Putative polyubiquitin

Quick info Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

polyubiquitin - putative

Species:

Leishmania infantum

UniProt:

E9AHX6_LEIIN

TriTrypDb:

LINF_360043900

Length:

684

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:0005840	ribosome	5	1
GO:0032991	protein-containing complex	1	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:1990904	ribonucleoprotein complex	2	1

Phosphorylation

Amastigote: 133, 209, 285, 361, 437, 513, 57, 589, 665

Expansion

Sequence features

E9AHX6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHX6

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	2
GO:0016567	protein ubiquitination	7	1
GO:0019538	protein metabolic process	3	2
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901575	organic substance catabolic process	3	1
GO:0006412	translation	4	1
GO:0006518	peptide metabolic process	4	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	1
GO:0043043	peptide biosynthetic process	5	1
GO:0043603	amide metabolic process	3	1
GO:0043604	amide biosynthetic process	4	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0019899	enzyme binding	3	1
GO:0031386	protein tag	1	1
GO:0031625	ubiquitin protein ligase binding	5	1
GO:0044389	ubiquitin-like protein ligase binding	4	1
GO:0003735	structural constituent of ribosome	2	1
GO:0005198	structural molecule activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	118	122	PF00082	0.341
CLV_PCSK_SKI1_1	158	162	PF00082	0.320
CLV_PCSK_SKI1_1	194	198	PF00082	0.395
CLV_PCSK_SKI1_1	234	238	PF00082	0.320
CLV_PCSK_SKI1_1	270	274	PF00082	0.370
CLV_PCSK_SKI1_1	310	314	PF00082	0.320
CLV_PCSK_SKI1_1	346	350	PF00082	0.404
CLV_PCSK_SKI1_1	386	390	PF00082	0.379
CLV_PCSK_SKI1_1	42	46	PF00082	0.320
CLV_PCSK_SKI1_1	422	426	PF00082	0.329
CLV_PCSK_SKI1_1	462	466	PF00082	0.374
CLV_PCSK_SKI1_1	498	502	PF00082	0.320
CLV_PCSK_SKI1_1	538	542	PF00082	0.320
CLV_PCSK_SKI1_1	574	578	PF00082	0.320
CLV_PCSK_SKI1_1	6	10	PF00082	0.320
CLV_PCSK_SKI1_1	614	618	PF00082	0.320
CLV_PCSK_SKI1_1	650	654	PF00082	0.320
CLV_PCSK_SKI1_1	82	86	PF00082	0.320
DEG_Nend_UBRbox_3	1	3	PF02207	0.270
DOC_MAPK_gen_1	148	157	PF00069	0.520
DOC_MAPK_gen_1	224	233	PF00069	0.520
DOC_MAPK_gen_1	300	309	PF00069	0.520
DOC_MAPK_gen_1	376	385	PF00069	0.545
DOC_MAPK_gen_1	452	461	PF00069	0.520
DOC_MAPK_gen_1	528	537	PF00069	0.520
DOC_MAPK_gen_1	604	613	PF00069	0.520
DOC_MAPK_gen_1	72	81	PF00069	0.520
DOC_MAPK_HePTP_8	145	157	PF00069	0.520
DOC_MAPK_HePTP_8	221	233	PF00069	0.520
DOC_MAPK_HePTP_8	297	309	PF00069	0.520
DOC_MAPK_HePTP_8	373	385	PF00069	0.520
DOC_MAPK_HePTP_8	449	461	PF00069	0.520
DOC_MAPK_HePTP_8	525	537	PF00069	0.520
DOC_MAPK_HePTP_8	601	613	PF00069	0.520
DOC_MAPK_HePTP_8	69	81	PF00069	0.520
DOC_MAPK_MEF2A_6	139	147	PF00069	0.520
DOC_MAPK_MEF2A_6	148	157	PF00069	0.445
DOC_MAPK_MEF2A_6	215	223	PF00069	0.520
DOC_MAPK_MEF2A_6	224	233	PF00069	0.445
DOC_MAPK_MEF2A_6	291	299	PF00069	0.520
DOC_MAPK_MEF2A_6	300	309	PF00069	0.445
DOC_MAPK_MEF2A_6	367	375	PF00069	0.520
DOC_MAPK_MEF2A_6	376	385	PF00069	0.445
DOC_MAPK_MEF2A_6	443	451	PF00069	0.520
DOC_MAPK_MEF2A_6	452	461	PF00069	0.445
DOC_MAPK_MEF2A_6	519	527	PF00069	0.520
DOC_MAPK_MEF2A_6	528	537	PF00069	0.445
DOC_MAPK_MEF2A_6	595	603	PF00069	0.520
DOC_MAPK_MEF2A_6	604	613	PF00069	0.445
DOC_MAPK_MEF2A_6	63	71	PF00069	0.520
DOC_MAPK_MEF2A_6	671	679	PF00069	0.520
DOC_MAPK_MEF2A_6	72	81	PF00069	0.445
DOC_PP1_RVXF_1	116	122	PF00149	0.520
DOC_PP1_RVXF_1	192	198	PF00149	0.520
DOC_PP1_RVXF_1	268	274	PF00149	0.520
DOC_PP1_RVXF_1	344	350	PF00149	0.520
DOC_PP1_RVXF_1	40	46	PF00149	0.520
DOC_PP1_RVXF_1	420	426	PF00149	0.520
DOC_PP1_RVXF_1	496	502	PF00149	0.520
DOC_PP1_RVXF_1	572	578	PF00149	0.520
DOC_PP1_RVXF_1	648	654	PF00149	0.520
DOC_USP7_UBL2_3	105	109	PF12436	0.520
DOC_USP7_UBL2_3	181	185	PF12436	0.520
DOC_USP7_UBL2_3	257	261	PF12436	0.520
DOC_USP7_UBL2_3	29	33	PF12436	0.520
DOC_USP7_UBL2_3	333	337	PF12436	0.520
DOC_USP7_UBL2_3	409	413	PF12436	0.520
DOC_USP7_UBL2_3	485	489	PF12436	0.520
DOC_USP7_UBL2_3	561	565	PF12436	0.520
DOC_USP7_UBL2_3	637	641	PF12436	0.520
LIG_14-3-3_CanoR_1	130	137	PF00244	0.520
LIG_14-3-3_CanoR_1	206	213	PF00244	0.545
LIG_14-3-3_CanoR_1	282	289	PF00244	0.520
LIG_14-3-3_CanoR_1	358	365	PF00244	0.520
LIG_14-3-3_CanoR_1	434	441	PF00244	0.520
LIG_14-3-3_CanoR_1	510	517	PF00244	0.520
LIG_14-3-3_CanoR_1	54	61	PF00244	0.545
LIG_14-3-3_CanoR_1	586	593	PF00244	0.520
LIG_14-3-3_CanoR_1	662	669	PF00244	0.520
LIG_FHA_1	10	16	PF00498	0.520
LIG_FHA_1	140	146	PF00498	0.533
LIG_FHA_1	162	168	PF00498	0.520
LIG_FHA_1	216	222	PF00498	0.520
LIG_FHA_1	238	244	PF00498	0.520
LIG_FHA_1	292	298	PF00498	0.520
LIG_FHA_1	314	320	PF00498	0.553
LIG_FHA_1	368	374	PF00498	0.520
LIG_FHA_1	390	396	PF00498	0.520
LIG_FHA_1	444	450	PF00498	0.520
LIG_FHA_1	466	472	PF00498	0.520
LIG_FHA_1	520	526	PF00498	0.520
LIG_FHA_1	542	548	PF00498	0.520
LIG_FHA_1	596	602	PF00498	0.520
LIG_FHA_1	618	624	PF00498	0.520
LIG_FHA_1	64	70	PF00498	0.520
LIG_FHA_1	672	678	PF00498	0.520
LIG_FHA_1	86	92	PF00498	0.520
LIG_FHA_2	129	135	PF00498	0.520
LIG_FHA_2	205	211	PF00498	0.558
LIG_FHA_2	281	287	PF00498	0.604
LIG_FHA_2	357	363	PF00498	0.520
LIG_FHA_2	433	439	PF00498	0.520
LIG_FHA_2	509	515	PF00498	0.520
LIG_FHA_2	53	59	PF00498	0.520
LIG_FHA_2	585	591	PF00498	0.574
LIG_FHA_2	661	667	PF00498	0.520
LIG_GBD_Chelix_1	145	153	PF00786	0.320
LIG_GBD_Chelix_1	221	229	PF00786	0.320
LIG_GBD_Chelix_1	297	305	PF00786	0.320
LIG_GBD_Chelix_1	373	381	PF00786	0.320
LIG_GBD_Chelix_1	449	457	PF00786	0.320
LIG_GBD_Chelix_1	525	533	PF00786	0.320
LIG_GBD_Chelix_1	601	609	PF00786	0.320
LIG_NRBOX	66	72	PF00104	0.374
LIG_SH2_STAT3	135	138	PF00017	0.520
LIG_SH2_STAT3	211	214	PF00017	0.520
LIG_SH2_STAT3	287	290	PF00017	0.520
LIG_SH2_STAT3	363	366	PF00017	0.520
LIG_SH2_STAT3	439	442	PF00017	0.520
LIG_SH2_STAT3	515	518	PF00017	0.520
LIG_SH2_STAT3	59	62	PF00017	0.520
LIG_SH2_STAT3	591	594	PF00017	0.520
LIG_SH2_STAT3	667	670	PF00017	0.520
LIG_SUMO_SIM_par_1	11	16	PF11976	0.520
LIG_SUMO_SIM_par_1	163	168	PF11976	0.520
LIG_SUMO_SIM_par_1	239	244	PF11976	0.520
LIG_SUMO_SIM_par_1	315	320	PF11976	0.520
LIG_SUMO_SIM_par_1	391	396	PF11976	0.520
LIG_SUMO_SIM_par_1	467	472	PF11976	0.520
LIG_SUMO_SIM_par_1	543	548	PF11976	0.520
LIG_SUMO_SIM_par_1	619	624	PF11976	0.520
LIG_SUMO_SIM_par_1	87	92	PF11976	0.520
MOD_NEK2_1	156	161	PF00069	0.558
MOD_NEK2_1	232	237	PF00069	0.520
MOD_NEK2_1	308	313	PF00069	0.574
MOD_NEK2_1	384	389	PF00069	0.520
MOD_NEK2_1	4	9	PF00069	0.520
MOD_NEK2_1	460	465	PF00069	0.520
MOD_NEK2_1	536	541	PF00069	0.520
MOD_NEK2_1	612	617	PF00069	0.520
MOD_NEK2_1	80	85	PF00069	0.520
MOD_Plk_1	139	145	PF00069	0.579
MOD_Plk_1	215	221	PF00069	0.520
MOD_Plk_1	291	297	PF00069	0.520
MOD_Plk_1	367	373	PF00069	0.520
MOD_Plk_1	443	449	PF00069	0.520
MOD_Plk_1	519	525	PF00069	0.520
MOD_Plk_1	595	601	PF00069	0.520
MOD_Plk_1	63	69	PF00069	0.520
MOD_Plk_1	671	677	PF00069	0.520
MOD_Plk_2-3	128	134	PF00069	0.520
MOD_Plk_2-3	204	210	PF00069	0.520
MOD_Plk_2-3	280	286	PF00069	0.520
MOD_Plk_2-3	356	362	PF00069	0.520
MOD_Plk_2-3	432	438	PF00069	0.520
MOD_Plk_2-3	508	514	PF00069	0.520
MOD_Plk_2-3	52	58	PF00069	0.520
MOD_Plk_2-3	584	590	PF00069	0.520
MOD_Plk_2-3	660	666	PF00069	0.520
TRG_DiLeu_BaEn_4	127	133	PF01217	0.520
TRG_DiLeu_BaEn_4	203	209	PF01217	0.520
TRG_DiLeu_BaEn_4	279	285	PF01217	0.520
TRG_DiLeu_BaEn_4	355	361	PF01217	0.520
TRG_DiLeu_BaEn_4	431	437	PF01217	0.520
TRG_DiLeu_BaEn_4	507	513	PF01217	0.520
TRG_DiLeu_BaEn_4	51	57	PF01217	0.520
TRG_DiLeu_BaEn_4	583	589	PF01217	0.520
TRG_DiLeu_BaEn_4	659	665	PF01217	0.520
TRG_DiLeu_BaLyEn_6	115	120	PF01217	0.537
TRG_DiLeu_BaLyEn_6	191	196	PF01217	0.520
TRG_DiLeu_BaLyEn_6	267	272	PF01217	0.520
TRG_DiLeu_BaLyEn_6	343	348	PF01217	0.520
TRG_DiLeu_BaLyEn_6	39	44	PF01217	0.520
TRG_DiLeu_BaLyEn_6	419	424	PF01217	0.520
TRG_DiLeu_BaLyEn_6	495	500	PF01217	0.520
TRG_DiLeu_BaLyEn_6	571	576	PF01217	0.520
TRG_DiLeu_BaLyEn_6	647	652	PF01217	0.520
TRG_ER_diArg_1	147	150	PF00400	0.520
TRG_ER_diArg_1	223	226	PF00400	0.520
TRG_ER_diArg_1	299	302	PF00400	0.579
TRG_ER_diArg_1	375	378	PF00400	0.541
TRG_ER_diArg_1	451	454	PF00400	0.524
TRG_ER_diArg_1	527	530	PF00400	0.520
TRG_ER_diArg_1	603	606	PF00400	0.520
TRG_ER_diArg_1	679	682	PF00400	0.545
TRG_ER_diArg_1	71	74	PF00400	0.520
TRG_Pf-PMV_PEXEL_1	124	128	PF00026	0.349
TRG_Pf-PMV_PEXEL_1	130	134	PF00026	0.295
TRG_Pf-PMV_PEXEL_1	200	204	PF00026	0.320
TRG_Pf-PMV_PEXEL_1	206	210	PF00026	0.270
TRG_Pf-PMV_PEXEL_1	276	280	PF00026	0.379
TRG_Pf-PMV_PEXEL_1	282	286	PF00026	0.353
TRG_Pf-PMV_PEXEL_1	352	356	PF00026	0.353
TRG_Pf-PMV_PEXEL_1	358	362	PF00026	0.329
TRG_Pf-PMV_PEXEL_1	428	432	PF00026	0.320
TRG_Pf-PMV_PEXEL_1	434	438	PF00026	0.270
TRG_Pf-PMV_PEXEL_1	48	52	PF00026	0.320
TRG_Pf-PMV_PEXEL_1	504	508	PF00026	0.320
TRG_Pf-PMV_PEXEL_1	510	514	PF00026	0.270
TRG_Pf-PMV_PEXEL_1	54	58	PF00026	0.245
TRG_Pf-PMV_PEXEL_1	580	584	PF00026	0.320
TRG_Pf-PMV_PEXEL_1	586	590	PF00026	0.270
TRG_Pf-PMV_PEXEL_1	656	660	PF00026	0.320
TRG_Pf-PMV_PEXEL_1	662	666	PF00026	0.270

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HPM0	Leishmania braziliensis	99%	100%
A4HU11	Leishmania infantum	100%	100%
P0CG48	Homo sapiens	97%	100%
P0CG50	Mus musculus	97%	93%
P0CG61	Pongo pygmaeus	97%	90%
P0CG64	Pan troglodytes	97%	90%
P0CG66	Gorilla gorilla gorilla	97%	100%
P0CG68	Sus scrofa	97%	100%
P0CG69	Drosophila melanogaster	97%	90%
P0CG71	Caenorhabditis elegans	96%	82%
P0CG78	Dictyostelium discoideum	95%	100%
P0CG85	Nicotiana sylvestris	93%	100%
P0CH04	Petroselinum crispum	93%	100%
P0CH05	Petroselinum crispum	93%	100%
P0CH28	Bos taurus	97%	99%
P42740	Aglaothamnion neglectum	94%	100%
P59669	Geodia cydonium	96%	100%
P62976	Cricetulus griseus	96%	100%
Q39256	Arabidopsis thaliana	72%	100%
Q4Q165	Leishmania major	100%	100%
Q63429	Rattus norvegicus	97%	84%
Q8H159	Arabidopsis thaliana	93%	100%