LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
E9AHX5_LEIIN
TriTrypDb:
LINF_360041500
Length:
815

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005929 cilium 4 1
GO:0042995 cell projection 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0110165 cellular anatomical entity 1 2
GO:0120025 plasma membrane bounded cell projection 3 1
GO:0016020 membrane 2 1

Expansion

Sequence features

E9AHX5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHX5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 416 420 PF00656 0.424
CLV_NRD_NRD_1 122 124 PF00675 0.822
CLV_NRD_NRD_1 276 278 PF00675 0.703
CLV_NRD_NRD_1 402 404 PF00675 0.473
CLV_NRD_NRD_1 414 416 PF00675 0.424
CLV_NRD_NRD_1 438 440 PF00675 0.460
CLV_NRD_NRD_1 47 49 PF00675 0.663
CLV_NRD_NRD_1 499 501 PF00675 0.557
CLV_NRD_NRD_1 512 514 PF00675 0.496
CLV_NRD_NRD_1 523 525 PF00675 0.482
CLV_NRD_NRD_1 539 541 PF00675 0.439
CLV_NRD_NRD_1 576 578 PF00675 0.504
CLV_NRD_NRD_1 586 588 PF00675 0.464
CLV_NRD_NRD_1 606 608 PF00675 0.347
CLV_NRD_NRD_1 628 630 PF00675 0.525
CLV_NRD_NRD_1 647 649 PF00675 0.347
CLV_NRD_NRD_1 657 659 PF00675 0.453
CLV_NRD_NRD_1 677 679 PF00675 0.379
CLV_NRD_NRD_1 739 741 PF00675 0.480
CLV_NRD_NRD_1 775 777 PF00675 0.625
CLV_NRD_NRD_1 92 94 PF00675 0.516
CLV_NRD_NRD_1 98 100 PF00675 0.591
CLV_PCSK_FUR_1 537 541 PF00082 0.577
CLV_PCSK_FUR_1 584 588 PF00082 0.549
CLV_PCSK_KEX2_1 276 278 PF00082 0.709
CLV_PCSK_KEX2_1 402 404 PF00082 0.456
CLV_PCSK_KEX2_1 414 416 PF00082 0.481
CLV_PCSK_KEX2_1 438 440 PF00082 0.428
CLV_PCSK_KEX2_1 47 49 PF00082 0.663
CLV_PCSK_KEX2_1 512 514 PF00082 0.526
CLV_PCSK_KEX2_1 522 524 PF00082 0.457
CLV_PCSK_KEX2_1 539 541 PF00082 0.465
CLV_PCSK_KEX2_1 576 578 PF00082 0.504
CLV_PCSK_KEX2_1 586 588 PF00082 0.464
CLV_PCSK_KEX2_1 605 607 PF00082 0.376
CLV_PCSK_KEX2_1 628 630 PF00082 0.545
CLV_PCSK_KEX2_1 646 648 PF00082 0.375
CLV_PCSK_KEX2_1 657 659 PF00082 0.529
CLV_PCSK_KEX2_1 677 679 PF00082 0.387
CLV_PCSK_KEX2_1 739 741 PF00082 0.478
CLV_PCSK_KEX2_1 775 777 PF00082 0.591
CLV_PCSK_PC1ET2_1 605 607 PF00082 0.555
CLV_PCSK_PC1ET2_1 646 648 PF00082 0.574
CLV_PCSK_PC1ET2_1 775 777 PF00082 0.591
CLV_PCSK_PC7_1 410 416 PF00082 0.511
CLV_PCSK_PC7_1 642 648 PF00082 0.570
CLV_PCSK_SKI1_1 209 213 PF00082 0.570
CLV_PCSK_SKI1_1 298 302 PF00082 0.436
CLV_PCSK_SKI1_1 331 335 PF00082 0.540
CLV_PCSK_SKI1_1 410 414 PF00082 0.565
CLV_PCSK_SKI1_1 470 474 PF00082 0.485
CLV_PCSK_SKI1_1 609 613 PF00082 0.573
CLV_PCSK_SKI1_1 628 632 PF00082 0.387
CLV_PCSK_SKI1_1 658 662 PF00082 0.608
CLV_PCSK_SKI1_1 731 735 PF00082 0.455
CLV_PCSK_SKI1_1 804 808 PF00082 0.498
DOC_CKS1_1 272 277 PF01111 0.682
DOC_CKS1_1 278 283 PF01111 0.590
DOC_CYCLIN_RxL_1 295 302 PF00134 0.483
DOC_CYCLIN_yCln2_LP_2 278 284 PF00134 0.602
DOC_PP2B_LxvP_1 301 304 PF13499 0.483
DOC_USP7_MATH_1 122 126 PF00917 0.683
DOC_USP7_MATH_1 128 132 PF00917 0.643
DOC_USP7_MATH_1 146 150 PF00917 0.770
DOC_USP7_MATH_1 245 249 PF00917 0.763
DOC_USP7_MATH_1 372 376 PF00917 0.682
DOC_USP7_MATH_1 377 381 PF00917 0.662
DOC_USP7_UBL2_3 30 34 PF12436 0.580
DOC_USP7_UBL2_3 598 602 PF12436 0.499
DOC_USP7_UBL2_3 605 609 PF12436 0.488
DOC_WW_Pin1_4 124 129 PF00397 0.701
DOC_WW_Pin1_4 142 147 PF00397 0.764
DOC_WW_Pin1_4 154 159 PF00397 0.710
DOC_WW_Pin1_4 173 178 PF00397 0.700
DOC_WW_Pin1_4 212 217 PF00397 0.683
DOC_WW_Pin1_4 241 246 PF00397 0.649
DOC_WW_Pin1_4 264 269 PF00397 0.690
DOC_WW_Pin1_4 271 276 PF00397 0.643
DOC_WW_Pin1_4 277 282 PF00397 0.582
DOC_WW_Pin1_4 343 348 PF00397 0.619
DOC_WW_Pin1_4 350 355 PF00397 0.272
DOC_WW_Pin1_4 363 368 PF00397 0.373
LIG_14-3-3_CanoR_1 221 226 PF00244 0.703
LIG_14-3-3_CanoR_1 264 268 PF00244 0.777
LIG_14-3-3_CanoR_1 331 340 PF00244 0.518
LIG_14-3-3_CanoR_1 414 418 PF00244 0.539
LIG_14-3-3_CanoR_1 731 738 PF00244 0.561
LIG_Actin_WH2_2 308 326 PF00022 0.477
LIG_BIR_II_1 1 5 PF00653 0.689
LIG_deltaCOP1_diTrp_1 735 744 PF00928 0.429
LIG_EH1_1 766 774 PF00400 0.504
LIG_FHA_1 291 297 PF00498 0.551
LIG_FHA_1 473 479 PF00498 0.536
LIG_FHA_1 55 61 PF00498 0.552
LIG_FHA_1 590 596 PF00498 0.555
LIG_FHA_1 749 755 PF00498 0.422
LIG_FHA_2 174 180 PF00498 0.765
LIG_FHA_2 414 420 PF00498 0.504
LIG_FHA_2 711 717 PF00498 0.609
LIG_FHA_2 766 772 PF00498 0.454
LIG_FHA_2 78 84 PF00498 0.515
LIG_LIR_Gen_1 183 194 PF02991 0.603
LIG_LIR_Gen_1 419 429 PF02991 0.378
LIG_LIR_Gen_1 751 760 PF02991 0.418
LIG_LIR_Gen_1 762 770 PF02991 0.354
LIG_LIR_Nem_3 12 17 PF02991 0.712
LIG_LIR_Nem_3 183 189 PF02991 0.617
LIG_LIR_Nem_3 37 42 PF02991 0.475
LIG_LIR_Nem_3 419 424 PF02991 0.365
LIG_LIR_Nem_3 751 755 PF02991 0.427
LIG_LIR_Nem_3 762 766 PF02991 0.345
LIG_MAD2 295 303 PF02301 0.508
LIG_MYND_1 226 230 PF01753 0.668
LIG_NRBOX 296 302 PF00104 0.408
LIG_Pex14_2 318 322 PF04695 0.519
LIG_SH2_CRK 14 18 PF00017 0.705
LIG_SH2_CRK 421 425 PF00017 0.429
LIG_SH2_CRK 437 441 PF00017 0.335
LIG_SH2_CRK 752 756 PF00017 0.484
LIG_SH2_STAP1 307 311 PF00017 0.490
LIG_SH2_STAT3 544 547 PF00017 0.409
LIG_SH2_STAT5 35 38 PF00017 0.594
LIG_SH2_STAT5 405 408 PF00017 0.498
LIG_SH2_STAT5 640 643 PF00017 0.566
LIG_SH3_2 272 277 PF14604 0.733
LIG_SH3_3 145 151 PF00018 0.779
LIG_SH3_3 17 23 PF00018 0.539
LIG_SH3_3 195 201 PF00018 0.658
LIG_SH3_3 269 275 PF00018 0.610
LIG_SUMO_SIM_anti_2 768 774 PF11976 0.461
LIG_SUMO_SIM_par_1 768 774 PF11976 0.461
LIG_TRAF2_1 136 139 PF00917 0.652
LIG_TRAF2_1 168 171 PF00917 0.692
LIG_TRAF2_1 450 453 PF00917 0.683
LIG_TRAF2_1 516 519 PF00917 0.543
LIG_TRAF2_1 705 708 PF00917 0.536
LIG_TYR_ITSM 10 17 PF00017 0.574
LIG_UBA3_1 480 488 PF00899 0.482
LIG_WRC_WIRS_1 315 320 PF05994 0.409
MOD_CDK_SPK_2 271 276 PF00069 0.682
MOD_CDK_SPK_2 350 355 PF00069 0.358
MOD_CDK_SPK_2 363 368 PF00069 0.373
MOD_CDK_SPxK_1 271 277 PF00069 0.783
MOD_CDK_SPxxK_3 343 350 PF00069 0.621
MOD_CK1_1 147 153 PF00069 0.696
MOD_CK1_1 166 172 PF00069 0.631
MOD_CK1_1 203 209 PF00069 0.745
MOD_CK1_1 353 359 PF00069 0.376
MOD_CK1_1 375 381 PF00069 0.680
MOD_CK1_1 457 463 PF00069 0.574
MOD_CK2_1 173 179 PF00069 0.752
MOD_CK2_1 34 40 PF00069 0.643
MOD_CK2_1 77 83 PF00069 0.558
MOD_Cter_Amidation 91 94 PF01082 0.545
MOD_DYRK1A_RPxSP_1 264 268 PF00069 0.770
MOD_GlcNHglycan 105 108 PF01048 0.694
MOD_GlcNHglycan 152 155 PF01048 0.695
MOD_GlcNHglycan 165 168 PF01048 0.757
MOD_GlcNHglycan 209 212 PF01048 0.753
MOD_GlcNHglycan 247 250 PF01048 0.785
MOD_GlcNHglycan 374 377 PF01048 0.649
MOD_GlcNHglycan 379 382 PF01048 0.678
MOD_GSK3_1 124 131 PF00069 0.643
MOD_GSK3_1 142 149 PF00069 0.732
MOD_GSK3_1 150 157 PF00069 0.612
MOD_GSK3_1 203 210 PF00069 0.718
MOD_GSK3_1 211 218 PF00069 0.674
MOD_GSK3_1 232 239 PF00069 0.773
MOD_GSK3_1 241 248 PF00069 0.747
MOD_GSK3_1 263 270 PF00069 0.701
MOD_GSK3_1 286 293 PF00069 0.592
MOD_GSK3_1 371 378 PF00069 0.643
MOD_GSK3_1 413 420 PF00069 0.446
MOD_GSK3_1 5 12 PF00069 0.663
MOD_GSK3_1 727 734 PF00069 0.462
MOD_LATS_1 207 213 PF00433 0.569
MOD_NEK2_1 313 318 PF00069 0.478
MOD_NEK2_1 413 418 PF00069 0.416
MOD_NEK2_1 588 593 PF00069 0.472
MOD_NEK2_1 69 74 PF00069 0.718
MOD_NEK2_2 307 312 PF00069 0.459
MOD_PIKK_1 128 134 PF00454 0.746
MOD_PIKK_1 215 221 PF00454 0.701
MOD_PIKK_1 385 391 PF00454 0.511
MOD_PIKK_1 5 11 PF00454 0.625
MOD_PIKK_1 698 704 PF00454 0.495
MOD_PKA_1 646 652 PF00069 0.468
MOD_PKA_2 122 128 PF00069 0.708
MOD_PKA_2 263 269 PF00069 0.747
MOD_PKA_2 372 378 PF00069 0.603
MOD_PKA_2 413 419 PF00069 0.545
MOD_PKA_2 589 595 PF00069 0.523
MOD_PKA_2 646 652 PF00069 0.584
MOD_PKA_2 718 724 PF00069 0.600
MOD_PKA_2 727 733 PF00069 0.544
MOD_PKB_1 3 11 PF00069 0.627
MOD_Plk_1 232 238 PF00069 0.583
MOD_Plk_1 313 319 PF00069 0.518
MOD_Plk_1 494 500 PF00069 0.468
MOD_Plk_1 69 75 PF00069 0.587
MOD_Plk_2-3 314 320 PF00069 0.413
MOD_Plk_4 419 425 PF00069 0.477
MOD_Plk_4 72 78 PF00069 0.581
MOD_Plk_4 765 771 PF00069 0.442
MOD_ProDKin_1 124 130 PF00069 0.699
MOD_ProDKin_1 142 148 PF00069 0.763
MOD_ProDKin_1 154 160 PF00069 0.711
MOD_ProDKin_1 173 179 PF00069 0.701
MOD_ProDKin_1 212 218 PF00069 0.681
MOD_ProDKin_1 241 247 PF00069 0.649
MOD_ProDKin_1 264 270 PF00069 0.688
MOD_ProDKin_1 271 277 PF00069 0.643
MOD_ProDKin_1 343 349 PF00069 0.607
MOD_ProDKin_1 350 356 PF00069 0.268
MOD_ProDKin_1 363 369 PF00069 0.377
MOD_SUMO_for_1 611 614 PF00179 0.561
MOD_SUMO_for_1 705 708 PF00179 0.495
MOD_SUMO_for_1 807 810 PF00179 0.537
MOD_SUMO_rev_2 591 600 PF00179 0.583
MOD_SUMO_rev_2 745 751 PF00179 0.421
TRG_DiLeu_BaEn_4 170 176 PF01217 0.694
TRG_DiLeu_BaEn_4 626 632 PF01217 0.668
TRG_ENDOCYTIC_2 14 17 PF00928 0.713
TRG_ENDOCYTIC_2 421 424 PF00928 0.360
TRG_ENDOCYTIC_2 437 440 PF00928 0.358
TRG_ENDOCYTIC_2 752 755 PF00928 0.490
TRG_ER_diArg_1 220 223 PF00400 0.811
TRG_ER_diArg_1 275 277 PF00400 0.756
TRG_ER_diArg_1 413 415 PF00400 0.490
TRG_ER_diArg_1 437 439 PF00400 0.447
TRG_ER_diArg_1 46 48 PF00400 0.606
TRG_ER_diArg_1 511 513 PF00400 0.532
TRG_ER_diArg_1 522 524 PF00400 0.515
TRG_ER_diArg_1 537 540 PF00400 0.367
TRG_ER_diArg_1 584 587 PF00400 0.538
TRG_ER_diArg_1 738 740 PF00400 0.495
TRG_ER_diArg_1 783 786 PF00400 0.500
TRG_ER_diArg_1 794 797 PF00400 0.367
TRG_Pf-PMV_PEXEL_1 298 302 PF00026 0.473
TRG_Pf-PMV_PEXEL_1 34 38 PF00026 0.566
TRG_Pf-PMV_PEXEL_1 415 419 PF00026 0.431
TRG_Pf-PMV_PEXEL_1 438 442 PF00026 0.459
TRG_Pf-PMV_PEXEL_1 463 467 PF00026 0.449
TRG_Pf-PMV_PEXEL_1 488 492 PF00026 0.569
TRG_Pf-PMV_PEXEL_1 500 505 PF00026 0.425
TRG_Pf-PMV_PEXEL_1 515 519 PF00026 0.465
TRG_Pf-PMV_PEXEL_1 523 527 PF00026 0.486
TRG_Pf-PMV_PEXEL_1 629 633 PF00026 0.665
TRG_Pf-PMV_PEXEL_1 731 735 PF00026 0.596
TRG_Pf-PMV_PEXEL_1 786 791 PF00026 0.489

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PCJ0 Leptomonas seymouri 47% 99%
A0A1X0P4M8 Trypanosomatidae 30% 97%
A0A3Q8IW63 Leishmania donovani 100% 100%
A0A3R7KTP5 Trypanosoma rangeli 31% 100%
A4HPJ7 Leishmania braziliensis 73% 100%
D0A8L7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 94%
E9ATA9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
Q4Q188 Leishmania major 95% 100%
V5BS35 Trypanosoma cruzi 29% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS