LeishMANIAdb
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Putative ras-like small GTPases

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative ras-like small GTPases
Gene product:
ras-like small GTPases - putative
Species:
Leishmania infantum
UniProt:
E9AHQ8_LEIIN
TriTrypDb:
LINF_330033100
Length:
567

Annotations

Annotations by Jardim et al.

Intracellular protein trafficking, ras-like small GTPases

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005654 nucleoplasm 2 1
GO:0005730 nucleolus 5 1
GO:0043226 organelle 2 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9AHQ8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHQ8

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 11
GO:0003824 catalytic activity 1 5
GO:0003924 GTPase activity 7 5
GO:0003925 G protein activity 2 5
GO:0005488 binding 1 11
GO:0005525 GTP binding 5 11
GO:0016462 pyrophosphatase activity 5 5
GO:0016787 hydrolase activity 2 5
GO:0016817 hydrolase activity, acting on acid anhydrides 3 5
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 5
GO:0017076 purine nucleotide binding 4 11
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 5
GO:0019001 guanyl nucleotide binding 5 11
GO:0032553 ribonucleotide binding 3 11
GO:0032555 purine ribonucleotide binding 4 11
GO:0032561 guanyl ribonucleotide binding 5 11
GO:0035639 purine ribonucleoside triphosphate binding 4 11
GO:0036094 small molecule binding 2 11
GO:0043167 ion binding 2 11
GO:0043168 anion binding 3 11
GO:0097159 organic cyclic compound binding 2 11
GO:0097367 carbohydrate derivative binding 2 11
GO:0098772 molecular function regulator activity 1 5
GO:1901265 nucleoside phosphate binding 3 11
GO:1901363 heterocyclic compound binding 2 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 248 252 PF00656 0.337
CLV_C14_Caspase3-7 466 470 PF00656 0.324
CLV_C14_Caspase3-7 556 560 PF00656 0.552
CLV_NRD_NRD_1 132 134 PF00675 0.434
CLV_NRD_NRD_1 178 180 PF00675 0.477
CLV_NRD_NRD_1 230 232 PF00675 0.464
CLV_NRD_NRD_1 286 288 PF00675 0.390
CLV_NRD_NRD_1 299 301 PF00675 0.451
CLV_NRD_NRD_1 323 325 PF00675 0.240
CLV_NRD_NRD_1 444 446 PF00675 0.388
CLV_NRD_NRD_1 53 55 PF00675 0.583
CLV_PCSK_KEX2_1 131 133 PF00082 0.456
CLV_PCSK_KEX2_1 178 180 PF00082 0.477
CLV_PCSK_KEX2_1 286 288 PF00082 0.390
CLV_PCSK_KEX2_1 323 325 PF00082 0.240
CLV_PCSK_KEX2_1 444 446 PF00082 0.385
CLV_PCSK_KEX2_1 53 55 PF00082 0.646
CLV_PCSK_KEX2_1 546 548 PF00082 0.600
CLV_PCSK_PC1ET2_1 323 325 PF00082 0.240
CLV_PCSK_PC1ET2_1 546 548 PF00082 0.654
CLV_PCSK_SKI1_1 133 137 PF00082 0.473
CLV_PCSK_SKI1_1 247 251 PF00082 0.542
CLV_PCSK_SKI1_1 29 33 PF00082 0.554
CLV_PCSK_SKI1_1 461 465 PF00082 0.321
CLV_PCSK_SKI1_1 520 524 PF00082 0.468
DEG_Kelch_Keap1_1 294 299 PF01344 0.507
DOC_CYCLIN_yCln2_LP_2 378 384 PF00134 0.336
DOC_MAPK_DCC_7 413 422 PF00069 0.461
DOC_MAPK_gen_1 131 140 PF00069 0.457
DOC_MAPK_gen_1 231 238 PF00069 0.310
DOC_MAPK_gen_1 29 37 PF00069 0.640
DOC_MAPK_gen_1 300 307 PF00069 0.357
DOC_MAPK_gen_1 323 330 PF00069 0.410
DOC_MAPK_gen_1 53 61 PF00069 0.614
DOC_MAPK_HePTP_8 128 140 PF00069 0.552
DOC_MAPK_MEF2A_6 131 140 PF00069 0.552
DOC_MAPK_MEF2A_6 231 238 PF00069 0.308
DOC_MAPK_MEF2A_6 300 307 PF00069 0.357
DOC_MAPK_NFAT4_5 133 141 PF00069 0.558
DOC_MIT_MIM_1 210 219 PF04212 0.337
DOC_PP2B_LxvP_1 35 38 PF13499 0.620
DOC_PP2B_LxvP_1 59 62 PF13499 0.632
DOC_USP7_MATH_1 272 276 PF00917 0.505
DOC_USP7_MATH_1 494 498 PF00917 0.629
DOC_USP7_MATH_1 505 509 PF00917 0.654
DOC_USP7_UBL2_3 29 33 PF12436 0.553
DOC_USP7_UBL2_3 545 549 PF12436 0.632
DOC_USP7_UBL2_3 6 10 PF12436 0.547
DOC_WW_Pin1_4 356 361 PF00397 0.423
LIG_14-3-3_CanoR_1 141 149 PF00244 0.513
LIG_14-3-3_CanoR_1 215 223 PF00244 0.363
LIG_14-3-3_CanoR_1 224 228 PF00244 0.382
LIG_14-3-3_CanoR_1 286 292 PF00244 0.479
LIG_14-3-3_CanoR_1 374 382 PF00244 0.399
LIG_14-3-3_CanoR_1 493 501 PF00244 0.636
LIG_14-3-3_CanoR_1 520 525 PF00244 0.466
LIG_14-3-3_CanoR_1 53 59 PF00244 0.555
LIG_14-3-3_CanoR_1 547 555 PF00244 0.552
LIG_Actin_WH2_2 28 43 PF00022 0.556
LIG_APCC_ABBA_1 530 535 PF00400 0.390
LIG_deltaCOP1_diTrp_1 251 257 PF00928 0.352
LIG_Dynein_DLC8_1 44 50 PF01221 0.516
LIG_EH_1 379 383 PF12763 0.402
LIG_FHA_1 135 141 PF00498 0.463
LIG_FHA_1 527 533 PF00498 0.349
LIG_FHA_1 53 59 PF00498 0.626
LIG_FHA_2 125 131 PF00498 0.585
LIG_FHA_2 215 221 PF00498 0.363
LIG_FHA_2 224 230 PF00498 0.396
LIG_FHA_2 339 345 PF00498 0.441
LIG_FHA_2 508 514 PF00498 0.678
LIG_LIR_Apic_2 148 152 PF02991 0.630
LIG_LIR_Apic_2 552 558 PF02991 0.549
LIG_LIR_Gen_1 191 196 PF02991 0.321
LIG_LIR_Nem_3 191 195 PF02991 0.349
LIG_LIR_Nem_3 251 256 PF02991 0.358
LIG_LIR_Nem_3 282 288 PF02991 0.343
LIG_LIR_Nem_3 489 495 PF02991 0.545
LIG_LRP6_Inhibitor_1 368 374 PF00058 0.305
LIG_LYPXL_yS_3 310 313 PF13949 0.410
LIG_PDZ_Class_3 562 567 PF00595 0.688
LIG_Pex14_1 253 257 PF04695 0.297
LIG_Pex14_2 188 192 PF04695 0.339
LIG_SH2_CRK 475 479 PF00017 0.320
LIG_SH2_CRK 492 496 PF00017 0.552
LIG_SH2_NCK_1 555 559 PF00017 0.677
LIG_SH2_SRC 555 558 PF00017 0.548
LIG_SH2_STAT3 256 259 PF00017 0.371
LIG_SH2_STAT5 256 259 PF00017 0.440
LIG_SH2_STAT5 280 283 PF00017 0.315
LIG_SH2_STAT5 475 478 PF00017 0.327
LIG_SH3_3 354 360 PF00018 0.410
LIG_SH3_3 378 384 PF00018 0.336
LIG_SUMO_SIM_par_1 136 144 PF11976 0.565
LIG_TYR_ITIM 308 313 PF00017 0.244
LIG_UBA3_1 318 325 PF00899 0.287
LIG_WRC_WIRS_1 527 532 PF05994 0.336
MOD_CK1_1 294 300 PF00069 0.553
MOD_CK1_1 5 11 PF00069 0.667
MOD_CK1_1 57 63 PF00069 0.575
MOD_CK1_1 73 79 PF00069 0.613
MOD_CK2_1 214 220 PF00069 0.388
MOD_CK2_1 223 229 PF00069 0.449
MOD_CK2_1 338 344 PF00069 0.244
MOD_CK2_1 356 362 PF00069 0.244
MOD_CK2_1 507 513 PF00069 0.642
MOD_GlcNHglycan 116 119 PF01048 0.593
MOD_GlcNHglycan 293 296 PF01048 0.644
MOD_GlcNHglycan 362 366 PF01048 0.358
MOD_GlcNHglycan 414 417 PF01048 0.414
MOD_GlcNHglycan 497 500 PF01048 0.605
MOD_GlcNHglycan 515 518 PF01048 0.503
MOD_GlcNHglycan 7 10 PF01048 0.686
MOD_GlcNHglycan 77 80 PF01048 0.647
MOD_GSK3_1 272 279 PF00069 0.471
MOD_GSK3_1 287 294 PF00069 0.393
MOD_GSK3_1 334 341 PF00069 0.248
MOD_GSK3_1 401 408 PF00069 0.510
MOD_N-GLC_1 495 500 PF02516 0.529
MOD_NEK2_1 173 178 PF00069 0.600
MOD_NEK2_1 276 281 PF00069 0.356
MOD_NEK2_1 412 417 PF00069 0.431
MOD_NEK2_1 47 52 PF00069 0.475
MOD_NEK2_1 75 80 PF00069 0.649
MOD_NEK2_1 85 90 PF00069 0.478
MOD_PIKK_1 101 107 PF00454 0.726
MOD_PIKK_1 214 220 PF00454 0.340
MOD_PIKK_1 424 430 PF00454 0.356
MOD_PIKK_1 45 51 PF00454 0.588
MOD_PIKK_1 507 513 PF00454 0.542
MOD_PK_1 287 293 PF00069 0.308
MOD_PK_1 54 60 PF00069 0.579
MOD_PKA_2 140 146 PF00069 0.591
MOD_PKA_2 214 220 PF00069 0.351
MOD_PKA_2 223 229 PF00069 0.380
MOD_PKA_2 373 379 PF00069 0.415
MOD_PKA_2 390 396 PF00069 0.406
MOD_PKA_2 412 418 PF00069 0.481
MOD_PKA_2 446 452 PF00069 0.539
MOD_PKA_2 45 51 PF00069 0.579
MOD_PKA_2 52 58 PF00069 0.585
MOD_PKA_2 73 79 PF00069 0.652
MOD_PKA_2 85 91 PF00069 0.472
MOD_Plk_1 124 130 PF00069 0.530
MOD_Plk_1 181 187 PF00069 0.408
MOD_Plk_4 276 282 PF00069 0.362
MOD_Plk_4 314 320 PF00069 0.274
MOD_Plk_4 54 60 PF00069 0.614
MOD_ProDKin_1 356 362 PF00069 0.263
MOD_SUMO_rev_2 225 234 PF00179 0.384
MOD_SUMO_rev_2 294 303 PF00179 0.552
MOD_SUMO_rev_2 34 43 PF00179 0.482
TRG_DiLeu_BaEn_3 229 235 PF01217 0.486
TRG_DiLeu_BaLyEn_6 384 389 PF01217 0.305
TRG_ENDOCYTIC_2 189 192 PF00928 0.384
TRG_ENDOCYTIC_2 310 313 PF00928 0.278
TRG_ENDOCYTIC_2 492 495 PF00928 0.549
TRG_ER_diArg_1 131 133 PF00400 0.571
TRG_ER_diArg_1 285 287 PF00400 0.384
TRG_ER_diArg_1 443 445 PF00400 0.392
TRG_NES_CRM1_1 525 538 PF08389 0.503
TRG_NLS_MonoExtC_3 544 549 PF00514 0.622
TRG_NLS_MonoExtN_4 543 550 PF00514 0.630

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6X1 Leptomonas seymouri 75% 100%
A0A1X0P4K3 Trypanosomatidae 56% 100%
A0A3R7M8S7 Trypanosoma rangeli 54% 100%
A0A3S7X732 Leishmania donovani 100% 100%
A4HLV2 Leishmania braziliensis 84% 100%
D0A671 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 56% 100%
E9B479 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
Q3T0J9 Bos taurus 34% 99%
Q4Q3U7 Leishmania major 95% 100%
Q6PGG6 Mus musculus 34% 98%
Q9SHS8 Arabidopsis thaliana 26% 100%
V5B8N5 Trypanosoma cruzi 60% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS