LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

SH3 domain-containing protein

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
SH3 domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
E9AHR2_LEIIN
TriTrypDb:
LINF_330033600
Length:
506

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 6
Silverman et al. no yes: 0
Pissara et al. no yes: 4
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Could not find GO cellular_component term for this entry.

Phosphorylation

Amastigote: 191, 417, 440, 490
Promastigote: 230, 405, 430, 472
Promastigote/Amastigote: 113, 13, 228, 377, 407, 418, 442, 474, 480, 482, 485, 491, 5

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

E9AHR2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHR2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 133 137 PF00656 0.459
CLV_C14_Caspase3-7 41 45 PF00656 0.792
CLV_NRD_NRD_1 225 227 PF00675 0.666
CLV_NRD_NRD_1 266 268 PF00675 0.521
CLV_NRD_NRD_1 352 354 PF00675 0.498
CLV_NRD_NRD_1 427 429 PF00675 0.628
CLV_PCSK_FUR_1 223 227 PF00082 0.446
CLV_PCSK_KEX2_1 166 168 PF00082 0.462
CLV_PCSK_KEX2_1 205 207 PF00082 0.390
CLV_PCSK_KEX2_1 211 213 PF00082 0.439
CLV_PCSK_KEX2_1 222 224 PF00082 0.477
CLV_PCSK_KEX2_1 225 227 PF00082 0.341
CLV_PCSK_KEX2_1 266 268 PF00082 0.495
CLV_PCSK_KEX2_1 352 354 PF00082 0.478
CLV_PCSK_KEX2_1 427 429 PF00082 0.631
CLV_PCSK_PC1ET2_1 166 168 PF00082 0.462
CLV_PCSK_PC1ET2_1 205 207 PF00082 0.438
CLV_PCSK_PC1ET2_1 211 213 PF00082 0.464
CLV_PCSK_PC1ET2_1 222 224 PF00082 0.502
CLV_PCSK_SKI1_1 104 108 PF00082 0.588
CLV_PCSK_SKI1_1 346 350 PF00082 0.503
CLV_PCSK_SKI1_1 355 359 PF00082 0.501
CLV_PCSK_SKI1_1 393 397 PF00082 0.711
CLV_PCSK_SKI1_1 98 102 PF00082 0.545
DEG_Nend_UBRbox_1 1 4 PF02207 0.696
DOC_CDC14_PxL_1 108 116 PF14671 0.413
DOC_MAPK_gen_1 98 108 PF00069 0.529
DOC_USP7_MATH_1 404 408 PF00917 0.548
DOC_USP7_MATH_1 414 418 PF00917 0.490
DOC_USP7_MATH_1 437 441 PF00917 0.757
DOC_USP7_MATH_1 453 457 PF00917 0.494
DOC_USP7_MATH_1 493 497 PF00917 0.646
DOC_USP7_UBL2_3 283 287 PF12436 0.599
DOC_WW_Pin1_4 10 15 PF00397 0.729
DOC_WW_Pin1_4 29 34 PF00397 0.781
DOC_WW_Pin1_4 59 64 PF00397 0.736
LIG_14-3-3_CanoR_1 121 129 PF00244 0.526
LIG_14-3-3_CanoR_1 2 10 PF00244 0.692
LIG_14-3-3_CanoR_1 206 211 PF00244 0.504
LIG_14-3-3_CanoR_1 212 221 PF00244 0.493
LIG_14-3-3_CanoR_1 226 236 PF00244 0.398
LIG_14-3-3_CanoR_1 381 385 PF00244 0.668
LIG_14-3-3_CanoR_1 427 435 PF00244 0.697
LIG_14-3-3_CanoR_1 439 444 PF00244 0.637
LIG_14-3-3_CanoR_1 479 484 PF00244 0.622
LIG_14-3-3_CanoR_1 488 493 PF00244 0.643
LIG_Actin_WH2_2 195 213 PF00022 0.441
LIG_BRCT_BRCA1_1 4 8 PF00533 0.693
LIG_FHA_1 297 303 PF00498 0.547
LIG_FHA_1 343 349 PF00498 0.582
LIG_FHA_2 181 187 PF00498 0.525
LIG_FHA_2 360 366 PF00498 0.613
LIG_FHA_2 39 45 PF00498 0.693
LIG_FHA_2 50 56 PF00498 0.754
LIG_LIR_Gen_1 420 426 PF02991 0.571
LIG_LIR_Gen_1 482 492 PF02991 0.750
LIG_LIR_Nem_3 482 487 PF02991 0.748
LIG_LYPXL_SIV_4 168 176 PF13949 0.456
LIG_PCNA_PIPBox_1 1 10 PF02747 0.557
LIG_PCNA_yPIPBox_3 188 199 PF02747 0.516
LIG_SH2_GRB2like 384 387 PF00017 0.678
LIG_SH2_SRC 169 172 PF00017 0.455
LIG_SH2_SRC 384 387 PF00017 0.678
LIG_SH2_STAP1 384 388 PF00017 0.715
LIG_SH2_STAT5 198 201 PF00017 0.421
LIG_SH2_STAT5 79 82 PF00017 0.604
LIG_TRAF2_1 113 116 PF00917 0.553
LIG_TRAF2_1 183 186 PF00917 0.531
LIG_TRAF2_1 215 218 PF00917 0.599
LIG_TRAF2_1 52 55 PF00917 0.596
MOD_CK1_1 110 116 PF00069 0.574
MOD_CK1_1 296 302 PF00069 0.506
MOD_CK1_1 374 380 PF00069 0.654
MOD_CK1_1 387 393 PF00069 0.556
MOD_CK1_1 402 408 PF00069 0.697
MOD_CK1_1 415 421 PF00069 0.502
MOD_CK1_1 451 457 PF00069 0.713
MOD_CK1_1 459 465 PF00069 0.633
MOD_CK1_1 482 488 PF00069 0.646
MOD_CK1_1 496 502 PF00069 0.696
MOD_CK1_1 74 80 PF00069 0.592
MOD_CK2_1 110 116 PF00069 0.562
MOD_CK2_1 180 186 PF00069 0.478
MOD_CK2_1 188 194 PF00069 0.418
MOD_CK2_1 414 420 PF00069 0.571
MOD_CK2_1 49 55 PF00069 0.777
MOD_Cter_Amidation 285 288 PF01082 0.383
MOD_GlcNHglycan 227 230 PF01048 0.483
MOD_GlcNHglycan 282 286 PF01048 0.519
MOD_GlcNHglycan 461 464 PF01048 0.567
MOD_GlcNHglycan 469 474 PF01048 0.495
MOD_GSK3_1 225 232 PF00069 0.573
MOD_GSK3_1 270 277 PF00069 0.516
MOD_GSK3_1 380 387 PF00069 0.649
MOD_GSK3_1 427 434 PF00069 0.646
MOD_GSK3_1 435 442 PF00069 0.703
MOD_GSK3_1 469 476 PF00069 0.619
MOD_GSK3_1 55 62 PF00069 0.693
MOD_N-GLC_1 2 7 PF02516 0.690
MOD_N-GLC_1 374 379 PF02516 0.724
MOD_N-GLC_1 55 60 PF02516 0.609
MOD_NEK2_1 293 298 PF00069 0.512
MOD_NEK2_1 399 404 PF00069 0.715
MOD_NEK2_1 448 453 PF00069 0.674
MOD_NEK2_1 477 482 PF00069 0.661
MOD_NEK2_2 71 76 PF00069 0.428
MOD_PIKK_1 213 219 PF00454 0.595
MOD_PIKK_1 248 254 PF00454 0.529
MOD_PIKK_1 322 328 PF00454 0.555
MOD_PIKK_1 404 410 PF00454 0.481
MOD_PIKK_1 437 443 PF00454 0.757
MOD_PIKK_1 453 459 PF00454 0.568
MOD_PIKK_1 496 502 PF00454 0.686
MOD_PK_1 107 113 PF00069 0.426
MOD_PKA_1 225 231 PF00069 0.481
MOD_PKA_1 427 433 PF00069 0.645
MOD_PKA_2 122 128 PF00069 0.532
MOD_PKA_2 225 231 PF00069 0.578
MOD_PKA_2 293 299 PF00069 0.490
MOD_PKA_2 380 386 PF00069 0.706
MOD_PKA_2 415 421 PF00069 0.630
MOD_PKA_2 427 433 PF00069 0.603
MOD_PKA_2 459 465 PF00069 0.628
MOD_PKA_2 487 493 PF00069 0.679
MOD_PKB_1 223 231 PF00069 0.508
MOD_Plk_1 102 108 PF00069 0.577
MOD_Plk_1 172 178 PF00069 0.523
MOD_Plk_1 180 186 PF00069 0.525
MOD_Plk_1 43 49 PF00069 0.608
MOD_Plk_1 55 61 PF00069 0.491
MOD_Plk_2-3 38 44 PF00069 0.569
MOD_Plk_4 479 485 PF00069 0.753
MOD_ProDKin_1 10 16 PF00069 0.730
MOD_ProDKin_1 29 35 PF00069 0.780
MOD_ProDKin_1 59 65 PF00069 0.733
MOD_SUMO_rev_2 238 248 PF00179 0.524
MOD_SUMO_rev_2 99 106 PF00179 0.566
TRG_DiLeu_BaEn_1 354 359 PF01217 0.491
TRG_DiLeu_BaEn_4 185 191 PF01217 0.459
TRG_ENDOCYTIC_2 369 372 PF00928 0.666
TRG_ER_diArg_1 121 124 PF00400 0.466
TRG_ER_diArg_1 223 226 PF00400 0.443
TRG_ER_diArg_1 265 267 PF00400 0.492
TRG_ER_diArg_1 426 428 PF00400 0.618
TRG_NLS_Bipartite_1 205 226 PF00514 0.530
TRG_NLS_MonoExtC_3 221 226 PF00514 0.509
TRG_Pf-PMV_PEXEL_1 182 186 PF00026 0.517
TRG_Pf-PMV_PEXEL_1 2 6 PF00026 0.650
TRG_Pf-PMV_PEXEL_1 346 350 PF00026 0.586
TRG_Pf-PMV_PEXEL_1 98 102 PF00026 0.588

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IMH4 Leptomonas seymouri 61% 100%
A0A1X0P3T7 Trypanosomatidae 38% 100%
A0A3S7X729 Leishmania donovani 100% 100%
A0A422P039 Trypanosoma rangeli 37% 100%
A4HLV5 Leishmania braziliensis 56% 100%
E9B483 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 99%
Q4Q3U3 Leishmania major 91% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS