LeishMANIAdb
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Radial spoke head protein 9 homolog

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Radial spoke head protein 9 homolog
Gene product:
Radial spokehead-like protein - putative
Species:
Leishmania infantum
UniProt:
E9AHR8_LEIIN
TriTrypDb:
LINF_330034200
Length:
319

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0001534 radial spoke 2 7
GO:0032991 protein-containing complex 1 7
GO:0005930 axoneme 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9AHR8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHR8

Function

Biological processes
Term Name Level Count
GO:0003341 cilium movement 4 7
GO:0006996 organelle organization 4 7
GO:0007017 microtubule-based process 2 7
GO:0007018 microtubule-based movement 3 7
GO:0009987 cellular process 1 7
GO:0016043 cellular component organization 3 7
GO:0022607 cellular component assembly 4 7
GO:0030030 cell projection organization 4 7
GO:0030031 cell projection assembly 5 7
GO:0044782 cilium organization 5 7
GO:0060271 cilium assembly 6 7
GO:0060294 cilium movement involved in cell motility 5 7
GO:0070925 organelle assembly 5 7
GO:0071840 cellular component organization or biogenesis 2 7
GO:0120031 plasma membrane bounded cell projection assembly 6 7
GO:0120036 plasma membrane bounded cell projection organization 5 7
GO:0000226 microtubule cytoskeleton organization 3 1
GO:0001578 microtubule bundle formation 4 1
GO:0007010 cytoskeleton organization 5 1
GO:0035082 axoneme assembly 5 1
GO:0044458 motile cilium assembly 7 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 133 137 PF00656 0.496
CLV_NRD_NRD_1 197 199 PF00675 0.540
CLV_NRD_NRD_1 228 230 PF00675 0.443
CLV_NRD_NRD_1 232 234 PF00675 0.481
CLV_NRD_NRD_1 37 39 PF00675 0.265
CLV_PCSK_KEX2_1 197 199 PF00082 0.425
CLV_PCSK_KEX2_1 228 230 PF00082 0.443
CLV_PCSK_KEX2_1 37 39 PF00082 0.254
CLV_PCSK_PC1ET2_1 37 39 PF00082 0.254
CLV_PCSK_PC7_1 193 199 PF00082 0.447
CLV_PCSK_SKI1_1 149 153 PF00082 0.300
CLV_PCSK_SKI1_1 174 178 PF00082 0.538
CLV_PCSK_SKI1_1 228 232 PF00082 0.479
CLV_PCSK_SKI1_1 241 245 PF00082 0.527
DEG_SCF_FBW7_1 1 6 PF00400 0.312
DOC_MAPK_gen_1 37 43 PF00069 0.513
DOC_MAPK_HePTP_8 142 154 PF00069 0.232
DOC_MAPK_MEF2A_6 108 115 PF00069 0.447
DOC_MAPK_MEF2A_6 145 154 PF00069 0.287
DOC_MAPK_NFAT4_5 108 116 PF00069 0.452
DOC_PP1_RVXF_1 281 288 PF00149 0.394
DOC_USP7_MATH_1 13 17 PF00917 0.418
DOC_USP7_MATH_1 256 260 PF00917 0.393
DOC_USP7_MATH_1 3 7 PF00917 0.325
DOC_WW_Pin1_4 15 20 PF00397 0.513
LIG_14-3-3_CanoR_1 197 206 PF00244 0.405
LIG_14-3-3_CanoR_1 233 239 PF00244 0.408
LIG_14-3-3_CanoR_1 78 83 PF00244 0.495
LIG_APCC_ABBA_1 150 155 PF00400 0.280
LIG_APCC_ABBAyCdc20_2 149 155 PF00400 0.280
LIG_BRCT_BRCA1_1 86 90 PF00533 0.356
LIG_deltaCOP1_diTrp_1 106 110 PF00928 0.353
LIG_FHA_1 175 181 PF00498 0.647
LIG_FHA_1 24 30 PF00498 0.530
LIG_FHA_1 266 272 PF00498 0.501
LIG_FHA_1 77 83 PF00498 0.394
LIG_FHA_2 182 188 PF00498 0.553
LIG_FHA_2 71 77 PF00498 0.435
LIG_IBAR_NPY_1 225 227 PF08397 0.401
LIG_LIR_Apic_2 290 296 PF02991 0.253
LIG_LIR_Gen_1 254 265 PF02991 0.410
LIG_LIR_Gen_1 274 281 PF02991 0.182
LIG_LIR_Gen_1 53 60 PF02991 0.411
LIG_LIR_Gen_1 6 17 PF02991 0.439
LIG_LIR_Gen_1 79 86 PF02991 0.284
LIG_LIR_Nem_3 106 110 PF02991 0.493
LIG_LIR_Nem_3 200 205 PF02991 0.405
LIG_LIR_Nem_3 254 260 PF02991 0.333
LIG_LIR_Nem_3 274 279 PF02991 0.194
LIG_LIR_Nem_3 290 295 PF02991 0.137
LIG_LIR_Nem_3 298 304 PF02991 0.274
LIG_LIR_Nem_3 53 57 PF02991 0.411
LIG_LIR_Nem_3 69 74 PF02991 0.290
LIG_LIR_Nem_3 79 83 PF02991 0.271
LIG_LIR_Nem_3 85 89 PF02991 0.220
LIG_Pex14_1 269 273 PF04695 0.324
LIG_Pex14_1 44 48 PF04695 0.411
LIG_Pex14_2 153 157 PF04695 0.399
LIG_Pex14_2 7 11 PF04695 0.463
LIG_Pex14_2 86 90 PF04695 0.430
LIG_SH2_CRK 227 231 PF00017 0.479
LIG_SH2_CRK 301 305 PF00017 0.309
LIG_SH2_PTP2 54 57 PF00017 0.459
LIG_SH2_SRC 54 57 PF00017 0.478
LIG_SH2_STAP1 125 129 PF00017 0.347
LIG_SH2_STAP1 9 13 PF00017 0.463
LIG_SH2_STAT5 54 57 PF00017 0.428
LIG_SH2_STAT5 72 75 PF00017 0.382
LIG_SH3_3 62 68 PF00018 0.323
LIG_SUMO_SIM_par_1 140 147 PF11976 0.452
LIG_SUMO_SIM_par_1 30 36 PF11976 0.463
LIG_TRAF2_1 18 21 PF00917 0.436
LIG_WRC_WIRS_1 4 9 PF05994 0.331
LIG_WRC_WIRS_1 83 88 PF05994 0.434
MOD_CDK_SPxxK_3 15 22 PF00069 0.320
MOD_CK1_1 130 136 PF00069 0.545
MOD_CK1_1 237 243 PF00069 0.432
MOD_CK1_1 33 39 PF00069 0.391
MOD_CK1_1 88 94 PF00069 0.530
MOD_CK1_1 97 103 PF00069 0.381
MOD_CK2_1 140 146 PF00069 0.329
MOD_CK2_1 15 21 PF00069 0.247
MOD_CK2_1 181 187 PF00069 0.667
MOD_CK2_1 239 245 PF00069 0.403
MOD_CK2_1 256 262 PF00069 0.342
MOD_CK2_1 70 76 PF00069 0.361
MOD_GlcNHglycan 241 244 PF01048 0.380
MOD_GlcNHglycan 265 268 PF01048 0.472
MOD_GlcNHglycan 287 290 PF01048 0.319
MOD_GlcNHglycan 99 102 PF01048 0.468
MOD_GSK3_1 127 134 PF00069 0.455
MOD_GSK3_1 140 147 PF00069 0.341
MOD_GSK3_1 176 183 PF00069 0.632
MOD_GSK3_1 78 85 PF00069 0.410
MOD_N-GLC_1 130 135 PF02516 0.456
MOD_NEK2_1 239 244 PF00069 0.534
MOD_NEK2_1 25 30 PF00069 0.256
MOD_NEK2_1 287 292 PF00069 0.312
MOD_NEK2_1 82 87 PF00069 0.405
MOD_NEK2_2 211 216 PF00069 0.454
MOD_OFUCOSY 93 99 PF10250 0.364
MOD_PKA_1 197 203 PF00069 0.505
MOD_PKA_2 127 133 PF00069 0.504
MOD_PKA_2 197 203 PF00069 0.505
MOD_PKA_2 285 291 PF00069 0.347
MOD_Plk_2-3 140 146 PF00069 0.410
MOD_Plk_4 234 240 PF00069 0.454
MOD_Plk_4 287 293 PF00069 0.297
MOD_Plk_4 300 306 PF00069 0.239
MOD_Plk_4 85 91 PF00069 0.380
MOD_ProDKin_1 15 21 PF00069 0.391
MOD_SUMO_for_1 170 173 PF00179 0.520
MOD_SUMO_rev_2 100 110 PF00179 0.474
TRG_DiLeu_BaEn_2 105 111 PF01217 0.309
TRG_DiLeu_BaEn_4 20 26 PF01217 0.282
TRG_DiLeu_BaLyEn_6 226 231 PF01217 0.506
TRG_DiLeu_BaLyEn_6 248 253 PF01217 0.435
TRG_DiLeu_BaLyEn_6 27 32 PF01217 0.262
TRG_ENDOCYTIC_2 218 221 PF00928 0.283
TRG_ENDOCYTIC_2 227 230 PF00928 0.333
TRG_ENDOCYTIC_2 273 276 PF00928 0.342
TRG_ENDOCYTIC_2 301 304 PF00928 0.302
TRG_ENDOCYTIC_2 54 57 PF00928 0.272
TRG_ENDOCYTIC_2 71 74 PF00928 0.370
TRG_ENDOCYTIC_2 9 12 PF00928 0.437
TRG_ER_diArg_1 196 198 PF00400 0.530
TRG_ER_diArg_1 227 229 PF00400 0.438

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P8E1 Leptomonas seymouri 73% 100%
A0A0S4IRW1 Bodo saltans 34% 100%
A0A1X0P3V0 Trypanosomatidae 47% 100%
A0A3Q8IKD9 Leishmania donovani 100% 100%
A0A422P0B0 Trypanosoma rangeli 47% 100%
A4H541 Leishmania braziliensis 24% 95%
A4HLW1 Leishmania braziliensis 85% 100%
A4HTB7 Leishmania infantum 24% 92%
D0A660 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 48% 100%
E9ALB0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 93%
E9B489 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
Q2KIU7 Bos taurus 25% 100%
Q4Q3T7 Leishmania major 95% 100%
Q4QIJ4 Leishmania major 25% 90%
Q5TYW6 Danio rerio 31% 100%
Q6DFN5 Xenopus tropicalis 28% 100%
Q9D9V4 Mus musculus 26% 100%
Q9H1X1 Homo sapiens 25% 100%
V5B8M6 Trypanosoma cruzi 45% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS