Putative 60S ribosomal subunit protein L31

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60S ribosomal subunit protein L31 - putative

Species:

Leishmania infantum

UniProt:

E9AHW6_LEIIN

TriTrypDb:

LINF_350038300

Length:

229

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 8

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	10
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:1990904	ribonucleoprotein complex	2	11
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0015934	large ribosomal subunit	4	1
GO:0022625	cytosolic large ribosomal subunit	5	1
GO:0044391	ribosomal subunit	3	1

Expansion

Sequence features

E9AHW6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHW6

PDB structure(s): 6az3_e

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	11
GO:0006518	peptide metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009059	macromolecule biosynthetic process	4	11
GO:0009987	cellular process	1	11
GO:0019538	protein metabolic process	3	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	11
GO:0043043	peptide biosynthetic process	5	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043603	amide metabolic process	3	11
GO:0043604	amide biosynthetic process	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0044271	cellular nitrogen compound biosynthetic process	4	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901566	organonitrogen compound biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11
GO:0002181	cytoplasmic translation	5	1

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	11
GO:0005198	structural molecule activity	1	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	114	116	PF00675	0.517
CLV_NRD_NRD_1	119	121	PF00675	0.492
CLV_NRD_NRD_1	193	195	PF00675	0.326
CLV_NRD_NRD_1	63	65	PF00675	0.519
CLV_NRD_NRD_1	70	72	PF00675	0.571
CLV_NRD_NRD_1	90	92	PF00675	0.357
CLV_PCSK_FUR_1	78	82	PF00082	0.499
CLV_PCSK_KEX2_1	116	118	PF00082	0.548
CLV_PCSK_KEX2_1	144	146	PF00082	0.329
CLV_PCSK_KEX2_1	151	153	PF00082	0.329
CLV_PCSK_KEX2_1	77	79	PF00082	0.510
CLV_PCSK_KEX2_1	80	82	PF00082	0.516
CLV_PCSK_KEX2_1	90	92	PF00082	0.474
CLV_PCSK_PC1ET2_1	116	118	PF00082	0.548
CLV_PCSK_PC1ET2_1	144	146	PF00082	0.308
CLV_PCSK_PC1ET2_1	151	153	PF00082	0.312
CLV_PCSK_PC1ET2_1	77	79	PF00082	0.511
CLV_PCSK_PC1ET2_1	80	82	PF00082	0.493
CLV_PCSK_PC1ET2_1	90	92	PF00082	0.465
CLV_PCSK_SKI1_1	107	111	PF00082	0.547
CLV_PCSK_SKI1_1	135	139	PF00082	0.301
CLV_PCSK_SKI1_1	151	155	PF00082	0.301
CLV_PCSK_SKI1_1	159	163	PF00082	0.286
CLV_PCSK_SKI1_1	179	183	PF00082	0.301
CLV_PCSK_SKI1_1	220	224	PF00082	0.411
CLV_PCSK_SKI1_1	80	84	PF00082	0.476
DEG_Nend_UBRbox_1	1	4	PF02207	0.413
DOC_CKS1_1	1	6	PF01111	0.412
DOC_MAPK_FxFP_2	29	32	PF00069	0.403
DOC_MAPK_gen_1	144	150	PF00069	0.301
DOC_PP4_FxxP_1	29	32	PF00568	0.403
DOC_USP7_MATH_1	101	105	PF00917	0.530
DOC_USP7_MATH_1	215	219	PF00917	0.431
DOC_USP7_UBL2_3	135	139	PF12436	0.307
DOC_USP7_UBL2_3	140	144	PF12436	0.295
DOC_USP7_UBL2_3	50	54	PF12436	0.497
DOC_WW_Pin1_4	15	20	PF00397	0.433
LIG_14-3-3_CanoR_1	111	115	PF00244	0.583
LIG_FHA_1	128	134	PF00498	0.326
LIG_FHA_1	222	228	PF00498	0.431
LIG_LIR_Nem_3	218	222	PF02991	0.423
LIG_LIR_Nem_3	76	82	PF02991	0.501
LIG_NRBOX	132	138	PF00104	0.301
LIG_SH2_CRK	208	212	PF00017	0.337
LIG_SH2_NCK_1	208	212	PF00017	0.337
LIG_SH2_STAT5	175	178	PF00017	0.326
LIG_SH2_STAT5	208	211	PF00017	0.338
LIG_WRC_WIRS_1	216	221	PF05994	0.416
MOD_CK1_1	171	177	PF00069	0.312
MOD_CK1_1	196	202	PF00069	0.379
MOD_CK1_1	40	46	PF00069	0.413
MOD_Cter_Amidation	118	121	PF01082	0.496
MOD_GlcNHglycan	21	24	PF01048	0.436
MOD_GSK3_1	123	130	PF00069	0.316
MOD_GSK3_1	9	16	PF00069	0.431
MOD_GSK3_1	97	104	PF00069	0.541
MOD_N-GLC_2	11	13	PF02516	0.436
MOD_NEK2_1	127	132	PF00069	0.358
MOD_NEK2_1	7	12	PF00069	0.429
MOD_NEK2_2	215	220	PF00069	0.437
MOD_PKA_1	115	121	PF00069	0.505
MOD_PKA_1	138	144	PF00069	0.301
MOD_PKA_2	110	116	PF00069	0.550
MOD_PKA_2	193	199	PF00069	0.328
MOD_PKB_1	105	113	PF00069	0.534
MOD_Plk_1	127	133	PF00069	0.330
MOD_Plk_1	168	174	PF00069	0.316
MOD_Plk_2-3	123	129	PF00069	0.361
MOD_Plk_4	171	177	PF00069	0.319
MOD_Plk_4	206	212	PF00069	0.341
MOD_Plk_4	37	43	PF00069	0.410
MOD_ProDKin_1	15	21	PF00069	0.434
TRG_ENDOCYTIC_2	208	211	PF00928	0.338
TRG_ER_diArg_1	114	117	PF00400	0.534
TRG_ER_diArg_1	187	190	PF00400	0.314
TRG_NLS_Bipartite_1	120	142	PF00514	0.301
TRG_NLS_Bipartite_1	77	95	PF00514	0.493
TRG_NLS_MonoExtN_4	135	142	PF00514	0.301
TRG_NLS_MonoExtN_4	90	95	PF00514	0.507
TRG_Pf-PMV_PEXEL_1	189	193	PF00026	0.424

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P5A7	Trypanosomatidae	81%	100%
A0A3Q8IJL7	Leishmania donovani	100%	100%
A0A3R7R8B8	Trypanosoma rangeli	81%	100%
A4HMZ5	Leishmania braziliensis	93%	100%
A4IBL9	Leishmania infantum	100%	100%
C9ZZ18	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	80%	100%
E9AFF2	Leishmania major	99%	100%
E9B6K7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
V5C333	Trypanosoma cruzi	82%	100%