Diphthamide biosynthesis protein 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative diphthamide synthesis protein - putative

Species:

Leishmania infantum

UniProt:

E9AHQ9_LEIIN

TriTrypDb:

LINF_330033200

Length:

771

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AHQ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHQ9

Function

Biological processes
Term	Name	Level	Count
GO:0006417	regulation of translation	6	11
GO:0006448	regulation of translational elongation	7	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009889	regulation of biosynthetic process	4	11
GO:0009987	cellular process	1	11
GO:0010468	regulation of gene expression	5	11
GO:0010556	regulation of macromolecule biosynthetic process	5	11
GO:0010608	post-transcriptional regulation of gene expression	6	11
GO:0017182	peptidyl-diphthamide metabolic process	7	11
GO:0017183	peptidyl-diphthamide biosynthetic process from peptidyl-histidine	4	11
GO:0018193	peptidyl-amino acid modification	5	11
GO:0018202	peptidyl-histidine modification	6	11
GO:0019222	regulation of metabolic process	3	11
GO:0019538	protein metabolic process	3	11
GO:0031323	regulation of cellular metabolic process	4	11
GO:0031326	regulation of cellular biosynthetic process	5	11
GO:0034248	regulation of amide metabolic process	5	11
GO:0036211	protein modification process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0050789	regulation of biological process	2	11
GO:0050794	regulation of cellular process	3	11
GO:0051171	regulation of nitrogen compound metabolic process	4	11
GO:0051246	regulation of protein metabolic process	5	11
GO:0060255	regulation of macromolecule metabolic process	4	11
GO:0065007	biological regulation	1	11
GO:0071704	organic substance metabolic process	2	11
GO:0080090	regulation of primary metabolic process	4	11
GO:1900247	regulation of cytoplasmic translational elongation	8	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016740	transferase activity	2	11
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3	11
GO:0090560	2-(3-amino-3-carboxypropyl)histidine synthase activity	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	265	269	PF00656	0.317
CLV_C14_Caspase3-7	491	495	PF00656	0.502
CLV_C14_Caspase3-7	612	616	PF00656	0.523
CLV_MEL_PAP_1	732	738	PF00089	0.675
CLV_NRD_NRD_1	19	21	PF00675	0.523
CLV_NRD_NRD_1	331	333	PF00675	0.463
CLV_NRD_NRD_1	526	528	PF00675	0.362
CLV_NRD_NRD_1	667	669	PF00675	0.445
CLV_PCSK_FUR_1	17	21	PF00082	0.634
CLV_PCSK_KEX2_1	19	21	PF00082	0.524
CLV_PCSK_KEX2_1	331	333	PF00082	0.507
CLV_PCSK_KEX2_1	526	528	PF00082	0.282
CLV_PCSK_KEX2_1	572	574	PF00082	0.282
CLV_PCSK_KEX2_1	613	615	PF00082	0.356
CLV_PCSK_KEX2_1	661	663	PF00082	0.535
CLV_PCSK_KEX2_1	667	669	PF00082	0.502
CLV_PCSK_PC1ET2_1	572	574	PF00082	0.282
CLV_PCSK_PC1ET2_1	613	615	PF00082	0.362
CLV_PCSK_PC1ET2_1	661	663	PF00082	0.560
CLV_PCSK_PC7_1	15	21	PF00082	0.515
CLV_PCSK_PC7_1	568	574	PF00082	0.282
CLV_PCSK_SKI1_1	102	106	PF00082	0.367
CLV_PCSK_SKI1_1	182	186	PF00082	0.621
CLV_Separin_Metazoa	276	280	PF03568	0.377
DEG_APCC_DBOX_1	94	102	PF00400	0.408
DEG_COP1_1	63	72	PF00400	0.453
DEG_Kelch_Keap1_1	375	380	PF01344	0.635
DEG_Nend_Nbox_1	1	3	PF02207	0.559
DEG_SPOP_SBC_1	373	377	PF00917	0.628
DEG_SPOP_SBC_1	393	397	PF00917	0.650
DOC_MAPK_gen_1	572	579	PF00069	0.482
DOC_MAPK_MEF2A_6	539	548	PF00069	0.482
DOC_MAPK_RevD_3	655	668	PF00069	0.375
DOC_PP2B_LxvP_1	96	99	PF13499	0.522
DOC_PP2B_PxIxI_1	311	317	PF00149	0.408
DOC_PP4_FxxP_1	617	620	PF00568	0.496
DOC_USP7_MATH_1	178	182	PF00917	0.612
DOC_USP7_MATH_1	192	196	PF00917	0.346
DOC_USP7_MATH_1	230	234	PF00917	0.496
DOC_USP7_MATH_1	365	369	PF00917	0.640
DOC_USP7_MATH_1	413	417	PF00917	0.469
DOC_USP7_MATH_1	447	451	PF00917	0.511
DOC_USP7_MATH_1	482	486	PF00917	0.460
DOC_USP7_MATH_1	630	634	PF00917	0.581
DOC_USP7_MATH_1	666	670	PF00917	0.517
DOC_USP7_MATH_1	91	95	PF00917	0.684
DOC_WW_Pin1_4	620	625	PF00397	0.482
DOC_WW_Pin1_4	736	741	PF00397	0.552
LIG_14-3-3_CanoR_1	17	25	PF00244	0.528
LIG_14-3-3_CanoR_1	182	187	PF00244	0.689
LIG_14-3-3_CanoR_1	279	289	PF00244	0.471
LIG_14-3-3_CanoR_1	331	341	PF00244	0.532
LIG_14-3-3_CanoR_1	351	356	PF00244	0.627
LIG_14-3-3_CanoR_1	392	401	PF00244	0.620
LIG_14-3-3_CanoR_1	519	525	PF00244	0.491
LIG_14-3-3_CanoR_1	539	548	PF00244	0.452
LIG_14-3-3_CanoR_1	692	700	PF00244	0.702
LIG_BH_BH3_1	36	52	PF00452	0.295
LIG_deltaCOP1_diTrp_1	380	390	PF00928	0.484
LIG_FHA_1	252	258	PF00498	0.606
LIG_FHA_1	320	326	PF00498	0.459
LIG_FHA_1	491	497	PF00498	0.512
LIG_FHA_1	558	564	PF00498	0.497
LIG_FHA_1	87	93	PF00498	0.531
LIG_FHA_2	263	269	PF00498	0.332
LIG_FHA_2	333	339	PF00498	0.600
LIG_FHA_2	630	636	PF00498	0.554
LIG_FHA_2	676	682	PF00498	0.663
LIG_GBD_Chelix_1	281	289	PF00786	0.411
LIG_LIR_Apic_2	615	620	PF02991	0.515
LIG_LIR_Gen_1	404	414	PF02991	0.511
LIG_LIR_Gen_1	426	436	PF02991	0.536
LIG_LIR_Gen_1	595	603	PF02991	0.482
LIG_LIR_Gen_1	650	660	PF02991	0.412
LIG_LIR_Nem_3	137	141	PF02991	0.426
LIG_LIR_Nem_3	344	348	PF02991	0.373
LIG_LIR_Nem_3	404	410	PF02991	0.475
LIG_LIR_Nem_3	426	431	PF02991	0.529
LIG_LIR_Nem_3	554	559	PF02991	0.534
LIG_LIR_Nem_3	574	578	PF02991	0.350
LIG_LIR_Nem_3	595	600	PF02991	0.482
LIG_LIR_Nem_3	650	656	PF02991	0.407
LIG_LIR_Nem_3	726	732	PF02991	0.559
LIG_NRBOX	562	568	PF00104	0.496
LIG_SH2_CRK	100	104	PF00017	0.407
LIG_SH2_PTP2	242	245	PF00017	0.562
LIG_SH2_PTP2	729	732	PF00017	0.636
LIG_SH2_SRC	132	135	PF00017	0.567
LIG_SH2_STAP1	649	653	PF00017	0.427
LIG_SH2_STAT5	132	135	PF00017	0.567
LIG_SH2_STAT5	219	222	PF00017	0.552
LIG_SH2_STAT5	242	245	PF00017	0.482
LIG_SH2_STAT5	407	410	PF00017	0.375
LIG_SH2_STAT5	440	443	PF00017	0.456
LIG_SH2_STAT5	578	581	PF00017	0.490
LIG_SH2_STAT5	649	652	PF00017	0.498
LIG_SH2_STAT5	729	732	PF00017	0.636
LIG_SH3_3	154	160	PF00018	0.742
LIG_SH3_3	186	192	PF00018	0.668
LIG_SH3_3	306	312	PF00018	0.568
LIG_SH3_3	385	391	PF00018	0.505
LIG_SH3_3	597	603	PF00018	0.562
LIG_SH3_3	64	70	PF00018	0.451
LIG_SUMO_SIM_anti_2	114	120	PF11976	0.424
LIG_SUMO_SIM_par_1	626	633	PF11976	0.513
LIG_TYR_ITIM	98	103	PF00017	0.347
MOD_CK1_1	233	239	PF00069	0.337
MOD_CK1_1	375	381	PF00069	0.570
MOD_CK1_1	395	401	PF00069	0.463
MOD_CK1_1	53	59	PF00069	0.519
MOD_CK1_1	605	611	PF00069	0.398
MOD_CK1_1	703	709	PF00069	0.744
MOD_CK2_1	331	337	PF00069	0.606
MOD_CK2_1	374	380	PF00069	0.591
MOD_CK2_1	620	626	PF00069	0.335
MOD_CK2_1	666	672	PF00069	0.621
MOD_Cter_Amidation	570	573	PF01082	0.335
MOD_GlcNHglycan	249	252	PF01048	0.537
MOD_GlcNHglycan	282	285	PF01048	0.531
MOD_GlcNHglycan	302	305	PF01048	0.561
MOD_GlcNHglycan	366	370	PF01048	0.682
MOD_GlcNHglycan	377	380	PF01048	0.644
MOD_GlcNHglycan	398	401	PF01048	0.565
MOD_GlcNHglycan	416	419	PF01048	0.403
MOD_GlcNHglycan	486	489	PF01048	0.528
MOD_GlcNHglycan	500	503	PF01048	0.412
MOD_GlcNHglycan	52	55	PF01048	0.488
MOD_GlcNHglycan	541	544	PF01048	0.354
MOD_GlcNHglycan	632	635	PF01048	0.460
MOD_GlcNHglycan	64	67	PF01048	0.516
MOD_GlcNHglycan	695	698	PF01048	0.620
MOD_GlcNHglycan	705	708	PF01048	0.605
MOD_GlcNHglycan	73	76	PF01048	0.473
MOD_GlcNHglycan	767	770	PF01048	0.755
MOD_GSK3_1	178	185	PF00069	0.614
MOD_GSK3_1	247	254	PF00069	0.424
MOD_GSK3_1	332	339	PF00069	0.511
MOD_GSK3_1	392	399	PF00069	0.608
MOD_GSK3_1	482	489	PF00069	0.587
MOD_GSK3_1	630	637	PF00069	0.419
MOD_GSK3_1	666	673	PF00069	0.568
MOD_GSK3_1	675	682	PF00069	0.668
MOD_LATS_1	180	186	PF00433	0.621
MOD_N-GLC_1	473	478	PF02516	0.501
MOD_NEK2_1	232	237	PF00069	0.340
MOD_NEK2_1	247	252	PF00069	0.401
MOD_NEK2_1	394	399	PF00069	0.637
MOD_NEK2_1	50	55	PF00069	0.444
MOD_NEK2_1	547	552	PF00069	0.426
MOD_NEK2_1	85	90	PF00069	0.457
MOD_NEK2_2	192	197	PF00069	0.316
MOD_PIKK_1	557	563	PF00454	0.447
MOD_PIKK_1	634	640	PF00454	0.586
MOD_PIKK_1	679	685	PF00454	0.719
MOD_PIKK_1	714	720	PF00454	0.635
MOD_PK_1	351	357	PF00069	0.632
MOD_PKA_1	331	337	PF00069	0.447
MOD_PKA_2	18	24	PF00069	0.682
MOD_PKA_2	233	239	PF00069	0.320
MOD_PKA_2	287	293	PF00069	0.558
MOD_PKA_2	331	337	PF00069	0.649
MOD_PKA_2	538	544	PF00069	0.342
MOD_PKA_2	605	611	PF00069	0.371
MOD_PKA_2	666	672	PF00069	0.588
MOD_PKA_2	691	697	PF00069	0.693
MOD_PKA_2	700	706	PF00069	0.604
MOD_Plk_1	202	208	PF00069	0.335
MOD_Plk_1	336	342	PF00069	0.618
MOD_Plk_4	262	268	PF00069	0.433
MOD_ProDKin_1	620	626	PF00069	0.335
MOD_ProDKin_1	736	742	PF00069	0.552
MOD_SUMO_rev_2	134	141	PF00179	0.612
TRG_DiLeu_BaEn_1	404	409	PF01217	0.406
TRG_DiLeu_BaLyEn_6	655	660	PF01217	0.385
TRG_ENDOCYTIC_2	100	103	PF00928	0.479
TRG_ENDOCYTIC_2	407	410	PF00928	0.424
TRG_ENDOCYTIC_2	428	431	PF00928	0.435
TRG_ENDOCYTIC_2	433	436	PF00928	0.440
TRG_ENDOCYTIC_2	556	559	PF00928	0.389
TRG_ENDOCYTIC_2	729	732	PF00928	0.636
TRG_ER_diArg_1	17	20	PF00400	0.593
TRG_ER_diArg_1	285	288	PF00400	0.404
TRG_ER_diArg_1	310	313	PF00400	0.367
TRG_ER_diArg_1	331	333	PF00400	0.507
TRG_ER_diArg_1	526	529	PF00400	0.361
TRG_Pf-PMV_PEXEL_1	36	40	PF00026	0.480

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8D8	Leptomonas seymouri	53%	100%
A0A1X0P3T2	Trypanosomatidae	39%	100%
A0A3S5ISG6	Trypanosoma rangeli	38%	100%
A0A3S7X6Z1	Leishmania donovani	98%	100%
A4HLV3	Leishmania braziliensis	72%	99%
D0A670	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9B480	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	99%
Q4Q3U6	Leishmania major	91%	99%
V5BP75	Trypanosoma cruzi	37%	100%