LeishMANIAdb
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Mitochondrial RNA binding complex 1 subunit

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Mitochondrial RNA binding complex 1 subunit
Gene product:
mitochondrial RNA binding complex 1 subunit
Species:
Leishmania infantum
UniProt:
E9AHR9_LEIIN
TriTrypDb:
LINF_330034300
Length:
677

Annotations

Annotations by Jardim et al.

Mitochondrial protein, mitochondrial edited mRNA stability factor 1 subunit Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

E9AHR9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHR9

PDB structure(s): 7ane_l

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009892 negative regulation of metabolic process 4 1
GO:0009893 positive regulation of metabolic process 4 1
GO:0009894 regulation of catabolic process 4 1
GO:0009895 negative regulation of catabolic process 5 1
GO:0009987 cellular process 1 1
GO:0010468 regulation of gene expression 5 1
GO:0010604 positive regulation of macromolecule metabolic process 5 1
GO:0010605 negative regulation of macromolecule metabolic process 5 1
GO:0010608 post-transcriptional regulation of gene expression 6 1
GO:0010628 positive regulation of gene expression 6 1
GO:0016070 RNA metabolic process 5 1
GO:0019219 regulation of nucleobase-containing compound metabolic process 5 1
GO:0019222 regulation of metabolic process 3 1
GO:0031323 regulation of cellular metabolic process 4 1
GO:0031324 negative regulation of cellular metabolic process 5 1
GO:0031329 regulation of cellular catabolic process 5 1
GO:0031330 negative regulation of cellular catabolic process 6 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043487 regulation of RNA stability 3 1
GO:0043488 regulation of mRNA stability 4 1
GO:0043489 RNA stabilization 4 1
GO:0043631 RNA polyadenylation 6 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 6 1
GO:0046483 heterocycle metabolic process 3 1
GO:0048255 mRNA stabilization 5 1
GO:0048518 positive regulation of biological process 3 1
GO:0048519 negative regulation of biological process 3 1
GO:0048523 negative regulation of cellular process 4 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0051171 regulation of nitrogen compound metabolic process 4 1
GO:0051172 negative regulation of nitrogen compound metabolic process 5 1
GO:0051252 regulation of RNA metabolic process 5 1
GO:0051253 negative regulation of RNA metabolic process 6 1
GO:0060255 regulation of macromolecule metabolic process 4 1
GO:0061013 regulation of mRNA catabolic process 6 1
GO:0065007 biological regulation 1 1
GO:0065008 regulation of biological quality 2 1
GO:0071704 organic substance metabolic process 2 1
GO:0080090 regulation of primary metabolic process 4 1
GO:0090304 nucleic acid metabolic process 4 1
GO:1901360 organic cyclic compound metabolic process 3 1
GO:1902369 negative regulation of RNA catabolic process 7 1
GO:1902373 negative regulation of mRNA catabolic process 7 1
GO:1903311 regulation of mRNA metabolic process 6 1
GO:1903312 negative regulation of mRNA metabolic process 7 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 1
GO:0003723 RNA binding 4 1
GO:0005488 binding 1 1
GO:0097159 organic cyclic compound binding 2 1
GO:1901363 heterocyclic compound binding 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 192 196 PF00656 0.507
CLV_C14_Caspase3-7 376 380 PF00656 0.604
CLV_C14_Caspase3-7 483 487 PF00656 0.469
CLV_NRD_NRD_1 228 230 PF00675 0.397
CLV_NRD_NRD_1 33 35 PF00675 0.440
CLV_NRD_NRD_1 388 390 PF00675 0.686
CLV_NRD_NRD_1 435 437 PF00675 0.415
CLV_NRD_NRD_1 601 603 PF00675 0.296
CLV_NRD_NRD_1 641 643 PF00675 0.349
CLV_NRD_NRD_1 78 80 PF00675 0.343
CLV_NRD_NRD_1 85 87 PF00675 0.332
CLV_PCSK_FUR_1 599 603 PF00082 0.289
CLV_PCSK_KEX2_1 228 230 PF00082 0.397
CLV_PCSK_KEX2_1 388 390 PF00082 0.686
CLV_PCSK_KEX2_1 411 413 PF00082 0.349
CLV_PCSK_KEX2_1 435 437 PF00082 0.415
CLV_PCSK_KEX2_1 601 603 PF00082 0.296
CLV_PCSK_KEX2_1 641 643 PF00082 0.330
CLV_PCSK_KEX2_1 78 80 PF00082 0.343
CLV_PCSK_KEX2_1 85 87 PF00082 0.332
CLV_PCSK_PC1ET2_1 411 413 PF00082 0.368
CLV_PCSK_PC7_1 637 643 PF00082 0.449
CLV_PCSK_PC7_1 74 80 PF00082 0.416
CLV_PCSK_SKI1_1 146 150 PF00082 0.257
CLV_PCSK_SKI1_1 151 155 PF00082 0.262
CLV_PCSK_SKI1_1 166 170 PF00082 0.169
CLV_PCSK_SKI1_1 485 489 PF00082 0.461
CLV_PCSK_SKI1_1 517 521 PF00082 0.514
CLV_PCSK_SKI1_1 590 594 PF00082 0.416
CLV_PCSK_SKI1_1 617 621 PF00082 0.371
CLV_Separin_Metazoa 265 269 PF03568 0.516
DEG_Nend_Nbox_1 1 3 PF02207 0.393
DEG_ODPH_VHL_1 416 427 PF01847 0.476
DEG_SPOP_SBC_1 361 365 PF00917 0.383
DOC_CYCLIN_RxL_1 329 338 PF00134 0.301
DOC_MAPK_gen_1 119 128 PF00069 0.303
DOC_MAPK_gen_1 544 551 PF00069 0.295
DOC_MAPK_gen_1 601 610 PF00069 0.327
DOC_MAPK_gen_1 641 649 PF00069 0.308
DOC_MAPK_HePTP_8 105 117 PF00069 0.315
DOC_MAPK_MEF2A_6 108 117 PF00069 0.297
DOC_MAPK_MEF2A_6 544 551 PF00069 0.314
DOC_MAPK_MEF2A_6 586 595 PF00069 0.332
DOC_PP1_RVXF_1 330 337 PF00149 0.260
DOC_PP1_RVXF_1 506 512 PF00149 0.456
DOC_PP2B_LxvP_1 212 215 PF13499 0.364
DOC_PP2B_LxvP_1 415 418 PF13499 0.496
DOC_PP2B_PxIxI_1 112 118 PF00149 0.294
DOC_PP4_FxxP_1 255 258 PF00568 0.358
DOC_USP7_MATH_1 179 183 PF00917 0.523
DOC_USP7_MATH_1 196 200 PF00917 0.448
DOC_USP7_MATH_1 23 27 PF00917 0.440
DOC_USP7_MATH_1 248 252 PF00917 0.440
DOC_USP7_MATH_1 361 365 PF00917 0.513
DOC_USP7_MATH_1 370 374 PF00917 0.611
DOC_USP7_MATH_1 547 551 PF00917 0.417
DOC_USP7_MATH_1 569 573 PF00917 0.541
DOC_USP7_MATH_1 629 633 PF00917 0.414
DOC_USP7_MATH_1 673 677 PF00917 0.412
DOC_USP7_MATH_1 73 77 PF00917 0.486
DOC_WW_Pin1_4 10 15 PF00397 0.312
DOC_WW_Pin1_4 362 367 PF00397 0.544
LIG_14-3-3_CanoR_1 157 162 PF00244 0.338
LIG_14-3-3_CanoR_1 310 316 PF00244 0.491
LIG_14-3-3_CanoR_1 360 366 PF00244 0.497
LIG_14-3-3_CanoR_1 490 494 PF00244 0.524
LIG_14-3-3_CanoR_1 617 625 PF00244 0.293
LIG_14-3-3_CanoR_1 641 649 PF00244 0.380
LIG_14-3-3_CanoR_1 72 78 PF00244 0.398
LIG_Actin_RPEL_3 115 134 PF02755 0.293
LIG_Actin_WH2_2 13 31 PF00022 0.498
LIG_APCC_ABBA_1 126 131 PF00400 0.334
LIG_APCC_ABBA_1 333 338 PF00400 0.244
LIG_APCC_ABBAyCdc20_2 332 338 PF00400 0.264
LIG_CtBP_PxDLS_1 174 180 PF00389 0.448
LIG_deltaCOP1_diTrp_1 135 144 PF00928 0.446
LIG_deltaCOP1_diTrp_1 471 475 PF00928 0.324
LIG_EH_1 345 349 PF12763 0.317
LIG_FHA_1 209 215 PF00498 0.402
LIG_FHA_2 496 502 PF00498 0.332
LIG_GBD_Chelix_1 580 588 PF00786 0.402
LIG_LIR_Apic_2 252 258 PF02991 0.361
LIG_LIR_Apic_2 379 384 PF02991 0.559
LIG_LIR_Apic_2 471 477 PF02991 0.303
LIG_LIR_Gen_1 217 227 PF02991 0.395
LIG_LIR_Gen_1 345 356 PF02991 0.337
LIG_LIR_Gen_1 446 457 PF02991 0.395
LIG_LIR_Gen_1 470 480 PF02991 0.315
LIG_LIR_LC3C_4 578 582 PF02991 0.429
LIG_LIR_Nem_3 164 168 PF02991 0.353
LIG_LIR_Nem_3 18 24 PF02991 0.313
LIG_LIR_Nem_3 217 223 PF02991 0.286
LIG_LIR_Nem_3 313 318 PF02991 0.351
LIG_LIR_Nem_3 345 351 PF02991 0.344
LIG_LIR_Nem_3 38 44 PF02991 0.253
LIG_LIR_Nem_3 470 475 PF02991 0.343
LIG_LIR_Nem_3 518 523 PF02991 0.390
LIG_LIR_Nem_3 644 649 PF02991 0.370
LIG_LYPXL_yS_3 315 318 PF13949 0.315
LIG_MAD2 652 660 PF02301 0.444
LIG_PCNA_PIPBox_1 264 273 PF02747 0.386
LIG_PCNA_PIPBox_1 99 108 PF02747 0.364
LIG_PCNA_yPIPBox_3 261 271 PF02747 0.471
LIG_PCNA_yPIPBox_3 323 334 PF02747 0.366
LIG_PCNA_yPIPBox_3 92 106 PF02747 0.373
LIG_SH2_CRK 150 154 PF00017 0.241
LIG_SH2_CRK 165 169 PF00017 0.280
LIG_SH2_CRK 381 385 PF00017 0.557
LIG_SH2_GRB2like 474 477 PF00017 0.285
LIG_SH2_NCK_1 499 503 PF00017 0.309
LIG_SH2_NCK_1 561 565 PF00017 0.499
LIG_SH2_SRC 499 502 PF00017 0.320
LIG_SH2_STAP1 668 672 PF00017 0.296
LIG_SH2_STAT5 16 19 PF00017 0.295
LIG_SH2_STAT5 167 170 PF00017 0.324
LIG_SH2_STAT5 222 225 PF00017 0.234
LIG_SH2_STAT5 231 234 PF00017 0.251
LIG_SH2_STAT5 30 33 PF00017 0.360
LIG_SH2_STAT5 357 360 PF00017 0.505
LIG_SH2_STAT5 474 477 PF00017 0.288
LIG_SH2_STAT5 532 535 PF00017 0.342
LIG_SH2_STAT5 646 649 PF00017 0.379
LIG_SH3_3 107 113 PF00018 0.290
LIG_SH3_3 306 312 PF00018 0.483
LIG_SH3_3 346 352 PF00018 0.320
LIG_SH3_3 531 537 PF00018 0.343
LIG_SH3_3 552 558 PF00018 0.345
LIG_SH3_3 59 65 PF00018 0.435
LIG_SH3_3 625 631 PF00018 0.465
LIG_SUMO_SIM_par_1 101 107 PF11976 0.308
LIG_TRAF2_1 50 53 PF00917 0.429
LIG_TYR_ITIM 148 153 PF00017 0.241
MOD_CK1_1 182 188 PF00069 0.605
MOD_CK1_1 189 195 PF00069 0.594
MOD_CK1_1 199 205 PF00069 0.642
MOD_CK1_1 362 368 PF00069 0.486
MOD_CK1_1 403 409 PF00069 0.419
MOD_CK1_1 467 473 PF00069 0.396
MOD_CK1_1 489 495 PF00069 0.503
MOD_CK1_1 550 556 PF00069 0.343
MOD_CK2_1 195 201 PF00069 0.720
MOD_CK2_1 370 376 PF00069 0.609
MOD_CK2_1 495 501 PF00069 0.402
MOD_GlcNHglycan 181 184 PF01048 0.663
MOD_GlcNHglycan 201 204 PF01048 0.710
MOD_GlcNHglycan 300 303 PF01048 0.604
MOD_GlcNHglycan 455 458 PF01048 0.548
MOD_GlcNHglycan 466 469 PF01048 0.416
MOD_GlcNHglycan 517 520 PF01048 0.537
MOD_GlcNHglycan 643 646 PF01048 0.418
MOD_GlcNHglycan 655 659 PF01048 0.394
MOD_GSK3_1 157 164 PF00069 0.307
MOD_GSK3_1 182 189 PF00069 0.644
MOD_GSK3_1 195 202 PF00069 0.631
MOD_GSK3_1 272 279 PF00069 0.519
MOD_GSK3_1 298 305 PF00069 0.644
MOD_GSK3_1 356 363 PF00069 0.411
MOD_GSK3_1 528 535 PF00069 0.433
MOD_GSK3_1 654 661 PF00069 0.373
MOD_N-GLC_1 189 194 PF02516 0.534
MOD_N-GLC_1 199 204 PF02516 0.472
MOD_N-GLC_1 248 253 PF02516 0.400
MOD_NEK2_1 253 258 PF00069 0.349
MOD_NEK2_1 426 431 PF00069 0.393
MOD_NEK2_1 44 49 PF00069 0.539
MOD_NEK2_1 453 458 PF00069 0.411
MOD_NEK2_1 654 659 PF00069 0.347
MOD_NEK2_2 67 72 PF00069 0.500
MOD_NEK2_2 73 78 PF00069 0.453
MOD_PIKK_1 276 282 PF00454 0.575
MOD_PK_1 282 288 PF00069 0.629
MOD_PKA_1 641 647 PF00069 0.414
MOD_PKA_2 179 185 PF00069 0.591
MOD_PKA_2 196 202 PF00069 0.542
MOD_PKA_2 298 304 PF00069 0.541
MOD_PKA_2 359 365 PF00069 0.535
MOD_PKA_2 453 459 PF00069 0.435
MOD_PKA_2 489 495 PF00069 0.399
MOD_PKA_2 641 647 PF00069 0.346
MOD_PKA_2 73 79 PF00069 0.459
MOD_PKB_1 308 316 PF00069 0.417
MOD_Plk_1 282 288 PF00069 0.629
MOD_Plk_1 470 476 PF00069 0.320
MOD_Plk_4 208 214 PF00069 0.505
MOD_Plk_4 403 409 PF00069 0.430
MOD_Plk_4 528 534 PF00069 0.412
MOD_Plk_4 547 553 PF00069 0.357
MOD_Plk_4 610 616 PF00069 0.301
MOD_ProDKin_1 10 16 PF00069 0.309
MOD_ProDKin_1 362 368 PF00069 0.558
MOD_SUMO_for_1 260 263 PF00179 0.425
MOD_SUMO_rev_2 32 37 PF00179 0.380
TRG_DiLeu_BaEn_1 326 331 PF01217 0.356
TRG_DiLeu_BaEn_1 338 343 PF01217 0.364
TRG_DiLeu_BaEn_4 460 466 PF01217 0.547
TRG_DiLeu_BaEn_4 483 489 PF01217 0.351
TRG_ENDOCYTIC_2 150 153 PF00928 0.256
TRG_ENDOCYTIC_2 165 168 PF00928 0.397
TRG_ENDOCYTIC_2 220 223 PF00928 0.245
TRG_ENDOCYTIC_2 315 318 PF00928 0.315
TRG_ENDOCYTIC_2 646 649 PF00928 0.319
TRG_ER_diArg_1 227 229 PF00400 0.396
TRG_ER_diArg_1 308 311 PF00400 0.539
TRG_ER_diArg_1 434 436 PF00400 0.408
TRG_ER_diArg_1 599 602 PF00400 0.347
TRG_ER_diArg_1 641 643 PF00400 0.350
TRG_ER_diArg_1 71 74 PF00400 0.407
TRG_ER_diArg_1 77 79 PF00400 0.330
TRG_NES_CRM1_1 583 594 PF08389 0.207
TRG_Pf-PMV_PEXEL_1 166 170 PF00026 0.437
TRG_Pf-PMV_PEXEL_1 435 439 PF00026 0.385
TRG_Pf-PMV_PEXEL_1 652 656 PF00026 0.311

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I7Z6 Leptomonas seymouri 70% 92%
A0A0S4IW89 Bodo saltans 35% 100%
A0A1X0P3U7 Trypanosomatidae 50% 93%
A0A3S7X701 Leishmania donovani 100% 100%
A0A422P030 Trypanosoma rangeli 52% 96%
A4HLW2 Leishmania braziliensis 87% 100%
D0A659 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 48% 91%
E9B490 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
Q4Q3T6 Leishmania major 95% 100%
V5BP67 Trypanosoma cruzi 50% 98%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS