Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2946), putative

Species:

Leishmania infantum

UniProt:

E9AHX7_LEIIN

TriTrypDb:

Length:

474

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AHX7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHX7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	19	21	PF00675	0.562
CLV_NRD_NRD_1	339	341	PF00675	0.739
CLV_NRD_NRD_1	359	361	PF00675	0.436
CLV_NRD_NRD_1	436	438	PF00675	0.465
CLV_PCSK_KEX2_1	19	21	PF00082	0.509
CLV_PCSK_KEX2_1	304	306	PF00082	0.612
CLV_PCSK_KEX2_1	339	341	PF00082	0.747
CLV_PCSK_KEX2_1	359	361	PF00082	0.436
CLV_PCSK_KEX2_1	425	427	PF00082	0.526
CLV_PCSK_KEX2_1	65	67	PF00082	0.724
CLV_PCSK_PC1ET2_1	304	306	PF00082	0.612
CLV_PCSK_PC1ET2_1	425	427	PF00082	0.526
CLV_PCSK_PC1ET2_1	65	67	PF00082	0.729
CLV_PCSK_PC7_1	61	67	PF00082	0.723
CLV_PCSK_SKI1_1	352	356	PF00082	0.696
CLV_PCSK_SKI1_1	448	452	PF00082	0.434
CLV_PCSK_SKI1_1	65	69	PF00082	0.774
DEG_APCC_DBOX_1	152	160	PF00400	0.443
DEG_ODPH_VHL_1	267	280	PF01847	0.442
DEG_SCF_FBW7_1	320	327	PF00400	0.610
DEG_SCF_FBW7_2	137	143	PF00400	0.429
DEG_SPOP_SBC_1	232	236	PF00917	0.618
DOC_CKS1_1	137	142	PF01111	0.492
DOC_CKS1_1	433	438	PF01111	0.507
DOC_MAPK_gen_1	19	25	PF00069	0.513
DOC_MAPK_gen_1	437	443	PF00069	0.531
DOC_PP2B_LxvP_1	23	26	PF13499	0.542
DOC_PP2B_LxvP_1	278	281	PF13499	0.547
DOC_PP4_FxxP_1	113	116	PF00568	0.587
DOC_USP7_MATH_1	116	120	PF00917	0.617
DOC_USP7_MATH_1	129	133	PF00917	0.285
DOC_USP7_MATH_1	232	236	PF00917	0.596
DOC_USP7_MATH_1	284	288	PF00917	0.682
DOC_USP7_MATH_1	348	352	PF00917	0.708
DOC_USP7_MATH_1	388	392	PF00917	0.545
DOC_USP7_UBL2_3	444	448	PF12436	0.373
DOC_WW_Pin1_4	136	141	PF00397	0.487
DOC_WW_Pin1_4	192	197	PF00397	0.469
DOC_WW_Pin1_4	320	325	PF00397	0.683
DOC_WW_Pin1_4	333	338	PF00397	0.688
DOC_WW_Pin1_4	432	437	PF00397	0.508
DOC_WW_Pin1_4	53	58	PF00397	0.662
DOC_WW_Pin1_4	98	103	PF00397	0.574
LIG_14-3-3_CanoR_1	134	138	PF00244	0.433
LIG_14-3-3_CanoR_1	251	259	PF00244	0.392
LIG_14-3-3_CanoR_1	317	326	PF00244	0.593
LIG_14-3-3_CanoR_1	339	346	PF00244	0.776
LIG_14-3-3_CanoR_1	359	367	PF00244	0.483
LIG_14-3-3_CanoR_1	52	57	PF00244	0.516
LIG_14-3-3_CanoR_1	66	73	PF00244	0.573
LIG_Actin_WH2_2	206	224	PF00022	0.474
LIG_Actin_WH2_2	342	358	PF00022	0.671
LIG_BIR_II_1	1	5	PF00653	0.540
LIG_BRCT_BRCA1_1	29	33	PF00533	0.513
LIG_CSL_BTD_1	137	140	PF09270	0.478
LIG_FHA_1	216	222	PF00498	0.551
LIG_FHA_1	238	244	PF00498	0.618
LIG_FHA_1	321	327	PF00498	0.746
LIG_FHA_1	411	417	PF00498	0.462
LIG_FHA_1	467	473	PF00498	0.552
LIG_FHA_2	137	143	PF00498	0.545
LIG_FHA_2	156	162	PF00498	0.292
LIG_FHA_2	261	267	PF00498	0.417
LIG_GBD_Chelix_1	80	88	PF00786	0.598
LIG_LIR_Apic_2	111	116	PF02991	0.611
LIG_LIR_Gen_1	34	44	PF02991	0.504
LIG_LIR_Gen_1	455	464	PF02991	0.508
LIG_LIR_Gen_1	9	16	PF02991	0.388
LIG_LIR_Nem_3	183	187	PF02991	0.379
LIG_LIR_Nem_3	30	36	PF02991	0.493
LIG_LIR_Nem_3	4	10	PF02991	0.422
LIG_LIR_Nem_3	455	460	PF02991	0.543
LIG_NRBOX	177	183	PF00104	0.371
LIG_PCNA_yPIPBox_3	193	207	PF02747	0.422
LIG_PDZ_Class_2	469	474	PF00595	0.553
LIG_RPA_C_Fungi	354	366	PF08784	0.491
LIG_SH2_NCK_1	397	401	PF00017	0.429
LIG_SH2_SRC	397	400	PF00017	0.510
LIG_SH2_SRC	46	49	PF00017	0.464
LIG_SH2_STAP1	308	312	PF00017	0.573
LIG_SH2_STAT5	410	413	PF00017	0.441
LIG_SH3_3	266	272	PF00018	0.560
LIG_SH3_3	278	284	PF00018	0.379
LIG_SH3_3	347	353	PF00018	0.693
LIG_SUMO_SIM_par_1	239	245	PF11976	0.572
LIG_TRAF2_1	108	111	PF00917	0.650
LIG_TRAF2_1	158	161	PF00917	0.495
LIG_TRAF2_1	224	227	PF00917	0.344
LIG_TRAF2_1	331	334	PF00917	0.620
LIG_UBA3_1	416	425	PF00899	0.440
LIG_WRC_WIRS_1	7	12	PF05994	0.497
MOD_CDC14_SPxK_1	336	339	PF00782	0.619
MOD_CDK_SPK_2	432	437	PF00069	0.508
MOD_CDK_SPxK_1	333	339	PF00069	0.688
MOD_CDK_SPxK_1	432	438	PF00069	0.506
MOD_CDK_SPxxK_3	192	199	PF00069	0.329
MOD_CDK_SPxxK_3	333	340	PF00069	0.625
MOD_CK1_1	215	221	PF00069	0.475
MOD_CK1_1	231	237	PF00069	0.572
MOD_CK1_1	27	33	PF00069	0.504
MOD_CK1_1	287	293	PF00069	0.693
MOD_CK1_1	91	97	PF00069	0.581
MOD_CK2_1	155	161	PF00069	0.497
MOD_CK2_1	328	334	PF00069	0.616
MOD_CK2_1	91	97	PF00069	0.588
MOD_CMANNOS	430	433	PF00535	0.538
MOD_GlcNHglycan	118	121	PF01048	0.617
MOD_GlcNHglycan	13	16	PF01048	0.501
MOD_GlcNHglycan	230	233	PF01048	0.575
MOD_GlcNHglycan	236	239	PF01048	0.631
MOD_GlcNHglycan	253	256	PF01048	0.453
MOD_GlcNHglycan	361	364	PF01048	0.621
MOD_GlcNHglycan	367	370	PF01048	0.569
MOD_GlcNHglycan	383	386	PF01048	0.641
MOD_GlcNHglycan	75	78	PF01048	0.633
MOD_GSK3_1	129	136	PF00069	0.420
MOD_GSK3_1	228	235	PF00069	0.565
MOD_GSK3_1	27	34	PF00069	0.528
MOD_GSK3_1	318	325	PF00069	0.601
MOD_GSK3_1	365	372	PF00069	0.609
MOD_GSK3_1	377	384	PF00069	0.591
MOD_GSK3_1	71	78	PF00069	0.719
MOD_NEK2_1	318	323	PF00069	0.575
MOD_NEK2_1	6	11	PF00069	0.442
MOD_NEK2_1	88	93	PF00069	0.606
MOD_NEK2_2	129	134	PF00069	0.231
MOD_NEK2_2	324	329	PF00069	0.571
MOD_NEK2_2	410	415	PF00069	0.452
MOD_OFUCOSY	408	414	PF10250	0.460
MOD_PIKK_1	338	344	PF00454	0.625
MOD_PIKK_1	369	375	PF00454	0.623
MOD_PIKK_1	388	394	PF00454	0.456
MOD_PIKK_1	46	52	PF00454	0.574
MOD_PIKK_1	91	97	PF00454	0.535
MOD_PKA_1	359	365	PF00069	0.587
MOD_PKA_2	133	139	PF00069	0.461
MOD_PKA_2	338	344	PF00069	0.625
MOD_PKA_2	358	364	PF00069	0.436
MOD_PKA_2	365	371	PF00069	0.675
MOD_Plk_1	129	135	PF00069	0.394
MOD_Plk_2-3	242	248	PF00069	0.481
MOD_Plk_4	133	139	PF00069	0.464
MOD_Plk_4	245	251	PF00069	0.479
MOD_Plk_4	287	293	PF00069	0.710
MOD_ProDKin_1	136	142	PF00069	0.488
MOD_ProDKin_1	192	198	PF00069	0.470
MOD_ProDKin_1	320	326	PF00069	0.684
MOD_ProDKin_1	333	339	PF00069	0.688
MOD_ProDKin_1	432	438	PF00069	0.506
MOD_ProDKin_1	53	59	PF00069	0.666
MOD_ProDKin_1	98	104	PF00069	0.578
MOD_SUMO_for_1	67	70	PF00179	0.718
MOD_SUMO_rev_2	298	306	PF00179	0.616
TRG_DiLeu_BaEn_1	273	278	PF01217	0.514
TRG_ENDOCYTIC_2	169	172	PF00928	0.473
TRG_ENDOCYTIC_2	36	39	PF00928	0.502
TRG_ER_diArg_1	151	154	PF00400	0.518
TRG_NES_CRM1_1	192	204	PF08389	0.395
TRG_NLS_Bipartite_1	425	441	PF00514	0.448
TRG_NLS_MonoExtC_3	64	70	PF00514	0.726
TRG_NLS_MonoExtN_4	434	441	PF00514	0.428
TRG_NLS_MonoExtN_4	62	69	PF00514	0.726
TRG_Pf-PMV_PEXEL_1	157	161	PF00026	0.474

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I528	Leptomonas seymouri	50%	98%
A0A1X0P3J4	Trypanosomatidae	29%	100%
A0A3S7XBB1	Leishmania donovani	100%	100%
A4HPM7	Leishmania braziliensis	75%	100%
D0A8J0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9ATD9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q158	Leishmania major	93%	100%
V5BML3	Trypanosoma cruzi	26%	100%