Proteophosphoglycan 5

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

proteophosphoglycan ppg3 - putative

Species:

Leishmania infantum

UniProt:

E9AHU2_LEIIN

TriTrypDb:

LINF_350010100

Length:

999

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	2
GO:0016020	membrane	2	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

E9AHU2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHU2

Function

Biological processes
Term	Name	Level	Count
GO:0002218	activation of innate immune response	3	2
GO:0002221	pattern recognition receptor signaling pathway	5	2
GO:0002224	toll-like receptor signaling pathway	6	2
GO:0002253	activation of immune response	2	2
GO:0002376	immune system process	1	2
GO:0002682	regulation of immune system process	3	2
GO:0002684	positive regulation of immune system process	4	2
GO:0002757	immune response-activating signaling pathway	3	2
GO:0002758	innate immune response-activating signaling pathway	4	2
GO:0002764	immune response-regulating signaling pathway	3	2
GO:0002831	regulation of response to biotic stimulus	4	2
GO:0002833	positive regulation of response to biotic stimulus	5	2
GO:0006955	immune response	2	2
GO:0007165	signal transduction	2	2
GO:0009987	cellular process	1	2
GO:0031347	regulation of defense response	5	2
GO:0031349	positive regulation of defense response	5	2
GO:0032101	regulation of response to external stimulus	4	2
GO:0032103	positive regulation of response to external stimulus	5	2
GO:0045088	regulation of innate immune response	5	2
GO:0045089	positive regulation of innate immune response	6	2
GO:0048518	positive regulation of biological process	3	2
GO:0048583	regulation of response to stimulus	3	2
GO:0048584	positive regulation of response to stimulus	4	2
GO:0050776	regulation of immune response	4	2
GO:0050778	positive regulation of immune response	5	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0050896	response to stimulus	1	2
GO:0065007	biological regulation	1	2
GO:0080134	regulation of response to stress	4	2

Molecular functions
Term	Name	Level	Count
GO:0004888	transmembrane signaling receptor activity	3	2
GO:0038023	signaling receptor activity	2	2
GO:0060089	molecular transducer activity	1	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	6	8	PF00675	0.441
CLV_NRD_NRD_1	997	999	PF00675	0.564
CLV_PCSK_KEX2_1	6	8	PF00082	0.441
CLV_PCSK_KEX2_1	996	998	PF00082	0.557
CLV_PCSK_PC1ET2_1	996	998	PF00082	0.511
CLV_PCSK_PC7_1	992	998	PF00082	0.496
CLV_PCSK_SKI1_1	797	801	PF00082	0.294
DEG_APCC_DBOX_1	796	804	PF00400	0.286
DEG_SPOP_SBC_1	563	567	PF00917	0.521
DEG_SPOP_SBC_1	568	572	PF00917	0.521
DEG_SPOP_SBC_1	578	582	PF00917	0.504
DEG_SPOP_SBC_1	583	587	PF00917	0.501
DEG_SPOP_SBC_1	594	598	PF00917	0.517
DEG_SPOP_SBC_1	599	603	PF00917	0.509
DEG_SPOP_SBC_1	610	614	PF00917	0.502
DEG_SPOP_SBC_1	615	619	PF00917	0.488
DEG_SPOP_SBC_1	625	629	PF00917	0.499
DEG_SPOP_SBC_1	630	634	PF00917	0.499
DEG_SPOP_SBC_1	641	645	PF00917	0.510
DEG_SPOP_SBC_1	646	650	PF00917	0.506
DEG_SPOP_SBC_1	657	661	PF00917	0.509
DEG_SPOP_SBC_1	662	666	PF00917	0.508
DEG_SPOP_SBC_1	673	677	PF00917	0.510
DEG_SPOP_SBC_1	678	682	PF00917	0.504
DEG_SPOP_SBC_1	688	692	PF00917	0.507
DEG_SPOP_SBC_1	693	697	PF00917	0.497
DEG_SPOP_SBC_1	704	708	PF00917	0.507
DEG_SPOP_SBC_1	709	713	PF00917	0.509
DEG_SPOP_SBC_1	720	724	PF00917	0.501
DEG_SPOP_SBC_1	725	729	PF00917	0.495
DEG_SPOP_SBC_1	736	740	PF00917	0.522
DEG_SPOP_SBC_1	741	745	PF00917	0.541
DEG_SPOP_SBC_1	751	755	PF00917	0.591
DEG_SPOP_SBC_1	756	760	PF00917	0.563
DEG_SPOP_SBC_1	767	771	PF00917	0.517
DEG_SPOP_SBC_1	772	776	PF00917	0.458
DOC_MAPK_DCC_7	6	16	PF00069	0.400
DOC_PP1_RVXF_1	858	865	PF00149	0.268
DOC_PP1_RVXF_1	990	996	PF00149	0.491
DOC_USP7_MATH_1	561	565	PF00917	0.514
DOC_USP7_MATH_1	569	573	PF00917	0.517
DOC_USP7_MATH_1	576	580	PF00917	0.504
DOC_USP7_MATH_1	584	588	PF00917	0.507
DOC_USP7_MATH_1	592	596	PF00917	0.509
DOC_USP7_MATH_1	600	604	PF00917	0.508
DOC_USP7_MATH_1	608	612	PF00917	0.556
DOC_USP7_MATH_1	616	620	PF00917	0.637
DOC_USP7_MATH_1	623	627	PF00917	0.739
DOC_USP7_MATH_1	631	635	PF00917	0.687
DOC_USP7_MATH_1	639	643	PF00917	0.585
DOC_USP7_MATH_1	647	651	PF00917	0.547
DOC_USP7_MATH_1	655	659	PF00917	0.506
DOC_USP7_MATH_1	663	667	PF00917	0.510
DOC_USP7_MATH_1	671	675	PF00917	0.510
DOC_USP7_MATH_1	679	683	PF00917	0.504
DOC_USP7_MATH_1	686	690	PF00917	0.504
DOC_USP7_MATH_1	694	698	PF00917	0.502
DOC_USP7_MATH_1	702	706	PF00917	0.510
DOC_USP7_MATH_1	710	714	PF00917	0.510
DOC_USP7_MATH_1	718	722	PF00917	0.504
DOC_USP7_MATH_1	726	730	PF00917	0.498
DOC_USP7_MATH_1	734	738	PF00917	0.500
DOC_USP7_MATH_1	742	746	PF00917	0.501
DOC_USP7_MATH_1	749	753	PF00917	0.504
DOC_USP7_MATH_1	757	761	PF00917	0.503
DOC_USP7_MATH_1	765	769	PF00917	0.503
DOC_USP7_MATH_1	773	777	PF00917	0.446
DOC_USP7_MATH_1	867	871	PF00917	0.380
DOC_USP7_MATH_1	907	911	PF00917	0.502
LIG_14-3-3_CanoR_1	87	92	PF00244	0.403
LIG_14-3-3_CterR_2	997	999	PF00244	0.521
LIG_Actin_WH2_2	11	29	PF00022	0.356
LIG_Actin_WH2_2	138	156	PF00022	0.364
LIG_Actin_WH2_2	168	186	PF00022	0.353
LIG_Actin_WH2_2	198	216	PF00022	0.336
LIG_Actin_WH2_2	228	246	PF00022	0.344
LIG_Actin_WH2_2	258	276	PF00022	0.329
LIG_Actin_WH2_2	288	306	PF00022	0.308
LIG_Actin_WH2_2	318	336	PF00022	0.300
LIG_Actin_WH2_2	348	366	PF00022	0.299
LIG_Actin_WH2_2	378	396	PF00022	0.284
LIG_Actin_WH2_2	408	426	PF00022	0.290
LIG_Actin_WH2_2	41	59	PF00022	0.333
LIG_Actin_WH2_2	438	456	PF00022	0.315
LIG_Actin_WH2_2	468	486	PF00022	0.303
LIG_Actin_WH2_2	498	516	PF00022	0.311
LIG_Actin_WH2_2	528	546	PF00022	0.332
LIG_Actin_WH2_2	71	89	PF00022	0.371
LIG_Actin_WH2_2	844	862	PF00022	0.301
LIG_Actin_WH2_2	94	111	PF00022	0.433
LIG_CaM_IQ_9	94	109	PF13499	0.424
LIG_FHA_2	874	880	PF00498	0.324
LIG_FHA_2	883	889	PF00498	0.274
LIG_FHA_2	985	991	PF00498	0.478
LIG_LIR_Gen_1	910	921	PF02991	0.259
LIG_LIR_Gen_1	951	961	PF02991	0.505
LIG_LIR_LC3C_4	90	94	PF02991	0.372
LIG_LIR_Nem_3	780	785	PF02991	0.356
LIG_LIR_Nem_3	805	810	PF02991	0.555
LIG_LIR_Nem_3	821	825	PF02991	0.317
LIG_LIR_Nem_3	879	884	PF02991	0.293
LIG_LIR_Nem_3	891	897	PF02991	0.265
LIG_LIR_Nem_3	910	916	PF02991	0.254
LIG_LIR_Nem_3	920	925	PF02991	0.261
LIG_LIR_Nem_3	928	932	PF02991	0.247
LIG_LIR_Nem_3	951	956	PF02991	0.496
LIG_MYND_1	808	812	PF01753	0.296
LIG_Pex14_1	822	826	PF04695	0.268
LIG_PTB_Apo_2	912	919	PF02174	0.256
LIG_PTB_Phospho_1	912	918	PF10480	0.258
LIG_SH2_CRK	826	830	PF00017	0.303
LIG_SH2_CRK	894	898	PF00017	0.290
LIG_SH2_GRB2like	913	916	PF00017	0.244
LIG_SH2_GRB2like	939	942	PF00017	0.268
LIG_SH2_STAT5	826	829	PF00017	0.300
LIG_SH2_STAT5	894	897	PF00017	0.289
LIG_SH2_STAT5	913	916	PF00017	0.244
LIG_SH2_STAT5	939	942	PF00017	0.268
LIG_SUMO_SIM_anti_2	90	95	PF11976	0.375
LIG_SUMO_SIM_par_1	15	21	PF11976	0.348
LIG_SUMO_SIM_par_1	172	178	PF11976	0.323
LIG_SUMO_SIM_par_1	532	538	PF11976	0.330
LIG_SUMO_SIM_par_1	960	965	PF11976	0.303
LIG_TYR_ITIM	785	790	PF00017	0.325
LIG_TYR_ITIM	892	897	PF00017	0.279
LIG_TYR_ITIM	911	916	PF00017	0.250
MOD_CK1_1	559	565	PF00069	0.506
MOD_CK1_1	567	573	PF00069	0.517
MOD_CK1_1	574	580	PF00069	0.505
MOD_CK1_1	582	588	PF00069	0.512
MOD_CK1_1	590	596	PF00069	0.524
MOD_CK1_1	598	604	PF00069	0.533
MOD_CK1_1	609	615	PF00069	0.517
MOD_CK1_1	617	623	PF00069	0.528
MOD_CK1_1	624	630	PF00069	0.569
MOD_CK1_1	632	638	PF00069	0.604
MOD_CK1_1	640	646	PF00069	0.571
MOD_CK1_1	648	654	PF00069	0.535
MOD_CK1_1	656	662	PF00069	0.510
MOD_CK1_1	664	670	PF00069	0.510
MOD_CK1_1	672	678	PF00069	0.510
MOD_CK1_1	680	686	PF00069	0.503
MOD_CK1_1	687	693	PF00069	0.508
MOD_CK1_1	695	701	PF00069	0.503
MOD_CK1_1	703	709	PF00069	0.508
MOD_CK1_1	711	717	PF00069	0.508
MOD_CK1_1	719	725	PF00069	0.501
MOD_CK1_1	727	733	PF00069	0.496
MOD_CK1_1	735	741	PF00069	0.517
MOD_CK1_1	743	749	PF00069	0.541
MOD_CK1_1	750	756	PF00069	0.571
MOD_CK1_1	758	764	PF00069	0.545
MOD_CK1_1	766	772	PF00069	0.510
MOD_CK1_1	774	780	PF00069	0.422
MOD_CK1_1	844	850	PF00069	0.328
MOD_CK1_1	882	888	PF00069	0.281
MOD_CK1_1	906	912	PF00069	0.278
MOD_CK1_1	972	978	PF00069	0.410
MOD_CK1_1	980	986	PF00069	0.432
MOD_CK2_1	774	780	PF00069	0.496
MOD_CK2_1	786	792	PF00069	0.546
MOD_CK2_1	799	805	PF00069	0.416
MOD_CK2_1	844	850	PF00069	0.328
MOD_CK2_1	873	879	PF00069	0.318
MOD_CK2_1	882	888	PF00069	0.271
MOD_CK2_1	906	912	PF00069	0.519
MOD_CK2_1	931	937	PF00069	0.365
MOD_CK2_1	984	990	PF00069	0.467
MOD_GlcNHglycan	558	561	PF01048	0.488
MOD_GlcNHglycan	566	569	PF01048	0.515
MOD_GlcNHglycan	573	576	PF01048	0.502
MOD_GlcNHglycan	581	584	PF01048	0.508
MOD_GlcNHglycan	589	592	PF01048	0.516
MOD_GlcNHglycan	597	600	PF01048	0.532
MOD_GlcNHglycan	608	611	PF01048	0.548
MOD_GlcNHglycan	613	616	PF01048	0.582
MOD_GlcNHglycan	623	626	PF01048	0.704
MOD_GlcNHglycan	628	631	PF01048	0.684
MOD_GlcNHglycan	636	639	PF01048	0.610
MOD_GlcNHglycan	644	647	PF01048	0.519
MOD_GlcNHglycan	652	655	PF01048	0.506
MOD_GlcNHglycan	660	663	PF01048	0.507
MOD_GlcNHglycan	668	671	PF01048	0.505
MOD_GlcNHglycan	676	679	PF01048	0.503
MOD_GlcNHglycan	683	686	PF01048	0.500
MOD_GlcNHglycan	691	694	PF01048	0.505
MOD_GlcNHglycan	699	702	PF01048	0.503
MOD_GlcNHglycan	707	710	PF01048	0.505
MOD_GlcNHglycan	715	718	PF01048	0.502
MOD_GlcNHglycan	723	726	PF01048	0.511
MOD_GlcNHglycan	731	734	PF01048	0.621
MOD_GlcNHglycan	739	742	PF01048	0.738
MOD_GlcNHglycan	746	749	PF01048	0.726
MOD_GlcNHglycan	754	757	PF01048	0.617
MOD_GlcNHglycan	762	765	PF01048	0.506
MOD_GlcNHglycan	770	773	PF01048	0.659
MOD_GlcNHglycan	872	876	PF01048	0.343
MOD_GlcNHglycan	881	884	PF01048	0.319
MOD_GlcNHglycan	897	900	PF01048	0.422
MOD_GlcNHglycan	905	908	PF01048	0.289
MOD_GlcNHglycan	945	948	PF01048	0.448
MOD_GSK3_1	559	566	PF00069	0.508
MOD_GSK3_1	567	574	PF00069	0.517
MOD_GSK3_1	578	585	PF00069	0.504
MOD_GSK3_1	586	593	PF00069	0.515
MOD_GSK3_1	594	601	PF00069	0.533
MOD_GSK3_1	602	609	PF00069	0.527
MOD_GSK3_1	610	617	PF00069	0.533
MOD_GSK3_1	621	628	PF00069	0.574
MOD_GSK3_1	629	636	PF00069	0.564
MOD_GSK3_1	637	644	PF00069	0.535
MOD_GSK3_1	645	652	PF00069	0.507
MOD_GSK3_1	653	660	PF00069	0.507
MOD_GSK3_1	661	668	PF00069	0.510
MOD_GSK3_1	669	676	PF00069	0.507
MOD_GSK3_1	677	684	PF00069	0.505
MOD_GSK3_1	688	695	PF00069	0.502
MOD_GSK3_1	696	703	PF00069	0.500
MOD_GSK3_1	704	711	PF00069	0.509
MOD_GSK3_1	712	719	PF00069	0.506
MOD_GSK3_1	720	727	PF00069	0.499
MOD_GSK3_1	728	735	PF00069	0.609
MOD_GSK3_1	736	743	PF00069	0.729
MOD_GSK3_1	747	754	PF00069	0.683
MOD_GSK3_1	755	762	PF00069	0.571
MOD_GSK3_1	763	770	PF00069	0.504
MOD_GSK3_1	771	778	PF00069	0.464
MOD_GSK3_1	799	806	PF00069	0.427
MOD_GSK3_1	867	874	PF00069	0.366
MOD_GSK3_1	903	910	PF00069	0.348
MOD_GSK3_1	921	928	PF00069	0.249
MOD_GSK3_1	972	979	PF00069	0.415
MOD_GSK3_1	980	987	PF00069	0.435
MOD_N-GLC_1	879	884	PF02516	0.293
MOD_N-GLC_2	818	820	PF02516	0.251
MOD_NEK2_1	799	804	PF00069	0.508
MOD_NEK2_1	841	846	PF00069	0.309
MOD_NEK2_1	890	895	PF00069	0.440
MOD_NEK2_1	921	926	PF00069	0.448
MOD_NEK2_1	962	967	PF00069	0.299
MOD_NEK2_1	969	974	PF00069	0.355
MOD_NEK2_1	976	981	PF00069	0.423
MOD_NEK2_1	984	989	PF00069	0.444
MOD_PIKK_1	977	983	PF00454	0.441
MOD_PK_1	87	93	PF00069	0.397
MOD_PKA_2	803	809	PF00069	0.572
MOD_Plk_1	793	799	PF00069	0.520
MOD_Plk_1	867	873	PF00069	0.366
MOD_Plk_1	890	896	PF00069	0.276
MOD_Plk_1	941	947	PF00069	0.277
MOD_Plk_4	87	93	PF00069	0.397
MOD_Plk_4	949	955	PF00069	0.314
MOD_Plk_4	972	978	PF00069	0.410
TRG_ENDOCYTIC_2	782	785	PF00928	0.355
TRG_ENDOCYTIC_2	787	790	PF00928	0.316
TRG_ENDOCYTIC_2	894	897	PF00928	0.289
TRG_ENDOCYTIC_2	913	916	PF00928	0.244
TRG_ENDOCYTIC_2	918	921	PF00928	0.264
TRG_ER_diArg_1	5	7	PF00400	0.444

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4IAV2	Leishmania infantum	58%	100%