Beta-fructofuranosidase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

beta-fructofuranosidase - putative

Species:

Leishmania infantum

UniProt:

E9AHU3_LEIIN

TriTrypDb:

LINF_350011100

Length:

372

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 13, no: 2
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

E9AHU3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHU3

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	4	2
GO:0004564	beta-fructofuranosidase activity	5	2
GO:0016787	hydrolase activity	2	13
GO:0016798	hydrolase activity, acting on glycosyl bonds	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_SCF_FBW7_1	159	166	PF00400	0.158
DOC_CYCLIN_yClb5_NLxxxL_5	211	220	PF00134	0.158
DOC_MAPK_MEF2A_6	294	301	PF00069	0.424
DOC_MAPK_NFAT4_5	294	302	PF00069	0.158
DOC_PP1_RVXF_1	37	43	PF00149	0.158
DOC_PP2B_PxIxI_1	318	324	PF00149	0.191
DOC_PP4_FxxP_1	137	140	PF00568	0.158
DOC_PP4_FxxP_1	69	72	PF00568	0.158
DOC_SPAK_OSR1_1	307	311	PF12202	0.309
DOC_USP7_MATH_1	285	289	PF00917	0.469
DOC_WW_Pin1_4	159	164	PF00397	0.203
DOC_WW_Pin1_4	214	219	PF00397	0.403
DOC_WW_Pin1_4	324	329	PF00397	0.344
DOC_WW_Pin1_4	64	69	PF00397	0.391
DOC_WW_Pin1_4	73	78	PF00397	0.275
LIG_14-3-3_CanoR_1	104	112	PF00244	0.332
LIG_14-3-3_CanoR_1	92	98	PF00244	0.304
LIG_BRCT_BRCA1_1	114	118	PF00533	0.453
LIG_BRCT_BRCA1_1	121	125	PF00533	0.452
LIG_BRCT_BRCA1_1	304	308	PF00533	0.263
LIG_FHA_1	112	118	PF00498	0.220
LIG_FHA_1	141	147	PF00498	0.175
LIG_FHA_1	211	217	PF00498	0.206
LIG_FHA_1	285	291	PF00498	0.216
LIG_FHA_1	343	349	PF00498	0.367
LIG_FHA_1	83	89	PF00498	0.366
LIG_FHA_2	111	117	PF00498	0.179
LIG_FHA_2	221	227	PF00498	0.182
LIG_FXI_DFP_1	338	342	PF00024	0.189
LIG_IRF3_LxIS_1	25	31	PF10401	0.369
LIG_LIR_Apic_2	134	140	PF02991	0.158
LIG_LIR_Apic_2	274	280	PF02991	0.177
LIG_LIR_Apic_2	67	72	PF02991	0.262
LIG_LIR_Gen_1	122	131	PF02991	0.427
LIG_LIR_Gen_1	305	316	PF02991	0.264
LIG_LIR_Gen_1	94	99	PF02991	0.171
LIG_LIR_Nem_3	115	121	PF02991	0.355
LIG_LIR_Nem_3	122	128	PF02991	0.395
LIG_LIR_Nem_3	175	180	PF02991	0.199
LIG_LIR_Nem_3	259	264	PF02991	0.395
LIG_LIR_Nem_3	305	311	PF02991	0.343
LIG_LIR_Nem_3	94	98	PF02991	0.178
LIG_MAD2	127	135	PF02301	0.158
LIG_MLH1_MIPbox_1	121	125	PF16413	0.158
LIG_PCNA_PIPBox_1	170	179	PF02747	0.158
LIG_PCNA_yPIPBox_3	257	266	PF02747	0.158
LIG_Pex14_1	278	282	PF04695	0.307
LIG_Pex14_2	98	102	PF04695	0.158
LIG_PTB_Apo_2	151	158	PF02174	0.176
LIG_SH2_CRK	177	181	PF00017	0.427
LIG_SH2_CRK	194	198	PF00017	0.156
LIG_SH2_CRK	286	290	PF00017	0.373
LIG_SH2_GRB2like	282	285	PF00017	0.158
LIG_SH2_NCK_1	48	52	PF00017	0.249
LIG_SH2_SRC	282	285	PF00017	0.158
LIG_SH2_SRC	336	339	PF00017	0.230
LIG_SH2_SRC	48	51	PF00017	0.205
LIG_SH2_STAP1	286	290	PF00017	0.423
LIG_SH2_STAP1	95	99	PF00017	0.249
LIG_SH2_STAT3	330	333	PF00017	0.240
LIG_SH2_STAT5	124	127	PF00017	0.208
LIG_SH2_STAT5	155	158	PF00017	0.292
LIG_SH2_STAT5	286	289	PF00017	0.253
LIG_SH2_STAT5	336	339	PF00017	0.349
LIG_SH2_STAT5	95	98	PF00017	0.386
LIG_SH3_3	114	120	PF00018	0.158
LIG_SH3_3	215	221	PF00018	0.376
LIG_SH3_3	252	258	PF00018	0.158
LIG_SH3_4	279	286	PF00018	0.176
LIG_SUMO_SIM_anti_2	295	300	PF11976	0.472
LIG_SUMO_SIM_par_1	127	132	PF11976	0.253
LIG_SUMO_SIM_par_1	79	87	PF11976	0.158
LIG_TRFH_1	214	218	PF08558	0.282
MOD_CK1_1	108	114	PF00069	0.227
MOD_CK1_1	288	294	PF00069	0.398
MOD_CK1_1	41	47	PF00069	0.383
MOD_CK2_1	362	368	PF00069	0.494
MOD_GlcNHglycan	14	17	PF01048	0.440
MOD_GlcNHglycan	194	197	PF01048	0.291
MOD_GlcNHglycan	198	201	PF01048	0.202
MOD_GlcNHglycan	30	33	PF01048	0.430
MOD_GlcNHglycan	364	367	PF01048	0.537
MOD_GlcNHglycan	55	58	PF01048	0.158
MOD_GlcNHglycan	64	67	PF01048	0.150
MOD_GSK3_1	106	113	PF00069	0.251
MOD_GSK3_1	129	136	PF00069	0.400
MOD_GSK3_1	159	166	PF00069	0.338
MOD_GSK3_1	179	186	PF00069	0.272
MOD_GSK3_1	192	199	PF00069	0.174
MOD_GSK3_1	206	213	PF00069	0.146
MOD_GSK3_1	284	291	PF00069	0.263
MOD_GSK3_1	53	60	PF00069	0.452
MOD_N-GLC_1	157	162	PF02516	0.324
MOD_N-GLC_1	180	185	PF02516	0.272
MOD_N-GLC_1	214	219	PF02516	0.478
MOD_N-GLC_1	61	66	PF02516	0.345
MOD_NEK2_1	107	112	PF00069	0.382
MOD_NEK2_1	157	162	PF00069	0.357
MOD_NEK2_1	179	184	PF00069	0.241
MOD_NEK2_1	210	215	PF00069	0.252
MOD_NEK2_1	28	33	PF00069	0.393
MOD_NEK2_1	289	294	PF00069	0.317
MOD_NEK2_1	302	307	PF00069	0.362
MOD_NEK2_2	93	98	PF00069	0.205
MOD_PIKK_1	119	125	PF00454	0.226
MOD_PIKK_1	166	172	PF00454	0.338
MOD_PIKK_1	180	186	PF00454	0.184
MOD_PKA_2	91	97	PF00069	0.402
MOD_Plk_4	141	147	PF00069	0.230
MOD_Plk_4	183	189	PF00069	0.469
MOD_Plk_4	206	212	PF00069	0.312
MOD_Plk_4	285	291	PF00069	0.373
MOD_Plk_4	38	44	PF00069	0.275
MOD_Plk_4	93	99	PF00069	0.391
MOD_ProDKin_1	159	165	PF00069	0.203
MOD_ProDKin_1	214	220	PF00069	0.403
MOD_ProDKin_1	324	330	PF00069	0.355
MOD_ProDKin_1	64	70	PF00069	0.391
MOD_ProDKin_1	73	79	PF00069	0.275
TRG_DiLeu_BaEn_1	175	180	PF01217	0.191
TRG_DiLeu_BaLyEn_6	316	321	PF01217	0.227
TRG_ENDOCYTIC_2	177	180	PF00928	0.243
TRG_ENDOCYTIC_2	194	197	PF00928	0.326
TRG_ENDOCYTIC_2	286	289	PF00928	0.329
TRG_ENDOCYTIC_2	95	98	PF00928	0.205
TRG_ER_diArg_1	351	354	PF00400	0.233
TRG_NES_CRM1_1	119	134	PF08389	0.426

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYJ4	Leptomonas seymouri	37%	73%
A0A0S4JMD5	Bodo saltans	32%	73%
A0A1X0PA11	Trypanosomatidae	31%	80%
A0A1X0PAC3	Trypanosomatidae	41%	72%
A0A3Q8IHH9	Leishmania donovani	36%	73%
A0A3R7K6I9	Trypanosoma rangeli	36%	80%
A0A3R7KT12	Trypanosoma rangeli	29%	72%
A4HB81	Leishmania braziliensis	39%	73%
A4IAC9	Leishmania infantum	36%	73%
C9ZLW4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	81%
C9ZLW5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	73%
E9B5F2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	73%
P70158	Mus musculus	24%	84%
Q3ZC91	Bos taurus	25%	83%
Q4Q2I1	Leishmania major	37%	72%
Q54SR8	Dictyostelium discoideum	24%	83%
Q55GC7	Dictyostelium discoideum	25%	85%
Q641Z7	Rattus norvegicus	24%	84%
Q92484	Homo sapiens	25%	82%
Q92485	Homo sapiens	25%	82%
V5DMV6	Trypanosoma cruzi	30%	73%