WD domain, G-beta repeat family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain - G-beta repeat - putative

Species:

Leishmania infantum

UniProt:

E9AHX8_LEIIN

TriTrypDb:

LINF_360051700

Length:

703

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AHX8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHX8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	202	206	PF00656	0.647
CLV_C14_Caspase3-7	567	571	PF00656	0.503
CLV_NRD_NRD_1	137	139	PF00675	0.581
CLV_NRD_NRD_1	184	186	PF00675	0.733
CLV_NRD_NRD_1	418	420	PF00675	0.537
CLV_NRD_NRD_1	506	508	PF00675	0.488
CLV_NRD_NRD_1	540	542	PF00675	0.524
CLV_NRD_NRD_1	58	60	PF00675	0.538
CLV_NRD_NRD_1	604	606	PF00675	0.564
CLV_NRD_NRD_1	81	83	PF00675	0.513
CLV_PCSK_KEX2_1	137	139	PF00082	0.581
CLV_PCSK_KEX2_1	184	186	PF00082	0.733
CLV_PCSK_KEX2_1	418	420	PF00082	0.537
CLV_PCSK_KEX2_1	506	508	PF00082	0.488
CLV_PCSK_KEX2_1	58	60	PF00082	0.538
CLV_PCSK_KEX2_1	81	83	PF00082	0.513
CLV_PCSK_SKI1_1	184	188	PF00082	0.530
CLV_PCSK_SKI1_1	361	365	PF00082	0.496
CLV_PCSK_SKI1_1	488	492	PF00082	0.494
CLV_PCSK_SKI1_1	506	510	PF00082	0.264
DEG_APCC_DBOX_1	685	693	PF00400	0.545
DEG_SPOP_SBC_1	196	200	PF00917	0.590
DEG_SPOP_SBC_1	323	327	PF00917	0.736
DEG_SPOP_SBC_1	407	411	PF00917	0.567
DEG_SPOP_SBC_1	656	660	PF00917	0.692
DOC_MAPK_gen_1	459	468	PF00069	0.425
DOC_MAPK_gen_1	541	549	PF00069	0.488
DOC_MAPK_gen_1	58	64	PF00069	0.516
DOC_MAPK_MEF2A_6	250	258	PF00069	0.529
DOC_MAPK_MEF2A_6	430	439	PF00069	0.496
DOC_MAPK_MEF2A_6	686	693	PF00069	0.554
DOC_MAPK_NFAT4_5	686	694	PF00069	0.561
DOC_PP1_RVXF_1	58	65	PF00149	0.515
DOC_PP2B_LxvP_1	258	261	PF13499	0.499
DOC_PP2B_LxvP_1	283	286	PF13499	0.591
DOC_PP4_FxxP_1	378	381	PF00568	0.686
DOC_USP7_MATH_1	145	149	PF00917	0.657
DOC_USP7_MATH_1	150	154	PF00917	0.637
DOC_USP7_MATH_1	196	200	PF00917	0.648
DOC_USP7_MATH_1	267	271	PF00917	0.508
DOC_USP7_MATH_1	286	290	PF00917	0.375
DOC_USP7_MATH_1	323	327	PF00917	0.790
DOC_USP7_MATH_1	381	385	PF00917	0.758
DOC_USP7_MATH_1	449	453	PF00917	0.471
DOC_USP7_MATH_1	478	482	PF00917	0.691
DOC_USP7_MATH_1	5	9	PF00917	0.558
DOC_USP7_MATH_1	510	514	PF00917	0.508
DOC_USP7_MATH_1	626	630	PF00917	0.731
DOC_USP7_MATH_1	656	660	PF00917	0.729
DOC_USP7_MATH_1	674	678	PF00917	0.229
DOC_USP7_MATH_2	267	273	PF00917	0.512
DOC_USP7_UBL2_3	364	368	PF12436	0.597
DOC_WW_Pin1_4	102	107	PF00397	0.482
DOC_WW_Pin1_4	124	129	PF00397	0.653
DOC_WW_Pin1_4	211	216	PF00397	0.626
DOC_WW_Pin1_4	243	248	PF00397	0.616
DOC_WW_Pin1_4	273	278	PF00397	0.452
DOC_WW_Pin1_4	640	645	PF00397	0.684
DOC_WW_Pin1_4	650	655	PF00397	0.629
DOC_WW_Pin1_4	83	88	PF00397	0.621
LIG_14-3-3_CanoR_1	167	175	PF00244	0.640
LIG_14-3-3_CanoR_1	184	191	PF00244	0.525
LIG_14-3-3_CanoR_1	418	424	PF00244	0.519
LIG_14-3-3_CanoR_1	436	440	PF00244	0.474
LIG_14-3-3_CanoR_1	59	65	PF00244	0.512
LIG_Actin_WH2_2	525	543	PF00022	0.450
LIG_BIR_III_4	45	49	PF00653	0.474
LIG_BRCT_BRCA1_1	116	120	PF00533	0.475
LIG_BRCT_BRCA1_1	23	27	PF00533	0.441
LIG_BRCT_BRCA1_1	37	41	PF00533	0.376
LIG_BRCT_BRCA1_1	383	387	PF00533	0.671
LIG_BRCT_BRCA1_1	411	415	PF00533	0.591
LIG_CtBP_PxDLS_1	122	126	PF00389	0.574
LIG_FHA_1	110	116	PF00498	0.369
LIG_FHA_1	186	192	PF00498	0.728
LIG_FHA_1	198	204	PF00498	0.583
LIG_FHA_1	303	309	PF00498	0.586
LIG_FHA_1	560	566	PF00498	0.473
LIG_FHA_1	620	626	PF00498	0.633
LIG_FHA_1	679	685	PF00498	0.476
LIG_FHA_2	2	8	PF00498	0.530
LIG_FHA_2	292	298	PF00498	0.505
LIG_FHA_2	581	587	PF00498	0.506
LIG_FHA_2	694	700	PF00498	0.534
LIG_LIR_Apic_2	169	175	PF02991	0.718
LIG_LIR_Apic_2	297	303	PF02991	0.579
LIG_LIR_Apic_2	375	381	PF02991	0.688
LIG_LIR_Gen_1	279	286	PF02991	0.528
LIG_LIR_Gen_1	63	70	PF02991	0.493
LIG_LIR_LC3C_4	688	693	PF02991	0.568
LIG_LIR_Nem_3	117	123	PF02991	0.487
LIG_LIR_Nem_3	279	285	PF02991	0.513
LIG_LIR_Nem_3	63	67	PF02991	0.491
LIG_PDZ_Class_2	698	703	PF00595	0.564
LIG_RPA_C_Fungi	132	144	PF08784	0.570
LIG_SH2_CRK	610	614	PF00017	0.555
LIG_SH2_PTP2	403	406	PF00017	0.547
LIG_SH2_SRC	403	406	PF00017	0.600
LIG_SH2_STAP1	520	524	PF00017	0.497
LIG_SH2_STAT5	222	225	PF00017	0.448
LIG_SH2_STAT5	231	234	PF00017	0.359
LIG_SH2_STAT5	282	285	PF00017	0.498
LIG_SH2_STAT5	403	406	PF00017	0.547
LIG_SH2_STAT5	649	652	PF00017	0.734
LIG_SH2_STAT5	671	674	PF00017	0.518
LIG_SH3_3	172	178	PF00018	0.666
LIG_SH3_3	601	607	PF00018	0.677
LIG_SUMO_SIM_par_1	121	127	PF11976	0.575
LIG_SUMO_SIM_par_1	253	259	PF11976	0.512
LIG_SUMO_SIM_par_1	464	470	PF11976	0.515
LIG_SUMO_SIM_par_1	572	578	PF11976	0.525
LIG_TRAF2_1	332	335	PF00917	0.592
LIG_TRAF2_1	356	359	PF00917	0.600
LIG_TRAF2_1	4	7	PF00917	0.528
LIG_TRAF2_1	664	667	PF00917	0.657
LIG_WRC_WIRS_1	420	425	PF05994	0.489
LIG_WRC_WIRS_1	61	66	PF05994	0.496
MOD_CDC14_SPxK_1	643	646	PF00782	0.707
MOD_CDK_SPxK_1	640	646	PF00069	0.710
MOD_CDK_SPxxK_3	243	250	PF00069	0.604
MOD_CDK_SPxxK_3	273	280	PF00069	0.438
MOD_CK1_1	114	120	PF00069	0.475
MOD_CK1_1	124	130	PF00069	0.546
MOD_CK1_1	190	196	PF00069	0.650
MOD_CK1_1	197	203	PF00069	0.661
MOD_CK1_1	246	252	PF00069	0.628
MOD_CK1_1	276	282	PF00069	0.511
MOD_CK1_1	373	379	PF00069	0.725
MOD_CK1_1	390	396	PF00069	0.523
MOD_CK1_1	413	419	PF00069	0.493
MOD_CK1_1	575	581	PF00069	0.520
MOD_CK1_1	618	624	PF00069	0.617
MOD_CK1_1	627	633	PF00069	0.602
MOD_CK1_1	65	71	PF00069	0.439
MOD_CK1_1	659	665	PF00069	0.659
MOD_CK2_1	1	7	PF00069	0.557
MOD_CK2_1	145	151	PF00069	0.655
MOD_CK2_1	286	292	PF00069	0.520
MOD_CK2_1	390	396	PF00069	0.672
MOD_CK2_1	580	586	PF00069	0.529
MOD_CK2_1	655	661	PF00069	0.650
MOD_CK2_1	693	699	PF00069	0.535
MOD_Cter_Amidation	504	507	PF01082	0.513
MOD_GlcNHglycan	153	156	PF01048	0.651
MOD_GlcNHglycan	205	208	PF01048	0.718
MOD_GlcNHglycan	288	291	PF01048	0.503
MOD_GlcNHglycan	326	329	PF01048	0.736
MOD_GlcNHglycan	342	345	PF01048	0.572
MOD_GlcNHglycan	384	387	PF01048	0.730
MOD_GlcNHglycan	42	45	PF01048	0.451
MOD_GlcNHglycan	423	426	PF01048	0.456
MOD_GlcNHglycan	451	454	PF01048	0.482
MOD_GlcNHglycan	496	499	PF01048	0.551
MOD_GlcNHglycan	503	506	PF01048	0.482
MOD_GlcNHglycan	521	525	PF01048	0.376
MOD_GlcNHglycan	64	67	PF01048	0.429
MOD_GlcNHglycan	674	677	PF01048	0.334
MOD_GSK3_1	1	8	PF00069	0.637
MOD_GSK3_1	124	131	PF00069	0.587
MOD_GSK3_1	180	187	PF00069	0.590
MOD_GSK3_1	190	197	PF00069	0.627
MOD_GSK3_1	211	218	PF00069	0.539
MOD_GSK3_1	242	249	PF00069	0.624
MOD_GSK3_1	269	276	PF00069	0.491
MOD_GSK3_1	302	309	PF00069	0.690
MOD_GSK3_1	36	43	PF00069	0.455
MOD_GSK3_1	366	373	PF00069	0.681
MOD_GSK3_1	406	413	PF00069	0.579
MOD_GSK3_1	421	428	PF00069	0.336
MOD_GSK3_1	586	593	PF00069	0.434
MOD_GSK3_1	615	622	PF00069	0.663
MOD_GSK3_1	624	631	PF00069	0.620
MOD_GSK3_1	655	662	PF00069	0.671
MOD_GSK3_1	674	681	PF00069	0.458
MOD_N-GLC_1	340	345	PF02516	0.576
MOD_N-GLC_1	413	418	PF02516	0.533
MOD_N-GLC_1	488	493	PF02516	0.487
MOD_N-GLC_1	53	58	PF02516	0.441
MOD_N-GLC_1	627	632	PF02516	0.589
MOD_NEK2_1	123	128	PF00069	0.621
MOD_NEK2_1	180	185	PF00069	0.736
MOD_NEK2_1	278	283	PF00069	0.533
MOD_NEK2_1	435	440	PF00069	0.479
MOD_NEK2_1	494	499	PF00069	0.474
MOD_NEK2_1	534	539	PF00069	0.523
MOD_NEK2_1	645	650	PF00069	0.642
MOD_NEK2_1	672	677	PF00069	0.451
MOD_NEK2_2	21	26	PF00069	0.352
MOD_NEK2_2	536	541	PF00069	0.504
MOD_NEK2_2	543	548	PF00069	0.390
MOD_NEK2_2	559	564	PF00069	0.300
MOD_PIKK_1	109	115	PF00454	0.498
MOD_PIKK_1	630	636	PF00454	0.705
MOD_PIKK_1	75	81	PF00454	0.612
MOD_PK_1	572	578	PF00069	0.525
MOD_PKA_1	184	190	PF00069	0.531
MOD_PKA_2	145	151	PF00069	0.655
MOD_PKA_2	166	172	PF00069	0.662
MOD_PKA_2	180	186	PF00069	0.630
MOD_PKA_2	306	312	PF00069	0.690
MOD_PKA_2	323	329	PF00069	0.587
MOD_PKA_2	370	376	PF00069	0.663
MOD_PKA_2	396	402	PF00069	0.653
MOD_PKA_2	435	441	PF00069	0.491
MOD_PKA_2	580	586	PF00069	0.536
MOD_PKA_2	645	651	PF00069	0.670
MOD_PKB_1	486	494	PF00069	0.408
MOD_Plk_1	291	297	PF00069	0.504
MOD_Plk_1	35	41	PF00069	0.520
MOD_Plk_1	413	419	PF00069	0.535
MOD_Plk_1	5	11	PF00069	0.617
MOD_Plk_1	559	565	PF00069	0.479
MOD_Plk_1	627	633	PF00069	0.569
MOD_Plk_1	678	684	PF00069	0.396
MOD_Plk_4	111	117	PF00069	0.463
MOD_Plk_4	128	134	PF00069	0.513
MOD_Plk_4	291	297	PF00069	0.504
MOD_Plk_4	36	42	PF00069	0.462
MOD_Plk_4	387	393	PF00069	0.722
MOD_Plk_4	396	402	PF00069	0.574
MOD_Plk_4	430	436	PF00069	0.439
MOD_Plk_4	543	549	PF00069	0.545
MOD_Plk_4	572	578	PF00069	0.573
MOD_Plk_4	645	651	PF00069	0.670
MOD_ProDKin_1	102	108	PF00069	0.468
MOD_ProDKin_1	124	130	PF00069	0.661
MOD_ProDKin_1	211	217	PF00069	0.614
MOD_ProDKin_1	243	249	PF00069	0.614
MOD_ProDKin_1	273	279	PF00069	0.444
MOD_ProDKin_1	640	646	PF00069	0.686
MOD_ProDKin_1	650	656	PF00069	0.647
MOD_ProDKin_1	83	89	PF00069	0.625
MOD_SUMO_rev_2	311	319	PF00179	0.702
TRG_DiLeu_BaEn_1	95	100	PF01217	0.653
TRG_DiLeu_BaEn_2	36	42	PF01217	0.506
TRG_ENDOCYTIC_2	282	285	PF00928	0.527
TRG_ENDOCYTIC_2	610	613	PF00928	0.609
TRG_ER_diArg_1	137	139	PF00400	0.583
TRG_ER_diArg_1	177	180	PF00400	0.726
TRG_ER_diArg_1	417	419	PF00400	0.567
TRG_ER_diArg_1	506	508	PF00400	0.488
TRG_NLS_MonoCore_2	604	609	PF00514	0.508

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IGF7	Leishmania donovani	99%	100%
A4HPU3	Leishmania braziliensis	74%	100%
E9ATK8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q0Z0	Leishmania major	89%	100%