LeishMANIAdb
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Short chain dehydrogenase family protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Short chain dehydrogenase family protein
Gene product:
short chain dehydrogenase - putative
Species:
Leishmania infantum
UniProt:
E9AHV8_LEIIN
TriTrypDb:
LINF_350026900
Length:
484

Annotations

Annotations by Jardim et al.

Oxidoreductase, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 27
NetGPI no yes: 0, no: 27
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 11
GO:0005737 cytoplasm 2 1
GO:0005739 mitochondrion 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Expansion

Sequence features

E9AHV8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHV8

Function

Biological processes
Term Name Level Count
GO:0006082 organic acid metabolic process 3 1
GO:0006629 lipid metabolic process 3 1
GO:0006631 fatty acid metabolic process 4 1
GO:0006633 fatty acid biosynthetic process 5 1
GO:0008152 metabolic process 1 1
GO:0008610 lipid biosynthetic process 4 1
GO:0009058 biosynthetic process 2 1
GO:0009987 cellular process 1 1
GO:0016053 organic acid biosynthetic process 4 1
GO:0019752 carboxylic acid metabolic process 5 1
GO:0030497 fatty acid elongation 6 1
GO:0032787 monocarboxylic acid metabolic process 6 1
GO:0043436 oxoacid metabolic process 4 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044249 cellular biosynthetic process 3 1
GO:0044255 cellular lipid metabolic process 3 1
GO:0044281 small molecule metabolic process 2 1
GO:0044283 small molecule biosynthetic process 3 1
GO:0046394 carboxylic acid biosynthetic process 5 1
GO:0071704 organic substance metabolic process 2 1
GO:0072330 monocarboxylic acid biosynthetic process 6 1
GO:1901576 organic substance biosynthetic process 3 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 3
GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity 5 1
GO:0016491 oxidoreductase activity 2 3
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 3 1
GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 4 1
GO:0004312 fatty acid synthase activity 5 2
GO:0004316 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity 5 2
GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 3 2
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 4 2
GO:0016740 transferase activity 2 2
GO:0016746 acyltransferase activity 3 2
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 4 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 343 347 PF00656 0.782
CLV_NRD_NRD_1 335 337 PF00675 0.551
CLV_PCSK_SKI1_1 107 111 PF00082 0.334
CLV_PCSK_SKI1_1 381 385 PF00082 0.328
CLV_PCSK_SKI1_1 72 76 PF00082 0.258
DEG_Nend_Nbox_1 1 3 PF02207 0.518
DOC_CDC14_PxL_1 392 400 PF14671 0.265
DOC_CYCLIN_RxL_1 167 177 PF00134 0.505
DOC_MAPK_FxFP_2 393 396 PF00069 0.399
DOC_MAPK_MEF2A_6 153 162 PF00069 0.456
DOC_MAPK_MEF2A_6 359 367 PF00069 0.613
DOC_PP1_RVXF_1 105 111 PF00149 0.418
DOC_PP1_RVXF_1 168 175 PF00149 0.497
DOC_PP2B_LxvP_1 215 218 PF13499 0.455
DOC_PP4_FxxP_1 243 246 PF00568 0.483
DOC_PP4_FxxP_1 393 396 PF00568 0.364
DOC_USP7_MATH_1 11 15 PF00917 0.316
DOC_USP7_MATH_1 124 128 PF00917 0.430
DOC_USP7_MATH_1 189 193 PF00917 0.418
DOC_USP7_MATH_1 194 198 PF00917 0.402
DOC_USP7_UBL2_3 121 125 PF12436 0.523
DOC_USP7_UBL2_3 327 331 PF12436 0.705
DOC_USP7_UBL2_3 337 341 PF12436 0.547
DOC_WW_Pin1_4 329 334 PF00397 0.728
DOC_WW_Pin1_4 351 356 PF00397 0.716
DOC_WW_Pin1_4 461 466 PF00397 0.380
LIG_14-3-3_CanoR_1 103 110 PF00244 0.466
LIG_14-3-3_CanoR_1 193 199 PF00244 0.589
LIG_14-3-3_CanoR_1 317 323 PF00244 0.540
LIG_Actin_WH2_2 168 184 PF00022 0.543
LIG_BRCT_BRCA1_1 396 400 PF00533 0.440
LIG_BRCT_BRCA1_1 46 50 PF00533 0.330
LIG_BRCT_BRCA1_2 396 402 PF00533 0.455
LIG_DCNL_PONY_1 1 4 PF03556 0.520
LIG_deltaCOP1_diTrp_1 291 297 PF00928 0.635
LIG_eIF4E_1 210 216 PF01652 0.418
LIG_FHA_1 103 109 PF00498 0.522
LIG_FHA_1 131 137 PF00498 0.461
LIG_FHA_1 228 234 PF00498 0.545
LIG_FHA_1 310 316 PF00498 0.445
LIG_FHA_1 330 336 PF00498 0.536
LIG_FHA_1 346 352 PF00498 0.811
LIG_FHA_1 374 380 PF00498 0.511
LIG_FHA_1 417 423 PF00498 0.357
LIG_FHA_1 462 468 PF00498 0.400
LIG_FHA_1 68 74 PF00498 0.548
LIG_FHA_1 78 84 PF00498 0.522
LIG_FHA_1 95 101 PF00498 0.426
LIG_FHA_2 341 347 PF00498 0.607
LIG_FHA_2 401 407 PF00498 0.351
LIG_LIR_Apic_2 242 246 PF02991 0.485
LIG_LIR_Apic_2 390 396 PF02991 0.432
LIG_LIR_Gen_1 291 301 PF02991 0.530
LIG_LIR_Gen_1 93 102 PF02991 0.569
LIG_LIR_Nem_3 291 297 PF02991 0.554
LIG_LIR_Nem_3 377 383 PF02991 0.546
LIG_LIR_Nem_3 390 395 PF02991 0.368
LIG_LIR_Nem_3 93 99 PF02991 0.493
LIG_LYPXL_yS_3 395 398 PF13949 0.260
LIG_PCNA_yPIPBox_3 34 42 PF02747 0.177
LIG_Pex14_1 387 391 PF04695 0.243
LIG_Pex14_2 400 404 PF04695 0.337
LIG_SH2_STAP1 85 89 PF00017 0.446
LIG_SH2_STAT5 145 148 PF00017 0.556
LIG_SH2_STAT5 210 213 PF00017 0.522
LIG_SH2_STAT5 26 29 PF00017 0.383
LIG_SH2_STAT5 288 291 PF00017 0.628
LIG_SH2_STAT5 378 381 PF00017 0.598
LIG_SH2_STAT5 391 394 PF00017 0.287
LIG_SH2_STAT5 427 430 PF00017 0.320
LIG_SH2_STAT5 69 72 PF00017 0.575
LIG_SH3_4 337 344 PF00018 0.578
LIG_SUMO_SIM_par_1 132 139 PF11976 0.420
LIG_TYR_ITIM 298 303 PF00017 0.296
MOD_CDK_SPxxK_3 329 336 PF00069 0.676
MOD_CDK_SPxxK_3 461 468 PF00069 0.305
MOD_CK1_1 111 117 PF00069 0.306
MOD_CK1_1 138 144 PF00069 0.375
MOD_CK1_1 228 234 PF00069 0.304
MOD_CK1_1 239 245 PF00069 0.327
MOD_CK1_1 347 353 PF00069 0.653
MOD_CK1_1 407 413 PF00069 0.453
MOD_CK2_1 400 406 PF00069 0.396
MOD_GlcNHglycan 184 187 PF01048 0.382
MOD_GlcNHglycan 406 409 PF01048 0.384
MOD_GlcNHglycan 429 432 PF01048 0.405
MOD_GlcNHglycan 436 439 PF01048 0.407
MOD_GlcNHglycan 442 445 PF01048 0.325
MOD_GlcNHglycan 64 67 PF01048 0.410
MOD_GlcNHglycan 80 83 PF01048 0.317
MOD_GSK3_1 180 187 PF00069 0.382
MOD_GSK3_1 220 227 PF00069 0.277
MOD_GSK3_1 235 242 PF00069 0.319
MOD_GSK3_1 325 332 PF00069 0.593
MOD_GSK3_1 340 347 PF00069 0.665
MOD_GSK3_1 400 407 PF00069 0.424
MOD_N-GLC_1 28 33 PF02516 0.488
MOD_NEK2_1 108 113 PF00069 0.335
MOD_NEK2_1 28 33 PF00069 0.352
MOD_NEK2_1 309 314 PF00069 0.516
MOD_NEK2_1 400 405 PF00069 0.499
MOD_NEK2_1 44 49 PF00069 0.349
MOD_NEK2_2 124 129 PF00069 0.243
MOD_NEK2_2 408 413 PF00069 0.418
MOD_PIKK_1 210 216 PF00454 0.316
MOD_PIKK_1 345 351 PF00454 0.695
MOD_PKA_2 102 108 PF00069 0.342
MOD_Plk_1 138 144 PF00069 0.329
MOD_Plk_1 224 230 PF00069 0.374
MOD_Plk_1 28 34 PF00069 0.391
MOD_Plk_1 290 296 PF00069 0.414
MOD_Plk_4 11 17 PF00069 0.343
MOD_Plk_4 239 245 PF00069 0.422
MOD_Plk_4 374 380 PF00069 0.478
MOD_Plk_4 394 400 PF00069 0.284
MOD_ProDKin_1 329 335 PF00069 0.678
MOD_ProDKin_1 351 357 PF00069 0.651
MOD_ProDKin_1 461 467 PF00069 0.471
MOD_SUMO_for_1 467 470 PF00179 0.574
MOD_SUMO_rev_2 177 183 PF00179 0.413
MOD_SUMO_rev_2 276 283 PF00179 0.699
TRG_DiLeu_BaLyEn_6 104 109 PF01217 0.305
TRG_DiLeu_BaLyEn_6 215 220 PF01217 0.259
TRG_DiLeu_BaLyEn_6 310 315 PF01217 0.438
TRG_ENDOCYTIC_2 22 25 PF00928 0.378
TRG_ENDOCYTIC_2 252 255 PF00928 0.505
TRG_ENDOCYTIC_2 300 303 PF00928 0.288
TRG_ENDOCYTIC_2 380 383 PF00928 0.378
TRG_ENDOCYTIC_2 395 398 PF00928 0.279
TRG_Pf-PMV_PEXEL_1 259 263 PF00026 0.557
TRG_Pf-PMV_PEXEL_1 313 318 PF00026 0.463

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I1M5 Leptomonas seymouri 63% 98%
A0A0S4IZG2 Bodo saltans 23% 100%
A0A0S4J1I6 Bodo saltans 25% 100%
A0A0S4J9U3 Bodo saltans 29% 100%
A0A1X0P5Q9 Trypanosomatidae 25% 100%
A0A1X0P5W3 Trypanosomatidae 45% 100%
A0A3Q8IM89 Leishmania donovani 26% 100%
A0A3R7K8J6 Trypanosoma rangeli 25% 100%
A0A3R7N7S2 Trypanosoma rangeli 42% 100%
A0A3S5H7D5 Leishmania donovani 24% 100%
A0A3S7X986 Leishmania donovani 100% 100%
A4HDP2 Leishmania braziliensis 23% 100%
A4HMN7 Leishmania braziliensis 25% 100%
A4HMN9 Leishmania braziliensis 85% 100%
C9ZWC1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 24% 97%
C9ZZF1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 100%
E9AF39 Leishmania major 26% 100%
E9AF41 Leishmania major 94% 100%
E9AH88 Leishmania infantum 24% 100%
E9AHV6 Leishmania infantum 27% 100%
E9AX26 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 96%
E9B694 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
E9B696 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q4QAF0 Leishmania major 24% 100%
V5BJC7 Trypanosoma cruzi 27% 100%
V5BNY6 Trypanosoma cruzi 43% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS