LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
E9AHW4_LEIIN
TriTrypDb:
LINF_350033200
Length:
399

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26167471
Might belong to a Kinetoplastid-specific lectin domain protein family. Experiments of homologues indicate them to localize to ER (PMID: 26167471). Extensively duplicated gene family.. Localization: ER (experimental)

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 3
Silverman et al. no yes: 0
Pissara et al. yes yes: 16
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 11, no: 5
NetGPI no yes: 0, no: 16
Cellular components
Term Name Level Count
GO:0016020 membrane 2 14
GO:0110165 cellular anatomical entity 1 14

Expansion

Sequence features

E9AHW4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHW4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 219 223 PF00656 0.540
CLV_PCSK_SKI1_1 259 263 PF00082 0.699
DEG_APCC_DBOX_1 14 22 PF00400 0.439
DEG_APCC_DBOX_1 143 151 PF00400 0.418
DEG_COP1_1 109 119 PF00400 0.398
DEG_Nend_UBRbox_2 1 3 PF02207 0.576
DEG_SCF_FBW7_2 292 299 PF00400 0.668
DOC_CKS1_1 46 51 PF01111 0.448
DOC_MAPK_MEF2A_6 15 23 PF00069 0.468
DOC_PP1_RVXF_1 257 264 PF00149 0.511
DOC_USP7_MATH_1 115 119 PF00917 0.545
DOC_USP7_MATH_1 128 132 PF00917 0.495
DOC_USP7_MATH_1 216 220 PF00917 0.547
DOC_USP7_MATH_1 366 370 PF00917 0.700
DOC_WW_Pin1_4 130 135 PF00397 0.476
DOC_WW_Pin1_4 292 297 PF00397 0.752
DOC_WW_Pin1_4 45 50 PF00397 0.543
LIG_14-3-3_CanoR_1 10 14 PF00244 0.619
LIG_14-3-3_CanoR_1 121 130 PF00244 0.494
LIG_14-3-3_CanoR_1 337 341 PF00244 0.669
LIG_APCC_ABBA_1 230 235 PF00400 0.361
LIG_APCC_ABBAyCdc20_2 229 235 PF00400 0.366
LIG_BRCT_BRCA1_1 235 239 PF00533 0.497
LIG_deltaCOP1_diTrp_1 260 269 PF00928 0.417
LIG_EH1_1 271 279 PF00400 0.439
LIG_FHA_1 151 157 PF00498 0.555
LIG_FHA_1 203 209 PF00498 0.497
LIG_FHA_1 245 251 PF00498 0.548
LIG_FHA_1 283 289 PF00498 0.370
LIG_FHA_2 147 153 PF00498 0.432
LIG_GBD_Chelix_1 275 283 PF00786 0.440
LIG_LIR_Gen_1 118 126 PF02991 0.538
LIG_LIR_Gen_1 266 277 PF02991 0.401
LIG_LIR_Gen_1 314 320 PF02991 0.814
LIG_LIR_Nem_3 102 108 PF02991 0.482
LIG_LIR_Nem_3 118 122 PF02991 0.540
LIG_LIR_Nem_3 142 148 PF02991 0.453
LIG_LIR_Nem_3 167 172 PF02991 0.473
LIG_LIR_Nem_3 228 233 PF02991 0.436
LIG_LIR_Nem_3 236 242 PF02991 0.493
LIG_LIR_Nem_3 266 272 PF02991 0.401
LIG_LIR_Nem_3 314 319 PF02991 0.814
LIG_LIR_Nem_3 38 44 PF02991 0.520
LIG_LIR_Nem_3 48 54 PF02991 0.413
LIG_LYPXL_S_1 168 172 PF13949 0.651
LIG_LYPXL_yS_3 169 172 PF13949 0.458
LIG_NRBOX 279 285 PF00104 0.466
LIG_PCNA_PIPBox_1 159 168 PF02747 0.451
LIG_Pex14_1 20 24 PF04695 0.524
LIG_Pex14_1 268 272 PF04695 0.384
LIG_Pex14_2 141 145 PF04695 0.474
LIG_SH2_CRK 289 293 PF00017 0.489
LIG_SH2_CRK 46 50 PF00017 0.460
LIG_SH2_GRB2like 316 319 PF00017 0.796
LIG_SH2_NCK_1 46 50 PF00017 0.529
LIG_SH2_PTP2 242 245 PF00017 0.450
LIG_SH2_PTP2 316 319 PF00017 0.696
LIG_SH2_SRC 242 245 PF00017 0.574
LIG_SH2_SRC 316 319 PF00017 0.787
LIG_SH2_STAP1 182 186 PF00017 0.550
LIG_SH2_STAT3 54 57 PF00017 0.399
LIG_SH2_STAT3 72 75 PF00017 0.401
LIG_SH2_STAT5 105 108 PF00017 0.469
LIG_SH2_STAT5 197 200 PF00017 0.405
LIG_SH2_STAT5 224 227 PF00017 0.465
LIG_SH2_STAT5 233 236 PF00017 0.406
LIG_SH2_STAT5 242 245 PF00017 0.474
LIG_SH2_STAT5 289 292 PF00017 0.514
LIG_SH2_STAT5 316 319 PF00017 0.786
LIG_SH2_STAT5 51 54 PF00017 0.353
LIG_SH2_STAT5 72 75 PF00017 0.478
LIG_SH3_3 240 246 PF00018 0.540
LIG_SH3_3 299 305 PF00018 0.765
LIG_SH3_3 34 40 PF00018 0.766
LIG_SUMO_SIM_par_1 146 153 PF11976 0.429
LIG_SUMO_SIM_par_1 279 285 PF11976 0.370
LIG_TRAF2_1 372 375 PF00917 0.671
LIG_TRFH_1 166 170 PF08558 0.436
LIG_TYR_ITIM 240 245 PF00017 0.477
LIG_TYR_ITIM 287 292 PF00017 0.489
LIG_WRC_WIRS_1 116 121 PF05994 0.432
MOD_CDK_SPxK_1 292 298 PF00069 0.758
MOD_CK1_1 223 229 PF00069 0.479
MOD_CK1_1 79 85 PF00069 0.431
MOD_CK2_1 108 114 PF00069 0.469
MOD_CK2_1 336 342 PF00069 0.862
MOD_GlcNHglycan 111 114 PF01048 0.682
MOD_GlcNHglycan 218 221 PF01048 0.749
MOD_GlcNHglycan 313 316 PF01048 0.510
MOD_GlcNHglycan 347 350 PF01048 0.583
MOD_GlcNHglycan 81 84 PF01048 0.608
MOD_GSK3_1 100 107 PF00069 0.436
MOD_GSK3_1 129 136 PF00069 0.495
MOD_GSK3_1 146 153 PF00069 0.457
MOD_GSK3_1 214 221 PF00069 0.493
MOD_GSK3_1 5 12 PF00069 0.573
MOD_N-GLC_1 311 316 PF02516 0.592
MOD_NEK2_1 100 105 PF00069 0.424
MOD_NEK2_1 106 111 PF00069 0.439
MOD_NEK2_1 199 204 PF00069 0.429
MOD_NEK2_2 139 144 PF00069 0.412
MOD_NEK2_2 5 10 PF00069 0.513
MOD_PIKK_1 121 127 PF00454 0.527
MOD_PIKK_1 233 239 PF00454 0.497
MOD_PKA_2 336 342 PF00069 0.671
MOD_PKA_2 9 15 PF00069 0.549
MOD_Plk_1 214 220 PF00069 0.561
MOD_Plk_1 259 265 PF00069 0.482
MOD_Plk_1 373 379 PF00069 0.752
MOD_Plk_4 146 152 PF00069 0.476
MOD_Plk_4 164 170 PF00069 0.421
MOD_Plk_4 220 226 PF00069 0.499
MOD_Plk_4 235 241 PF00069 0.399
MOD_Plk_4 244 250 PF00069 0.494
MOD_Plk_4 282 288 PF00069 0.440
MOD_Plk_4 366 372 PF00069 0.705
MOD_Plk_4 76 82 PF00069 0.421
MOD_Plk_4 9 15 PF00069 0.549
MOD_ProDKin_1 130 136 PF00069 0.470
MOD_ProDKin_1 292 298 PF00069 0.758
MOD_ProDKin_1 45 51 PF00069 0.533
TRG_DiLeu_BaEn_2 234 240 PF01217 0.410
TRG_ENDOCYTIC_2 165 168 PF00928 0.463
TRG_ENDOCYTIC_2 169 172 PF00928 0.458
TRG_ENDOCYTIC_2 196 199 PF00928 0.469
TRG_ENDOCYTIC_2 242 245 PF00928 0.555
TRG_ENDOCYTIC_2 258 261 PF00928 0.534
TRG_ENDOCYTIC_2 289 292 PF00928 0.489
TRG_ENDOCYTIC_2 316 319 PF00928 0.823

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I2I6 Leptomonas seymouri 30% 85%
A0A0N1I9Y8 Leptomonas seymouri 39% 100%
A0A1X0NJF7 Trypanosomatidae 25% 100%
A0A1X0NJQ9 Trypanosomatidae 24% 100%
A0A1X0NK39 Trypanosomatidae 24% 100%
A0A1X0NN75 Trypanosomatidae 23% 100%
A0A1X0NVE8 Trypanosomatidae 22% 100%
A0A3S7WSM6 Leishmania donovani 36% 86%
A0A3S7X9E7 Leishmania donovani 99% 100%
A4HMU5 Leishmania braziliensis 78% 100%
A4HVR0 Leishmania infantum 36% 86%
E9AFA3 Leishmania major 93% 100%
E9APF6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 86%
E9B6F8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q4QG22 Leishmania major 36% 86%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS