LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
E9AHR1_LEIIN
TriTrypDb:
LINF_330033400
Length:
650

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005777 peroxisome 6 1
GO:0020015 glycosome 7 1
GO:0042579 microbody 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9AHR1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHR1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 174 178 PF00656 0.553
CLV_C14_Caspase3-7 9 13 PF00656 0.364
CLV_NRD_NRD_1 279 281 PF00675 0.394
CLV_NRD_NRD_1 537 539 PF00675 0.468
CLV_NRD_NRD_1 541 543 PF00675 0.458
CLV_NRD_NRD_1 575 577 PF00675 0.490
CLV_NRD_NRD_1 613 615 PF00675 0.436
CLV_NRD_NRD_1 99 101 PF00675 0.525
CLV_PCSK_FUR_1 277 281 PF00082 0.456
CLV_PCSK_FUR_1 535 539 PF00082 0.505
CLV_PCSK_KEX2_1 279 281 PF00082 0.428
CLV_PCSK_KEX2_1 537 539 PF00082 0.474
CLV_PCSK_KEX2_1 541 543 PF00082 0.464
CLV_PCSK_KEX2_1 575 577 PF00082 0.490
CLV_PCSK_KEX2_1 99 101 PF00082 0.525
CLV_PCSK_PC7_1 537 543 PF00082 0.568
CLV_PCSK_SKI1_1 197 201 PF00082 0.508
CLV_PCSK_SKI1_1 280 284 PF00082 0.404
CLV_PCSK_SKI1_1 455 459 PF00082 0.431
CLV_PCSK_SKI1_1 537 541 PF00082 0.495
CLV_PCSK_SKI1_1 67 71 PF00082 0.392
CLV_Separin_Metazoa 426 430 PF03568 0.481
DEG_APCC_DBOX_1 279 287 PF00400 0.429
DEG_APCC_DBOX_1 536 544 PF00400 0.566
DEG_Nend_Nbox_1 1 3 PF02207 0.362
DEG_SPOP_SBC_1 388 392 PF00917 0.536
DEG_SPOP_SBC_1 620 624 PF00917 0.414
DOC_CKS1_1 16 21 PF01111 0.392
DOC_CYCLIN_RxL_1 450 461 PF00134 0.518
DOC_CYCLIN_yCln2_LP_2 384 387 PF00134 0.529
DOC_CYCLIN_yCln2_LP_2 409 415 PF00134 0.367
DOC_MAPK_gen_1 161 171 PF00069 0.639
DOC_MAPK_gen_1 185 193 PF00069 0.389
DOC_MAPK_gen_1 99 107 PF00069 0.474
DOC_MAPK_MEF2A_6 99 107 PF00069 0.432
DOC_MAPK_NFAT4_5 100 108 PF00069 0.476
DOC_PP1_SILK_1 286 291 PF00149 0.460
DOC_PP2B_LxvP_1 362 365 PF13499 0.491
DOC_PP2B_LxvP_1 384 387 PF13499 0.529
DOC_PP2B_LxvP_1 409 412 PF13499 0.345
DOC_USP7_MATH_1 394 398 PF00917 0.716
DOC_USP7_MATH_1 559 563 PF00917 0.621
DOC_USP7_MATH_1 613 617 PF00917 0.563
DOC_USP7_UBL2_3 611 615 PF12436 0.402
DOC_WW_Pin1_4 15 20 PF00397 0.381
DOC_WW_Pin1_4 240 245 PF00397 0.492
DOC_WW_Pin1_4 29 34 PF00397 0.407
DOC_WW_Pin1_4 477 482 PF00397 0.649
DOC_WW_Pin1_4 82 87 PF00397 0.597
LIG_14-3-3_CanoR_1 148 156 PF00244 0.573
LIG_14-3-3_CanoR_1 217 222 PF00244 0.410
LIG_14-3-3_CanoR_1 280 289 PF00244 0.463
LIG_14-3-3_CanoR_1 39 48 PF00244 0.419
LIG_14-3-3_CanoR_1 462 467 PF00244 0.595
LIG_14-3-3_CanoR_1 614 621 PF00244 0.534
LIG_Actin_WH2_2 44 59 PF00022 0.411
LIG_APCC_ABBA_1 515 520 PF00400 0.515
LIG_BRCT_BRCA1_1 31 35 PF00533 0.488
LIG_BRCT_BRCA1_1 416 420 PF00533 0.433
LIG_BRCT_BRCA1_1 439 443 PF00533 0.375
LIG_BRCT_BRCA1_2 439 445 PF00533 0.394
LIG_deltaCOP1_diTrp_1 467 474 PF00928 0.635
LIG_DLG_GKlike_1 217 225 PF00625 0.402
LIG_DLG_GKlike_1 563 570 PF00625 0.528
LIG_eIF4E_1 331 337 PF01652 0.496
LIG_FHA_1 151 157 PF00498 0.492
LIG_FHA_1 331 337 PF00498 0.437
LIG_FHA_1 376 382 PF00498 0.631
LIG_FHA_1 51 57 PF00498 0.479
LIG_FHA_1 544 550 PF00498 0.558
LIG_FHA_1 602 608 PF00498 0.477
LIG_FHA_2 172 178 PF00498 0.469
LIG_FHA_2 184 190 PF00498 0.364
LIG_FHA_2 50 56 PF00498 0.371
LIG_FHA_2 509 515 PF00498 0.441
LIG_FHA_2 620 626 PF00498 0.540
LIG_FHA_2 634 640 PF00498 0.492
LIG_FHA_2 7 13 PF00498 0.434
LIG_GBD_Chelix_1 403 411 PF00786 0.411
LIG_Integrin_isoDGR_2 23 25 PF01839 0.530
LIG_KLC1_Yacidic_2 189 194 PF13176 0.473
LIG_LIR_Gen_1 215 226 PF02991 0.473
LIG_LIR_Gen_1 440 448 PF02991 0.412
LIG_LIR_Gen_1 566 574 PF02991 0.545
LIG_LIR_Nem_3 189 195 PF02991 0.348
LIG_LIR_Nem_3 220 225 PF02991 0.385
LIG_LIR_Nem_3 3 8 PF02991 0.460
LIG_LIR_Nem_3 32 38 PF02991 0.406
LIG_LIR_Nem_3 440 446 PF02991 0.428
LIG_LIR_Nem_3 516 521 PF02991 0.436
LIG_LIR_Nem_3 566 570 PF02991 0.544
LIG_LIR_Nem_3 583 589 PF02991 0.479
LIG_LIR_Nem_3 60 66 PF02991 0.411
LIG_LIR_Nem_3 72 76 PF02991 0.490
LIG_MLH1_MIPbox_1 416 420 PF16413 0.433
LIG_NRBOX 358 364 PF00104 0.451
LIG_NRBOX 453 459 PF00104 0.497
LIG_NRBOX 602 608 PF00104 0.494
LIG_Pex14_1 271 275 PF04695 0.373
LIG_Pex14_1 470 474 PF04695 0.639
LIG_Pex14_2 416 420 PF04695 0.356
LIG_PTB_Apo_2 585 592 PF02174 0.446
LIG_PTB_Phospho_1 585 591 PF10480 0.452
LIG_SH2_CRK 499 503 PF00017 0.483
LIG_SH2_NCK_1 609 613 PF00017 0.440
LIG_SH2_SRC 26 29 PF00017 0.507
LIG_SH2_SRC 293 296 PF00017 0.503
LIG_SH2_STAP1 127 131 PF00017 0.425
LIG_SH2_STAP1 233 237 PF00017 0.385
LIG_SH2_STAP1 331 335 PF00017 0.470
LIG_SH2_STAP1 513 517 PF00017 0.433
LIG_SH2_STAP1 567 571 PF00017 0.565
LIG_SH2_STAP1 609 613 PF00017 0.440
LIG_SH2_STAT3 331 334 PF00017 0.489
LIG_SH2_STAT5 108 111 PF00017 0.360
LIG_SH2_STAT5 192 195 PF00017 0.422
LIG_SH2_STAT5 228 231 PF00017 0.347
LIG_SH2_STAT5 26 29 PF00017 0.404
LIG_SH2_STAT5 275 278 PF00017 0.433
LIG_SH2_STAT5 419 422 PF00017 0.420
LIG_SH2_STAT5 456 459 PF00017 0.390
LIG_SH2_STAT5 591 594 PF00017 0.389
LIG_SH2_STAT5 76 79 PF00017 0.482
LIG_SH3_3 238 244 PF00018 0.490
LIG_SH3_3 260 266 PF00018 0.586
LIG_SH3_3 382 388 PF00018 0.707
LIG_SH3_3 553 559 PF00018 0.604
LIG_SH3_3 59 65 PF00018 0.368
LIG_SUMO_SIM_par_1 103 109 PF11976 0.349
LIG_SUMO_SIM_par_1 243 249 PF11976 0.563
LIG_TRAF2_1 465 468 PF00917 0.474
LIG_TRFH_1 64 68 PF08558 0.305
LIG_TYR_ITIM 226 231 PF00017 0.466
LIG_UBA3_1 246 252 PF00899 0.490
LIG_WW_3 96 100 PF00397 0.566
MOD_CDK_SPK_2 477 482 PF00069 0.658
MOD_CDK_SPxK_1 15 21 PF00069 0.385
MOD_CK1_1 106 112 PF00069 0.344
MOD_CK1_1 150 156 PF00069 0.548
MOD_CK1_1 330 336 PF00069 0.395
MOD_CK1_1 449 455 PF00069 0.419
MOD_CK1_1 548 554 PF00069 0.528
MOD_CK2_1 183 189 PF00069 0.444
MOD_CK2_1 392 398 PF00069 0.552
MOD_CK2_1 462 468 PF00069 0.456
MOD_CK2_1 477 483 PF00069 0.531
MOD_CK2_1 508 514 PF00069 0.465
MOD_CK2_1 563 569 PF00069 0.613
MOD_CK2_1 619 625 PF00069 0.588
MOD_GlcNHglycan 128 131 PF01048 0.512
MOD_GlcNHglycan 157 161 PF01048 0.706
MOD_GlcNHglycan 177 180 PF01048 0.232
MOD_GlcNHglycan 200 203 PF01048 0.500
MOD_GlcNHglycan 576 579 PF01048 0.554
MOD_GlcNHglycan 646 649 PF01048 0.606
MOD_GSK3_1 11 18 PF00069 0.350
MOD_GSK3_1 171 178 PF00069 0.453
MOD_GSK3_1 375 382 PF00069 0.577
MOD_GSK3_1 388 395 PF00069 0.625
MOD_GSK3_1 437 444 PF00069 0.428
MOD_GSK3_1 559 566 PF00069 0.577
MOD_GSK3_1 570 577 PF00069 0.548
MOD_GSK3_1 82 89 PF00069 0.580
MOD_N-GLC_2 47 49 PF02516 0.326
MOD_NEK2_1 103 108 PF00069 0.334
MOD_NEK2_1 11 16 PF00069 0.353
MOD_NEK2_1 246 251 PF00069 0.566
MOD_NEK2_1 374 379 PF00069 0.611
MOD_NEK2_1 543 548 PF00069 0.552
MOD_NEK2_1 570 575 PF00069 0.545
MOD_NEK2_1 601 606 PF00069 0.474
MOD_NEK2_1 69 74 PF00069 0.464
MOD_NEK2_2 513 518 PF00069 0.431
MOD_OFUCOSY 170 175 PF10250 0.402
MOD_PIKK_1 212 218 PF00454 0.459
MOD_PIKK_1 305 311 PF00454 0.680
MOD_PIKK_1 330 336 PF00454 0.514
MOD_PIKK_1 484 490 PF00454 0.600
MOD_PIKK_1 527 533 PF00454 0.526
MOD_PIKK_1 543 549 PF00454 0.456
MOD_PK_1 462 468 PF00069 0.614
MOD_PK_1 545 551 PF00069 0.505
MOD_PKA_2 147 153 PF00069 0.521
MOD_PKA_2 171 177 PF00069 0.374
MOD_PKA_2 374 380 PF00069 0.601
MOD_PKA_2 574 580 PF00069 0.492
MOD_PKA_2 613 619 PF00069 0.567
MOD_Plk_1 375 381 PF00069 0.654
MOD_Plk_1 513 519 PF00069 0.432
MOD_Plk_2-3 265 271 PF00069 0.353
MOD_Plk_4 103 109 PF00069 0.405
MOD_Plk_4 11 17 PF00069 0.372
MOD_Plk_4 117 123 PF00069 0.427
MOD_Plk_4 150 156 PF00069 0.563
MOD_Plk_4 217 223 PF00069 0.406
MOD_Plk_4 251 257 PF00069 0.546
MOD_Plk_4 437 443 PF00069 0.414
MOD_Plk_4 513 519 PF00069 0.441
MOD_ProDKin_1 15 21 PF00069 0.386
MOD_ProDKin_1 240 246 PF00069 0.497
MOD_ProDKin_1 29 35 PF00069 0.404
MOD_ProDKin_1 477 483 PF00069 0.645
MOD_ProDKin_1 82 88 PF00069 0.604
MOD_SUMO_for_1 165 168 PF00179 0.403
MOD_SUMO_rev_2 265 273 PF00179 0.528
MOD_SUMO_rev_2 302 307 PF00179 0.611
TRG_DiLeu_BaEn_1 324 329 PF01217 0.530
TRG_DiLeu_BaEn_4 467 473 PF01217 0.511
TRG_DiLeu_BaLyEn_6 241 246 PF01217 0.496
TRG_ENDOCYTIC_2 218 221 PF00928 0.343
TRG_ENDOCYTIC_2 228 231 PF00928 0.360
TRG_ENDOCYTIC_2 26 29 PF00928 0.385
TRG_ENDOCYTIC_2 499 502 PF00928 0.522
TRG_ENDOCYTIC_2 5 8 PF00928 0.445
TRG_ENDOCYTIC_2 567 570 PF00928 0.549
TRG_ENDOCYTIC_2 63 66 PF00928 0.363
TRG_ER_diArg_1 184 187 PF00400 0.433
TRG_ER_diArg_1 276 279 PF00400 0.435
TRG_ER_diArg_1 535 538 PF00400 0.486
TRG_ER_diArg_1 540 542 PF00400 0.489
TRG_ER_diArg_1 574 576 PF00400 0.494
TRG_ER_diArg_1 98 100 PF00400 0.547
TRG_Pf-PMV_PEXEL_1 57 61 PF00026 0.407
TRG_PTS1 647 650 PF00515 0.577

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PF78 Leptomonas seymouri 63% 100%
A0A0S4IPL3 Bodo saltans 31% 100%
A0A1X0P3T8 Trypanosomatidae 34% 100%
A0A3Q8IHN4 Leishmania donovani 100% 100%
A0A3R7MTT7 Trypanosoma rangeli 36% 100%
A4HLV4 Leishmania braziliensis 75% 100%
D0A669 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 100%
E9B482 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
Q4Q3U4 Leishmania major 93% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS