LeishMANIAdb
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Protein PNS1

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Protein PNS1
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
E9AHR5_LEIIN
TriTrypDb:
LINF_330033900
Length:
399

Annotations

LeishMANIAdb annotations

A multi-pass protein with uncertain structure and function.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0000331 contractile vacuole 6 1
GO:0005739 mitochondrion 5 1
GO:0005741 mitochondrial outer membrane 5 1
GO:0005773 vacuole 5 1
GO:0016020 membrane 2 10
GO:0019867 outer membrane 3 1
GO:0031090 organelle membrane 3 1
GO:0031410 cytoplasmic vesicle 6 1
GO:0031966 mitochondrial membrane 4 1
GO:0031968 organelle outer membrane 4 1
GO:0031982 vesicle 4 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0097708 intracellular vesicle 5 1
GO:0098588 bounding membrane of organelle 4 1
GO:0110165 cellular anatomical entity 1 10

Expansion

Sequence features

E9AHR5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHR5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 279 283 PF00656 0.398
CLV_NRD_NRD_1 314 316 PF00675 0.577
CLV_PCSK_KEX2_1 138 140 PF00082 0.430
CLV_PCSK_KEX2_1 314 316 PF00082 0.577
CLV_PCSK_KEX2_1 81 83 PF00082 0.360
CLV_PCSK_PC1ET2_1 138 140 PF00082 0.408
CLV_PCSK_PC1ET2_1 81 83 PF00082 0.403
CLV_PCSK_PC7_1 310 316 PF00082 0.589
CLV_PCSK_SKI1_1 139 143 PF00082 0.431
CLV_PCSK_SKI1_1 228 232 PF00082 0.637
CLV_PCSK_SKI1_1 237 241 PF00082 0.623
CLV_PCSK_SKI1_1 288 292 PF00082 0.588
CLV_PCSK_SKI1_1 314 318 PF00082 0.576
CLV_PCSK_SKI1_1 82 86 PF00082 0.355
DEG_SPOP_SBC_1 318 322 PF00917 0.417
DOC_CYCLIN_yCln2_LP_2 186 192 PF00134 0.290
DOC_MAPK_gen_1 228 238 PF00069 0.387
DOC_MAPK_gen_1 27 36 PF00069 0.338
DOC_MAPK_gen_1 303 313 PF00069 0.411
DOC_MAPK_MEF2A_6 112 121 PF00069 0.305
DOC_MAPK_MEF2A_6 231 240 PF00069 0.348
DOC_MAPK_MEF2A_6 384 392 PF00069 0.399
DOC_PP1_RVXF_1 144 151 PF00149 0.531
DOC_PP1_RVXF_1 301 308 PF00149 0.420
DOC_PP2B_LxvP_1 134 137 PF13499 0.404
DOC_PP2B_LxvP_1 186 189 PF13499 0.290
DOC_USP7_MATH_1 103 107 PF00917 0.351
DOC_USP7_MATH_1 218 222 PF00917 0.422
DOC_USP7_MATH_1 318 322 PF00917 0.520
DOC_USP7_MATH_1 69 73 PF00917 0.670
DOC_WW_Pin1_4 16 21 PF00397 0.466
DOC_WW_Pin1_4 383 388 PF00397 0.332
LIG_14-3-3_CanoR_1 194 200 PF00244 0.454
LIG_14-3-3_CanoR_1 25 30 PF00244 0.349
LIG_14-3-3_CanoR_1 361 366 PF00244 0.370
LIG_14-3-3_CanoR_1 87 96 PF00244 0.507
LIG_BIR_II_1 1 5 PF00653 0.479
LIG_DLG_GKlike_1 30 37 PF00625 0.433
LIG_FHA_1 122 128 PF00498 0.358
LIG_FHA_1 150 156 PF00498 0.379
LIG_FHA_1 169 175 PF00498 0.252
LIG_FHA_1 247 253 PF00498 0.350
LIG_FHA_1 295 301 PF00498 0.379
LIG_FHA_1 369 375 PF00498 0.489
LIG_FHA_1 4 10 PF00498 0.426
LIG_FHA_1 72 78 PF00498 0.599
LIG_FHA_1 91 97 PF00498 0.201
LIG_LIR_Gen_1 266 272 PF02991 0.259
LIG_LIR_Gen_1 332 341 PF02991 0.460
LIG_LIR_Nem_3 110 114 PF02991 0.435
LIG_LIR_Nem_3 225 230 PF02991 0.459
LIG_LIR_Nem_3 266 271 PF02991 0.336
LIG_LIR_Nem_3 28 34 PF02991 0.262
LIG_LIR_Nem_3 297 302 PF02991 0.391
LIG_LIR_Nem_3 332 336 PF02991 0.447
LIG_PDZ_Class_2 394 399 PF00595 0.431
LIG_SH2_CRK 268 272 PF00017 0.395
LIG_SH2_CRK 302 306 PF00017 0.422
LIG_SH2_CRK 31 35 PF00017 0.434
LIG_SH2_NCK_1 94 98 PF00017 0.360
LIG_SH2_STAP1 94 98 PF00017 0.433
LIG_SH2_STAT5 191 194 PF00017 0.431
LIG_SH2_STAT5 199 202 PF00017 0.277
LIG_SH2_STAT5 299 302 PF00017 0.350
LIG_SH2_STAT5 359 362 PF00017 0.345
LIG_SH2_STAT5 40 43 PF00017 0.364
LIG_SH3_1 112 118 PF00018 0.418
LIG_SH3_3 112 118 PF00018 0.334
LIG_SH3_3 212 218 PF00018 0.423
LIG_SUMO_SIM_anti_2 211 216 PF11976 0.433
LIG_SUMO_SIM_anti_2 282 289 PF11976 0.211
LIG_SUMO_SIM_anti_2 33 38 PF11976 0.389
LIG_SUMO_SIM_par_1 117 125 PF11976 0.287
LIG_SUMO_SIM_par_1 99 106 PF11976 0.415
LIG_TRAF2_2 218 223 PF00917 0.400
LIG_TRFH_1 159 163 PF08558 0.433
LIG_TYR_ITIM 29 34 PF00017 0.433
LIG_TYR_ITIM 300 305 PF00017 0.514
LIG_UBA3_1 132 138 PF00899 0.380
LIG_WRC_WIRS_1 108 113 PF05994 0.502
LIG_WRC_WIRS_1 42 47 PF05994 0.351
MOD_CK1_1 153 159 PF00069 0.444
MOD_CK1_1 2 8 PF00069 0.664
MOD_CK1_1 208 214 PF00069 0.421
MOD_CK1_1 337 343 PF00069 0.582
MOD_CK1_1 386 392 PF00069 0.452
MOD_CK1_1 62 68 PF00069 0.421
MOD_CK1_1 88 94 PF00069 0.369
MOD_CK2_1 62 68 PF00069 0.455
MOD_CK2_1 69 75 PF00069 0.487
MOD_GlcNHglycan 105 108 PF01048 0.444
MOD_GlcNHglycan 201 204 PF01048 0.425
MOD_GlcNHglycan 207 210 PF01048 0.403
MOD_GlcNHglycan 223 227 PF01048 0.474
MOD_GlcNHglycan 346 349 PF01048 0.483
MOD_GlcNHglycan 394 397 PF01048 0.571
MOD_GlcNHglycan 64 67 PF01048 0.586
MOD_GlcNHglycan 98 101 PF01048 0.437
MOD_GSK3_1 103 110 PF00069 0.347
MOD_GSK3_1 149 156 PF00069 0.369
MOD_GSK3_1 195 202 PF00069 0.301
MOD_GSK3_1 204 211 PF00069 0.293
MOD_GSK3_1 218 225 PF00069 0.512
MOD_GSK3_1 344 351 PF00069 0.479
MOD_GSK3_1 88 95 PF00069 0.384
MOD_N-GLC_1 337 342 PF02516 0.633
MOD_NEK2_1 150 155 PF00069 0.308
MOD_NEK2_1 190 195 PF00069 0.449
MOD_NEK2_1 317 322 PF00069 0.644
MOD_NEK2_1 334 339 PF00069 0.502
MOD_NEK2_1 391 396 PF00069 0.597
MOD_NEK2_1 85 90 PF00069 0.412
MOD_NEK2_1 96 101 PF00069 0.305
MOD_NEK2_2 107 112 PF00069 0.369
MOD_PKA_2 344 350 PF00069 0.489
MOD_Plk_1 222 228 PF00069 0.410
MOD_Plk_1 337 343 PF00069 0.603
MOD_Plk_4 150 156 PF00069 0.414
MOD_Plk_4 168 174 PF00069 0.252
MOD_Plk_4 263 269 PF00069 0.409
MOD_Plk_4 295 301 PF00069 0.498
MOD_Plk_4 329 335 PF00069 0.596
MOD_Plk_4 349 355 PF00069 0.261
MOD_Plk_4 361 367 PF00069 0.405
MOD_Plk_4 370 376 PF00069 0.560
MOD_Plk_4 386 392 PF00069 0.390
MOD_Plk_4 41 47 PF00069 0.439
MOD_ProDKin_1 16 22 PF00069 0.583
MOD_ProDKin_1 383 389 PF00069 0.410
MOD_SUMO_rev_2 75 83 PF00179 0.349
TRG_DiLeu_BaLyEn_6 143 148 PF01217 0.501
TRG_DiLeu_BaLyEn_6 307 312 PF01217 0.488
TRG_ENDOCYTIC_2 268 271 PF00928 0.492
TRG_ENDOCYTIC_2 302 305 PF00928 0.534
TRG_ENDOCYTIC_2 31 34 PF00928 0.433
TRG_ER_diArg_1 24 27 PF00400 0.502
TRG_ER_diArg_1 313 315 PF00400 0.442
TRG_Pf-PMV_PEXEL_1 228 232 PF00026 0.475
TRG_Pf-PMV_PEXEL_1 315 319 PF00026 0.528

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I2S4 Leptomonas seymouri 70% 100%
A0A0S4KLU0 Bodo saltans 33% 100%
A0A1X0P431 Trypanosomatidae 44% 100%
A0A3Q8IMM4 Leishmania donovani 99% 100%
A0A422P095 Trypanosoma rangeli 42% 100%
A4HLV8 Leishmania braziliensis 80% 100%
D0A664 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 100%
E9B486 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
Q4Q3U0 Leishmania major 92% 100%
V5B8N1 Trypanosoma cruzi 43% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS