Putative amastin-like surface protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

amastin-like protein

Species:

Leishmania infantum

UniProt:

E9AHT2_LEIIN

TriTrypDb:

LINF_340015900

Length:

211

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Part of the greater amastin family, a cell adhesion protein critical for intracellular parasitism. Localization: Cell surface (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 9
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 12, no: 203
NetGPI	no	yes: 0, no: 215

Show entries

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	192
GO:0110165	cellular anatomical entity	1	192

Previous1Next

Expansion

Sequence features

E9AHT2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHT2

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016485	protein processing	5	1
GO:0016540	protein autoprocessing	6	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1

Previous1 2Next

Show entries

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004175	endopeptidase activity	4	1
GO:0004197	cysteine-type endopeptidase activity	5	1
GO:0008233	peptidase activity	3	1
GO:0008234	cysteine-type peptidase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0140096	catalytic activity, acting on a protein	2	1

Previous1Next

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	72	74	PF00675	0.506
CLV_PCSK_KEX2_1	72	74	PF00082	0.517
DEG_MDM2_SWIB_1	157	165	PF02201	0.335
DEG_Nend_UBRbox_3	1	3	PF02207	0.506
DOC_CKS1_1	23	28	PF01111	0.375
DOC_MAPK_gen_1	75	84	PF00069	0.286
DOC_MAPK_MEF2A_6	108	116	PF00069	0.589
DOC_PP2B_LxvP_1	171	174	PF13499	0.618
DOC_WW_Pin1_4	22	27	PF00397	0.385
LIG_BRCT_BRCA1_1	5	9	PF00533	0.527

Previous1 2 3 4 5 6 7Next

Homologs

Show entries


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2C4	Leptomonas seymouri	32%	100%
A0A0N0P547	Leptomonas seymouri	42%	100%
A0A0N0P6P9	Leptomonas seymouri	22%	92%
A0A0N0P993	Leptomonas seymouri	27%	94%
A0A0N1HWY5	Leptomonas seymouri	32%	100%
A0A0N1PAD5	Leptomonas seymouri	25%	84%
A0A0N1PDH0	Leptomonas seymouri	38%	100%
A0A0S4J784	Bodo saltans	24%	95%
A0A1X0NQ58	Trypanosomatidae	35%	100%
A0A1X0NUH1	Trypanosomatidae	33%	93%

Previous1 2 3 4 5…22Next