Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

E9AHT6_LEIIN

TriTrypDb:

LINF_340028400

Length:

615

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AHT6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHT6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	149	153	PF00656	0.558
CLV_C14_Caspase3-7	216	220	PF00656	0.549
CLV_C14_Caspase3-7	326	330	PF00656	0.629
CLV_C14_Caspase3-7	489	493	PF00656	0.407
CLV_NRD_NRD_1	34	36	PF00675	0.706
CLV_NRD_NRD_1	424	426	PF00675	0.442
CLV_NRD_NRD_1	562	564	PF00675	0.472
CLV_PCSK_KEX2_1	36	38	PF00082	0.690
CLV_PCSK_KEX2_1	424	426	PF00082	0.404
CLV_PCSK_KEX2_1	566	568	PF00082	0.496
CLV_PCSK_PC1ET2_1	36	38	PF00082	0.690
CLV_PCSK_PC1ET2_1	566	568	PF00082	0.437
CLV_PCSK_SKI1_1	107	111	PF00082	0.436
CLV_PCSK_SKI1_1	317	321	PF00082	0.475
CLV_PCSK_SKI1_1	349	353	PF00082	0.463
CLV_PCSK_SKI1_1	396	400	PF00082	0.501
CLV_PCSK_SKI1_1	407	411	PF00082	0.436
CLV_PCSK_SKI1_1	424	428	PF00082	0.229
CLV_PCSK_SKI1_1	519	523	PF00082	0.361
CLV_PCSK_SKI1_1	65	69	PF00082	0.503
DEG_APCC_DBOX_1	518	526	PF00400	0.426
DEG_APCC_DBOX_1	601	609	PF00400	0.467
DEG_Nend_UBRbox_3	1	3	PF02207	0.679
DEG_SPOP_SBC_1	28	32	PF00917	0.619
DEG_SPOP_SBC_1	306	310	PF00917	0.660
DOC_CDC14_PxL_1	257	265	PF14671	0.452
DOC_CKS1_1	56	61	PF01111	0.545
DOC_CYCLIN_RxL_1	314	323	PF00134	0.485
DOC_CYCLIN_RxL_1	346	353	PF00134	0.400
DOC_MAPK_gen_1	424	432	PF00069	0.328
DOC_MAPK_MEF2A_6	182	190	PF00069	0.417
DOC_MAPK_MEF2A_6	425	434	PF00069	0.324
DOC_MIT_MIM_1	178	186	PF04212	0.433
DOC_PP1_RVXF_1	422	429	PF00149	0.402
DOC_PP4_FxxP_1	21	24	PF00568	0.546
DOC_PP4_FxxP_1	537	540	PF00568	0.339
DOC_USP7_MATH_1	103	107	PF00917	0.650
DOC_USP7_MATH_1	144	148	PF00917	0.585
DOC_USP7_MATH_1	22	26	PF00917	0.670
DOC_USP7_MATH_1	28	32	PF00917	0.733
DOC_USP7_MATH_1	306	310	PF00917	0.643
DOC_USP7_MATH_1	342	346	PF00917	0.349
DOC_USP7_MATH_1	347	351	PF00917	0.340
DOC_USP7_MATH_1	382	386	PF00917	0.641
DOC_USP7_MATH_1	445	449	PF00917	0.482
DOC_USP7_MATH_1	562	566	PF00917	0.474
DOC_USP7_MATH_1	569	573	PF00917	0.474
DOC_WW_Pin1_4	142	147	PF00397	0.588
DOC_WW_Pin1_4	320	325	PF00397	0.600
DOC_WW_Pin1_4	366	371	PF00397	0.521
DOC_WW_Pin1_4	37	42	PF00397	0.687
DOC_WW_Pin1_4	47	52	PF00397	0.638
DOC_WW_Pin1_4	55	60	PF00397	0.581
DOC_WW_Pin1_4	555	560	PF00397	0.381
DOC_WW_Pin1_4	91	96	PF00397	0.566
LIG_14-3-3_CanoR_1	122	128	PF00244	0.432
LIG_14-3-3_CanoR_1	173	178	PF00244	0.452
LIG_14-3-3_CanoR_1	467	471	PF00244	0.443
LIG_14-3-3_CanoR_1	79	84	PF00244	0.390
LIG_14-3-3_CanoR_1	87	95	PF00244	0.463
LIG_Actin_WH2_2	127	144	PF00022	0.406
LIG_Actin_WH2_2	510	525	PF00022	0.415
LIG_BIR_III_2	204	208	PF00653	0.445
LIG_BIR_III_4	499	503	PF00653	0.271
LIG_BIR_III_4	532	536	PF00653	0.388
LIG_BRCT_BRCA1_1	473	477	PF00533	0.417
LIG_BRCT_BRCA1_1	557	561	PF00533	0.360
LIG_Clathr_ClatBox_1	544	548	PF01394	0.460
LIG_deltaCOP1_diTrp_1	280	286	PF00928	0.436
LIG_FHA_1	169	175	PF00498	0.528
LIG_FHA_1	282	288	PF00498	0.382
LIG_FHA_1	341	347	PF00498	0.342
LIG_FHA_1	56	62	PF00498	0.596
LIG_FHA_2	147	153	PF00498	0.582
LIG_FHA_2	173	179	PF00498	0.472
LIG_LIR_Gen_1	178	188	PF02991	0.332
LIG_LIR_Gen_1	243	252	PF02991	0.510
LIG_LIR_Gen_1	358	368	PF02991	0.526
LIG_LIR_Gen_1	548	557	PF02991	0.433
LIG_LIR_Gen_1	591	601	PF02991	0.363
LIG_LIR_Nem_3	178	183	PF02991	0.341
LIG_LIR_Nem_3	243	247	PF02991	0.474
LIG_LIR_Nem_3	358	363	PF02991	0.478
LIG_LIR_Nem_3	403	409	PF02991	0.489
LIG_LIR_Nem_3	548	552	PF02991	0.427
LIG_LIR_Nem_3	568	573	PF02991	0.231
LIG_LIR_Nem_3	591	597	PF02991	0.375
LIG_Pex14_1	282	286	PF04695	0.438
LIG_Pex14_1	414	418	PF04695	0.442
LIG_Pex14_1	473	477	PF04695	0.342
LIG_PTB_Apo_2	543	550	PF02174	0.456
LIG_Rb_pABgroove_1	346	354	PF01858	0.398
LIG_SH2_CRK	418	422	PF00017	0.391
LIG_SH2_CRK	570	574	PF00017	0.464
LIG_SH2_SRC	435	438	PF00017	0.273
LIG_SH2_STAP1	437	441	PF00017	0.446
LIG_SH2_STAT3	74	77	PF00017	0.531
LIG_SH2_STAT5	140	143	PF00017	0.615
LIG_SH2_STAT5	180	183	PF00017	0.329
LIG_SH2_STAT5	265	268	PF00017	0.331
LIG_SH3_2	6	11	PF14604	0.619
LIG_SH3_3	252	258	PF00018	0.443
LIG_SH3_3	3	9	PF00018	0.816
LIG_SH3_3	391	397	PF00018	0.559
LIG_SH3_3	53	59	PF00018	0.624
LIG_TYR_ITIM	552	557	PF00017	0.266
LIG_WRC_WIRS_1	241	246	PF05994	0.450
MOD_CDK_SPxxK_3	366	373	PF00069	0.511
MOD_CK1_1	27	33	PF00069	0.632
MOD_CK1_1	309	315	PF00069	0.518
MOD_CK1_1	323	329	PF00069	0.429
MOD_CK1_1	369	375	PF00069	0.500
MOD_CK1_1	385	391	PF00069	0.556
MOD_CK1_1	86	92	PF00069	0.543
MOD_CK2_1	172	178	PF00069	0.489
MOD_CK2_1	310	316	PF00069	0.443
MOD_CK2_1	562	568	PF00069	0.461
MOD_CMANNOS	463	466	PF00535	0.453
MOD_DYRK1A_RPxSP_1	142	146	PF00069	0.516
MOD_DYRK1A_RPxSP_1	37	41	PF00069	0.722
MOD_GlcNHglycan	135	139	PF01048	0.538
MOD_GlcNHglycan	26	29	PF01048	0.757
MOD_GlcNHglycan	325	328	PF01048	0.498
MOD_GlcNHglycan	387	390	PF01048	0.699
MOD_GlcNHglycan	473	476	PF01048	0.476
MOD_GlcNHglycan	485	489	PF01048	0.565
MOD_GlcNHglycan	511	514	PF01048	0.446
MOD_GSK3_1	142	149	PF00069	0.542
MOD_GSK3_1	168	175	PF00069	0.484
MOD_GSK3_1	22	29	PF00069	0.672
MOD_GSK3_1	305	312	PF00069	0.668
MOD_GSK3_1	31	38	PF00069	0.691
MOD_GSK3_1	383	390	PF00069	0.617
MOD_GSK3_1	441	448	PF00069	0.495
MOD_GSK3_1	47	54	PF00069	0.750
MOD_GSK3_1	569	576	PF00069	0.448
MOD_GSK3_1	588	595	PF00069	0.384
MOD_GSK3_1	79	86	PF00069	0.500
MOD_NEK2_1	134	139	PF00069	0.406
MOD_NEK2_1	232	237	PF00069	0.348
MOD_NEK2_1	240	245	PF00069	0.361
MOD_NEK2_1	315	320	PF00069	0.566
MOD_NEK2_1	491	496	PF00069	0.631
MOD_NEK2_1	83	88	PF00069	0.562
MOD_NEK2_2	347	352	PF00069	0.468
MOD_PIKK_1	281	287	PF00454	0.488
MOD_PIKK_1	330	336	PF00454	0.460
MOD_PKA_1	35	41	PF00069	0.756
MOD_PKA_2	172	178	PF00069	0.484
MOD_PKA_2	466	472	PF00069	0.461
MOD_PKA_2	562	568	PF00069	0.450
MOD_PKA_2	86	92	PF00069	0.481
MOD_Plk_1	218	224	PF00069	0.388
MOD_Plk_1	232	238	PF00069	0.268
MOD_Plk_1	245	251	PF00069	0.430
MOD_Plk_1	315	321	PF00069	0.474
MOD_Plk_1	491	497	PF00069	0.472
MOD_Plk_1	547	553	PF00069	0.373
MOD_Plk_2-3	400	406	PF00069	0.422
MOD_Plk_4	123	129	PF00069	0.321
MOD_Plk_4	232	238	PF00069	0.409
MOD_Plk_4	272	278	PF00069	0.410
MOD_Plk_4	310	316	PF00069	0.456
MOD_Plk_4	79	85	PF00069	0.609
MOD_ProDKin_1	142	148	PF00069	0.595
MOD_ProDKin_1	320	326	PF00069	0.607
MOD_ProDKin_1	366	372	PF00069	0.518
MOD_ProDKin_1	37	43	PF00069	0.686
MOD_ProDKin_1	47	53	PF00069	0.635
MOD_ProDKin_1	55	61	PF00069	0.571
MOD_ProDKin_1	555	561	PF00069	0.379
MOD_ProDKin_1	91	97	PF00069	0.563
MOD_SUMO_rev_2	400	409	PF00179	0.423
MOD_SUMO_rev_2	8	18	PF00179	0.785
TRG_DiLeu_BaLyEn_6	56	61	PF01217	0.495
TRG_DiLeu_LyEn_5	14	19	PF01217	0.497
TRG_ENDOCYTIC_2	180	183	PF00928	0.329
TRG_ENDOCYTIC_2	418	421	PF00928	0.378
TRG_ENDOCYTIC_2	554	557	PF00928	0.387
TRG_ENDOCYTIC_2	570	573	PF00928	0.463
TRG_ER_diArg_1	423	425	PF00400	0.370
TRG_NES_CRM1_1	123	135	PF08389	0.394
TRG_NES_CRM1_1	178	192	PF08389	0.323
TRG_NLS_MonoExtC_3	34	39	PF00514	0.687
TRG_NLS_MonoExtC_3	562	567	PF00514	0.407
TRG_NLS_MonoExtN_4	35	40	PF00514	0.695
TRG_Pf-PMV_PEXEL_1	268	272	PF00026	0.486
TRG_Pf-PMV_PEXEL_1	349	353	PF00026	0.404
TRG_Pf-PMV_PEXEL_1	424	429	PF00026	0.440

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PGH4	Leptomonas seymouri	47%	95%
A0A1X0P9M0	Trypanosomatidae	24%	100%
A0A3Q8IFL4	Leishmania donovani	99%	100%
A0A422P0J6	Trypanosoma rangeli	25%	100%
A4HAU2	Leishmania braziliensis	75%	100%
C9ZMM5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9B516	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q2X0	Leishmania major	89%	100%
V5BKG8	Trypanosoma cruzi	25%	100%