Uncharacterized protein

Quick info Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc finger protein family member - putative

Species:

Leishmania infantum

UniProt:

E9AHX0_LEIIN

TriTrypDb:

LINF_350055000

Length:

1022

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

E9AHX0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHX0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	149	153	PF00656	0.425
CLV_C14_Caspase3-7	2	6	PF00656	0.614
CLV_MEL_PAP_1	762	768	PF00089	0.483
CLV_NRD_NRD_1	514	516	PF00675	0.631
CLV_NRD_NRD_1	66	68	PF00675	0.540
CLV_NRD_NRD_1	833	835	PF00675	0.764
CLV_NRD_NRD_1	855	857	PF00675	0.767
CLV_NRD_NRD_1	977	979	PF00675	0.755
CLV_NRD_NRD_1	982	984	PF00675	0.674
CLV_PCSK_KEX2_1	514	516	PF00082	0.631
CLV_PCSK_KEX2_1	855	857	PF00082	0.767
CLV_PCSK_KEX2_1	925	927	PF00082	0.637
CLV_PCSK_KEX2_1	977	979	PF00082	0.755
CLV_PCSK_KEX2_1	982	984	PF00082	0.674
CLV_PCSK_KEX2_1	986	988	PF00082	0.607
CLV_PCSK_PC1ET2_1	925	927	PF00082	0.637
CLV_PCSK_PC1ET2_1	986	988	PF00082	0.755
CLV_PCSK_PC7_1	978	984	PF00082	0.758
CLV_PCSK_SKI1_1	161	165	PF00082	0.428
CLV_PCSK_SKI1_1	293	297	PF00082	0.757
CLV_PCSK_SKI1_1	466	470	PF00082	0.685
CLV_PCSK_SKI1_1	625	629	PF00082	0.704
CLV_PCSK_SKI1_1	727	731	PF00082	0.764
CLV_PCSK_SKI1_1	758	762	PF00082	0.475
CLV_PCSK_SKI1_1	784	788	PF00082	0.602
CLV_PCSK_SKI1_1	809	813	PF00082	0.524
CLV_PCSK_SKI1_1	835	839	PF00082	0.674
DEG_SCF_FBW7_1	947	954	PF00400	0.757
DEG_SPOP_SBC_1	407	411	PF00917	0.684
DEG_SPOP_SBC_1	664	668	PF00917	0.718
DEG_SPOP_SBC_1	811	815	PF00917	0.589
DOC_CKS1_1	396	401	PF01111	0.721
DOC_CKS1_1	470	475	PF01111	0.725
DOC_CYCLIN_yCln2_LP_2	382	385	PF00134	0.685
DOC_MAPK_DCC_7	502	512	PF00069	0.668
DOC_MAPK_gen_1	793	803	PF00069	0.476
DOC_MAPK_MEF2A_6	418	425	PF00069	0.734
DOC_MAPK_MEF2A_6	794	803	PF00069	0.522
DOC_MAPK_NFAT4_5	796	804	PF00069	0.601
DOC_PP1_RVXF_1	109	116	PF00149	0.525
DOC_PP1_RVXF_1	785	792	PF00149	0.594
DOC_PP2B_LxvP_1	382	385	PF13499	0.772
DOC_PP2B_LxvP_1	468	471	PF13499	0.773
DOC_PP4_FxxP_1	916	919	PF00568	0.715
DOC_USP7_MATH_1	246	250	PF00917	0.664
DOC_USP7_MATH_1	254	258	PF00917	0.652
DOC_USP7_MATH_1	364	368	PF00917	0.719
DOC_USP7_MATH_1	389	393	PF00917	0.687
DOC_USP7_MATH_1	394	398	PF00917	0.655
DOC_USP7_MATH_1	402	406	PF00917	0.501
DOC_USP7_MATH_1	438	442	PF00917	0.755
DOC_USP7_MATH_1	449	453	PF00917	0.550
DOC_USP7_MATH_1	534	538	PF00917	0.622
DOC_USP7_MATH_1	539	543	PF00917	0.589
DOC_USP7_MATH_1	630	634	PF00917	0.623
DOC_USP7_MATH_1	648	652	PF00917	0.714
DOC_USP7_MATH_1	660	664	PF00917	0.550
DOC_USP7_MATH_1	764	768	PF00917	0.476
DOC_USP7_MATH_1	817	821	PF00917	0.644
DOC_USP7_MATH_1	829	833	PF00917	0.749
DOC_USP7_MATH_1	848	852	PF00917	0.655
DOC_USP7_MATH_1	867	871	PF00917	0.517
DOC_USP7_MATH_1	912	916	PF00917	0.763
DOC_USP7_MATH_1	955	959	PF00917	0.761
DOC_USP7_MATH_1	968	972	PF00917	0.512
DOC_USP7_UBL2_3	921	925	PF12436	0.658
DOC_WW_Pin1_4	231	236	PF00397	0.744
DOC_WW_Pin1_4	29	34	PF00397	0.708
DOC_WW_Pin1_4	385	390	PF00397	0.775
DOC_WW_Pin1_4	395	400	PF00397	0.650
DOC_WW_Pin1_4	408	413	PF00397	0.563
DOC_WW_Pin1_4	454	459	PF00397	0.608
DOC_WW_Pin1_4	46	51	PF00397	0.451
DOC_WW_Pin1_4	466	471	PF00397	0.739
DOC_WW_Pin1_4	599	604	PF00397	0.634
DOC_WW_Pin1_4	615	620	PF00397	0.755
DOC_WW_Pin1_4	633	638	PF00397	0.706
DOC_WW_Pin1_4	649	654	PF00397	0.506
DOC_WW_Pin1_4	655	660	PF00397	0.753
DOC_WW_Pin1_4	863	868	PF00397	0.684
DOC_WW_Pin1_4	871	876	PF00397	0.633
DOC_WW_Pin1_4	907	912	PF00397	0.759
DOC_WW_Pin1_4	915	920	PF00397	0.566
DOC_WW_Pin1_4	931	936	PF00397	0.484
DOC_WW_Pin1_4	941	946	PF00397	0.693
DOC_WW_Pin1_4	947	952	PF00397	0.634
DOC_WW_Pin1_4	957	962	PF00397	0.545
LIG_14-3-3_CanoR_1	18	25	PF00244	0.643
LIG_14-3-3_CanoR_1	227	232	PF00244	0.766
LIG_14-3-3_CanoR_1	269	275	PF00244	0.721
LIG_14-3-3_CanoR_1	293	301	PF00244	0.762
LIG_14-3-3_CanoR_1	347	353	PF00244	0.680
LIG_14-3-3_CanoR_1	395	399	PF00244	0.524
LIG_14-3-3_CanoR_1	559	564	PF00244	0.640
LIG_14-3-3_CanoR_1	575	581	PF00244	0.774
LIG_14-3-3_CanoR_1	727	734	PF00244	0.648
LIG_14-3-3_CanoR_1	765	773	PF00244	0.464
LIG_14-3-3_CanoR_1	809	818	PF00244	0.451
LIG_14-3-3_CanoR_1	834	841	PF00244	0.729
LIG_14-3-3_CanoR_1	992	1000	PF00244	0.527
LIG_Actin_WH2_2	771	789	PF00022	0.581
LIG_BIR_II_1	1	5	PF00653	0.629
LIG_BRCT_BRCA1_1	130	134	PF00533	0.552
LIG_EH1_1	139	147	PF00400	0.413
LIG_EH1_1	686	694	PF00400	0.750
LIG_FHA_1	125	131	PF00498	0.427
LIG_FHA_1	136	142	PF00498	0.442
LIG_FHA_1	269	275	PF00498	0.677
LIG_FHA_1	296	302	PF00498	0.676
LIG_FHA_1	455	461	PF00498	0.716
LIG_FHA_1	501	507	PF00498	0.691
LIG_FHA_1	605	611	PF00498	0.614
LIG_FHA_1	710	716	PF00498	0.559
LIG_FHA_1	761	767	PF00498	0.565
LIG_FHA_1	770	776	PF00498	0.443
LIG_FHA_1	836	842	PF00498	0.717
LIG_FHA_1	941	947	PF00498	0.657
LIG_FHA_2	147	153	PF00498	0.513
LIG_FHA_2	728	734	PF00498	0.584
LIG_FHA_2	961	967	PF00498	0.750
LIG_Integrin_isoDGR_2	747	749	PF01839	0.711
LIG_LIR_Apic_2	913	919	PF02991	0.719
LIG_LIR_Gen_1	152	163	PF02991	0.408
LIG_LIR_Gen_1	93	103	PF02991	0.459
LIG_LIR_Nem_3	152	158	PF02991	0.396
LIG_LIR_Nem_3	93	98	PF02991	0.448
LIG_LIR_Nem_3	99	105	PF02991	0.488
LIG_PCNA_yPIPBox_3	83	95	PF02747	0.531
LIG_PTB_Apo_2	199	206	PF02174	0.610
LIG_PTB_Phospho_1	199	205	PF10480	0.609
LIG_SH2_CRK	95	99	PF00017	0.445
LIG_SH2_PTP2	102	105	PF00017	0.514
LIG_SH2_STAP1	170	174	PF00017	0.429
LIG_SH2_STAT3	184	187	PF00017	0.694
LIG_SH2_STAT5	102	105	PF00017	0.446
LIG_SH2_STAT5	140	143	PF00017	0.515
LIG_SH2_STAT5	148	151	PF00017	0.375
LIG_SH2_STAT5	773	776	PF00017	0.472
LIG_SH2_STAT5	788	791	PF00017	0.586
LIG_SH3_1	418	424	PF00018	0.736
LIG_SH3_2	243	248	PF14604	0.659
LIG_SH3_2	497	502	PF14604	0.594
LIG_SH3_3	240	246	PF00018	0.650
LIG_SH3_3	393	399	PF00018	0.741
LIG_SH3_3	418	424	PF00018	0.787
LIG_SH3_3	467	473	PF00018	0.735
LIG_SH3_3	494	500	PF00018	0.595
LIG_SH3_3	568	574	PF00018	0.764
LIG_SH3_3	597	603	PF00018	0.719
LIG_SH3_3	607	613	PF00018	0.687
LIG_SH3_3	69	75	PF00018	0.429
LIG_SH3_3	716	722	PF00018	0.733
LIG_SH3_3	851	857	PF00018	0.725
LIG_SH3_3	861	867	PF00018	0.733
LIG_SH3_3	878	884	PF00018	0.524
LIG_SH3_3	905	911	PF00018	0.674
LIG_SH3_3	939	945	PF00018	0.769
LIG_SUMO_SIM_par_1	799	804	PF11976	0.540
LIG_TRAF2_1	621	624	PF00917	0.707
LIG_TRAF2_1	843	846	PF00917	0.665
LIG_TRAF2_1	971	974	PF00917	0.670
LIG_UBA3_1	154	161	PF00899	0.497
LIG_WW_3	290	294	PF00397	0.618
LIG_WW_3	383	387	PF00397	0.687
MOD_CDC14_SPxK_1	918	921	PF00782	0.770
MOD_CDK_SPxK_1	915	921	PF00069	0.763
MOD_CDK_SPxxK_3	871	878	PF00069	0.631
MOD_CDK_SPxxK_3	957	964	PF00069	0.660
MOD_CK1_1	157	163	PF00069	0.414
MOD_CK1_1	173	179	PF00069	0.473
MOD_CK1_1	21	27	PF00069	0.753
MOD_CK1_1	29	35	PF00069	0.614
MOD_CK1_1	332	338	PF00069	0.553
MOD_CK1_1	354	360	PF00069	0.635
MOD_CK1_1	388	394	PF00069	0.771
MOD_CK1_1	405	411	PF00069	0.657
MOD_CK1_1	454	460	PF00069	0.643
MOD_CK1_1	543	549	PF00069	0.574
MOD_CK1_1	633	639	PF00069	0.663
MOD_CK1_1	649	655	PF00069	0.768
MOD_CK1_1	663	669	PF00069	0.554
MOD_CK1_1	769	775	PF00069	0.493
MOD_CK1_1	820	826	PF00069	0.672
MOD_CK1_1	828	834	PF00069	0.646
MOD_CK1_1	866	872	PF00069	0.676
MOD_CK1_1	874	880	PF00069	0.636
MOD_CK1_1	915	921	PF00069	0.734
MOD_CK1_1	934	940	PF00069	0.678
MOD_CK1_1	954	960	PF00069	0.750
MOD_CK2_1	273	279	PF00069	0.663
MOD_CK2_1	322	328	PF00069	0.683
MOD_CK2_1	364	370	PF00069	0.670
MOD_CK2_1	914	920	PF00069	0.763
MOD_CK2_1	960	966	PF00069	0.752
MOD_CK2_1	968	974	PF00069	0.593
MOD_Cter_Amidation	980	983	PF01082	0.756
MOD_Cter_Amidation	984	987	PF01082	0.689
MOD_DYRK1A_RPxSP_1	395	399	PF00069	0.721
MOD_GlcNHglycan	1	4	PF01048	0.729
MOD_GlcNHglycan	175	178	PF01048	0.572
MOD_GlcNHglycan	187	190	PF01048	0.527
MOD_GlcNHglycan	249	252	PF01048	0.768
MOD_GlcNHglycan	316	319	PF01048	0.680
MOD_GlcNHglycan	339	342	PF01048	0.771
MOD_GlcNHglycan	374	377	PF01048	0.603
MOD_GlcNHglycan	440	443	PF01048	0.703
MOD_GlcNHglycan	453	456	PF01048	0.583
MOD_GlcNHglycan	474	477	PF01048	0.721
MOD_GlcNHglycan	536	539	PF01048	0.649
MOD_GlcNHglycan	542	545	PF01048	0.620
MOD_GlcNHglycan	548	551	PF01048	0.589
MOD_GlcNHglycan	561	564	PF01048	0.665
MOD_GlcNHglycan	567	570	PF01048	0.572
MOD_GlcNHglycan	613	616	PF01048	0.688
MOD_GlcNHglycan	648	651	PF01048	0.779
MOD_GlcNHglycan	667	670	PF01048	0.480
MOD_GlcNHglycan	699	702	PF01048	0.678
MOD_GlcNHglycan	768	771	PF01048	0.429
MOD_GlcNHglycan	814	817	PF01048	0.583
MOD_GlcNHglycan	826	830	PF01048	0.599
MOD_GlcNHglycan	83	86	PF01048	0.433
MOD_GlcNHglycan	838	841	PF01048	0.676
MOD_GlcNHglycan	850	853	PF01048	0.619
MOD_GlcNHglycan	905	908	PF01048	0.773
MOD_GlcNHglycan	938	941	PF01048	0.676
MOD_GlcNHglycan	979	982	PF01048	0.683
MOD_GSK3_1	124	131	PF00069	0.529
MOD_GSK3_1	146	153	PF00069	0.427
MOD_GSK3_1	166	173	PF00069	0.196
MOD_GSK3_1	19	26	PF00069	0.705
MOD_GSK3_1	227	234	PF00069	0.714
MOD_GSK3_1	269	276	PF00069	0.620
MOD_GSK3_1	329	336	PF00069	0.664
MOD_GSK3_1	385	392	PF00069	0.655
MOD_GSK3_1	402	409	PF00069	0.736
MOD_GSK3_1	438	445	PF00069	0.719
MOD_GSK3_1	447	454	PF00069	0.604
MOD_GSK3_1	539	546	PF00069	0.620
MOD_GSK3_1	611	618	PF00069	0.726
MOD_GSK3_1	655	662	PF00069	0.748
MOD_GSK3_1	760	767	PF00069	0.480
MOD_GSK3_1	769	776	PF00069	0.462
MOD_GSK3_1	825	832	PF00069	0.656
MOD_GSK3_1	859	866	PF00069	0.683
MOD_GSK3_1	867	874	PF00069	0.682
MOD_GSK3_1	903	910	PF00069	0.677
MOD_GSK3_1	927	934	PF00069	0.717
MOD_GSK3_1	936	943	PF00069	0.705
MOD_GSK3_1	947	954	PF00069	0.718
MOD_GSK3_1	955	962	PF00069	0.640
MOD_N-GLC_1	219	224	PF02516	0.716
MOD_N-GLC_1	534	539	PF02516	0.657
MOD_N-GLC_1	540	545	PF02516	0.627
MOD_N-GLC_1	559	564	PF02516	0.565
MOD_N-GLC_1	87	92	PF02516	0.541
MOD_N-GLC_1	955	960	PF02516	0.762
MOD_N-GLC_1	96	101	PF02516	0.371
MOD_NEK2_1	141	146	PF00069	0.394
MOD_NEK2_1	154	159	PF00069	0.383
MOD_NEK2_1	20	25	PF00069	0.670
MOD_NEK2_1	226	231	PF00069	0.671
MOD_NEK2_1	353	358	PF00069	0.554
MOD_NEK2_1	545	550	PF00069	0.531
MOD_NEK2_1	565	570	PF00069	0.740
MOD_NEK2_1	760	765	PF00069	0.488
MOD_NEK2_1	812	817	PF00069	0.561
MOD_NEK2_1	87	92	PF00069	0.484
MOD_NEK2_1	995	1000	PF00069	0.546
MOD_NEK2_2	150	155	PF00069	0.505
MOD_PIKK_1	124	130	PF00454	0.425
MOD_PIKK_1	273	279	PF00454	0.634
MOD_PIKK_1	389	395	PF00454	0.684
MOD_PIKK_1	402	408	PF00454	0.470
MOD_PIKK_1	487	493	PF00454	0.693
MOD_PIKK_1	817	823	PF00454	0.638
MOD_PIKK_1	895	901	PF00454	0.672
MOD_PK_1	227	233	PF00069	0.760
MOD_PKA_1	977	983	PF00069	0.712
MOD_PKA_2	194	200	PF00069	0.649
MOD_PKA_2	226	232	PF00069	0.671
MOD_PKA_2	247	253	PF00069	0.667
MOD_PKA_2	262	268	PF00069	0.658
MOD_PKA_2	332	338	PF00069	0.587
MOD_PKA_2	346	352	PF00069	0.709
MOD_PKA_2	394	400	PF00069	0.639
MOD_PKA_2	513	519	PF00069	0.765
MOD_PKA_2	764	770	PF00069	0.456
MOD_PKA_2	833	839	PF00069	0.713
MOD_PKA_2	977	983	PF00069	0.712
MOD_Plk_1	116	122	PF00069	0.511
MOD_Plk_1	303	309	PF00069	0.634
MOD_Plk_1	327	333	PF00069	0.771
MOD_Plk_1	87	93	PF00069	0.542
MOD_Plk_1	912	918	PF00069	0.762
MOD_Plk_1	955	961	PF00069	0.761
MOD_Plk_2-3	262	268	PF00069	0.658
MOD_Plk_4	141	147	PF00069	0.396
MOD_Plk_4	150	156	PF00069	0.403
MOD_Plk_4	159	165	PF00069	0.420
MOD_Plk_4	170	176	PF00069	0.205
MOD_Plk_4	200	206	PF00069	0.742
MOD_Plk_4	769	775	PF00069	0.430
MOD_Plk_4	87	93	PF00069	0.523
MOD_ProDKin_1	231	237	PF00069	0.744
MOD_ProDKin_1	29	35	PF00069	0.708
MOD_ProDKin_1	385	391	PF00069	0.776
MOD_ProDKin_1	395	401	PF00069	0.651
MOD_ProDKin_1	408	414	PF00069	0.561
MOD_ProDKin_1	454	460	PF00069	0.607
MOD_ProDKin_1	46	52	PF00069	0.449
MOD_ProDKin_1	466	472	PF00069	0.740
MOD_ProDKin_1	599	605	PF00069	0.633
MOD_ProDKin_1	615	621	PF00069	0.755
MOD_ProDKin_1	633	639	PF00069	0.705
MOD_ProDKin_1	649	655	PF00069	0.504
MOD_ProDKin_1	863	869	PF00069	0.683
MOD_ProDKin_1	871	877	PF00069	0.632
MOD_ProDKin_1	907	913	PF00069	0.761
MOD_ProDKin_1	915	921	PF00069	0.566
MOD_ProDKin_1	931	937	PF00069	0.484
MOD_ProDKin_1	941	947	PF00069	0.693
MOD_ProDKin_1	951	957	PF00069	0.614
MOD_SUMO_rev_2	790	795	PF00179	0.425
TRG_DiLeu_BaEn_3	755	761	PF01217	0.592
TRG_DiLeu_BaEn_4	781	787	PF01217	0.600
TRG_ENDOCYTIC_2	102	105	PF00928	0.487
TRG_ENDOCYTIC_2	788	791	PF00928	0.486
TRG_ENDOCYTIC_2	95	98	PF00928	0.445
TRG_ER_diArg_1	805	808	PF00400	0.524
TRG_ER_diArg_1	854	856	PF00400	0.765

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMU9	Leptomonas seymouri	41%	86%
A0A3Q8IIU2	Leishmania donovani	98%	99%
A4HNF8	Leishmania braziliensis	77%	98%
E9AFW9	Leishmania major	93%	100%
E9B722	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%