Multidrug and toxic compound extrusion protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

membrane transporter protein - putative

Species:

Leishmania infantum

UniProt:

E9AHW7_LEIIN

TriTrypDb:

LINF_350041200

Length:

698

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	19
GO:0110165	cellular anatomical entity	1	19

Expansion

Sequence features

E9AHW7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHW7

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	8
GO:0009987	cellular process	1	8
GO:0042908	xenobiotic transport	4	8
GO:0046618	xenobiotic export from cell	3	8
GO:0051179	localization	1	8
GO:0051234	establishment of localization	2	8
GO:0055085	transmembrane transport	2	8
GO:0140115	export across plasma membrane	3	8
GO:0140352	export from cell	2	8
GO:1990961	xenobiotic detoxification by transmembrane export across the plasma membrane	4	8

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	19
GO:0015291	secondary active transmembrane transporter activity	4	19
GO:0015297	antiporter activity	5	19
GO:0022804	active transmembrane transporter activity	3	19
GO:0022857	transmembrane transporter activity	2	19
GO:0042910	xenobiotic transmembrane transporter activity	3	19

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	185	187	PF00675	0.285
CLV_NRD_NRD_1	334	336	PF00675	0.314
CLV_NRD_NRD_1	341	343	PF00675	0.295
CLV_NRD_NRD_1	383	385	PF00675	0.225
CLV_NRD_NRD_1	576	578	PF00675	0.382
CLV_NRD_NRD_1	692	694	PF00675	0.372
CLV_PCSK_FUR_1	690	694	PF00082	0.373
CLV_PCSK_KEX2_1	185	187	PF00082	0.225
CLV_PCSK_KEX2_1	341	343	PF00082	0.228
CLV_PCSK_KEX2_1	576	578	PF00082	0.382
CLV_PCSK_KEX2_1	692	694	PF00082	0.372
CLV_PCSK_PC7_1	688	694	PF00082	0.374
CLV_PCSK_SKI1_1	269	273	PF00082	0.402
CLV_PCSK_SKI1_1	336	340	PF00082	0.235
CLV_PCSK_SKI1_1	342	346	PF00082	0.241
CLV_PCSK_SKI1_1	384	388	PF00082	0.224
CLV_PCSK_SKI1_1	494	498	PF00082	0.432
CLV_PCSK_SKI1_1	639	643	PF00082	0.594
CLV_PCSK_SKI1_1	673	677	PF00082	0.371
CLV_Separin_Metazoa	182	186	PF03568	0.262
DEG_APCC_DBOX_1	127	135	PF00400	0.409
DEG_APCC_DBOX_1	168	176	PF00400	0.356
DEG_APCC_DBOX_1	341	349	PF00400	0.388
DEG_APCC_DBOX_1	506	514	PF00400	0.580
DEG_Nend_UBRbox_3	1	3	PF02207	0.597
DEG_SPOP_SBC_1	496	500	PF00917	0.649
DEG_SPOP_SBC_1	680	684	PF00917	0.700
DOC_CYCLIN_yClb5_NLxxxL_5	354	363	PF00134	0.210
DOC_CYCLIN_yCln2_LP_2	49	55	PF00134	0.381
DOC_MAPK_gen_1	341	348	PF00069	0.434
DOC_MAPK_HePTP_8	338	350	PF00069	0.436
DOC_MAPK_MEF2A_6	128	136	PF00069	0.409
DOC_MAPK_MEF2A_6	341	350	PF00069	0.450
DOC_MAPK_MEF2A_6	48	55	PF00069	0.434
DOC_MAPK_NFAT4_5	128	136	PF00069	0.436
DOC_MAPK_NFAT4_5	48	56	PF00069	0.492
DOC_PP1_RVXF_1	215	222	PF00149	0.289
DOC_PP1_RVXF_1	267	273	PF00149	0.215
DOC_PP1_RVXF_1	383	390	PF00149	0.180
DOC_PP2B_LxvP_1	49	52	PF13499	0.210
DOC_PP4_FxxP_1	139	142	PF00568	0.282
DOC_SPAK_OSR1_1	388	392	PF12202	0.168
DOC_USP7_MATH_1	271	275	PF00917	0.266
DOC_USP7_MATH_1	496	500	PF00917	0.737
DOC_USP7_MATH_1	589	593	PF00917	0.652
DOC_USP7_MATH_1	59	63	PF00917	0.356
DOC_USP7_MATH_1	634	638	PF00917	0.743
DOC_USP7_MATH_1	645	649	PF00917	0.739
DOC_USP7_MATH_1	681	685	PF00917	0.704
DOC_WW_Pin1_4	3	8	PF00397	0.581
DOC_WW_Pin1_4	34	39	PF00397	0.543
DOC_WW_Pin1_4	497	502	PF00397	0.640
DOC_WW_Pin1_4	534	539	PF00397	0.737
DOC_WW_Pin1_4	547	552	PF00397	0.732
DOC_WW_Pin1_4	618	623	PF00397	0.733
DOC_WW_Pin1_4	647	652	PF00397	0.603
LIG_14-3-3_CanoR_1	128	132	PF00244	0.405
LIG_14-3-3_CanoR_1	169	173	PF00244	0.460
LIG_14-3-3_CanoR_1	494	503	PF00244	0.562
LIG_14-3-3_CanoR_1	576	582	PF00244	0.690
LIG_14-3-3_CanoR_1	633	642	PF00244	0.587
LIG_14-3-3_CanoR_1	667	672	PF00244	0.722
LIG_14-3-3_CanoR_1	673	680	PF00244	0.675
LIG_14-3-3_CanoR_1	690	696	PF00244	0.573
LIG_Actin_WH2_2	35	50	PF00022	0.437
LIG_APCC_ABBA_1	475	480	PF00400	0.575
LIG_BRCT_BRCA1_1	206	210	PF00533	0.315
LIG_BRCT_BRCA1_1	317	321	PF00533	0.297
LIG_Clathr_ClatBox_1	178	182	PF01394	0.210
LIG_eIF4E_1	390	396	PF01652	0.210
LIG_FHA_1	116	122	PF00498	0.442
LIG_FHA_1	360	366	PF00498	0.309
LIG_FHA_1	372	378	PF00498	0.357
LIG_FHA_1	39	45	PF00498	0.536
LIG_FHA_1	465	471	PF00498	0.250
LIG_FHA_1	498	504	PF00498	0.694
LIG_FHA_1	524	530	PF00498	0.612
LIG_FHA_1	535	541	PF00498	0.659
LIG_FHA_1	599	605	PF00498	0.566
LIG_FHA_1	674	680	PF00498	0.682
LIG_FHA_1	681	687	PF00498	0.762
LIG_FHA_2	504	510	PF00498	0.760
LIG_IRF3_LxIS_1	146	153	PF10401	0.378
LIG_LIR_Apic_2	444	450	PF02991	0.198
LIG_LIR_Gen_1	164	175	PF02991	0.189
LIG_LIR_Gen_1	238	245	PF02991	0.198
LIG_LIR_Gen_1	301	309	PF02991	0.327
LIG_LIR_Gen_1	351	361	PF02991	0.344
LIG_LIR_Gen_1	471	479	PF02991	0.517
LIG_LIR_Gen_1	564	573	PF02991	0.693
LIG_LIR_Nem_3	164	170	PF02991	0.196
LIG_LIR_Nem_3	171	176	PF02991	0.212
LIG_LIR_Nem_3	207	211	PF02991	0.260
LIG_LIR_Nem_3	238	243	PF02991	0.230
LIG_LIR_Nem_3	301	306	PF02991	0.327
LIG_LIR_Nem_3	351	357	PF02991	0.344
LIG_LIR_Nem_3	471	475	PF02991	0.583
LIG_LIR_Nem_3	564	569	PF02991	0.691
LIG_PCNA_yPIPBox_3	376	388	PF02747	0.369
LIG_PCNA_yPIPBox_3	400	408	PF02747	0.450
LIG_Pex14_2	163	167	PF04695	0.292
LIG_SH2_CRK	294	298	PF00017	0.292
LIG_SH2_CRK	424	428	PF00017	0.262
LIG_SH2_CRK	462	466	PF00017	0.356
LIG_SH2_NCK_1	294	298	PF00017	0.188
LIG_SH2_NCK_1	424	428	PF00017	0.262
LIG_SH2_SRC	294	297	PF00017	0.188
LIG_SH2_STAP1	176	180	PF00017	0.210
LIG_SH2_STAP1	95	99	PF00017	0.198
LIG_SH2_STAT5	187	190	PF00017	0.389
LIG_SH2_STAT5	242	245	PF00017	0.287
LIG_SH2_STAT5	390	393	PF00017	0.298
LIG_SH2_STAT5	464	467	PF00017	0.258
LIG_SH2_STAT5	469	472	PF00017	0.465
LIG_SH3_3	1	7	PF00018	0.770
LIG_SH3_3	424	430	PF00018	0.256
LIG_SH3_3	454	460	PF00018	0.295
LIG_SUMO_SIM_anti_2	130	136	PF11976	0.329
LIG_SUMO_SIM_anti_2	177	182	PF11976	0.210
LIG_SUMO_SIM_anti_2	360	365	PF11976	0.286
LIG_SUMO_SIM_anti_2	419	425	PF11976	0.180
LIG_SUMO_SIM_anti_2	43	48	PF11976	0.433
LIG_SUMO_SIM_anti_2	62	67	PF11976	0.227
LIG_SUMO_SIM_par_1	40	45	PF11976	0.508
LIG_TYR_ITIM	391	396	PF00017	0.311
LIG_TYR_ITIM	422	427	PF00017	0.356
LIG_UBA3_1	239	248	PF00899	0.297
LIG_WRC_WIRS_1	396	401	PF05994	0.226
LIG_WRC_WIRS_1	566	571	PF05994	0.706
MOD_CK1_1	13	19	PF00069	0.662
MOD_CK1_1	315	321	PF00069	0.327
MOD_CK1_1	398	404	PF00069	0.210
MOD_CK1_1	499	505	PF00069	0.624
MOD_CK1_1	565	571	PF00069	0.667
MOD_CK1_1	580	586	PF00069	0.662
MOD_CK1_1	6	12	PF00069	0.700
MOD_CK1_1	637	643	PF00069	0.671
MOD_CK1_1	657	663	PF00069	0.769
MOD_CK2_1	485	491	PF00069	0.542
MOD_CK2_1	512	518	PF00069	0.702
MOD_CK2_1	539	545	PF00069	0.754
MOD_CK2_1	600	606	PF00069	0.587
MOD_CK2_1	656	662	PF00069	0.612
MOD_CMANNOS	253	256	PF00535	0.282
MOD_GlcNHglycan	19	22	PF01048	0.434
MOD_GlcNHglycan	317	320	PF01048	0.272
MOD_GlcNHglycan	552	555	PF01048	0.533
MOD_GlcNHglycan	639	642	PF01048	0.386
MOD_GlcNHglycan	651	654	PF01048	0.527
MOD_GlcNHglycan	673	676	PF01048	0.533
MOD_GlcNHglycan	683	686	PF01048	0.370
MOD_GlcNHglycan	97	100	PF01048	0.215
MOD_GSK3_1	146	153	PF00069	0.210
MOD_GSK3_1	226	233	PF00069	0.455
MOD_GSK3_1	277	284	PF00069	0.232
MOD_GSK3_1	308	315	PF00069	0.389
MOD_GSK3_1	34	41	PF00069	0.554
MOD_GSK3_1	481	488	PF00069	0.675
MOD_GSK3_1	495	502	PF00069	0.666
MOD_GSK3_1	519	526	PF00069	0.661
MOD_GSK3_1	530	537	PF00069	0.620
MOD_GSK3_1	539	546	PF00069	0.604
MOD_GSK3_1	561	568	PF00069	0.754
MOD_GSK3_1	598	605	PF00069	0.655
MOD_GSK3_1	6	13	PF00069	0.722
MOD_GSK3_1	643	650	PF00069	0.732
MOD_GSK3_1	667	674	PF00069	0.757
MOD_GSK3_1	691	698	PF00069	0.724
MOD_N-GLC_1	357	362	PF02516	0.210
MOD_N-GLC_1	485	490	PF02516	0.418
MOD_N-GLC_1	562	567	PF02516	0.453
MOD_N-GLC_1	589	594	PF02516	0.363
MOD_N-GLC_1	618	623	PF02516	0.403
MOD_N-GLC_1	90	95	PF02516	0.256
MOD_N-GLC_2	570	572	PF02516	0.387
MOD_NEK2_1	10	15	PF00069	0.700
MOD_NEK2_1	109	114	PF00069	0.410
MOD_NEK2_1	146	151	PF00069	0.332
MOD_NEK2_1	230	235	PF00069	0.303
MOD_NEK2_1	243	248	PF00069	0.364
MOD_NEK2_1	348	353	PF00069	0.399
MOD_NEK2_1	359	364	PF00069	0.167
MOD_NEK2_1	395	400	PF00069	0.299
MOD_NEK2_1	422	427	PF00069	0.262
MOD_NEK2_1	436	441	PF00069	0.329
MOD_NEK2_1	452	457	PF00069	0.286
MOD_NEK2_1	47	52	PF00069	0.480
MOD_NEK2_1	485	490	PF00069	0.549
MOD_NEK2_1	503	508	PF00069	0.590
MOD_NEK2_1	543	548	PF00069	0.777
MOD_NEK2_1	600	605	PF00069	0.760
MOD_NEK2_1	671	676	PF00069	0.697
MOD_NEK2_1	80	85	PF00069	0.266
MOD_NEK2_1	90	95	PF00069	0.231
MOD_NEK2_2	168	173	PF00069	0.210
MOD_PIKK_1	107	113	PF00454	0.425
MOD_PIKK_1	192	198	PF00454	0.517
MOD_PIKK_1	281	287	PF00454	0.219
MOD_PIKK_1	571	577	PF00454	0.581
MOD_PIKK_1	673	679	PF00454	0.676
MOD_PK_1	577	583	PF00069	0.563
MOD_PKA_2	127	133	PF00069	0.473
MOD_PKA_2	168	174	PF00069	0.407
MOD_PKA_2	530	536	PF00069	0.658
MOD_PKA_2	635	641	PF00069	0.717
MOD_PKA_2	666	672	PF00069	0.722
MOD_PKA_2	691	697	PF00069	0.588
MOD_Plk_1	357	363	PF00069	0.464
MOD_Plk_1	485	491	PF00069	0.665
MOD_Plk_1	561	567	PF00069	0.692
MOD_Plk_1	90	96	PF00069	0.252
MOD_Plk_4	104	110	PF00069	0.274
MOD_Plk_4	127	133	PF00069	0.460
MOD_Plk_4	146	152	PF00069	0.393
MOD_Plk_4	174	180	PF00069	0.464
MOD_Plk_4	235	241	PF00069	0.244
MOD_Plk_4	308	314	PF00069	0.291
MOD_Plk_4	348	354	PF00069	0.232
MOD_Plk_4	359	365	PF00069	0.271
MOD_Plk_4	368	374	PF00069	0.273
MOD_Plk_4	422	428	PF00069	0.319
MOD_Plk_4	452	458	PF00069	0.217
MOD_Plk_4	667	673	PF00069	0.575
MOD_Plk_4	80	86	PF00069	0.359
MOD_ProDKin_1	3	9	PF00069	0.584
MOD_ProDKin_1	34	40	PF00069	0.542
MOD_ProDKin_1	497	503	PF00069	0.640
MOD_ProDKin_1	534	540	PF00069	0.741
MOD_ProDKin_1	547	553	PF00069	0.732
MOD_ProDKin_1	618	624	PF00069	0.736
MOD_ProDKin_1	647	653	PF00069	0.603
TRG_DiLeu_BaEn_1	257	262	PF01217	0.441
TRG_DiLeu_BaEn_1	323	328	PF01217	0.356
TRG_DiLeu_BaLyEn_6	263	268	PF01217	0.468
TRG_DiLeu_BaLyEn_6	595	600	PF01217	0.590
TRG_ENDOCYTIC_2	176	179	PF00928	0.340
TRG_ENDOCYTIC_2	242	245	PF00928	0.262
TRG_ENDOCYTIC_2	294	297	PF00928	0.188
TRG_ENDOCYTIC_2	393	396	PF00928	0.272
TRG_ENDOCYTIC_2	424	427	PF00928	0.249
TRG_ENDOCYTIC_2	462	465	PF00928	0.256
TRG_ER_diArg_1	184	186	PF00400	0.475
TRG_ER_diArg_1	27	30	PF00400	0.608
TRG_ER_diArg_1	576	579	PF00400	0.561
TRG_ER_diArg_1	690	693	PF00400	0.574

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I213	Leptomonas seymouri	38%	100%
A0A0N1IJ56	Leptomonas seymouri	55%	99%
A0A0S4JTQ3	Bodo saltans	25%	100%
A0A0S4JV08	Bodo saltans	22%	100%
A0A0S4JZ61	Bodo saltans	24%	100%
A0A1X0NU76	Trypanosomatidae	47%	100%
A0A3Q8IGH9	Leishmania donovani	99%	100%
A0A3Q8II95	Leishmania donovani	38%	100%
A0A3R7M3E2	Trypanosoma rangeli	48%	100%
A0A3R7NUJ8	Trypanosoma rangeli	44%	100%
A1L1P9	Danio rerio	27%	100%
A4HN33	Leishmania braziliensis	38%	100%
A4HN34	Leishmania braziliensis	38%	100%
A4IBQ2	Leishmania infantum	38%	100%
C9ZYX8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
C9ZYX9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
C9ZYY0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AFI2	Leishmania major	89%	100%
E9AFI7	Leishmania major	41%	100%
E9B6N7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	98%
E9B6P2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
Q38956	Arabidopsis thaliana	22%	100%
Q3V050	Mus musculus	28%	100%
Q5R7E4	Pongo abelii	28%	100%
Q5RFD2	Pongo abelii	30%	100%
Q86VL8	Homo sapiens	26%	100%
Q96FL8	Homo sapiens	30%	100%
Q9FH21	Arabidopsis thaliana	24%	100%
Q9FKQ1	Arabidopsis thaliana	24%	100%
Q9LUH2	Arabidopsis thaliana	26%	100%
Q9SIA4	Arabidopsis thaliana	24%	100%