NmrA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

E9AHS6_LEIIN

TriTrypDb:

LINF_340013300

Length:

469

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

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Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0016020	membrane	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

E9AHS6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHS6

Function

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Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	1
GO:0006120	mitochondrial electron transport, NADH to ubiquinone	7	1
GO:0008152	metabolic process	1	1
GO:0009060	aerobic respiration	6	1
GO:0009987	cellular process	1	1
GO:0010257	NADH dehydrogenase complex assembly	6	1
GO:0015980	energy derivation by oxidation of organic compounds	4	1
GO:0016043	cellular component organization	3	1
GO:0019646	aerobic electron transport chain	6	1
GO:0022607	cellular component assembly	4	1

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Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0051082	unfolded protein binding	3	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	452	456	PF00656	0.558
CLV_NRD_NRD_1	112	114	PF00675	0.388
CLV_NRD_NRD_1	171	173	PF00675	0.572
CLV_NRD_NRD_1	267	269	PF00675	0.539
CLV_NRD_NRD_1	280	282	PF00675	0.463
CLV_NRD_NRD_1	306	308	PF00675	0.461
CLV_PCSK_KEX2_1	112	114	PF00082	0.391
CLV_PCSK_KEX2_1	171	173	PF00082	0.524
CLV_PCSK_KEX2_1	267	269	PF00082	0.543
CLV_PCSK_KEX2_1	280	282	PF00082	0.463

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZN2	Leptomonas seymouri	67%	98%
A0A0S4IVY0	Bodo saltans	24%	100%
A0A1X0P965	Trypanosomatidae	33%	100%
A0A3Q8IIA0	Leishmania donovani	99%	100%
A4HAI5	Leishmania braziliensis	80%	100%
E9B4P6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q3D0	Leishmania major	94%	100%
V5BEX5	Trypanosoma cruzi	34%	100%

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