LeishMANIAdb
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TLDc domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
TLDc domain-containing protein
Gene product:
TLD - putative
Species:
Leishmania infantum
UniProt:
E9AHX4_LEIIN
TriTrypDb:
LINF_360026200 *
Length:
362

Annotations

LeishMANIAdb annotations

Distantly related to a domain found in MEAK7, a regulatory subunit of animal mTOR complex. The hydrophobic segment is likely a perimembrane anchor, not a TM region (used instead of a mirystoylation site found in mammals)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 9
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 5
GO:0110165 cellular anatomical entity 1 5

Expansion

Sequence features

E9AHX4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHX4

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 3
GO:0004386 helicase activity 2 3
GO:0140640 catalytic activity, acting on a nucleic acid 2 3
GO:0140657 ATP-dependent activity 1 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 335 339 PF00656 0.457
CLV_NRD_NRD_1 356 358 PF00675 0.503
CLV_PCSK_KEX2_1 356 358 PF00082 0.503
CLV_PCSK_KEX2_1 90 92 PF00082 0.320
CLV_PCSK_PC1ET2_1 90 92 PF00082 0.320
CLV_PCSK_SKI1_1 177 181 PF00082 0.311
CLV_PCSK_SKI1_1 90 94 PF00082 0.477
DOC_ANK_TNKS_1 218 225 PF00023 0.297
DOC_CKS1_1 47 52 PF01111 0.548
DOC_CKS1_1 94 99 PF01111 0.520
DOC_MAPK_HePTP_8 142 154 PF00069 0.377
DOC_MAPK_MEF2A_6 145 154 PF00069 0.377
DOC_MAPK_MEF2A_6 340 348 PF00069 0.545
DOC_PP2B_PxIxI_1 146 152 PF00149 0.381
DOC_PP4_FxxP_1 290 293 PF00568 0.249
DOC_PP4_FxxP_1 47 50 PF00568 0.549
DOC_USP7_MATH_1 183 187 PF00917 0.387
DOC_USP7_UBL2_3 65 69 PF12436 0.529
DOC_WW_Pin1_4 154 159 PF00397 0.395
DOC_WW_Pin1_4 23 28 PF00397 0.402
DOC_WW_Pin1_4 46 51 PF00397 0.718
DOC_WW_Pin1_4 76 81 PF00397 0.483
DOC_WW_Pin1_4 93 98 PF00397 0.518
LIG_14-3-3_CanoR_1 141 149 PF00244 0.234
LIG_14-3-3_CanoR_1 197 202 PF00244 0.259
LIG_14-3-3_CanoR_1 286 291 PF00244 0.271
LIG_14-3-3_CanoR_1 294 303 PF00244 0.268
LIG_BIR_III_2 105 109 PF00653 0.388
LIG_BRCT_BRCA1_1 205 209 PF00533 0.292
LIG_BRCT_BRCA1_1 21 25 PF00533 0.311
LIG_FHA_1 146 152 PF00498 0.268
LIG_FHA_1 223 229 PF00498 0.302
LIG_FHA_1 249 255 PF00498 0.360
LIG_FHA_1 325 331 PF00498 0.641
LIG_FHA_1 94 100 PF00498 0.434
LIG_FHA_2 228 234 PF00498 0.420
LIG_GBD_Chelix_1 99 107 PF00786 0.371
LIG_LIR_Apic_2 22 27 PF02991 0.362
LIG_LIR_Apic_2 288 293 PF02991 0.252
LIG_LIR_Apic_2 46 50 PF02991 0.547
LIG_LIR_Gen_1 134 142 PF02991 0.228
LIG_LIR_Gen_1 166 173 PF02991 0.283
LIG_LIR_Gen_1 243 253 PF02991 0.328
LIG_LIR_Gen_1 3 12 PF02991 0.331
LIG_LIR_Nem_3 120 126 PF02991 0.345
LIG_LIR_Nem_3 134 138 PF02991 0.170
LIG_LIR_Nem_3 166 172 PF02991 0.290
LIG_LIR_Nem_3 208 213 PF02991 0.247
LIG_LIR_Nem_3 243 248 PF02991 0.328
LIG_LIR_Nem_3 3 7 PF02991 0.544
LIG_MLH1_MIPbox_1 21 25 PF16413 0.311
LIG_PDZ_Class_1 357 362 PF00595 0.585
LIG_Pex14_1 122 126 PF04695 0.290
LIG_Pex14_2 245 249 PF04695 0.249
LIG_Pex14_2 272 276 PF04695 0.249
LIG_REV1ctd_RIR_1 269 279 PF16727 0.147
LIG_SH2_CRK 71 75 PF00017 0.565
LIG_SH2_PTP2 8 11 PF00017 0.315
LIG_SH2_SRC 12 15 PF00017 0.288
LIG_SH2_SRC 129 132 PF00017 0.234
LIG_SH2_SRC 221 224 PF00017 0.247
LIG_SH2_SRC 8 11 PF00017 0.315
LIG_SH2_STAP1 126 130 PF00017 0.328
LIG_SH2_STAT5 123 126 PF00017 0.292
LIG_SH2_STAT5 129 132 PF00017 0.292
LIG_SH2_STAT5 24 27 PF00017 0.352
LIG_SH2_STAT5 247 250 PF00017 0.290
LIG_SH2_STAT5 8 11 PF00017 0.315
LIG_SH3_3 72 78 PF00018 0.671
LIG_SH3_3 91 97 PF00018 0.289
LIG_SUMO_SIM_anti_2 148 153 PF11976 0.268
LIG_SUMO_SIM_par_1 91 96 PF11976 0.354
LIG_TRAF2_1 253 256 PF00917 0.381
LIG_TRAF2_1 64 67 PF00917 0.659
LIG_UBA3_1 149 155 PF00899 0.381
LIG_UBA3_1 92 98 PF00899 0.341
LIG_WRC_WIRS_1 1 6 PF05994 0.313
MOD_CDK_SPK_2 154 159 PF00069 0.322
MOD_CDK_SPK_2 93 98 PF00069 0.350
MOD_CK1_1 117 123 PF00069 0.467
MOD_CK1_1 237 243 PF00069 0.322
MOD_CK1_1 297 303 PF00069 0.405
MOD_CK1_1 324 330 PF00069 0.602
MOD_CK1_1 46 52 PF00069 0.731
MOD_CK2_1 197 203 PF00069 0.184
MOD_CK2_1 227 233 PF00069 0.372
MOD_CK2_1 293 299 PF00069 0.292
MOD_Cter_Amidation 88 91 PF01082 0.243
MOD_GlcNHglycan 116 119 PF01048 0.418
MOD_GlcNHglycan 180 183 PF01048 0.252
MOD_GlcNHglycan 185 188 PF01048 0.236
MOD_GlcNHglycan 199 202 PF01048 0.328
MOD_GlcNHglycan 327 330 PF01048 0.640
MOD_GSK3_1 141 148 PF00069 0.395
MOD_GSK3_1 164 171 PF00069 0.379
MOD_GSK3_1 183 190 PF00069 0.266
MOD_GSK3_1 19 26 PF00069 0.338
MOD_GSK3_1 222 229 PF00069 0.406
MOD_GSK3_1 236 243 PF00069 0.312
MOD_GSK3_1 293 300 PF00069 0.322
MOD_GSK3_1 321 328 PF00069 0.489
MOD_GSK3_1 35 42 PF00069 0.666
MOD_N-GLC_1 348 353 PF02516 0.555
MOD_N-GLC_2 57 59 PF02516 0.596
MOD_NEK2_1 124 129 PF00069 0.252
MOD_NEK2_1 248 253 PF00069 0.365
MOD_NEK2_1 319 324 PF00069 0.487
MOD_NEK2_1 43 48 PF00069 0.608
MOD_NMyristoyl 1 7 PF02799 0.306
MOD_PKA_2 140 146 PF00069 0.234
MOD_PKA_2 187 193 PF00069 0.344
MOD_PKA_2 196 202 PF00069 0.312
MOD_PKA_2 285 291 PF00069 0.287
MOD_PKA_2 293 299 PF00069 0.244
MOD_PKA_2 325 331 PF00069 0.553
MOD_Plk_2-3 227 233 PF00069 0.247
MOD_Plk_4 125 131 PF00069 0.361
MOD_Plk_4 145 151 PF00069 0.214
MOD_Plk_4 19 25 PF00069 0.357
MOD_Plk_4 205 211 PF00069 0.346
MOD_Plk_4 297 303 PF00069 0.418
MOD_ProDKin_1 154 160 PF00069 0.395
MOD_ProDKin_1 23 29 PF00069 0.407
MOD_ProDKin_1 46 52 PF00069 0.717
MOD_ProDKin_1 76 82 PF00069 0.474
MOD_ProDKin_1 93 99 PF00069 0.512
MOD_SUMO_for_1 64 67 PF00179 0.580
MOD_SUMO_rev_2 250 258 PF00179 0.328
MOD_SUMO_rev_2 61 70 PF00179 0.656
TRG_ENDOCYTIC_2 12 15 PF00928 0.283
TRG_ENDOCYTIC_2 268 271 PF00928 0.361
TRG_ENDOCYTIC_2 8 11 PF00928 0.310

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HZW5 Leptomonas seymouri 61% 100%
A0A0S4JCM6 Bodo saltans 25% 100%
A0A0S4JIE3 Bodo saltans 42% 100%
A0A1X0P7Q9 Trypanosomatidae 49% 100%
A0A3R7M9V1 Trypanosoma rangeli 46% 100%
A0A3S7XAT0 Leishmania donovani 96% 97%
A4HP62 Leishmania braziliensis 79% 100%
E9AG16 Leishmania major 89% 100%
E9ASX0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%
Q8K0P3 Mus musculus 28% 80%
V5BGD9 Trypanosoma cruzi 46% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS