NmrA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

E9AHS6_LEIIN

TriTrypDb:

LINF_340013300

Length:

469

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

E9AHS6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHS6

Function

Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	1
GO:0006120	mitochondrial electron transport, NADH to ubiquinone	7	1
GO:0008152	metabolic process	1	1
GO:0009060	aerobic respiration	6	1
GO:0009987	cellular process	1	1
GO:0010257	NADH dehydrogenase complex assembly	6	1
GO:0015980	energy derivation by oxidation of organic compounds	4	1
GO:0016043	cellular component organization	3	1
GO:0019646	aerobic electron transport chain	6	1
GO:0022607	cellular component assembly	4	1
GO:0022900	electron transport chain	4	1
GO:0022904	respiratory electron transport chain	5	1
GO:0032981	mitochondrial respiratory chain complex I assembly	7	1
GO:0033108	mitochondrial respiratory chain complex assembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0044237	cellular metabolic process	2	1
GO:0045333	cellular respiration	5	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0051082	unfolded protein binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	452	456	PF00656	0.558
CLV_NRD_NRD_1	112	114	PF00675	0.388
CLV_NRD_NRD_1	171	173	PF00675	0.572
CLV_NRD_NRD_1	267	269	PF00675	0.539
CLV_NRD_NRD_1	280	282	PF00675	0.463
CLV_NRD_NRD_1	306	308	PF00675	0.461
CLV_PCSK_KEX2_1	112	114	PF00082	0.391
CLV_PCSK_KEX2_1	171	173	PF00082	0.524
CLV_PCSK_KEX2_1	267	269	PF00082	0.543
CLV_PCSK_KEX2_1	280	282	PF00082	0.463
CLV_PCSK_KEX2_1	306	308	PF00082	0.463
CLV_PCSK_SKI1_1	128	132	PF00082	0.435
CLV_PCSK_SKI1_1	175	179	PF00082	0.399
CLV_PCSK_SKI1_1	203	207	PF00082	0.372
CLV_PCSK_SKI1_1	306	310	PF00082	0.453
DEG_APCC_DBOX_1	202	210	PF00400	0.414
DEG_APCC_DBOX_1	376	384	PF00400	0.384
DOC_CKS1_1	7	12	PF01111	0.549
DOC_CYCLIN_RxL_1	122	136	PF00134	0.478
DOC_MAPK_gen_1	112	119	PF00069	0.338
DOC_MAPK_gen_1	126	134	PF00069	0.362
DOC_MAPK_gen_1	371	378	PF00069	0.461
DOC_MAPK_gen_1	399	409	PF00069	0.572
DOC_MAPK_MEF2A_6	112	119	PF00069	0.338
DOC_MAPK_MEF2A_6	126	134	PF00069	0.362
DOC_PP1_RVXF_1	64	71	PF00149	0.540
DOC_PP2B_LxvP_1	130	133	PF13499	0.473
DOC_USP7_MATH_1	196	200	PF00917	0.660
DOC_USP7_MATH_1	335	339	PF00917	0.439
DOC_WW_Pin1_4	255	260	PF00397	0.633
DOC_WW_Pin1_4	287	292	PF00397	0.425
DOC_WW_Pin1_4	297	302	PF00397	0.475
DOC_WW_Pin1_4	329	334	PF00397	0.454
DOC_WW_Pin1_4	371	376	PF00397	0.499
DOC_WW_Pin1_4	6	11	PF00397	0.698
LIG_14-3-3_CanoR_1	112	118	PF00244	0.460
LIG_14-3-3_CanoR_1	143	148	PF00244	0.578
LIG_14-3-3_CanoR_1	183	189	PF00244	0.545
LIG_14-3-3_CanoR_1	224	229	PF00244	0.359
LIG_14-3-3_CanoR_1	249	259	PF00244	0.670
LIG_14-3-3_CanoR_1	306	312	PF00244	0.512
LIG_14-3-3_CanoR_1	336	340	PF00244	0.428
LIG_14-3-3_CanoR_1	358	368	PF00244	0.624
LIG_14-3-3_CanoR_1	377	381	PF00244	0.274
LIG_14-3-3_CanoR_1	382	389	PF00244	0.431
LIG_Actin_WH2_2	434	450	PF00022	0.583
LIG_Actin_WH2_2	99	114	PF00022	0.429
LIG_APCC_ABBA_1	30	35	PF00400	0.533
LIG_BIR_II_1	1	5	PF00653	0.679
LIG_BRCT_BRCA1_1	226	230	PF00533	0.372
LIG_CSL_BTD_1	256	259	PF09270	0.501
LIG_deltaCOP1_diTrp_1	352	357	PF00928	0.540
LIG_eIF4E_1	303	309	PF01652	0.532
LIG_FHA_1	160	166	PF00498	0.477
LIG_FHA_1	214	220	PF00498	0.531
LIG_FHA_1	90	96	PF00498	0.408
LIG_FHA_2	41	47	PF00498	0.503
LIG_FHA_2	7	13	PF00498	0.545
LIG_GBD_Chelix_1	228	236	PF00786	0.443
LIG_LIR_Apic_2	253	259	PF02991	0.532
LIG_LIR_Gen_1	283	294	PF02991	0.459
LIG_LIR_Gen_1	359	369	PF02991	0.424
LIG_LIR_Gen_1	461	469	PF02991	0.596
LIG_LIR_Nem_3	129	134	PF02991	0.512
LIG_LIR_Nem_3	146	152	PF02991	0.664
LIG_LIR_Nem_3	283	289	PF02991	0.453
LIG_LIR_Nem_3	359	364	PF02991	0.412
LIG_LIR_Nem_3	385	391	PF02991	0.621
LIG_LIR_Nem_3	461	466	PF02991	0.587
LIG_LYPXL_yS_3	57	60	PF13949	0.589
LIG_Pex14_1	357	361	PF04695	0.424
LIG_SH2_CRK	149	153	PF00017	0.571
LIG_SH2_CRK	305	309	PF00017	0.473
LIG_SH2_STAT5	110	113	PF00017	0.472
LIG_SH2_STAT5	231	234	PF00017	0.404
LIG_SH2_STAT5	29	32	PF00017	0.530
LIG_SH2_STAT5	315	318	PF00017	0.390
LIG_SH2_STAT5	69	72	PF00017	0.524
LIG_SH3_3	185	191	PF00018	0.532
LIG_SH3_3	383	389	PF00018	0.578
LIG_SH3_3	4	10	PF00018	0.704
LIG_SUMO_SIM_anti_2	116	121	PF11976	0.339
LIG_SUMO_SIM_anti_2	91	97	PF11976	0.370
LIG_TRAF2_1	235	238	PF00917	0.533
LIG_WRC_WIRS_1	388	393	PF05994	0.537
MOD_CDC14_SPxK_1	374	377	PF00782	0.506
MOD_CDK_SPxK_1	371	377	PF00069	0.488
MOD_CDK_SPxxK_3	329	336	PF00069	0.462
MOD_CK1_1	192	198	PF00069	0.689
MOD_CK1_1	258	264	PF00069	0.681
MOD_CK1_1	297	303	PF00069	0.465
MOD_CK1_1	359	365	PF00069	0.492
MOD_CK2_1	167	173	PF00069	0.514
MOD_CK2_1	387	393	PF00069	0.527
MOD_CK2_1	40	46	PF00069	0.490
MOD_CK2_1	432	438	PF00069	0.480
MOD_CMANNOS	353	356	PF00535	0.558
MOD_Cter_Amidation	265	268	PF01082	0.515
MOD_DYRK1A_RPxSP_1	6	10	PF00069	0.569
MOD_GlcNHglycan	152	155	PF01048	0.590
MOD_GlcNHglycan	191	194	PF01048	0.633
MOD_GlcNHglycan	237	242	PF01048	0.490
MOD_GlcNHglycan	252	255	PF01048	0.672
MOD_GlcNHglycan	264	267	PF01048	0.471
MOD_GlcNHglycan	329	332	PF01048	0.522
MOD_GSK3_1	192	199	PF00069	0.698
MOD_GSK3_1	258	265	PF00069	0.626
MOD_GSK3_1	325	332	PF00069	0.491
MOD_GSK3_1	432	439	PF00069	0.520
MOD_N-GLC_1	196	201	PF02516	0.522
MOD_NEK2_1	159	164	PF00069	0.635
MOD_NEK2_1	182	187	PF00069	0.447
MOD_NEK2_1	219	224	PF00069	0.454
MOD_NEK2_1	250	255	PF00069	0.652
MOD_NEK2_1	327	332	PF00069	0.533
MOD_NEK2_1	369	374	PF00069	0.542
MOD_NEK2_1	426	431	PF00069	0.439
MOD_NEK2_1	432	437	PF00069	0.517
MOD_NEK2_2	28	33	PF00069	0.585
MOD_PIKK_1	213	219	PF00454	0.388
MOD_PIKK_1	325	331	PF00454	0.565
MOD_PK_1	113	119	PF00069	0.387
MOD_PK_1	224	230	PF00069	0.389
MOD_PKA_2	167	173	PF00069	0.484
MOD_PKA_2	182	188	PF00069	0.362
MOD_PKA_2	248	254	PF00069	0.686
MOD_PKA_2	335	341	PF00069	0.456
MOD_PKA_2	359	365	PF00069	0.662
MOD_PKA_2	376	382	PF00069	0.279
MOD_Plk_1	219	225	PF00069	0.461
MOD_Plk_1	322	328	PF00069	0.527
MOD_Plk_4	115	121	PF00069	0.359
MOD_Plk_4	126	132	PF00069	0.352
MOD_Plk_4	224	230	PF00069	0.329
MOD_Plk_4	258	264	PF00069	0.638
MOD_Plk_4	322	328	PF00069	0.497
MOD_Plk_4	40	46	PF00069	0.588
MOD_Plk_4	432	438	PF00069	0.590
MOD_Plk_4	91	97	PF00069	0.387
MOD_ProDKin_1	255	261	PF00069	0.623
MOD_ProDKin_1	287	293	PF00069	0.427
MOD_ProDKin_1	297	303	PF00069	0.465
MOD_ProDKin_1	329	335	PF00069	0.453
MOD_ProDKin_1	371	377	PF00069	0.488
MOD_ProDKin_1	6	12	PF00069	0.692
TRG_DiLeu_BaEn_1	91	96	PF01217	0.461
TRG_DiLeu_BaLyEn_6	304	309	PF01217	0.442
TRG_DiLeu_BaLyEn_6	417	422	PF01217	0.522
TRG_DiLeu_BaLyEn_6	63	68	PF01217	0.542
TRG_ENDOCYTIC_2	149	152	PF00928	0.636
TRG_ENDOCYTIC_2	29	32	PF00928	0.492
TRG_ENDOCYTIC_2	305	308	PF00928	0.467
TRG_ENDOCYTIC_2	57	60	PF00928	0.589
TRG_ER_diArg_1	111	113	PF00400	0.387
TRG_ER_diArg_1	17	20	PF00400	0.524
TRG_ER_diArg_1	267	269	PF00400	0.543
TRG_ER_diArg_1	280	282	PF00400	0.455
TRG_ER_diArg_1	305	307	PF00400	0.469
TRG_ER_diArg_1	357	360	PF00400	0.553
TRG_NES_CRM1_1	442	455	PF08389	0.456

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZN2	Leptomonas seymouri	67%	98%
A0A0S4IVY0	Bodo saltans	24%	100%
A0A1X0P965	Trypanosomatidae	33%	100%
A0A3Q8IIA0	Leishmania donovani	99%	100%
A4HAI5	Leishmania braziliensis	80%	100%
E9B4P6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q3D0	Leishmania major	94%	100%
V5BEX5	Trypanosoma cruzi	34%	100%