LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
CBF/Mak21 family - putative
Species:
Leishmania infantum
UniProt:
E9AHS4_LEIIN
TriTrypDb:
LINF_340013100
Length:
468

Annotations

Annotations by Jardim et al.

Ribosomal Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 11
GO:0043226 organelle 2 12
GO:0043227 membrane-bounded organelle 3 11
GO:0043229 intracellular organelle 3 12
GO:0043231 intracellular membrane-bounded organelle 4 11
GO:0110165 cellular anatomical entity 1 12
GO:0005730 nucleolus 5 1
GO:0030684 preribosome 3 1
GO:0030689 Noc complex 3 1
GO:0030692 Noc4p-Nop14p complex 4 1
GO:0032040 small-subunit processome 4 1
GO:0032991 protein-containing complex 1 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0140513 nuclear protein-containing complex 2 1
GO:1990904 ribonucleoprotein complex 2 1

Expansion

Sequence features

E9AHS4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHS4

Function

Biological processes
Term Name Level Count
GO:0009987 cellular process 1 12
GO:0022613 ribonucleoprotein complex biogenesis 4 12
GO:0042254 ribosome biogenesis 5 12
GO:0044085 cellular component biogenesis 3 12
GO:0071840 cellular component organization or biogenesis 2 12
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 146 150 PF00656 0.370
CLV_NRD_NRD_1 159 161 PF00675 0.499
CLV_NRD_NRD_1 321 323 PF00675 0.221
CLV_NRD_NRD_1 97 99 PF00675 0.402
CLV_PCSK_KEX2_1 159 161 PF00082 0.499
CLV_PCSK_KEX2_1 300 302 PF00082 0.277
CLV_PCSK_KEX2_1 99 101 PF00082 0.365
CLV_PCSK_PC1ET2_1 300 302 PF00082 0.277
CLV_PCSK_PC1ET2_1 99 101 PF00082 0.365
CLV_PCSK_PC7_1 95 101 PF00082 0.344
CLV_PCSK_SKI1_1 179 183 PF00082 0.541
CLV_PCSK_SKI1_1 322 326 PF00082 0.253
CLV_PCSK_SKI1_1 434 438 PF00082 0.312
CLV_PCSK_SKI1_1 62 66 PF00082 0.273
DEG_APCC_DBOX_1 273 281 PF00400 0.410
DEG_COP1_1 284 293 PF00400 0.435
DEG_MDM2_SWIB_1 182 190 PF02201 0.296
DEG_Nend_UBRbox_2 1 3 PF02207 0.533
DEG_SPOP_SBC_1 390 394 PF00917 0.430
DEG_SPOP_SBC_1 415 419 PF00917 0.561
DOC_CDC14_PxL_1 308 316 PF14671 0.421
DOC_CKS1_1 263 268 PF01111 0.421
DOC_CYCLIN_RxL_1 273 287 PF00134 0.420
DOC_CYCLIN_yCln2_LP_2 214 220 PF00134 0.250
DOC_MAPK_DCC_7 403 413 PF00069 0.421
DOC_MAPK_gen_1 300 307 PF00069 0.435
DOC_MAPK_MEF2A_6 403 411 PF00069 0.421
DOC_PP1_RVXF_1 130 136 PF00149 0.313
DOC_PP2B_LxvP_1 288 291 PF13499 0.421
DOC_PP2B_LxvP_1 307 310 PF13499 0.512
DOC_PP4_FxxP_1 316 319 PF00568 0.410
DOC_USP7_MATH_1 303 307 PF00917 0.512
DOC_USP7_MATH_1 390 394 PF00917 0.443
DOC_USP7_MATH_1 415 419 PF00917 0.519
DOC_USP7_MATH_1 443 447 PF00917 0.547
DOC_WW_Pin1_4 104 109 PF00397 0.369
DOC_WW_Pin1_4 262 267 PF00397 0.421
DOC_WW_Pin1_4 27 32 PF00397 0.562
DOC_WW_Pin1_4 36 41 PF00397 0.492
DOC_WW_Pin1_4 421 426 PF00397 0.565
DOC_WW_Pin1_4 47 52 PF00397 0.422
DOC_WW_Pin1_4 72 77 PF00397 0.596
LIG_AP2alpha_2 377 379 PF02296 0.421
LIG_APCC_ABBA_1 170 175 PF00400 0.239
LIG_BRCT_BRCA1_1 316 320 PF00533 0.500
LIG_Clathr_ClatBox_1 244 248 PF01394 0.262
LIG_eIF4E_1 275 281 PF01652 0.410
LIG_FHA_1 120 126 PF00498 0.408
LIG_FHA_1 165 171 PF00498 0.306
LIG_FHA_1 213 219 PF00498 0.253
LIG_FHA_1 263 269 PF00498 0.430
LIG_FHA_1 367 373 PF00498 0.476
LIG_FHA_1 386 392 PF00498 0.318
LIG_FHA_1 435 441 PF00498 0.510
LIG_FHA_1 461 467 PF00498 0.639
LIG_FHA_2 15 21 PF00498 0.464
LIG_FHA_2 392 398 PF00498 0.435
LIG_FHA_2 417 423 PF00498 0.542
LIG_FHA_2 47 53 PF00498 0.616
LIG_FHA_2 73 79 PF00498 0.555
LIG_LIR_Apic_2 313 319 PF02991 0.477
LIG_LIR_Apic_2 451 457 PF02991 0.556
LIG_LIR_Gen_1 114 125 PF02991 0.375
LIG_LIR_Gen_1 17 25 PF02991 0.462
LIG_LIR_Gen_1 183 190 PF02991 0.317
LIG_LIR_Gen_1 258 269 PF02991 0.477
LIG_LIR_Nem_3 114 120 PF02991 0.375
LIG_LIR_Nem_3 17 21 PF02991 0.450
LIG_LIR_Nem_3 252 256 PF02991 0.413
LIG_LIR_Nem_3 258 264 PF02991 0.406
LIG_LIR_Nem_3 276 281 PF02991 0.337
LIG_LIR_Nem_3 313 318 PF02991 0.477
LIG_LIR_Nem_3 402 408 PF02991 0.498
LIG_LIR_Nem_3 429 435 PF02991 0.503
LIG_LIR_Nem_3 79 85 PF02991 0.444
LIG_NRBOX 259 265 PF00104 0.419
LIG_NRBOX 276 282 PF00104 0.376
LIG_PDZ_Class_2 463 468 PF00595 0.585
LIG_Pex14_1 82 86 PF04695 0.457
LIG_Pex14_2 182 186 PF04695 0.229
LIG_Pex14_2 316 320 PF04695 0.410
LIG_SH2_CRK 261 265 PF00017 0.419
LIG_SH2_CRK 432 436 PF00017 0.497
LIG_SH2_CRK 86 90 PF00017 0.485
LIG_SH2_NCK_1 454 458 PF00017 0.608
LIG_SH2_STAP1 257 261 PF00017 0.477
LIG_SH2_STAP1 428 432 PF00017 0.514
LIG_SH2_STAT3 256 259 PF00017 0.450
LIG_SH2_STAT5 151 154 PF00017 0.292
LIG_SH2_STAT5 223 226 PF00017 0.269
LIG_SH2_STAT5 293 296 PF00017 0.411
LIG_SH2_STAT5 315 318 PF00017 0.433
LIG_SH3_3 206 212 PF00018 0.257
LIG_SH3_3 39 45 PF00018 0.638
LIG_SH3_3 404 410 PF00018 0.450
LIG_SUMO_SIM_par_1 167 175 PF11976 0.258
LIG_SUMO_SIM_par_1 215 222 PF11976 0.255
LIG_SUMO_SIM_par_1 232 238 PF11976 0.299
LIG_SUMO_SIM_par_1 243 248 PF11976 0.197
LIG_SUMO_SIM_par_1 279 284 PF11976 0.421
LIG_SUMO_SIM_par_1 409 414 PF11976 0.431
LIG_TYR_ITIM 84 89 PF00017 0.485
LIG_WRC_WIRS_1 181 186 PF05994 0.188
MOD_CDK_SPK_2 52 57 PF00069 0.596
MOD_CDK_SPxK_1 421 427 PF00069 0.585
MOD_CDK_SPxxK_3 36 43 PF00069 0.547
MOD_CK1_1 154 160 PF00069 0.368
MOD_CK1_1 168 174 PF00069 0.174
MOD_CK1_1 235 241 PF00069 0.361
MOD_CK1_1 262 268 PF00069 0.459
MOD_CK1_1 284 290 PF00069 0.421
MOD_CK1_1 3 9 PF00069 0.475
MOD_CK1_1 414 420 PF00069 0.538
MOD_CK2_1 335 341 PF00069 0.421
MOD_CK2_1 391 397 PF00069 0.431
MOD_CK2_1 415 421 PF00069 0.512
MOD_CK2_1 47 53 PF00069 0.525
MOD_CK2_1 72 78 PF00069 0.585
MOD_GlcNHglycan 229 232 PF01048 0.281
MOD_GlcNHglycan 359 362 PF01048 0.300
MOD_GlcNHglycan 413 416 PF01048 0.289
MOD_GlcNHglycan 6 9 PF01048 0.357
MOD_GSK3_1 104 111 PF00069 0.554
MOD_GSK3_1 145 152 PF00069 0.288
MOD_GSK3_1 164 171 PF00069 0.303
MOD_GSK3_1 222 229 PF00069 0.302
MOD_GSK3_1 310 317 PF00069 0.521
MOD_GSK3_1 385 392 PF00069 0.457
MOD_GSK3_1 411 418 PF00069 0.487
MOD_GSK3_1 434 441 PF00069 0.501
MOD_GSK3_1 460 467 PF00069 0.621
MOD_N-GLC_1 154 159 PF02516 0.573
MOD_N-GLC_1 164 169 PF02516 0.567
MOD_NEK2_1 119 124 PF00069 0.432
MOD_NEK2_1 164 169 PF00069 0.296
MOD_NEK2_1 281 286 PF00069 0.432
MOD_NEK2_1 314 319 PF00069 0.512
MOD_NEK2_1 366 371 PF00069 0.450
MOD_NEK2_1 385 390 PF00069 0.408
MOD_NEK2_1 391 396 PF00069 0.421
MOD_NEK2_1 411 416 PF00069 0.393
MOD_PK_1 205 211 PF00069 0.346
MOD_PKA_1 98 104 PF00069 0.640
MOD_PKA_2 336 342 PF00069 0.410
MOD_PKA_2 366 372 PF00069 0.447
MOD_Plk_1 164 170 PF00069 0.411
MOD_Plk_1 281 287 PF00069 0.435
MOD_Plk_1 396 402 PF00069 0.469
MOD_Plk_1 428 434 PF00069 0.507
MOD_Plk_2-3 455 461 PF00069 0.613
MOD_Plk_4 108 114 PF00069 0.423
MOD_Plk_4 165 171 PF00069 0.302
MOD_Plk_4 205 211 PF00069 0.346
MOD_Plk_4 259 265 PF00069 0.410
MOD_Plk_4 289 295 PF00069 0.421
MOD_Plk_4 303 309 PF00069 0.318
MOD_Plk_4 310 316 PF00069 0.463
MOD_Plk_4 391 397 PF00069 0.421
MOD_ProDKin_1 104 110 PF00069 0.369
MOD_ProDKin_1 262 268 PF00069 0.421
MOD_ProDKin_1 27 33 PF00069 0.559
MOD_ProDKin_1 36 42 PF00069 0.499
MOD_ProDKin_1 421 427 PF00069 0.567
MOD_ProDKin_1 47 53 PF00069 0.422
MOD_ProDKin_1 72 78 PF00069 0.588
MOD_SUMO_for_1 138 141 PF00179 0.336
MOD_SUMO_for_1 143 146 PF00179 0.350
MOD_SUMO_rev_2 20 30 PF00179 0.554
MOD_SUMO_rev_2 417 425 PF00179 0.621
TRG_DiLeu_BaEn_1 276 281 PF01217 0.477
TRG_DiLeu_LyEn_5 276 281 PF01217 0.512
TRG_ENDOCYTIC_2 18 21 PF00928 0.456
TRG_ENDOCYTIC_2 257 260 PF00928 0.410
TRG_ENDOCYTIC_2 261 264 PF00928 0.410
TRG_ENDOCYTIC_2 275 278 PF00928 0.410
TRG_ENDOCYTIC_2 315 318 PF00928 0.410
TRG_ENDOCYTIC_2 432 435 PF00928 0.494
TRG_ENDOCYTIC_2 86 89 PF00928 0.485
TRG_ER_diArg_1 272 275 PF00400 0.391
TRG_NES_CRM1_1 60 72 PF08389 0.524
TRG_NLS_MonoExtC_3 97 102 PF00514 0.556
TRG_NLS_MonoExtN_4 95 102 PF00514 0.551
TRG_Pf-PMV_PEXEL_1 123 127 PF00026 0.492

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HSH0 Leptomonas seymouri 81% 100%
A0A0S4JK57 Bodo saltans 48% 100%
A0A1X0P9H6 Trypanosomatidae 59% 100%
A0A3S7X7L0 Leishmania donovani 100% 100%
A0A422N8P2 Trypanosoma rangeli 59% 100%
A4HAI3 Leishmania braziliensis 91% 100%
C9ZN09 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 59% 100%
E9B4P4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
F4IMH3 Arabidopsis thaliana 30% 81%
Q4Q3D2 Leishmania major 96% 100%
Q5ZJC7 Gallus gallus 27% 92%
V5BAB5 Trypanosoma cruzi 61% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS