LeishMANIAdb
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Nucleoporin

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Nucleoporin
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
E9AHQ5_LEIIN
TriTrypDb:
LINF_330032700
Length:
563

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AHQ5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHQ5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 173 175 PF00675 0.432
CLV_NRD_NRD_1 362 364 PF00675 0.535
CLV_NRD_NRD_1 399 401 PF00675 0.536
CLV_NRD_NRD_1 505 507 PF00675 0.456
CLV_NRD_NRD_1 90 92 PF00675 0.501
CLV_PCSK_KEX2_1 173 175 PF00082 0.405
CLV_PCSK_KEX2_1 190 192 PF00082 0.383
CLV_PCSK_KEX2_1 21 23 PF00082 0.607
CLV_PCSK_KEX2_1 29 31 PF00082 0.565
CLV_PCSK_KEX2_1 364 366 PF00082 0.399
CLV_PCSK_PC1ET2_1 190 192 PF00082 0.482
CLV_PCSK_PC1ET2_1 21 23 PF00082 0.576
CLV_PCSK_PC1ET2_1 29 31 PF00082 0.523
CLV_PCSK_PC1ET2_1 364 366 PF00082 0.334
CLV_PCSK_SKI1_1 174 178 PF00082 0.441
CLV_PCSK_SKI1_1 29 33 PF00082 0.484
CLV_PCSK_SKI1_1 364 368 PF00082 0.364
CLV_PCSK_SKI1_1 390 394 PF00082 0.512
CLV_PCSK_SKI1_1 409 413 PF00082 0.263
CLV_PCSK_SKI1_1 515 519 PF00082 0.366
CLV_PCSK_SKI1_1 91 95 PF00082 0.411
DEG_APCC_DBOX_1 362 370 PF00400 0.505
DEG_SPOP_SBC_1 229 233 PF00917 0.613
DEG_SPOP_SBC_1 331 335 PF00917 0.732
DOC_CYCLIN_RxL_1 158 166 PF00134 0.540
DOC_CYCLIN_yCln2_LP_2 208 214 PF00134 0.589
DOC_PIKK_1 57 65 PF02985 0.455
DOC_PP1_RVXF_1 144 150 PF00149 0.539
DOC_PP1_RVXF_1 513 520 PF00149 0.491
DOC_PP4_FxxP_1 75 78 PF00568 0.594
DOC_USP7_MATH_1 178 182 PF00917 0.543
DOC_USP7_MATH_1 197 201 PF00917 0.599
DOC_USP7_MATH_1 217 221 PF00917 0.484
DOC_USP7_MATH_1 246 250 PF00917 0.647
DOC_USP7_MATH_1 254 258 PF00917 0.663
DOC_USP7_MATH_1 284 288 PF00917 0.712
DOC_USP7_MATH_1 3 7 PF00917 0.633
DOC_USP7_MATH_1 331 335 PF00917 0.756
DOC_USP7_MATH_1 340 344 PF00917 0.747
DOC_USP7_MATH_1 440 444 PF00917 0.544
DOC_USP7_MATH_1 457 461 PF00917 0.389
DOC_USP7_MATH_1 498 502 PF00917 0.423
DOC_USP7_MATH_1 509 513 PF00917 0.423
DOC_USP7_UBL2_3 29 33 PF12436 0.576
DOC_USP7_UBL2_3 507 511 PF12436 0.330
DOC_USP7_UBL2_3 518 522 PF12436 0.494
DOC_WW_Pin1_4 207 212 PF00397 0.706
DOC_WW_Pin1_4 240 245 PF00397 0.561
DOC_WW_Pin1_4 259 264 PF00397 0.664
DOC_WW_Pin1_4 312 317 PF00397 0.691
DOC_WW_Pin1_4 98 103 PF00397 0.398
LIG_14-3-3_CanoR_1 363 373 PF00244 0.437
LIG_14-3-3_CanoR_1 73 78 PF00244 0.472
LIG_14-3-3_CanoR_1 97 102 PF00244 0.488
LIG_Actin_WH2_2 471 487 PF00022 0.357
LIG_BIR_II_1 1 5 PF00653 0.684
LIG_BRCT_BRCA1_1 209 213 PF00533 0.629
LIG_BRCT_BRCA1_1 291 295 PF00533 0.581
LIG_BRCT_BRCA1_1 308 312 PF00533 0.691
LIG_BRCT_BRCA1_1 459 463 PF00533 0.378
LIG_deltaCOP1_diTrp_1 428 437 PF00928 0.516
LIG_deltaCOP1_diTrp_1 86 90 PF00928 0.489
LIG_EH_1 555 559 PF12763 0.476
LIG_FHA_1 203 209 PF00498 0.727
LIG_FHA_1 351 357 PF00498 0.475
LIG_FHA_1 387 393 PF00498 0.531
LIG_FHA_1 440 446 PF00498 0.539
LIG_FHA_1 66 72 PF00498 0.554
LIG_LIR_Apic_2 74 78 PF02991 0.588
LIG_LIR_Gen_1 460 471 PF02991 0.362
LIG_LIR_Gen_1 86 94 PF02991 0.413
LIG_LIR_Nem_3 460 466 PF02991 0.390
LIG_LIR_Nem_3 512 517 PF02991 0.380
LIG_LIR_Nem_3 86 90 PF02991 0.399
LIG_OCRL_FandH_1 462 474 PF00620 0.459
LIG_PALB2_WD40_1 100 108 PF16756 0.397
LIG_PCNA_yPIPBox_3 33 45 PF02747 0.518
LIG_Pex14_2 265 269 PF04695 0.658
LIG_Pex14_2 293 297 PF04695 0.583
LIG_PTB_Apo_2 411 418 PF02174 0.351
LIG_PTB_Apo_2 465 472 PF02174 0.330
LIG_PTB_Phospho_1 465 471 PF10480 0.327
LIG_SH2_CRK 471 475 PF00017 0.359
LIG_SH2_NCK_1 151 155 PF00017 0.558
LIG_SH2_NCK_1 471 475 PF00017 0.359
LIG_SH2_SRC 128 131 PF00017 0.491
LIG_SH2_STAP1 471 475 PF00017 0.469
LIG_SH2_STAT5 128 131 PF00017 0.448
LIG_SH2_STAT5 143 146 PF00017 0.319
LIG_SH3_3 144 150 PF00018 0.539
LIG_SH3_3 301 307 PF00018 0.701
LIG_SH3_3 325 331 PF00018 0.717
LIG_SH3_3 543 549 PF00018 0.452
LIG_SUMO_SIM_par_1 480 488 PF11976 0.403
LIG_UBA3_1 357 364 PF00899 0.329
LIG_UBA3_1 412 419 PF00899 0.395
LIG_UBA3_1 499 507 PF00899 0.420
LIG_WRPW_2 528 531 PF00400 0.475
LIG_WW_2 328 331 PF00397 0.656
MOD_CDK_SPK_2 98 103 PF00069 0.398
MOD_CK1_1 218 224 PF00069 0.576
MOD_CK1_1 257 263 PF00069 0.682
MOD_CK1_1 285 291 PF00069 0.640
MOD_CK1_1 315 321 PF00069 0.748
MOD_CK1_1 535 541 PF00069 0.469
MOD_CK2_1 149 155 PF00069 0.407
MOD_CK2_1 272 278 PF00069 0.628
MOD_GlcNHglycan 114 117 PF01048 0.504
MOD_GlcNHglycan 17 20 PF01048 0.494
MOD_GlcNHglycan 195 198 PF01048 0.620
MOD_GlcNHglycan 199 202 PF01048 0.628
MOD_GlcNHglycan 217 220 PF01048 0.559
MOD_GlcNHglycan 233 236 PF01048 0.671
MOD_GlcNHglycan 244 247 PF01048 0.710
MOD_GlcNHglycan 256 259 PF01048 0.708
MOD_GlcNHglycan 284 287 PF01048 0.721
MOD_GlcNHglycan 341 345 PF01048 0.676
MOD_GlcNHglycan 374 377 PF01048 0.389
MOD_GlcNHglycan 442 445 PF01048 0.506
MOD_GlcNHglycan 510 514 PF01048 0.398
MOD_GlcNHglycan 534 537 PF01048 0.451
MOD_GlcNHglycan 6 9 PF01048 0.529
MOD_GSK3_1 11 18 PF00069 0.681
MOD_GSK3_1 193 200 PF00069 0.712
MOD_GSK3_1 215 222 PF00069 0.570
MOD_GSK3_1 236 243 PF00069 0.677
MOD_GSK3_1 246 253 PF00069 0.658
MOD_GSK3_1 285 292 PF00069 0.685
MOD_GSK3_1 451 458 PF00069 0.321
MOD_GSK3_1 73 80 PF00069 0.464
MOD_GSK3_1 93 100 PF00069 0.497
MOD_N-GLC_1 97 102 PF02516 0.338
MOD_N-GLC_2 432 434 PF02516 0.468
MOD_NEK2_1 215 220 PF00069 0.603
MOD_NEK2_1 293 298 PF00069 0.619
MOD_NEK2_1 386 391 PF00069 0.557
MOD_NEK2_1 462 467 PF00069 0.400
MOD_NEK2_1 65 70 PF00069 0.451
MOD_PIKK_1 315 321 PF00454 0.720
MOD_PIKK_1 498 504 PF00454 0.504
MOD_PIKK_1 73 79 PF00454 0.561
MOD_PKA_1 11 17 PF00069 0.601
MOD_PKA_1 364 370 PF00069 0.427
MOD_PKA_1 4 10 PF00069 0.592
MOD_PKA_2 364 370 PF00069 0.427
MOD_PKA_2 484 490 PF00069 0.487
MOD_PKB_1 449 457 PF00069 0.319
MOD_Plk_2-3 121 127 PF00069 0.463
MOD_ProDKin_1 207 213 PF00069 0.701
MOD_ProDKin_1 240 246 PF00069 0.561
MOD_ProDKin_1 259 265 PF00069 0.665
MOD_ProDKin_1 312 318 PF00069 0.690
MOD_ProDKin_1 98 104 PF00069 0.391
MOD_SUMO_rev_2 341 348 PF00179 0.656
MOD_SUMO_rev_2 501 509 PF00179 0.400
TRG_DiLeu_BaLyEn_6 47 52 PF01217 0.536
TRG_DiLeu_BaLyEn_6 512 517 PF01217 0.371
TRG_ENDOCYTIC_2 471 474 PF00928 0.394
TRG_ER_diArg_1 172 174 PF00400 0.439
TRG_ER_diArg_1 363 366 PF00400 0.519
TRG_NLS_Bipartite_1 173 194 PF00514 0.443
TRG_NLS_MonoExtC_3 362 368 PF00514 0.361
TRG_Pf-PMV_PEXEL_1 161 166 PF00026 0.411
TRG_Pf-PMV_PEXEL_1 30 34 PF00026 0.551
TRG_Pf-PMV_PEXEL_1 429 433 PF00026 0.348
TRG_Pf-PMV_PEXEL_1 451 455 PF00026 0.526
TRG_Pf-PMV_PEXEL_1 506 510 PF00026 0.446

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I8T0 Leptomonas seymouri 64% 100%
A0A0S4J4Z2 Bodo saltans 40% 100%
A0A1X0P580 Trypanosomatidae 46% 100%
A0A3R7NSX9 Trypanosoma rangeli 50% 100%
A0A3S7X6X9 Leishmania donovani 99% 100%
A4HHX8 Leishmania braziliensis 78% 100%
D0A676 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 48% 100%
E9B476 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q4Q3V0 Leishmania major 92% 100%
V5BYJ7 Trypanosoma cruzi 46% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS