253
MOD_CK1_1	305	311	PF00069	0.484
MOD_CK1_1	468	474	PF00069	0.490
MOD_CK1_1	478	484	PF00069	0.486
MOD_CK2_1	190	196	PF00069	0.268
MOD_CK2_1	259	265	PF00069	0.276
MOD_CK2_1	288	294	PF00069	0.427
MOD_CK2_1	325	331	PF00069	0.333
MOD_CK2_1	381	387	PF00069	0.317
MOD_CK2_1	424	430	PF00069	0.278
MOD_CK2_1	443	449	PF00069	0.470
MOD_CK2_1	477	483	PF00069	0.484
MOD_CK2_1	65	71	PF00069	0.298
MOD_GlcNHglycan	170	173	PF01048	0.275
MOD_GlcNHglycan	25	28	PF01048	0.387
MOD_GlcNHglycan	290	293	PF01048	0.442
MOD_GlcNHglycan	308	311	PF01048	0.485
MOD_GlcNHglycan	438	441	PF01048	0.435
MOD_GlcNHglycan	458	462	PF01048	0.501
MOD_GlcNHglycan	467	470	PF01048	0.492
MOD_GlcNHglycan	473	476	PF01048	0.490
MOD_GlcNHglycan	505	508	PF01048	0.481
MOD_GlcNHglycan	67	70	PF01048	0.306
MOD_GSK3_1	110	117	PF00069	0.452
MOD_GSK3_1	284	291	PF00069	0.371
MOD_GSK3_1	298	305	PF00069	0.498
MOD_GSK3_1	308	315	PF00069	0.483
MOD_GSK3_1	319	326	PF00069	0.415
MOD_GSK3_1	388	395	PF00069	0.255
MOD_GSK3_1	40	47	PF00069	0.368
MOD_GSK3_1	443	450	PF00069	0.470
MOD_GSK3_1	464	471	PF00069	0.498
MOD_GSK3_1	477	484	PF00069	0.486
MOD_GSK3_1	519	526	PF00069	0.409
MOD_GSK3_1	61	68	PF00069	0.267
MOD_GSK3_1	83	90	PF00069	0.247
MOD_N-GLC_1	465	470	PF02516	0.497
MOD_N-GLC_1	577	582	PF02516	0.430
MOD_NEK2_1	138	143	PF00069	0.411
MOD_NEK2_1	213	218	PF00069	0.245
MOD_NEK2_1	283	288	PF00069	0.322
MOD_NEK2_1	374	379	PF00069	0.253
MOD_NEK2_1	400	405	PF00069	0.275
MOD_NEK2_1	60	65	PF00069	0.256
MOD_NEK2_1	606	611	PF00069	0.431
MOD_NEK2_2	352	357	PF00069	0.273
MOD_PKA_2	259	265	PF00069	0.276
MOD_PKA_2	288	294	PF00069	0.427
MOD_PKA_2	436	442	PF00069	0.434
MOD_PKA_2	503	509	PF00069	0.485
MOD_Plk_1	284	290	PF00069	0.358
MOD_Plk_1	313	319	PF00069	0.472
MOD_Plk_1	330	336	PF00069	0.280
MOD_Plk_1	523	529	PF00069	0.384
MOD_Plk_4	114	120	PF00069	0.464
MOD_Plk_4	213	219	PF00069	0.242
MOD_Plk_4	278	284	PF00069	0.253
MOD_Plk_4	330	336	PF00069	0.280
MOD_Plk_4	424	430	PF00069	0.278
MOD_ProDKin_1	149	155	PF00069	0.265
MOD_ProDKin_1	29	35	PF00069	0.413
MOD_ProDKin_1	293	299	PF00069	0.485
MOD_ProDKin_1	303	309	PF00069	0.491
MOD_ProDKin_1	317	323	PF00069	0.448
MOD_ProDKin_1	392	398	PF00069	0.245
TRG_DiLeu_BaEn_1	56	61	PF01217	0.263
TRG_DiLeu_BaLyEn_6	533	538	PF01217	0.301
TRG_DiLeu_BaLyEn_6	80	85	PF01217	0.239
TRG_DiLeu_LyEn_5	56	61	PF01217	0.263
TRG_ENDOCYTIC_2	118	121	PF00928	0.466
TRG_ENDOCYTIC_2	214	217	PF00928	0.240
TRG_ENDOCYTIC_2	81	84	PF00928	0.232
TRG_ER_diArg_1	51	54	PF00400	0.292
TRG_ER_diArg_1	588	590	PF00400	0.404
TRG_NES_CRM1_1	206	221	PF08389	0.234
TRG_Pf-PMV_PEXEL_1	245	250	PF00026	0.227