LeishMANIAdb
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Putative UDP-N-acetylglucosamine pyrophosphorylase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative UDP-N-acetylglucosamine pyrophosphorylase
Gene product:
UDP-N-acetylglucosamine pyrophosphorylase - putative
Species:
Leishmania infantum
UniProt:
E9AHS0_LEIIN
TriTrypDb:
LINF_330034400
Length:
571

Annotations

Annotations by Jardim et al.

Glycosylation, UDP-N-acetylglucosamine pyrophosphorylase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 2
GO:0016020 membrane 2 1

Expansion

Sequence features

E9AHS0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHS0

Function

Biological processes
Term Name Level Count
GO:0006040 amino sugar metabolic process 4 1
GO:0006047 UDP-N-acetylglucosamine metabolic process 4 1
GO:0006048 UDP-N-acetylglucosamine biosynthetic process 5 1
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006793 phosphorus metabolic process 3 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009058 biosynthetic process 2 1
GO:0009225 nucleotide-sugar metabolic process 4 1
GO:0009226 nucleotide-sugar biosynthetic process 5 1
GO:0009987 cellular process 1 1
GO:0018130 heterocycle biosynthetic process 4 1
GO:0019438 aromatic compound biosynthetic process 4 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0034654 nucleobase-containing compound biosynthetic process 4 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044249 cellular biosynthetic process 3 1
GO:0044271 cellular nitrogen compound biosynthetic process 4 1
GO:0044281 small molecule metabolic process 2 1
GO:0046349 amino sugar biosynthetic process 5 1
GO:0046483 heterocycle metabolic process 3 1
GO:0055086 nucleobase-containing small molecule metabolic process 3 1
GO:0071704 organic substance metabolic process 2 1
GO:1901135 carbohydrate derivative metabolic process 3 1
GO:1901137 carbohydrate derivative biosynthetic process 4 1
GO:1901360 organic cyclic compound metabolic process 3 1
GO:1901362 organic cyclic compound biosynthetic process 4 1
GO:1901576 organic substance biosynthetic process 3 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 12
GO:0003977 UDP-N-acetylglucosamine diphosphorylase activity 6 8
GO:0016740 transferase activity 2 12
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 12
GO:0016779 nucleotidyltransferase activity 4 12
GO:0070569 uridylyltransferase activity 5 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_MEL_PAP_1 301 307 PF00089 0.250
CLV_NRD_NRD_1 160 162 PF00675 0.225
CLV_NRD_NRD_1 356 358 PF00675 0.348
CLV_NRD_NRD_1 401 403 PF00675 0.246
CLV_PCSK_KEX2_1 356 358 PF00082 0.287
CLV_PCSK_KEX2_1 98 100 PF00082 0.323
CLV_PCSK_PC1ET2_1 98 100 PF00082 0.294
CLV_PCSK_SKI1_1 138 142 PF00082 0.186
CLV_PCSK_SKI1_1 150 154 PF00082 0.203
CLV_PCSK_SKI1_1 212 216 PF00082 0.219
CLV_PCSK_SKI1_1 4 8 PF00082 0.521
CLV_PCSK_SKI1_1 426 430 PF00082 0.264
CLV_PCSK_SKI1_1 551 555 PF00082 0.439
DEG_APCC_DBOX_1 53 61 PF00400 0.475
DOC_CDC14_PxL_1 89 97 PF14671 0.507
DOC_CKS1_1 503 508 PF01111 0.392
DOC_CKS1_1 80 85 PF01111 0.449
DOC_MAPK_gen_1 288 298 PF00069 0.507
DOC_MAPK_MEF2A_6 194 201 PF00069 0.472
DOC_MAPK_NFAT4_5 194 202 PF00069 0.450
DOC_USP7_MATH_1 125 129 PF00917 0.438
DOC_USP7_MATH_1 172 176 PF00917 0.421
DOC_USP7_MATH_1 250 254 PF00917 0.562
DOC_USP7_MATH_1 269 273 PF00917 0.469
DOC_USP7_MATH_1 327 331 PF00917 0.431
DOC_USP7_MATH_1 499 503 PF00917 0.603
DOC_USP7_MATH_1 532 536 PF00917 0.337
DOC_USP7_UBL2_3 324 328 PF12436 0.403
DOC_WW_Pin1_4 170 175 PF00397 0.392
DOC_WW_Pin1_4 24 29 PF00397 0.565
DOC_WW_Pin1_4 468 473 PF00397 0.490
DOC_WW_Pin1_4 502 507 PF00397 0.595
DOC_WW_Pin1_4 528 533 PF00397 0.302
DOC_WW_Pin1_4 79 84 PF00397 0.507
LIG_14-3-3_CanoR_1 232 237 PF00244 0.524
LIG_14-3-3_CanoR_1 356 363 PF00244 0.512
LIG_14-3-3_CanoR_1 514 521 PF00244 0.460
LIG_BRCT_BRCA1_1 380 384 PF00533 0.420
LIG_BRCT_BRCA1_1 454 458 PF00533 0.441
LIG_FHA_1 194 200 PF00498 0.450
LIG_FHA_1 241 247 PF00498 0.420
LIG_FHA_1 34 40 PF00498 0.403
LIG_FHA_1 363 369 PF00498 0.428
LIG_FHA_1 482 488 PF00498 0.434
LIG_FHA_2 200 206 PF00498 0.418
LIG_FHA_2 388 394 PF00498 0.403
LIG_FHA_2 508 514 PF00498 0.484
LIG_LIR_Gen_1 21 28 PF02991 0.464
LIG_LIR_Gen_1 342 353 PF02991 0.463
LIG_LIR_Gen_1 381 392 PF02991 0.428
LIG_LIR_Nem_3 21 26 PF02991 0.463
LIG_LIR_Nem_3 217 223 PF02991 0.461
LIG_LIR_Nem_3 307 313 PF02991 0.414
LIG_LIR_Nem_3 342 348 PF02991 0.440
LIG_LIR_Nem_3 349 353 PF02991 0.428
LIG_LIR_Nem_3 381 387 PF02991 0.428
LIG_LIR_Nem_3 455 461 PF02991 0.431
LIG_REV1ctd_RIR_1 227 236 PF16727 0.527
LIG_SH2_CRK 23 27 PF00017 0.417
LIG_SH2_GRB2like 41 44 PF00017 0.389
LIG_SH2_NCK_1 239 243 PF00017 0.450
LIG_SH2_NCK_1 350 354 PF00017 0.403
LIG_SH2_NCK_1 41 45 PF00017 0.494
LIG_SH2_PTP2 292 295 PF00017 0.407
LIG_SH2_SRC 239 242 PF00017 0.507
LIG_SH2_STAP1 265 269 PF00017 0.507
LIG_SH2_STAP1 427 431 PF00017 0.450
LIG_SH2_STAT3 155 158 PF00017 0.450
LIG_SH2_STAT3 509 512 PF00017 0.366
LIG_SH2_STAT3 544 547 PF00017 0.318
LIG_SH2_STAT5 292 295 PF00017 0.407
LIG_SH2_STAT5 309 312 PF00017 0.507
LIG_SH2_STAT5 350 353 PF00017 0.434
LIG_SH2_STAT5 41 44 PF00017 0.502
LIG_SH2_STAT5 509 512 PF00017 0.421
LIG_SH2_STAT5 544 547 PF00017 0.391
LIG_SH3_3 302 308 PF00018 0.446
LIG_SUMO_SIM_par_1 196 205 PF11976 0.451
LIG_SUMO_SIM_par_1 294 299 PF11976 0.507
LIG_SUMO_SIM_par_1 478 484 PF11976 0.470
LIG_TRAF2_1 14 17 PF00917 0.446
LIG_TRAF2_1 510 513 PF00917 0.512
LIG_TRFH_1 221 225 PF08558 0.494
LIG_TYR_ITIM 290 295 PF00017 0.407
LIG_TYR_ITIM 348 353 PF00017 0.403
LIG_UBA3_1 478 485 PF00899 0.411
MOD_CK1_1 148 154 PF00069 0.507
MOD_CK1_1 175 181 PF00069 0.423
MOD_CK1_1 272 278 PF00069 0.434
MOD_CK1_1 29 35 PF00069 0.325
MOD_CK1_1 502 508 PF00069 0.621
MOD_CK1_1 79 85 PF00069 0.364
MOD_CK2_1 11 17 PF00069 0.423
MOD_CK2_1 24 30 PF00069 0.386
MOD_CK2_1 327 333 PF00069 0.428
MOD_CK2_1 387 393 PF00069 0.403
MOD_CK2_1 430 436 PF00069 0.450
MOD_CK2_1 507 513 PF00069 0.397
MOD_GlcNHglycan 127 130 PF01048 0.238
MOD_GlcNHglycan 13 16 PF01048 0.410
MOD_GlcNHglycan 147 150 PF01048 0.277
MOD_GlcNHglycan 177 180 PF01048 0.336
MOD_GlcNHglycan 271 274 PF01048 0.294
MOD_GlcNHglycan 275 278 PF01048 0.234
MOD_GlcNHglycan 329 332 PF01048 0.287
MOD_GlcNHglycan 357 360 PF01048 0.309
MOD_GlcNHglycan 551 554 PF01048 0.451
MOD_GSK3_1 170 177 PF00069 0.518
MOD_GSK3_1 228 235 PF00069 0.481
MOD_GSK3_1 26 33 PF00069 0.475
MOD_GSK3_1 269 276 PF00069 0.489
MOD_GSK3_1 374 381 PF00069 0.457
MOD_GSK3_1 387 394 PF00069 0.504
MOD_GSK3_1 528 535 PF00069 0.300
MOD_GSK3_1 561 568 PF00069 0.542
MOD_N-GLC_1 206 211 PF02516 0.203
MOD_N-GLC_1 60 65 PF02516 0.421
MOD_NEK2_1 11 16 PF00069 0.406
MOD_NEK2_1 132 137 PF00069 0.478
MOD_NEK2_1 199 204 PF00069 0.417
MOD_NEK2_1 387 392 PF00069 0.515
MOD_NEK2_1 39 44 PF00069 0.537
MOD_NEK2_1 53 58 PF00069 0.297
MOD_NEK2_1 561 566 PF00069 0.395
MOD_NEK2_1 60 65 PF00069 0.452
MOD_PIKK_1 172 178 PF00454 0.529
MOD_PIKK_1 275 281 PF00454 0.403
MOD_PIKK_1 33 39 PF00454 0.455
MOD_PIKK_1 508 514 PF00454 0.294
MOD_PIKK_1 76 82 PF00454 0.202
MOD_PKA_1 98 104 PF00069 0.403
MOD_PKA_2 193 199 PF00069 0.554
MOD_PKA_2 250 256 PF00069 0.558
MOD_PKA_2 355 361 PF00069 0.504
MOD_PKA_2 401 407 PF00069 0.450
MOD_PKA_2 513 519 PF00069 0.468
MOD_PKA_2 53 59 PF00069 0.389
MOD_PKA_2 98 104 PF00069 0.486
MOD_Plk_1 206 212 PF00069 0.449
MOD_Plk_1 29 35 PF00069 0.372
MOD_Plk_1 392 398 PF00069 0.556
MOD_Plk_1 452 458 PF00069 0.450
MOD_Plk_4 277 283 PF00069 0.459
MOD_Plk_4 387 393 PF00069 0.514
MOD_Plk_4 6 12 PF00069 0.412
MOD_Plk_4 85 91 PF00069 0.470
MOD_ProDKin_1 170 176 PF00069 0.392
MOD_ProDKin_1 24 30 PF00069 0.559
MOD_ProDKin_1 468 474 PF00069 0.490
MOD_ProDKin_1 502 508 PF00069 0.581
MOD_ProDKin_1 528 534 PF00069 0.301
MOD_ProDKin_1 79 85 PF00069 0.507
MOD_SUMO_for_1 415 418 PF00179 0.403
TRG_DiLeu_BaEn_1 118 123 PF01217 0.507
TRG_DiLeu_BaEn_1 142 147 PF01217 0.434
TRG_DiLeu_BaLyEn_6 195 200 PF01217 0.494
TRG_ENDOCYTIC_2 23 26 PF00928 0.499
TRG_ENDOCYTIC_2 265 268 PF00928 0.414
TRG_ENDOCYTIC_2 292 295 PF00928 0.407
TRG_ENDOCYTIC_2 350 353 PF00928 0.410
TRG_Pf-PMV_PEXEL_1 245 249 PF00026 0.203

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PG62 Leptomonas seymouri 64% 100%
A0A0S4IVW9 Bodo saltans 39% 100%
A0A1X0P444 Trypanosomatidae 45% 100%
A0A3S7X721 Leishmania donovani 100% 100%
A0A422P028 Trypanosoma rangeli 39% 100%
D0A658 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 100%
E9AIV6 Leishmania braziliensis 80% 98%
E9B491 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 98%
O64765 Arabidopsis thaliana 34% 100%
O74933 Candida albicans 34% 100%
O94617 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 34% 100%
P43123 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 28% 100%
Q16222 Homo sapiens 30% 100%
Q18493 Caenorhabditis elegans 28% 100%
Q28CH3 Xenopus tropicalis 32% 100%
Q2FEW1 Staphylococcus aureus (strain USA300) 29% 100%
Q2FW81 Staphylococcus aureus (strain NCTC 8325 / PS 47) 29% 100%
Q2YYH4 Staphylococcus aureus (strain bovine RF122 / ET3-1) 28% 100%
Q3KQV9 Homo sapiens 32% 100%
Q3TW96 Mus musculus 31% 100%
Q4L846 Staphylococcus haemolyticus (strain JCSC1435) 29% 100%
Q4Q3T5 Leishmania major 93% 100%
Q54GN5 Dictyostelium discoideum 29% 100%
Q5HE34 Staphylococcus aureus (strain COL) 29% 100%
Q5HM59 Staphylococcus epidermidis (strain ATCC 35984 / RP62A) 30% 100%
Q6G7E3 Staphylococcus aureus (strain MSSA476) 29% 100%
Q6GEQ8 Staphylococcus aureus (strain MRSA252) 29% 100%
Q7A0A0 Staphylococcus aureus (strain MW2) 29% 100%
Q7A4A4 Staphylococcus aureus (strain N315) 29% 100%
Q7ZWD4 Danio rerio 31% 100%
Q8CNG6 Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200) 29% 100%
Q91YN5 Mus musculus 31% 100%
Q940S3 Arabidopsis thaliana 33% 100%
Q99S95 Staphylococcus aureus (strain Mu50 / ATCC 700699) 29% 100%
V5BYI4 Trypanosoma cruzi 42% 95%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS