Putative Golgi reassembly stacking protein (GRASP homologue)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Golgi reassembly stacking protein (GRASP homologue) - putative

Species:

Leishmania infantum

UniProt:

E9AHQ6_LEIIN

TriTrypDb:

LINF_330032900

Length:

542

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0043229	intracellular organelle	3	6
GO:0043231	intracellular membrane-bounded organelle	4	6
GO:0110165	cellular anatomical entity	1	6
GO:0016020	membrane	2	4

Expansion

Sequence features

E9AHQ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHQ6

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	1
GO:0007030	Golgi organization	5	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0071840	cellular component organization or biogenesis	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	137	141	PF00656	0.405
CLV_C14_Caspase3-7	244	248	PF00656	0.296
CLV_NRD_NRD_1	207	209	PF00675	0.405
CLV_NRD_NRD_1	280	282	PF00675	0.365
CLV_NRD_NRD_1	287	289	PF00675	0.495
CLV_PCSK_KEX2_1	287	289	PF00082	0.520
CLV_PCSK_KEX2_1	538	540	PF00082	0.682
CLV_PCSK_PC1ET2_1	538	540	PF00082	0.658
CLV_PCSK_SKI1_1	203	207	PF00082	0.405
CLV_PCSK_SKI1_1	209	213	PF00082	0.343
CLV_PCSK_SKI1_1	75	79	PF00082	0.448
CLV_PCSK_SKI1_1	83	87	PF00082	0.368
DOC_CYCLIN_yCln2_LP_2	309	315	PF00134	0.589
DOC_CYCLIN_yCln2_LP_2	35	41	PF00134	0.404
DOC_CYCLIN_yCln2_LP_2	526	532	PF00134	0.683
DOC_CYCLIN_yCln2_LP_2	97	103	PF00134	0.323
DOC_MAPK_FxFP_2	466	469	PF00069	0.556
DOC_MAPK_MEF2A_6	521	528	PF00069	0.673
DOC_PP2B_LxvP_1	35	38	PF13499	0.439
DOC_PP4_FxxP_1	466	469	PF00568	0.556
DOC_PP4_MxPP_1	522	525	PF00568	0.665
DOC_USP7_MATH_1	13	17	PF00917	0.585
DOC_USP7_MATH_1	158	162	PF00917	0.356
DOC_USP7_MATH_1	21	25	PF00917	0.641
DOC_USP7_MATH_1	273	277	PF00917	0.548
DOC_USP7_MATH_1	364	368	PF00917	0.722
DOC_USP7_MATH_1	392	396	PF00917	0.628
DOC_USP7_MATH_1	470	474	PF00917	0.621
DOC_USP7_MATH_1	497	501	PF00917	0.637
DOC_USP7_MATH_1	516	520	PF00917	0.564
DOC_WW_Pin1_4	153	158	PF00397	0.405
DOC_WW_Pin1_4	335	340	PF00397	0.632
DOC_WW_Pin1_4	348	353	PF00397	0.663
DOC_WW_Pin1_4	427	432	PF00397	0.702
DOC_WW_Pin1_4	501	506	PF00397	0.575
DOC_WW_Pin1_4	53	58	PF00397	0.546
LIG_14-3-3_CanoR_1	23	30	PF00244	0.525
LIG_14-3-3_CanoR_1	281	287	PF00244	0.414
LIG_APCC_ABBA_1	63	68	PF00400	0.421
LIG_BIR_III_2	140	144	PF00653	0.405
LIG_BRCT_BRCA1_1	462	466	PF00533	0.573
LIG_CtBP_PxDLS_1	38	42	PF00389	0.431
LIG_deltaCOP1_diTrp_1	196	204	PF00928	0.525
LIG_EH_1	422	426	PF12763	0.704
LIG_EH1_1	46	54	PF00400	0.438
LIG_EVH1_2	524	528	PF00568	0.677
LIG_FHA_1	103	109	PF00498	0.501
LIG_FHA_1	254	260	PF00498	0.405
LIG_FHA_1	308	314	PF00498	0.693
LIG_FHA_2	110	116	PF00498	0.356
LIG_FHA_2	135	141	PF00498	0.405
LIG_FHA_2	174	180	PF00498	0.356
LIG_FHA_2	232	238	PF00498	0.407
LIG_FHA_2	242	248	PF00498	0.311
LIG_FHA_2	265	271	PF00498	0.420
LIG_FHA_2	69	75	PF00498	0.439
LIG_LIR_Apic_2	115	120	PF02991	0.405
LIG_LIR_Apic_2	367	371	PF02991	0.658
LIG_LIR_Apic_2	463	469	PF02991	0.564
LIG_LIR_Gen_1	190	197	PF02991	0.405
LIG_LIR_Gen_1	430	441	PF02991	0.689
LIG_LIR_Gen_1	45	55	PF02991	0.399
LIG_LIR_Nem_3	104	109	PF02991	0.390
LIG_LIR_Nem_3	110	116	PF02991	0.328
LIG_LIR_Nem_3	190	195	PF02991	0.405
LIG_LIR_Nem_3	430	436	PF02991	0.649
LIG_LIR_Nem_3	45	50	PF02991	0.385
LIG_LIR_Nem_3	465	471	PF02991	0.643
LIG_LYPXL_yS_3	468	471	PF13949	0.610
LIG_PCNA_yPIPBox_3	178	189	PF02747	0.405
LIG_REV1ctd_RIR_1	86	94	PF16727	0.466
LIG_SH2_CRK	117	121	PF00017	0.405
LIG_SH2_CRK	388	392	PF00017	0.616
LIG_SH2_NCK_1	388	392	PF00017	0.616
LIG_SH2_SRC	170	173	PF00017	0.356
LIG_SH2_STAP1	109	113	PF00017	0.356
LIG_SH2_STAP1	464	468	PF00017	0.654
LIG_SH2_STAT5	117	120	PF00017	0.385
LIG_SH2_STAT5	170	173	PF00017	0.405
LIG_SH3_1	368	374	PF00018	0.608
LIG_SH3_1	51	57	PF00018	0.455
LIG_SH3_3	214	220	PF00018	0.405
LIG_SH3_3	287	293	PF00018	0.704
LIG_SH3_3	331	337	PF00018	0.716
LIG_SH3_3	346	352	PF00018	0.548
LIG_SH3_3	357	363	PF00018	0.624
LIG_SH3_3	368	374	PF00018	0.585
LIG_SH3_3	395	401	PF00018	0.665
LIG_SH3_3	418	424	PF00018	0.659
LIG_SH3_3	499	505	PF00018	0.702
LIG_SH3_3	51	57	PF00018	0.560
LIG_SH3_3	526	532	PF00018	0.683
LIG_SUMO_SIM_anti_2	179	187	PF11976	0.356
LIG_SUMO_SIM_par_1	148	154	PF11976	0.405
LIG_SxIP_EBH_1	507	521	PF03271	0.568
LIG_TRAF2_1	176	179	PF00917	0.356
LIG_TRAF2_1	234	237	PF00917	0.356
LIG_TRAF2_1	338	341	PF00917	0.608
LIG_UBA3_1	181	189	PF00899	0.519
LIG_UBA3_1	69	75	PF00899	0.330
LIG_WRC_WIRS_1	103	108	PF05994	0.356
LIG_WRC_WIRS_1	393	398	PF05994	0.651
LIG_WW_3	332	336	PF00397	0.589
LIG_WW_3	372	376	PF00397	0.643
LIG_WW_3	400	404	PF00397	0.651
MOD_CDK_SPxxK_3	53	60	PF00069	0.459
MOD_CK1_1	253	259	PF00069	0.405
MOD_CK1_1	26	32	PF00069	0.757
MOD_CK1_1	264	270	PF00069	0.447
MOD_CK1_1	323	329	PF00069	0.685
MOD_CK2_1	173	179	PF00069	0.363
MOD_CK2_1	190	196	PF00069	0.271
MOD_CK2_1	231	237	PF00069	0.407
MOD_CK2_1	335	341	PF00069	0.611
MOD_GlcNHglycan	15	18	PF01048	0.645
MOD_GlcNHglycan	25	28	PF01048	0.716
MOD_GlcNHglycan	267	270	PF01048	0.538
MOD_GlcNHglycan	30	33	PF01048	0.662
MOD_GlcNHglycan	478	481	PF01048	0.708
MOD_GlcNHglycan	499	502	PF01048	0.641
MOD_GSK3_1	130	137	PF00069	0.376
MOD_GSK3_1	173	180	PF00069	0.356
MOD_GSK3_1	227	234	PF00069	0.405
MOD_GSK3_1	261	268	PF00069	0.398
MOD_GSK3_1	282	289	PF00069	0.550
MOD_GSK3_1	320	327	PF00069	0.670
MOD_GSK3_1	456	463	PF00069	0.598
MOD_GSK3_1	497	504	PF00069	0.637
MOD_GSK3_1	84	91	PF00069	0.422
MOD_N-GLC_1	231	236	PF02516	0.320
MOD_N-GLC_1	486	491	PF02516	0.690
MOD_NEK2_1	184	189	PF00069	0.356
MOD_NEK2_1	486	491	PF00069	0.617
MOD_NEK2_1	509	514	PF00069	0.661
MOD_NEK2_1	88	93	PF00069	0.460
MOD_NEK2_2	84	89	PF00069	0.418
MOD_NMyristoyl	1	7	PF02799	0.695
MOD_PIKK_1	184	190	PF00454	0.356
MOD_PIKK_1	320	326	PF00454	0.663
MOD_PIKK_1	327	333	PF00454	0.633
MOD_PIKK_1	470	476	PF00454	0.609
MOD_PIKK_1	516	522	PF00454	0.691
MOD_PK_1	282	288	PF00069	0.568
MOD_PKA_2	286	292	PF00069	0.526
MOD_Plk_1	21	27	PF00069	0.667
MOD_Plk_1	231	237	PF00069	0.280
MOD_Plk_1	305	311	PF00069	0.651
MOD_Plk_1	324	330	PF00069	0.546
MOD_Plk_1	460	466	PF00069	0.592
MOD_Plk_2-3	231	237	PF00069	0.405
MOD_Plk_4	177	183	PF00069	0.367
MOD_Plk_4	261	267	PF00069	0.272
MOD_Plk_4	84	90	PF00069	0.458
MOD_ProDKin_1	153	159	PF00069	0.405
MOD_ProDKin_1	335	341	PF00069	0.633
MOD_ProDKin_1	348	354	PF00069	0.661
MOD_ProDKin_1	427	433	PF00069	0.699
MOD_ProDKin_1	501	507	PF00069	0.575
MOD_ProDKin_1	53	59	PF00069	0.545
MOD_SUMO_rev_2	201	211	PF00179	0.356
MOD_SUMO_rev_2	79	85	PF00179	0.433
TRG_DiLeu_BaLyEn_6	48	53	PF01217	0.436
TRG_ENDOCYTIC_2	113	116	PF00928	0.405
TRG_ENDOCYTIC_2	192	195	PF00928	0.405
TRG_ENDOCYTIC_2	433	436	PF00928	0.641
TRG_ENDOCYTIC_2	468	471	PF00928	0.634
TRG_ER_diArg_1	286	288	PF00400	0.534
TRG_NES_CRM1_1	68	81	PF08389	0.437

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IU65	Leishmania donovani	100%	100%
A4HLV0	Leishmania braziliensis	67%	100%
E9B477	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q3U9	Leishmania major	88%	100%