Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

E9AHS1_LEIIN

TriTrypDb:

LINF_330037700

Length:

437

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 3, no: 1
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

E9AHS1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHS1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	327	331	PF00656	0.776
CLV_NRD_NRD_1	287	289	PF00675	0.500
CLV_NRD_NRD_1	372	374	PF00675	0.653
CLV_NRD_NRD_1	8	10	PF00675	0.762
CLV_PCSK_KEX2_1	196	198	PF00082	0.765
CLV_PCSK_KEX2_1	287	289	PF00082	0.500
CLV_PCSK_KEX2_1	6	8	PF00082	0.774
CLV_PCSK_PC1ET2_1	196	198	PF00082	0.765
CLV_PCSK_PC1ET2_1	6	8	PF00082	0.711
CLV_PCSK_SKI1_1	156	160	PF00082	0.727
CLV_PCSK_SKI1_1	268	272	PF00082	0.477
DEG_SCF_FBW7_1	380	387	PF00400	0.778
DEG_SPOP_SBC_1	147	151	PF00917	0.656
DEG_SPOP_SBC_1	160	164	PF00917	0.492
DEG_SPOP_SBC_1	423	427	PF00917	0.795
DOC_USP7_MATH_1	101	105	PF00917	0.628
DOC_USP7_MATH_1	122	126	PF00917	0.593
DOC_USP7_MATH_1	130	134	PF00917	0.516
DOC_USP7_MATH_1	147	151	PF00917	0.553
DOC_USP7_MATH_1	152	156	PF00917	0.526
DOC_USP7_MATH_1	160	164	PF00917	0.502
DOC_USP7_MATH_1	2	6	PF00917	0.630
DOC_USP7_MATH_1	296	300	PF00917	0.694
DOC_USP7_MATH_1	328	332	PF00917	0.789
DOC_USP7_MATH_1	365	369	PF00917	0.754
DOC_USP7_MATH_1	384	388	PF00917	0.823
DOC_USP7_MATH_1	424	428	PF00917	0.728
DOC_USP7_UBL2_3	366	370	PF12436	0.783
DOC_USP7_UBL2_3	69	73	PF12436	0.543
DOC_WW_Pin1_4	173	178	PF00397	0.625
DOC_WW_Pin1_4	189	194	PF00397	0.616
DOC_WW_Pin1_4	380	385	PF00397	0.829
DOC_WW_Pin1_4	393	398	PF00397	0.711
DOC_WW_Pin1_4	400	405	PF00397	0.638
LIG_14-3-3_CanoR_1	13	19	PF00244	0.679
LIG_14-3-3_CanoR_1	132	137	PF00244	0.495
LIG_14-3-3_CanoR_1	256	261	PF00244	0.774
LIG_BIR_II_1	1	5	PF00653	0.728
LIG_BIR_III_1	1	5	PF00653	0.728
LIG_BIR_III_3	1	5	PF00653	0.728
LIG_BRCT_BRCA1_1	132	136	PF00533	0.560
LIG_BRCT_BRCA1_1	330	334	PF00533	0.785
LIG_deltaCOP1_diTrp_1	432	437	PF00928	0.844
LIG_FHA_1	100	106	PF00498	0.513
LIG_FHA_1	204	210	PF00498	0.372
LIG_FHA_1	312	318	PF00498	0.775
LIG_FHA_1	356	362	PF00498	0.756
LIG_FHA_2	164	170	PF00498	0.527
LIG_FHA_2	82	88	PF00498	0.554
LIG_LIR_Gen_1	304	313	PF02991	0.711
LIG_LIR_Gen_1	329	340	PF02991	0.840
LIG_LIR_Nem_3	304	309	PF02991	0.690
LIG_Pex14_2	212	216	PF04695	0.433
LIG_SH2_CRK	257	261	PF00017	0.840
LIG_SH2_CRK	33	37	PF00017	0.527
LIG_SH2_CRK	68	72	PF00017	0.480
LIG_SH2_STAT3	290	293	PF00017	0.767
LIG_SH2_STAT5	257	260	PF00017	0.727
LIG_SH3_3	356	362	PF00018	0.796
LIG_TRAF2_1	39	42	PF00917	0.476
LIG_TRAF2_1	86	89	PF00917	0.562
LIG_UBA3_1	305	312	PF00899	0.823
MOD_CDK_SPxxK_3	189	196	PF00069	0.583
MOD_CDK_SPxxK_3	400	407	PF00069	0.793
MOD_CK1_1	113	119	PF00069	0.524
MOD_CK1_1	135	141	PF00069	0.531
MOD_CK1_1	151	157	PF00069	0.583
MOD_CK1_1	161	167	PF00069	0.512
MOD_CK1_1	176	182	PF00069	0.486
MOD_CK1_1	350	356	PF00069	0.837
MOD_CK1_1	368	374	PF00069	0.757
MOD_CK1_1	387	393	PF00069	0.793
MOD_CK1_1	99	105	PF00069	0.603
MOD_CK2_1	159	165	PF00069	0.618
MOD_CK2_1	389	395	PF00069	0.792
MOD_CK2_1	83	89	PF00069	0.617
MOD_GlcNHglycan	115	118	PF01048	0.796
MOD_GlcNHglycan	120	123	PF01048	0.739
MOD_GlcNHglycan	150	153	PF01048	0.760
MOD_GlcNHglycan	229	232	PF01048	0.596
MOD_GlcNHglycan	238	241	PF01048	0.515
MOD_GlcNHglycan	243	246	PF01048	0.490
MOD_GlcNHglycan	318	321	PF01048	0.660
MOD_GlcNHglycan	324	327	PF01048	0.579
MOD_GlcNHglycan	349	352	PF01048	0.646
MOD_GlcNHglycan	389	392	PF01048	0.596
MOD_GlcNHglycan	413	416	PF01048	0.590
MOD_GlcNHglycan	50	53	PF01048	0.722
MOD_GlcNHglycan	98	101	PF01048	0.738
MOD_GSK3_1	113	120	PF00069	0.606
MOD_GSK3_1	122	129	PF00069	0.534
MOD_GSK3_1	131	138	PF00069	0.427
MOD_GSK3_1	147	154	PF00069	0.623
MOD_GSK3_1	156	163	PF00069	0.545
MOD_GSK3_1	173	180	PF00069	0.654
MOD_GSK3_1	182	189	PF00069	0.507
MOD_GSK3_1	236	243	PF00069	0.744
MOD_GSK3_1	322	329	PF00069	0.780
MOD_GSK3_1	346	353	PF00069	0.856
MOD_GSK3_1	364	371	PF00069	0.739
MOD_GSK3_1	380	387	PF00069	0.841
MOD_GSK3_1	389	396	PF00069	0.756
MOD_GSK3_1	405	412	PF00069	0.673
MOD_GSK3_1	92	99	PF00069	0.516
MOD_LATS_1	254	260	PF00433	0.772
MOD_N-GLC_1	182	187	PF02516	0.807
MOD_NEK2_1	158	163	PF00069	0.551
MOD_NEK2_1	181	186	PF00069	0.588
MOD_NEK2_1	204	209	PF00069	0.300
MOD_NEK2_1	270	275	PF00069	0.746
MOD_NEK2_1	289	294	PF00069	0.611
MOD_NEK2_1	346	351	PF00069	0.848
MOD_NEK2_1	405	410	PF00069	0.826
MOD_NEK2_2	313	318	PF00069	0.712
MOD_NEK2_2	365	370	PF00069	0.715
MOD_PIKK_1	141	147	PF00454	0.585
MOD_PIKK_1	289	295	PF00454	0.634
MOD_PIKK_1	424	430	PF00454	0.794
MOD_PKA_2	131	137	PF00069	0.494
MOD_PKA_2	14	20	PF00069	0.701
MOD_PKA_2	152	158	PF00069	0.593
MOD_PKA_2	255	261	PF00069	0.760
MOD_PKA_2	406	412	PF00069	0.834
MOD_Plk_4	101	107	PF00069	0.531
MOD_Plk_4	14	20	PF00069	0.681
MOD_Plk_4	204	210	PF00069	0.335
MOD_ProDKin_1	173	179	PF00069	0.624
MOD_ProDKin_1	189	195	PF00069	0.616
MOD_ProDKin_1	380	386	PF00069	0.830
MOD_ProDKin_1	393	399	PF00069	0.711
MOD_ProDKin_1	400	406	PF00069	0.639
MOD_SUMO_rev_2	74	82	PF00179	0.482
TRG_ENDOCYTIC_2	257	260	PF00928	0.727
TRG_ENDOCYTIC_2	267	270	PF00928	0.695
TRG_ENDOCYTIC_2	68	71	PF00928	0.551
TRG_ER_diArg_1	286	288	PF00400	0.691
TRG_ER_diArg_1	7	9	PF00400	0.635
TRG_NLS_MonoCore_2	5	10	PF00514	0.623
TRG_NLS_MonoExtN_4	370	377	PF00514	0.717
TRG_NLS_MonoExtN_4	4	10	PF00514	0.623
TRG_Pf-PMV_PEXEL_1	44	48	PF00026	0.800

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IH37	Leishmania donovani	90%	93%
A4HLZ5	Leishmania braziliensis	41%	88%
E9AEH4	Leishmania major	77%	100%