LeishMANIAdb
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ANK_REP_REGION domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
ANK_REP_REGION domain-containing protein
Gene product:
Ankyrin repeats (3 copies)/Ankyrin repeats (many copies)/Ankyrin repeat - putative
Species:
Leishmania infantum
UniProt:
E9AHS2_LEIIN
TriTrypDb:
LINF_340050600
Length:
399

Annotations

LeishMANIAdb annotations

An expanding group of Kinetoplastid proteins. Some members of this group have a hydrophobic C-terminal segment that might help membrane attachment

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0016020 membrane 2 4
GO:0110165 cellular anatomical entity 1 4

Expansion

Sequence features

E9AHS2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHS2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 294 296 PF00675 0.584
CLV_PCSK_KEX2_1 96 98 PF00082 0.537
CLV_PCSK_PC1ET2_1 96 98 PF00082 0.537
CLV_PCSK_SKI1_1 159 163 PF00082 0.528
CLV_PCSK_SKI1_1 25 29 PF00082 0.665
CLV_PCSK_SKI1_1 347 351 PF00082 0.631
DEG_Nend_UBRbox_2 1 3 PF02207 0.445
DEG_SPOP_SBC_1 264 268 PF00917 0.294
DOC_CKS1_1 109 114 PF01111 0.337
DOC_CYCLIN_yClb1_LxF_4 72 77 PF00134 0.427
DOC_MAPK_gen_1 375 384 PF00069 0.332
DOC_MAPK_MEF2A_6 126 135 PF00069 0.282
DOC_MAPK_MEF2A_6 52 60 PF00069 0.289
DOC_PP1_RVXF_1 247 253 PF00149 0.295
DOC_PP1_RVXF_1 72 78 PF00149 0.418
DOC_PP2B_LxvP_1 330 333 PF13499 0.450
DOC_USP7_MATH_1 265 269 PF00917 0.358
DOC_USP7_MATH_1 314 318 PF00917 0.518
DOC_USP7_MATH_1 44 48 PF00917 0.327
DOC_USP7_UBL2_3 336 340 PF12436 0.499
DOC_WW_Pin1_4 108 113 PF00397 0.328
DOC_WW_Pin1_4 141 146 PF00397 0.277
DOC_WW_Pin1_4 221 226 PF00397 0.424
DOC_WW_Pin1_4 312 317 PF00397 0.472
LIG_14-3-3_CanoR_1 119 128 PF00244 0.334
LIG_14-3-3_CanoR_1 299 305 PF00244 0.507
LIG_14-3-3_CanoR_1 308 316 PF00244 0.519
LIG_14-3-3_CanoR_1 74 82 PF00244 0.332
LIG_FHA_1 142 148 PF00498 0.287
LIG_FHA_1 224 230 PF00498 0.389
LIG_FHA_1 265 271 PF00498 0.355
LIG_FHA_1 378 384 PF00498 0.444
LIG_FHA_2 281 287 PF00498 0.426
LIG_LIR_Apic_2 194 198 PF02991 0.358
LIG_LIR_Gen_1 24 35 PF02991 0.420
LIG_LIR_Gen_1 256 265 PF02991 0.284
LIG_LIR_Nem_3 108 113 PF02991 0.262
LIG_LIR_Nem_3 24 30 PF02991 0.433
LIG_LIR_Nem_3 256 262 PF02991 0.312
LIG_NRP_CendR_1 397 399 PF00754 0.457
LIG_PTB_Apo_2 34 41 PF02174 0.389
LIG_PTB_Phospho_1 34 40 PF10480 0.391
LIG_SH2_CRK 82 86 PF00017 0.358
LIG_SH2_NCK_1 82 86 PF00017 0.358
LIG_SH2_STAP1 181 185 PF00017 0.356
LIG_SH2_STAP1 82 86 PF00017 0.358
LIG_SH2_STAT3 160 163 PF00017 0.337
LIG_SH2_STAT5 160 163 PF00017 0.337
LIG_SH2_STAT5 181 184 PF00017 0.296
LIG_SH2_STAT5 228 231 PF00017 0.360
LIG_SH2_STAT5 259 262 PF00017 0.322
LIG_SH2_STAT5 392 395 PF00017 0.395
LIG_SH3_3 231 237 PF00018 0.389
LIG_SH3_3 313 319 PF00018 0.554
LIG_SH3_3 320 326 PF00018 0.429
LIG_SH3_3 362 368 PF00018 0.488
LIG_SH3_4 336 343 PF00018 0.495
LIG_SUMO_SIM_anti_2 2 8 PF11976 0.425
LIG_SUMO_SIM_anti_2 203 208 PF11976 0.299
LIG_SUMO_SIM_anti_2 283 289 PF11976 0.296
LIG_SUMO_SIM_anti_2 380 386 PF11976 0.370
LIG_SUMO_SIM_par_1 380 386 PF11976 0.273
LIG_TRAF2_1 67 70 PF00917 0.383
LIG_UBA3_1 287 296 PF00899 0.393
MOD_CDK_SPxK_1 221 227 PF00069 0.428
MOD_CK2_1 11 17 PF00069 0.429
MOD_GlcNHglycan 121 124 PF01048 0.536
MOD_GlcNHglycan 13 16 PF01048 0.621
MOD_GSK3_1 137 144 PF00069 0.359
MOD_GSK3_1 314 321 PF00069 0.426
MOD_N-GLC_2 29 31 PF02516 0.610
MOD_NEK2_1 10 15 PF00069 0.410
MOD_NEK2_1 179 184 PF00069 0.311
MOD_NEK2_1 383 388 PF00069 0.335
MOD_NEK2_1 75 80 PF00069 0.370
MOD_PIKK_1 197 203 PF00454 0.369
MOD_PKA_1 295 301 PF00069 0.460
MOD_PKA_2 307 313 PF00069 0.566
MOD_Plk_1 23 29 PF00069 0.443
MOD_Plk_4 23 29 PF00069 0.433
MOD_Plk_4 258 264 PF00069 0.349
MOD_Plk_4 265 271 PF00069 0.338
MOD_Plk_4 280 286 PF00069 0.249
MOD_Plk_4 377 383 PF00069 0.335
MOD_ProDKin_1 108 114 PF00069 0.328
MOD_ProDKin_1 141 147 PF00069 0.277
MOD_ProDKin_1 221 227 PF00069 0.428
MOD_ProDKin_1 312 318 PF00069 0.467
MOD_SUMO_rev_2 17 27 PF00179 0.466
MOD_SUMO_rev_2 292 298 PF00179 0.412
TRG_DiLeu_BaEn_2 22 28 PF01217 0.414
TRG_ENDOCYTIC_2 259 262 PF00928 0.302
TRG_ENDOCYTIC_2 82 85 PF00928 0.364
TRG_ER_diArg_1 118 121 PF00400 0.337
TRG_Pf-PMV_PEXEL_1 126 130 PF00026 0.468
TRG_Pf-PMV_PEXEL_1 159 163 PF00026 0.528

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P716 Leptomonas seymouri 54% 100%
A0A0S4IPR4 Bodo saltans 39% 88%
A0A1X0PAB7 Trypanosomatidae 30% 100%
A0A3Q8IUY8 Leishmania donovani 99% 100%
E9B5M3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 100%
Q4Q2B3 Leishmania major 89% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS