Rab-GAP TBC domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

E9AHT9_LEIIN

TriTrypDb:

LINF_340040400

Length:

727

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AHT9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHT9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	261	265	PF00656	0.474
CLV_C14_Caspase3-7	504	508	PF00656	0.663
CLV_C14_Caspase3-7	576	580	PF00656	0.550
CLV_NRD_NRD_1	162	164	PF00675	0.610
CLV_NRD_NRD_1	200	202	PF00675	0.667
CLV_NRD_NRD_1	436	438	PF00675	0.744
CLV_NRD_NRD_1	543	545	PF00675	0.672
CLV_NRD_NRD_1	563	565	PF00675	0.492
CLV_NRD_NRD_1	573	575	PF00675	0.543
CLV_NRD_NRD_1	645	647	PF00675	0.731
CLV_PCSK_KEX2_1	162	164	PF00082	0.706
CLV_PCSK_KEX2_1	182	184	PF00082	0.305
CLV_PCSK_KEX2_1	35	37	PF00082	0.780
CLV_PCSK_KEX2_1	436	438	PF00082	0.744
CLV_PCSK_KEX2_1	457	459	PF00082	0.715
CLV_PCSK_KEX2_1	468	470	PF00082	0.595
CLV_PCSK_KEX2_1	543	545	PF00082	0.738
CLV_PCSK_KEX2_1	563	565	PF00082	0.492
CLV_PCSK_KEX2_1	573	575	PF00082	0.543
CLV_PCSK_KEX2_1	644	646	PF00082	0.693
CLV_PCSK_PC1ET2_1	182	184	PF00082	0.497
CLV_PCSK_PC1ET2_1	35	37	PF00082	0.768
CLV_PCSK_PC1ET2_1	457	459	PF00082	0.558
CLV_PCSK_PC1ET2_1	468	470	PF00082	0.524
CLV_PCSK_SKI1_1	102	106	PF00082	0.552
CLV_PCSK_SKI1_1	182	186	PF00082	0.510
CLV_PCSK_SKI1_1	320	324	PF00082	0.709
CLV_PCSK_SKI1_1	437	441	PF00082	0.748
CLV_PCSK_SKI1_1	458	462	PF00082	0.566
CLV_PCSK_SKI1_1	563	567	PF00082	0.468
CLV_PCSK_SKI1_1	63	67	PF00082	0.613
CLV_PCSK_SKI1_1	673	677	PF00082	0.533
DEG_Nend_UBRbox_3	1	3	PF02207	0.619
DOC_CDC14_PxL_1	331	339	PF14671	0.456
DOC_CKS1_1	559	564	PF01111	0.644
DOC_CKS1_1	76	81	PF01111	0.615
DOC_CYCLIN_RxL_1	561	569	PF00134	0.627
DOC_CYCLIN_yCln2_LP_2	66	69	PF00134	0.671
DOC_MAPK_gen_1	457	463	PF00069	0.707
DOC_MAPK_gen_1	596	606	PF00069	0.556
DOC_MAPK_gen_1	644	653	PF00069	0.504
DOC_MAPK_gen_1	98	107	PF00069	0.529
DOC_MAPK_MEF2A_6	610	618	PF00069	0.731
DOC_MAPK_MEF2A_6	646	655	PF00069	0.497
DOC_PP1_RVXF_1	562	569	PF00149	0.558
DOC_PP1_RVXF_1	581	587	PF00149	0.586
DOC_PP2B_LxvP_1	274	277	PF13499	0.420
DOC_PP2B_LxvP_1	478	481	PF13499	0.689
DOC_PP2B_LxvP_1	66	69	PF13499	0.671
DOC_PP4_FxxP_1	65	68	PF00568	0.679
DOC_USP7_MATH_1	203	207	PF00917	0.720
DOC_USP7_MATH_1	27	31	PF00917	0.684
DOC_USP7_MATH_1	383	387	PF00917	0.646
DOC_USP7_MATH_1	390	394	PF00917	0.700
DOC_USP7_MATH_1	420	424	PF00917	0.695
DOC_USP7_MATH_1	46	50	PF00917	0.705
DOC_USP7_MATH_1	495	499	PF00917	0.687
DOC_WW_Pin1_4	114	119	PF00397	0.713
DOC_WW_Pin1_4	168	173	PF00397	0.648
DOC_WW_Pin1_4	41	46	PF00397	0.660
DOC_WW_Pin1_4	481	486	PF00397	0.643
DOC_WW_Pin1_4	502	507	PF00397	0.480
DOC_WW_Pin1_4	521	526	PF00397	0.660
DOC_WW_Pin1_4	558	563	PF00397	0.646
DOC_WW_Pin1_4	605	610	PF00397	0.762
DOC_WW_Pin1_4	75	80	PF00397	0.623
LIG_14-3-3_CanoR_1	108	118	PF00244	0.664
LIG_14-3-3_CanoR_1	20	24	PF00244	0.713
LIG_14-3-3_CanoR_1	376	382	PF00244	0.758
LIG_14-3-3_CanoR_1	543	551	PF00244	0.703
LIG_14-3-3_CanoR_1	644	650	PF00244	0.618
LIG_14-3-3_CterR_2	723	727	PF00244	0.485
LIG_Actin_WH2_2	169	184	PF00022	0.529
LIG_Actin_WH2_2	5	22	PF00022	0.699
LIG_BIR_III_2	264	268	PF00653	0.618
LIG_BRCT_BRCA1_1	496	500	PF00533	0.558
LIG_BRCT_BRCA1_1	688	692	PF00533	0.606
LIG_BRCT_BRCA1_2	688	694	PF00533	0.606
LIG_Clathr_ClatBox_1	81	85	PF01394	0.653
LIG_deltaCOP1_diTrp_1	219	227	PF00928	0.476
LIG_FHA_1	183	189	PF00498	0.574
LIG_FHA_1	219	225	PF00498	0.588
LIG_FHA_1	35	41	PF00498	0.622
LIG_FHA_1	50	56	PF00498	0.627
LIG_FHA_1	589	595	PF00498	0.539
LIG_FHA_1	634	640	PF00498	0.780
LIG_FHA_1	646	652	PF00498	0.525
LIG_FHA_1	69	75	PF00498	0.783
LIG_FHA_1	76	82	PF00498	0.509
LIG_FHA_1	9	15	PF00498	0.597
LIG_FHA_2	259	265	PF00498	0.583
LIG_FHA_2	537	543	PF00498	0.678
LIG_LIR_Apic_2	353	359	PF02991	0.597
LIG_LIR_Apic_2	380	385	PF02991	0.704
LIG_LIR_Gen_1	125	134	PF02991	0.606
LIG_LIR_Gen_1	147	154	PF02991	0.535
LIG_LIR_Gen_1	328	337	PF02991	0.493
LIG_LIR_Gen_1	456	467	PF02991	0.597
LIG_LIR_Gen_1	497	506	PF02991	0.514
LIG_LIR_Gen_1	647	657	PF02991	0.686
LIG_LIR_Gen_1	689	699	PF02991	0.601
LIG_LIR_Nem_3	125	131	PF02991	0.611
LIG_LIR_Nem_3	147	151	PF02991	0.553
LIG_LIR_Nem_3	328	334	PF02991	0.525
LIG_LIR_Nem_3	456	462	PF02991	0.709
LIG_LIR_Nem_3	497	503	PF02991	0.528
LIG_LIR_Nem_3	647	652	PF02991	0.561
LIG_LIR_Nem_3	689	695	PF02991	0.669
LIG_MAD2	599	607	PF02301	0.563
LIG_Pex14_1	496	500	PF04695	0.558
LIG_SH2_CRK	331	335	PF00017	0.480
LIG_SH2_CRK	459	463	PF00017	0.701
LIG_SH2_STAP1	254	258	PF00017	0.571
LIG_SH2_STAP1	459	463	PF00017	0.701
LIG_SH2_STAT3	640	643	PF00017	0.776
LIG_SH3_2	24	29	PF14604	0.593
LIG_SH3_3	21	27	PF00018	0.591
LIG_SH3_3	287	293	PF00018	0.507
LIG_SH3_3	591	597	PF00018	0.704
LIG_SH3_3	601	607	PF00018	0.521
LIG_SH3_3	73	79	PF00018	0.627
LIG_SUMO_SIM_anti_2	171	177	PF11976	0.541
LIG_SUMO_SIM_par_1	103	109	PF11976	0.540
LIG_SUMO_SIM_par_1	80	85	PF11976	0.644
LIG_TRFH_1	65	69	PF08558	0.613
MOD_CDK_SPK_2	558	563	PF00069	0.576
MOD_CDK_SPK_2	605	610	PF00069	0.746
MOD_CDK_SPxK_1	558	564	PF00069	0.643
MOD_CK1_1	109	115	PF00069	0.713
MOD_CK1_1	116	122	PF00069	0.691
MOD_CK1_1	171	177	PF00069	0.556
MOD_CK1_1	206	212	PF00069	0.572
MOD_CK1_1	361	367	PF00069	0.686
MOD_CK1_1	386	392	PF00069	0.793
MOD_CK1_1	44	50	PF00069	0.753
MOD_CK1_1	502	508	PF00069	0.510
MOD_CK1_1	546	552	PF00069	0.713
MOD_CK1_1	621	627	PF00069	0.580
MOD_CK1_1	668	674	PF00069	0.646
MOD_CK1_1	70	76	PF00069	0.714
MOD_CK2_1	413	419	PF00069	0.741
MOD_CK2_1	536	542	PF00069	0.666
MOD_CK2_1	77	83	PF00069	0.747
MOD_Cter_Amidation	160	163	PF01082	0.591
MOD_Cter_Amidation	33	36	PF01082	0.694
MOD_GlcNHglycan	108	111	PF01048	0.590
MOD_GlcNHglycan	113	116	PF01048	0.619
MOD_GlcNHglycan	140	144	PF01048	0.681
MOD_GlcNHglycan	312	315	PF01048	0.671
MOD_GlcNHglycan	331	334	PF01048	0.621
MOD_GlcNHglycan	350	353	PF01048	0.681
MOD_GlcNHglycan	371	374	PF01048	0.657
MOD_GlcNHglycan	388	391	PF01048	0.621
MOD_GlcNHglycan	402	405	PF01048	0.769
MOD_GlcNHglycan	415	418	PF01048	0.560
MOD_GlcNHglycan	465	468	PF01048	0.543
MOD_GlcNHglycan	470	473	PF01048	0.601
MOD_GlcNHglycan	48	51	PF01048	0.704
MOD_GlcNHglycan	497	500	PF01048	0.748
MOD_GlcNHglycan	546	549	PF01048	0.557
MOD_GlcNHglycan	620	623	PF01048	0.566
MOD_GlcNHglycan	631	634	PF01048	0.630
MOD_GSK3_1	109	116	PF00069	0.600
MOD_GSK3_1	149	156	PF00069	0.615
MOD_GSK3_1	202	209	PF00069	0.653
MOD_GSK3_1	243	250	PF00069	0.514
MOD_GSK3_1	254	261	PF00069	0.438
MOD_GSK3_1	357	364	PF00069	0.700
MOD_GSK3_1	386	393	PF00069	0.735
MOD_GSK3_1	40	47	PF00069	0.741
MOD_GSK3_1	470	477	PF00069	0.670
MOD_GSK3_1	49	56	PF00069	0.629
MOD_GSK3_1	490	497	PF00069	0.529
MOD_GSK3_1	517	524	PF00069	0.685
MOD_GSK3_1	573	580	PF00069	0.614
MOD_GSK3_1	629	636	PF00069	0.681
MOD_GSK3_1	661	668	PF00069	0.621
MOD_N-GLC_1	386	391	PF02516	0.696
MOD_NEK2_1	106	111	PF00069	0.542
MOD_NEK2_1	19	24	PF00069	0.657
MOD_NEK2_1	410	415	PF00069	0.679
MOD_NEK2_1	618	623	PF00069	0.567
MOD_NEK2_1	675	680	PF00069	0.513
MOD_NEK2_1	8	13	PF00069	0.591
MOD_NEK2_2	243	248	PF00069	0.479
MOD_NEK2_2	254	259	PF00069	0.351
MOD_NEK2_2	420	425	PF00069	0.698
MOD_PIKK_1	203	209	PF00454	0.647
MOD_PIKK_1	27	33	PF00454	0.699
MOD_PIKK_1	346	352	PF00454	0.649
MOD_PIKK_1	665	671	PF00454	0.508
MOD_PK_1	162	168	PF00069	0.532
MOD_PKA_1	162	168	PF00069	0.619
MOD_PKA_1	182	188	PF00069	0.276
MOD_PKA_1	468	474	PF00069	0.609
MOD_PKA_1	543	549	PF00069	0.650
MOD_PKA_1	573	579	PF00069	0.542
MOD_PKA_1	644	650	PF00069	0.720
MOD_PKA_2	138	144	PF00069	0.661
MOD_PKA_2	149	155	PF00069	0.562
MOD_PKA_2	162	168	PF00069	0.506
MOD_PKA_2	182	188	PF00069	0.434
MOD_PKA_2	19	25	PF00069	0.785
MOD_PKA_2	247	253	PF00069	0.498
MOD_PKA_2	468	474	PF00069	0.662
MOD_PKA_2	543	549	PF00069	0.650
MOD_PKA_2	573	579	PF00069	0.550
MOD_PKA_2	644	650	PF00069	0.723
MOD_PKB_1	137	145	PF00069	0.660
MOD_Plk_1	139	145	PF00069	0.659
MOD_Plk_1	218	224	PF00069	0.617
MOD_Plk_1	302	308	PF00069	0.641
MOD_Plk_1	490	496	PF00069	0.677
MOD_Plk_2-3	77	83	PF00069	0.555
MOD_Plk_4	171	177	PF00069	0.597
MOD_Plk_4	302	308	PF00069	0.641
MOD_Plk_4	364	370	PF00069	0.607
MOD_Plk_4	377	383	PF00069	0.738
MOD_Plk_4	546	552	PF00069	0.736
MOD_Plk_4	655	661	PF00069	0.535
MOD_Plk_4	77	83	PF00069	0.712
MOD_ProDKin_1	114	120	PF00069	0.714
MOD_ProDKin_1	168	174	PF00069	0.637
MOD_ProDKin_1	41	47	PF00069	0.659
MOD_ProDKin_1	481	487	PF00069	0.641
MOD_ProDKin_1	502	508	PF00069	0.474
MOD_ProDKin_1	521	527	PF00069	0.662
MOD_ProDKin_1	558	564	PF00069	0.643
MOD_ProDKin_1	605	611	PF00069	0.756
MOD_ProDKin_1	75	81	PF00069	0.617
MOD_SUMO_rev_2	324	332	PF00179	0.530
TRG_DiLeu_BaEn_1	77	82	PF01217	0.566
TRG_DiLeu_BaEn_2	426	432	PF01217	0.663
TRG_DiLeu_BaLyEn_6	611	616	PF01217	0.600
TRG_ENDOCYTIC_2	331	334	PF00928	0.499
TRG_ENDOCYTIC_2	459	462	PF00928	0.695
TRG_ER_diArg_1	562	564	PF00400	0.510
TRG_ER_diArg_1	572	574	PF00400	0.521
TRG_ER_diArg_1	644	646	PF00400	0.569
TRG_NES_CRM1_1	5	18	PF08389	0.637
TRG_Pf-PMV_PEXEL_1	563	567	PF00026	0.557
TRG_Pf-PMV_PEXEL_1	637	642	PF00026	0.710
TRG_Pf-PMV_PEXEL_1	708	712	PF00026	0.656

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Q0	Leptomonas seymouri	34%	89%
A0A3S7X8B8	Leishmania donovani	100%	100%
A4HB53	Leishmania braziliensis	62%	99%
E9B5C3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q2L0	Leishmania major	87%	100%