Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase - putative

Species:

Leishmania infantum

UniProt:

E9AHW8_LEIIN

TriTrypDb:

LINF_350052000

Length:

288

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AHW8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHW8

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016310	phosphorylation	5	11
GO:0019538	protein metabolic process	3	11
GO:0036211	protein modification process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0004672	protein kinase activity	3	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016301	kinase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0140096	catalytic activity, acting on a protein	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	283	287	PF00656	0.732
CLV_NRD_NRD_1	22	24	PF00675	0.535
CLV_PCSK_KEX2_1	22	24	PF00082	0.533
CLV_PCSK_SKI1_1	22	26	PF00082	0.332
CLV_PCSK_SKI1_1	236	240	PF00082	0.423
CLV_Separin_Metazoa	168	172	PF03568	0.384
DEG_APCC_DBOX_1	235	243	PF00400	0.423
DEG_Nend_Nbox_1	1	3	PF02207	0.598
DEG_SPOP_SBC_1	9	13	PF00917	0.581
DOC_CKS1_1	2	7	PF01111	0.680
DOC_CKS1_1	63	68	PF01111	0.456
DOC_CYCLIN_yCln2_LP_2	243	249	PF00134	0.365
DOC_CYCLIN_yCln2_LP_2	82	88	PF00134	0.420
DOC_MAPK_JIP1_4	236	242	PF00069	0.456
DOC_PP2B_LxvP_1	82	85	PF13499	0.459
DOC_PP4_FxxP_1	224	227	PF00568	0.423
DOC_USP7_MATH_1	3	7	PF00917	0.710
DOC_USP7_MATH_1	9	13	PF00917	0.706
DOC_WW_Pin1_4	1	6	PF00397	0.682
DOC_WW_Pin1_4	208	213	PF00397	0.311
DOC_WW_Pin1_4	62	67	PF00397	0.429
LIG_14-3-3_CanoR_1	138	148	PF00244	0.417
LIG_14-3-3_CanoR_1	23	31	PF00244	0.533
LIG_14-3-3_CanoR_1	90	94	PF00244	0.466
LIG_FHA_1	147	153	PF00498	0.400
LIG_FHA_1	199	205	PF00498	0.311
LIG_FHA_1	2	8	PF00498	0.657
LIG_FHA_1	58	64	PF00498	0.514
LIG_FHA_2	140	146	PF00498	0.440
LIG_Integrin_RGD_1	171	173	PF01839	0.456
LIG_LIR_Apic_2	223	227	PF02991	0.425
LIG_LIR_Gen_1	65	73	PF02991	0.382
LIG_LIR_Nem_3	65	71	PF02991	0.393
LIG_MAD2	23	31	PF02301	0.323
LIG_MYND_1	5	9	PF01753	0.516
LIG_NRBOX	183	189	PF00104	0.423
LIG_SH2_CRK	154	158	PF00017	0.450
LIG_SH2_STAT5	68	71	PF00017	0.366
LIG_SH3_3	2	8	PF00018	0.640
LIG_SH3_3	60	66	PF00018	0.507
LIG_TYR_ITIM	152	157	PF00017	0.454
MOD_CK1_1	220	226	PF00069	0.315
MOD_CK1_1	269	275	PF00069	0.705
MOD_CK2_1	139	145	PF00069	0.441
MOD_CK2_1	272	278	PF00069	0.691
MOD_CK2_1	29	35	PF00069	0.462
MOD_GlcNHglycan	12	15	PF01048	0.730
MOD_GlcNHglycan	219	222	PF01048	0.350
MOD_GlcNHglycan	249	252	PF01048	0.536
MOD_GlcNHglycan	91	94	PF01048	0.571
MOD_GSK3_1	204	211	PF00069	0.360
MOD_GSK3_1	213	220	PF00069	0.222
MOD_GSK3_1	265	272	PF00069	0.690
MOD_GSK3_1	280	287	PF00069	0.710
MOD_N-GLC_1	272	277	PF02516	0.712
MOD_N-GLC_2	265	267	PF02516	0.543
MOD_NEK2_1	10	15	PF00069	0.522
MOD_NEK2_1	192	197	PF00069	0.378
MOD_NEK2_1	213	218	PF00069	0.373
MOD_NEK2_1	247	252	PF00069	0.462
MOD_PKA_2	89	95	PF00069	0.457
MOD_Plk_1	73	79	PF00069	0.539
MOD_Plk_2-3	266	272	PF00069	0.646
MOD_Plk_4	220	226	PF00069	0.334
MOD_ProDKin_1	1	7	PF00069	0.684
MOD_ProDKin_1	208	214	PF00069	0.311
MOD_ProDKin_1	62	68	PF00069	0.428
TRG_DiLeu_BaEn_1	205	210	PF01217	0.331
TRG_DiLeu_BaLyEn_6	234	239	PF01217	0.400
TRG_ENDOCYTIC_2	154	157	PF00928	0.509
TRG_ENDOCYTIC_2	68	71	PF00928	0.389
TRG_ER_diArg_1	22	24	PF00400	0.518
TRG_ER_diArg_1	37	40	PF00400	0.294
TRG_ER_diArg_1	44	47	PF00400	0.438
TRG_Pf-PMV_PEXEL_1	23	28	PF00026	0.528
TRG_Pf-PMV_PEXEL_1	236	241	PF00026	0.456

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAR1	Leptomonas seymouri	57%	97%
A0A1X0P5S2	Trypanosomatidae	34%	100%
A0A3Q8IFJ8	Leishmania donovani	100%	100%
A0A422P1C1	Trypanosoma rangeli	32%	100%
A4HNC9	Leishmania braziliensis	77%	99%
C9ZYK5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AFT9	Leishmania major	94%	100%
E9B6Z1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
O70150	Rattus norvegicus	28%	84%
Q14012	Homo sapiens	25%	78%
Q501V0	Danio rerio	25%	68%
Q63450	Rattus norvegicus	25%	77%
Q6P2M8	Homo sapiens	27%	84%
Q91YS8	Mus musculus	25%	77%
Q9P7I2	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	86%
Q9QYK9	Mus musculus	28%	84%
V5C2I6	Trypanosoma cruzi	32%	100%