NAD(P)-binding protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

short chain dehydrogenase - putative

Species:

Leishmania infantum

UniProt:

E9AHV6_LEIIN

TriTrypDb:

LINF_350026700

Length:

440

Annotations

Annotations by Jardim et al.

Oxidoreductase, short chain dehydrogenase, putative

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AHV6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHV6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	396	400	PF00656	0.612
CLV_MEL_PAP_1	246	252	PF00089	0.533
CLV_NRD_NRD_1	132	134	PF00675	0.419
CLV_NRD_NRD_1	170	172	PF00675	0.445
CLV_NRD_NRD_1	188	190	PF00675	0.381
CLV_NRD_NRD_1	27	29	PF00675	0.414
CLV_NRD_NRD_1	316	318	PF00675	0.517
CLV_PCSK_FUR_1	130	134	PF00082	0.503
CLV_PCSK_KEX2_1	129	131	PF00082	0.425
CLV_PCSK_KEX2_1	132	134	PF00082	0.418
CLV_PCSK_KEX2_1	27	29	PF00082	0.414
CLV_PCSK_KEX2_1	316	318	PF00082	0.517
CLV_PCSK_KEX2_1	79	81	PF00082	0.564
CLV_PCSK_PC1ET2_1	129	131	PF00082	0.493
CLV_PCSK_PC1ET2_1	79	81	PF00082	0.564
CLV_PCSK_SKI1_1	189	193	PF00082	0.440
CLV_PCSK_SKI1_1	27	31	PF00082	0.382
CLV_PCSK_SKI1_1	319	323	PF00082	0.615
CLV_PCSK_SKI1_1	53	57	PF00082	0.520
DEG_APCC_DBOX_1	380	388	PF00400	0.586
DEG_Nend_UBRbox_1	1	4	PF02207	0.605
DOC_CYCLIN_RxL_1	187	195	PF00134	0.242
DOC_MAPK_MEF2A_6	196	203	PF00069	0.244
DOC_PP1_RVXF_1	188	195	PF00149	0.229
DOC_PP2B_LxvP_1	218	221	PF13499	0.209
DOC_PP2B_LxvP_1	244	247	PF13499	0.320
DOC_PP4_FxxP_1	209	212	PF00568	0.209
DOC_PP4_FxxP_1	23	26	PF00568	0.382
DOC_SPAK_OSR1_1	249	253	PF12202	0.329
DOC_USP7_MATH_1	281	285	PF00917	0.408
DOC_USP7_UBL2_3	2	6	PF12436	0.631
DOC_WW_Pin1_4	139	144	PF00397	0.284
DOC_WW_Pin1_4	385	390	PF00397	0.563
DOC_WW_Pin1_4	399	404	PF00397	0.420
LIG_14-3-3_CanoR_1	239	245	PF00244	0.378
LIG_14-3-3_CanoR_1	249	253	PF00244	0.439
LIG_BRCT_BRCA1_1	358	362	PF00533	0.352
LIG_BRCT_BRCA1_1	401	405	PF00533	0.470
LIG_BRCT_BRCA1_1	9	13	PF00533	0.540
LIG_BRCT_BRCA1_2	358	364	PF00533	0.352
LIG_EH1_1	299	307	PF00400	0.237
LIG_eIF4E_1	300	306	PF01652	0.251
LIG_FHA_1	214	220	PF00498	0.239
LIG_FHA_1	411	417	PF00498	0.607
LIG_FHA_2	363	369	PF00498	0.511
LIG_FHA_2	380	386	PF00498	0.580
LIG_FHA_2	394	400	PF00498	0.592
LIG_FHA_2	54	60	PF00498	0.325
LIG_GBD_Chelix_1	266	274	PF00786	0.426
LIG_LIR_Gen_1	103	109	PF02991	0.334
LIG_LIR_Gen_1	157	166	PF02991	0.196
LIG_LIR_Gen_1	356	363	PF02991	0.417
LIG_LIR_Nem_3	103	108	PF02991	0.229
LIG_LIR_Nem_3	157	162	PF02991	0.196
LIG_LIR_Nem_3	251	256	PF02991	0.449
LIG_LIR_Nem_3	356	360	PF02991	0.392
LIG_MLH1_MIPbox_1	401	405	PF16413	0.470
LIG_MLH1_MIPbox_1	9	13	PF16413	0.416
LIG_MYND_3	220	224	PF01753	0.284
LIG_NRBOX	214	220	PF00104	0.209
LIG_Pex14_2	19	23	PF04695	0.449
LIG_Pex14_2	209	213	PF04695	0.264
LIG_RPA_C_Fungi	37	49	PF08784	0.359
LIG_SH2_SRC	139	142	PF00017	0.343
LIG_SH2_STAP1	105	109	PF00017	0.398
LIG_SH2_STAP1	329	333	PF00017	0.328
LIG_SH2_STAT5	232	235	PF00017	0.309
LIG_SH2_STAT5	404	407	PF00017	0.328
LIG_SUMO_SIM_anti_2	382	388	PF11976	0.397
LIG_SUMO_SIM_par_1	80	86	PF11976	0.345
LIG_TRAF2_1	365	368	PF00917	0.363
LIG_UBA3_1	270	275	PF00899	0.350
LIG_UBA3_1	360	364	PF00899	0.261
MOD_CK1_1	142	148	PF00069	0.437
MOD_CK1_1	356	362	PF00069	0.256
MOD_CK1_1	7	13	PF00069	0.337
MOD_CK2_1	362	368	PF00069	0.365
MOD_CK2_1	379	385	PF00069	0.478
MOD_GlcNHglycan	112	115	PF01048	0.409
MOD_GlcNHglycan	284	287	PF01048	0.431
MOD_GlcNHglycan	389	392	PF01048	0.546
MOD_GlcNHglycan	8	12	PF01048	0.328
MOD_GlcNHglycan	89	92	PF01048	0.287
MOD_GSK3_1	110	117	PF00069	0.372
MOD_GSK3_1	248	255	PF00069	0.552
MOD_GSK3_1	53	60	PF00069	0.516
MOD_GSK3_1	83	90	PF00069	0.249
MOD_LATS_1	51	57	PF00433	0.408
MOD_N-GLC_1	340	345	PF02516	0.419
MOD_NEK2_1	192	197	PF00069	0.268
MOD_NEK2_1	240	245	PF00069	0.340
MOD_NEK2_1	288	293	PF00069	0.435
MOD_NEK2_1	305	310	PF00069	0.348
MOD_NEK2_1	353	358	PF00069	0.346
MOD_NEK2_2	329	334	PF00069	0.305
MOD_NEK2_2	370	375	PF00069	0.325
MOD_PIKK_1	114	120	PF00454	0.300
MOD_PIKK_1	290	296	PF00454	0.505
MOD_PKA_2	248	254	PF00069	0.570
MOD_Plk_1	7	13	PF00069	0.382
MOD_Plk_4	142	148	PF00069	0.289
MOD_Plk_4	240	246	PF00069	0.445
MOD_Plk_4	356	362	PF00069	0.303
MOD_Plk_4	411	417	PF00069	0.486
MOD_ProDKin_1	139	145	PF00069	0.352
MOD_ProDKin_1	385	391	PF00069	0.478
MOD_ProDKin_1	399	405	PF00069	0.260
MOD_SUMO_for_1	321	324	PF00179	0.405
TRG_DiLeu_BaLyEn_6	39	44	PF01217	0.358
TRG_ENDOCYTIC_2	105	108	PF00928	0.343
TRG_ENDOCYTIC_2	318	321	PF00928	0.360
TRG_ER_diArg_1	130	133	PF00400	0.310
TRG_ER_diArg_1	26	28	PF00400	0.419
TRG_ER_diArg_1	316	318	PF00400	0.398
TRG_NLS_MonoCore_2	128	133	PF00514	0.180
TRG_NLS_MonoExtC_3	128	133	PF00514	0.180

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A023I4F1	Penicillium roqueforti	25%	100%
A0A078IS66	Brassica napus	24%	100%
A0A078ISJ6	Brassica napus	24%	100%
A0A0N0P2P0	Leptomonas seymouri	28%	100%
A0A0N0P2S5	Leptomonas seymouri	65%	98%
A0A0N0P2S7	Leptomonas seymouri	27%	86%
A0A0N1HZ81	Leptomonas seymouri	28%	79%
A0A0N1I1M5	Leptomonas seymouri	25%	89%
A0A0S4J1I6	Bodo saltans	23%	100%
A0A0S4JBQ4	Bodo saltans	28%	100%
A0A0S4JFU3	Bodo saltans	42%	100%
A0A1B7YCL6	Colletotrichum higginsianum (strain IMI 349063)	28%	100%
A0A1X0NVT8	Trypanosomatidae	29%	88%
A0A1X0P5Q9	Trypanosomatidae	48%	96%
A0A1X0P5W3	Trypanosomatidae	29%	99%
A0A2H3CZZ2	Armillaria gallica	24%	100%
A0A3Q8ID46	Leishmania donovani	28%	87%
A0A3Q8IM89	Leishmania donovani	100%	100%
A0A3R7K071	Trypanosoma rangeli	29%	91%
A0A3R7K8J6	Trypanosoma rangeli	52%	100%
A0A3R7N7S2	Trypanosoma rangeli	30%	100%
A0A3S5H7D5	Leishmania donovani	28%	100%
A0A3S7WQY1	Leishmania donovani	25%	100%
A0A3S7X986	Leishmania donovani	27%	91%
A0A422N2B6	Trypanosoma rangeli	28%	92%
A4H5Z1	Leishmania braziliensis	26%	100%
A4HDP2	Leishmania braziliensis	25%	100%
A4HDP3	Leishmania braziliensis	29%	100%
A4HMN7	Leishmania braziliensis	84%	100%
A4HMN9	Leishmania braziliensis	25%	100%
A4HUB6	Leishmania infantum	25%	100%
C9ZWC0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	93%
C9ZWC1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	88%
C9ZZF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
C9ZZF3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	95%
E9AF39	Leishmania major	96%	100%
E9AF41	Leishmania major	27%	100%
E9AH88	Leishmania infantum	29%	100%
E9AH89	Leishmania infantum	29%	87%
E9AHV8	Leishmania infantum	27%	91%
E9AN15	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AX27	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	87%
E9B694	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9B696	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
O74959	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	100%
P59837	Bos taurus	31%	100%
Q08651	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
Q17QU7	Bos taurus	30%	100%
Q17QW3	Bos taurus	28%	100%
Q4QAE9	Leishmania major	29%	87%
Q4QHL1	Leishmania major	26%	100%
Q5F389	Gallus gallus	27%	100%
Q5R9W5	Pongo abelii	29%	100%
Q5SS80	Mus musculus	30%	100%
Q6RVV4	Pisum sativum	29%	100%
Q6UX07	Homo sapiens	29%	100%
Q803A8	Danio rerio	30%	100%
Q8BYK4	Mus musculus	29%	100%
Q8N5I4	Homo sapiens	28%	100%
Q8TC12	Homo sapiens	30%	100%
Q91WL8	Mus musculus	28%	100%
Q96NR8	Homo sapiens	29%	100%
Q9ERI6	Mus musculus	27%	100%
Q9HBH5	Homo sapiens	27%	100%
Q9NZC7	Homo sapiens	29%	100%
Q9QYF1	Mus musculus	30%	100%
Q9VLU5	Drosophila melanogaster	28%	100%
V5BAF4	Trypanosoma cruzi	31%	92%
V5BJC7	Trypanosoma cruzi	53%	100%
V5BJI0	Trypanosoma cruzi	30%	99%
V5BNY6	Trypanosoma cruzi	31%	100%
W6QB10	Penicillium roqueforti (strain FM164)	25%	100%