Enoyl-CoA hydratase/isomerase family protein,conserved

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

enoyl-CoA hydratase/isomerase family protein - conserved

Species:

Leishmania infantum

UniProt:

E9AHU0_LEIIN

TriTrypDb:

LINF_350008700

Length:

297

Annotations

Annotations by Jardim et al.

Fatty acid metabolism, Enoyl-CoA hydratase/isomerase family ,conserved

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AHU0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHU0

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006629	lipid metabolic process	3	1
GO:0006631	fatty acid metabolic process	4	1
GO:0006635	fatty acid beta-oxidation	6	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009062	fatty acid catabolic process	5	1
GO:0009987	cellular process	1	1
GO:0016042	lipid catabolic process	4	1
GO:0016054	organic acid catabolic process	4	1
GO:0019395	fatty acid oxidation	5	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0030258	lipid modification	4	1
GO:0032787	monocarboxylic acid metabolic process	6	1
GO:0034440	lipid oxidation	5	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044242	cellular lipid catabolic process	4	1
GO:0044248	cellular catabolic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0044282	small molecule catabolic process	3	1
GO:0046395	carboxylic acid catabolic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:0072329	monocarboxylic acid catabolic process	6	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016853	isomerase activity	2	10
GO:0004300	enoyl-CoA hydratase activity	5	1
GO:0016829	lyase activity	2	2
GO:0016835	carbon-oxygen lyase activity	3	2
GO:0016836	hydro-lyase activity	4	2
GO:0004490	methylglutaconyl-CoA hydratase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	232	238	PF00089	0.169
CLV_NRD_NRD_1	107	109	PF00675	0.292
CLV_NRD_NRD_1	124	126	PF00675	0.272
CLV_NRD_NRD_1	208	210	PF00675	0.277
CLV_NRD_NRD_1	47	49	PF00675	0.344
CLV_PCSK_FUR_1	122	126	PF00082	0.193
CLV_PCSK_KEX2_1	124	126	PF00082	0.333
CLV_PCSK_KEX2_1	208	210	PF00082	0.277
DEG_Nend_UBRbox_1	1	4	PF02207	0.522
DOC_ANK_TNKS_1	158	165	PF00023	0.393
DOC_ANK_TNKS_1	47	54	PF00023	0.337
DOC_CYCLIN_RxL_1	191	201	PF00134	0.288
DOC_MAPK_gen_1	106	113	PF00069	0.265
DOC_MAPK_gen_1	208	215	PF00069	0.253
DOC_MAPK_gen_1	235	244	PF00069	0.301
DOC_MAPK_gen_1	257	265	PF00069	0.404
DOC_MAPK_gen_1	45	54	PF00069	0.448
DOC_MAPK_MEF2A_6	208	215	PF00069	0.253
DOC_MAPK_MEF2A_6	48	56	PF00069	0.437
DOC_MAPK_NFAT4_5	208	216	PF00069	0.193
DOC_MAPK_RevD_3	196	209	PF00069	0.253
DOC_USP7_MATH_1	16	20	PF00917	0.437
DOC_USP7_MATH_1	221	225	PF00917	0.393
DOC_USP7_MATH_1	6	10	PF00917	0.431
DOC_WW_Pin1_4	288	293	PF00397	0.326
LIG_14-3-3_CanoR_1	122	128	PF00244	0.314
LIG_BRCT_BRCA1_1	115	119	PF00533	0.284
LIG_FHA_2	124	130	PF00498	0.280
LIG_FHA_2	256	262	PF00498	0.403
LIG_LIR_Gen_1	126	135	PF02991	0.268
LIG_LIR_Gen_1	268	275	PF02991	0.325
LIG_LIR_Nem_3	126	130	PF02991	0.268
LIG_LIR_Nem_3	19	23	PF02991	0.482
LIG_LIR_Nem_3	268	273	PF02991	0.325
LIG_RPA_C_Fungi	112	124	PF08784	0.284
LIG_SH2_NCK_1	32	36	PF00017	0.361
LIG_SH2_STAP1	270	274	PF00017	0.265
LIG_SH3_3	164	170	PF00018	0.400
LIG_SH3_3	181	187	PF00018	0.426
LIG_SUMO_SIM_anti_2	171	178	PF11976	0.196
LIG_SUMO_SIM_anti_2	36	42	PF11976	0.434
MOD_CDK_SPxxK_3	288	295	PF00069	0.302
MOD_CK2_1	109	115	PF00069	0.298
MOD_CK2_1	221	227	PF00069	0.416
MOD_CK2_1	255	261	PF00069	0.344
MOD_GlcNHglycan	205	208	PF01048	0.397
MOD_GlcNHglycan	223	226	PF01048	0.393
MOD_GlcNHglycan	72	75	PF01048	0.543
MOD_GlcNHglycan	79	82	PF01048	0.532
MOD_GlcNHglycan	8	11	PF01048	0.610
MOD_GlcNHglycan	92	95	PF01048	0.147
MOD_GSK3_1	109	116	PF00069	0.305
MOD_GSK3_1	70	77	PF00069	0.521
MOD_NEK2_1	123	128	PF00069	0.276
MOD_NEK2_1	190	195	PF00069	0.253
MOD_NEK2_1	234	239	PF00069	0.326
MOD_NEK2_1	89	94	PF00069	0.314
MOD_NEK2_2	16	21	PF00069	0.336
MOD_NEK2_2	180	185	PF00069	0.393
MOD_PIKK_1	33	39	PF00454	0.446
MOD_PK_1	109	115	PF00069	0.344
MOD_PKA_2	123	129	PF00069	0.294
MOD_PKA_2	234	240	PF00069	0.326
MOD_Plk_1	109	115	PF00069	0.360
MOD_ProDKin_1	288	294	PF00069	0.326
MOD_SUMO_rev_2	104	111	PF00179	0.344
TRG_DiLeu_BaEn_2	114	120	PF01217	0.344
TRG_ENDOCYTIC_2	270	273	PF00928	0.265
TRG_ER_diArg_1	122	125	PF00400	0.193

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Z0	Leptomonas seymouri	32%	100%
A0A0N1HVP1	Leptomonas seymouri	29%	95%
A0A0N1PBS2	Leptomonas seymouri	27%	99%
A0A0N1PCQ9	Leptomonas seymouri	79%	100%
A0A0S4IPV6	Bodo saltans	36%	100%
A0A0S4JWH0	Bodo saltans	50%	100%
A0A1X0NJ83	Trypanosomatidae	57%	100%
A0A1X0P9A2	Trypanosomatidae	37%	100%
A0A3Q8IE71	Leishmania donovani	25%	100%
A0A3Q8IIZ5	Leishmania donovani	37%	100%
A0A3Q8IV04	Leishmania donovani	100%	100%
A0A3R7KI60	Trypanosoma rangeli	55%	100%
A0A3R7N7B2	Trypanosoma rangeli	35%	100%
A0A3S7WUX8	Leishmania donovani	29%	100%
A0A422NUW6	Trypanosoma rangeli	28%	100%
A0PJR5	Danio rerio	25%	100%
A0R4Q3	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)	30%	100%
A4HH09	Leishmania braziliensis	25%	100%
A4HHN0	Leishmania braziliensis	38%	100%
A4HM74	Leishmania braziliensis	88%	100%
A4HXT3	Leishmania infantum	29%	100%
A4I438	Leishmania infantum	24%	100%
A4I4U5	Leishmania infantum	37%	100%
A4I738	Leishmania infantum	28%	85%
A4YI89	Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)	38%	100%
A8ALR7	Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)	35%	100%
A9JS71	Xenopus laevis	31%	100%
A9MR28	Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)	35%	100%
A9MYJ5	Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)	36%	100%
B1IRE0	Escherichia coli (strain ATCC 8739 / DSM 1576 / NBRC 3972 / NCIMB 8545 / WDCM 00012 / Crooks)	36%	100%
B1LFW9	Escherichia coli (strain SMS-3-5 / SECEC)	36%	100%
B4EY26	Proteus mirabilis (strain HI4320)	37%	100%
B4T6J5	Salmonella newport (strain SL254)	36%	100%
B4TIG9	Salmonella heidelberg (strain SL476)	36%	100%
B4TWR3	Salmonella schwarzengrund (strain CVM19633)	36%	100%
B5BL54	Salmonella paratyphi A (strain AKU_12601)	36%	100%
B5F749	Salmonella agona (strain SL483)	36%	100%
B5FHG4	Salmonella dublin (strain CT_02021853)	36%	100%
B5R1Q9	Salmonella enteritidis PT4 (strain P125109)	36%	100%
B5RGA4	Salmonella gallinarum (strain 287/91 / NCTC 13346)	36%	100%
C0Q4L2	Salmonella paratyphi C (strain RKS4594)	36%	100%
C9ZKS4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	95%
C9ZLJ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
D0A2C1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9ADK3	Leishmania major	24%	100%
E9AE93	Leishmania major	36%	100%
E9AEL3	Leishmania major	96%	100%
E9ALJ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9ARJ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9B5S4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
F1LU71	Rattus norvegicus	39%	94%
F4JML5	Arabidopsis thaliana	44%	99%
F9XMX6	Zymoseptoria tritici (strain CBS 115943 / IPO323)	40%	97%
G4V4T7	Amycolatopsis orientalis	31%	100%
O07137	Mycobacterium leprae (strain TN)	33%	100%
O34893	Bacillus subtilis (strain 168)	42%	100%
O35459	Mus musculus	26%	91%
O53561	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	33%	100%
O69762	Pseudomonas fluorescens	25%	100%
O87873	Thauera aromatica	26%	100%
P0ABU0	Escherichia coli (strain K12)	26%	100%
P0ABU1	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	26%	100%
P14604	Rattus norvegicus	33%	100%
P23966	Bacillus subtilis (strain 168)	25%	100%
P24162	Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003)	26%	100%
P30084	Homo sapiens	31%	100%
P31551	Escherichia coli (strain K12)	36%	100%
P34559	Caenorhabditis elegans	38%	100%
P44960	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	26%	100%
P52045	Escherichia coli (strain K12)	26%	100%
P52046	Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)	39%	100%
P53526	Mycobacterium leprae (strain TN)	27%	100%
P59395	Shigella flexneri	36%	100%
P64015	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	26%	100%
P64017	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	34%	100%
P76082	Escherichia coli (strain K12)	36%	100%
P77467	Escherichia coli (strain K12)	30%	100%
P94549	Bacillus subtilis (strain 168)	34%	100%
P9WNN6	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	29%	100%
P9WNN7	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	29%	100%
P9WNN8	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	34%	100%
P9WNN9	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	34%	100%
P9WNP0	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	26%	100%
P9WNP1	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	26%	100%
Q0AVM1	Syntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen)	35%	100%
Q0TLV3	Escherichia coli O6:K15:H31 (strain 536 / UPEC)	36%	100%
Q13011	Homo sapiens	31%	91%
Q13825	Homo sapiens	40%	88%
Q1ZXF1	Dictyostelium discoideum	32%	100%
Q28C91	Xenopus tropicalis	30%	99%
Q2HJD5	Bos taurus	25%	97%
Q2TBT3	Bos taurus	41%	100%
Q3MIE0	Rattus norvegicus	26%	99%
Q3TLP5	Mus musculus	41%	100%
Q49WG8	Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41)	24%	100%
Q4L549	Staphylococcus haemolyticus (strain JCSC1435)	27%	100%
Q4PEN0	Ustilago maydis (strain 521 / FGSC 9021)	43%	100%
Q4WF54	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	29%	100%
Q50130	Mycobacterium leprae (strain TN)	27%	100%
Q52995	Rhizobium meliloti (strain 1021)	36%	100%
Q54HG7	Dictyostelium discoideum	42%	98%
Q57TJ1	Salmonella choleraesuis (strain SC-B67)	36%	100%
Q589W8	Alternaria alternata	26%	100%
Q58DM8	Bos taurus	34%	100%
Q5HH38	Staphylococcus aureus (strain COL)	26%	100%
Q5HQC3	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	25%	100%
Q5HZQ8	Xenopus laevis	30%	99%
Q5PIL1	Salmonella paratyphi A (strain ATCC 9150 / SARB42)	36%	100%
Q5R4W0	Pongo abelii	26%	99%
Q5R646	Pongo abelii	31%	100%
Q5RFG0	Pongo abelii	31%	91%
Q62651	Rattus norvegicus	26%	91%
Q6AYG5	Rattus norvegicus	26%	99%
Q6GAG7	Staphylococcus aureus (strain MSSA476)	26%	100%
Q6GI37	Staphylococcus aureus (strain MRSA252)	26%	100%
Q6NL24	Arabidopsis thaliana	28%	100%
Q78JN3	Mus musculus	27%	94%
Q7A6A9	Staphylococcus aureus (strain N315)	26%	100%
Q7CQ56	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	26%	100%
Q7U004	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	29%	100%
Q869N6	Dictyostelium discoideum	32%	99%
Q86YB7	Homo sapiens	42%	100%
Q8BH95	Mus musculus	32%	100%
Q8CPQ4	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	25%	100%
Q8DR19	Streptococcus pneumoniae (strain ATCC BAA-255 / R6)	25%	100%
Q8DSN0	Streptococcus mutans serotype c (strain ATCC 700610 / UA159)	27%	100%
Q8FLA6	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	36%	100%
Q8GB17	Proteus sp. (strain LE138)	37%	100%
Q8GYN9	Arabidopsis thaliana	26%	88%
Q8NXA0	Staphylococcus aureus (strain MW2)	26%	100%
Q8XA35	Escherichia coli O157:H7	36%	100%
Q8Z9L5	Salmonella typhi	36%	100%
Q8ZRX5	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	36%	100%
Q96DC8	Homo sapiens	26%	98%
Q96VB3	Alternaria alternata	26%	100%
Q99V48	Staphylococcus aureus (strain Mu50 / ATCC 700699)	26%	100%
Q9CLV5	Pasteurella multocida (strain Pm70)	27%	100%
Q9D7J9	Mus musculus	26%	99%
Q9D9V3	Mus musculus	26%	92%
Q9FHR8	Arabidopsis thaliana	25%	100%
Q9JLZ3	Mus musculus	40%	95%
Q9NTX5	Homo sapiens	26%	97%
Q9P4U7	Alternaria alternata	27%	100%
Q9P4U9	Alternaria alternata	26%	100%
Q9TM10	Cyanidium caldarium	27%	100%
Q9WUR2	Mus musculus	27%	76%
V5BNA5	Trypanosoma cruzi	55%	100%
V5DTT7	Trypanosoma cruzi	33%	100%