LeishMANIAdb
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Succinyl-CoA:3-ketoacid-coenzyme A transferase

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Succinyl-CoA:3-ketoacid-coenzyme A transferase
Gene product:
succinyl-coA:3-ketoacid-coenzyme A transferase - mitochondrial precursor - putative
Species:
Leishmania infantum
UniProt:
E9AHQ2_LEIIN
TriTrypDb:
LINF_330032400
Length:
489

Annotations

Annotations by Jardim et al.

Tricarboxylic acid cycle, Succinyl-CoA:3-ketoacid-coenzyme A transferase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 25
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005739 mitochondrion 5 12
GO:0043226 organelle 2 12
GO:0043227 membrane-bounded organelle 3 12
GO:0043229 intracellular organelle 3 12
GO:0043231 intracellular membrane-bounded organelle 4 12
GO:0110165 cellular anatomical entity 1 12
GO:0005737 cytoplasm 2 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

E9AHQ2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHQ2

Function

Biological processes
Term Name Level Count
GO:0006091 generation of precursor metabolites and energy 3 12
GO:0006629 lipid metabolic process 3 12
GO:0008152 metabolic process 1 12
GO:0009056 catabolic process 2 12
GO:0009987 cellular process 1 12
GO:0016042 lipid catabolic process 4 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0044248 cellular catabolic process 3 12
GO:0044281 small molecule metabolic process 2 12
GO:0044282 small molecule catabolic process 3 12
GO:0046950 cellular ketone body metabolic process 3 12
GO:0046952 ketone body catabolic process 4 12
GO:0071704 organic substance metabolic process 2 12
GO:1901568 fatty acid derivative metabolic process 4 12
GO:1901569 fatty acid derivative catabolic process 5 12
GO:1901575 organic substance catabolic process 3 12
GO:1902224 ketone body metabolic process 4 12
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 12
GO:0008260 succinyl-CoA:3-oxo-acid CoA-transferase activity 5 12
GO:0008410 CoA-transferase activity 4 12
GO:0016740 transferase activity 2 12
GO:0016782 transferase activity, transferring sulphur-containing groups 3 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 24 28 PF00656 0.434
CLV_C14_Caspase3-7 281 285 PF00656 0.399
CLV_NRD_NRD_1 211 213 PF00675 0.203
CLV_NRD_NRD_1 276 278 PF00675 0.197
CLV_NRD_NRD_1 3 5 PF00675 0.414
CLV_NRD_NRD_1 81 83 PF00675 0.257
CLV_NRD_NRD_1 96 98 PF00675 0.261
CLV_PCSK_KEX2_1 211 213 PF00082 0.203
CLV_PCSK_KEX2_1 252 254 PF00082 0.400
CLV_PCSK_KEX2_1 276 278 PF00082 0.198
CLV_PCSK_KEX2_1 3 5 PF00082 0.414
CLV_PCSK_KEX2_1 414 416 PF00082 0.337
CLV_PCSK_KEX2_1 81 83 PF00082 0.255
CLV_PCSK_KEX2_1 95 97 PF00082 0.255
CLV_PCSK_PC1ET2_1 252 254 PF00082 0.400
CLV_PCSK_PC1ET2_1 414 416 PF00082 0.337
CLV_PCSK_PC1ET2_1 95 97 PF00082 0.280
CLV_PCSK_SKI1_1 183 187 PF00082 0.272
CLV_PCSK_SKI1_1 277 281 PF00082 0.219
CLV_PCSK_SKI1_1 436 440 PF00082 0.188
CLV_PCSK_SKI1_1 441 445 PF00082 0.188
CLV_PCSK_SKI1_1 52 56 PF00082 0.260
CLV_PCSK_SKI1_1 92 96 PF00082 0.252
DEG_MDM2_SWIB_1 164 171 PF02201 0.492
DEG_Nend_Nbox_1 1 3 PF02207 0.439
DOC_MAPK_gen_1 186 195 PF00069 0.399
DOC_MAPK_gen_1 273 282 PF00069 0.421
DOC_MAPK_gen_1 51 59 PF00069 0.448
DOC_MAPK_MEF2A_6 359 367 PF00069 0.388
DOC_PP4_FxxP_1 202 205 PF00568 0.388
DOC_USP7_MATH_1 187 191 PF00917 0.412
DOC_USP7_MATH_1 260 264 PF00917 0.636
DOC_USP7_MATH_1 400 404 PF00917 0.492
DOC_USP7_UBL2_3 51 55 PF12436 0.470
LIG_14-3-3_CanoR_1 404 410 PF00244 0.547
LIG_14-3-3_CanoR_1 423 427 PF00244 0.341
LIG_14-3-3_CanoR_1 436 444 PF00244 0.345
LIG_14-3-3_CanoR_1 82 88 PF00244 0.466
LIG_Actin_WH2_2 439 456 PF00022 0.399
LIG_APCC_ABBA_1 308 313 PF00400 0.477
LIG_APCC_ABBA_1 57 62 PF00400 0.412
LIG_EH1_1 431 439 PF00400 0.492
LIG_FHA_1 24 30 PF00498 0.508
LIG_FHA_1 305 311 PF00498 0.492
LIG_FHA_1 433 439 PF00498 0.495
LIG_FHA_1 75 81 PF00498 0.464
LIG_FHA_2 110 116 PF00498 0.430
LIG_FHA_2 459 465 PF00498 0.422
LIG_Integrin_RGD_1 415 417 PF01839 0.203
LIG_LIR_Apic_2 245 249 PF02991 0.420
LIG_LIR_Gen_1 178 187 PF02991 0.389
LIG_LIR_Gen_1 284 295 PF02991 0.424
LIG_LIR_Gen_1 353 363 PF02991 0.433
LIG_LIR_Nem_3 178 182 PF02991 0.383
LIG_LIR_Nem_3 284 290 PF02991 0.424
LIG_LIR_Nem_3 353 358 PF02991 0.422
LIG_Pex14_2 164 168 PF04695 0.455
LIG_PTB_Apo_2 163 170 PF02174 0.387
LIG_PTB_Phospho_1 163 169 PF10480 0.387
LIG_SH2_CRK 179 183 PF00017 0.492
LIG_SH2_CRK 287 291 PF00017 0.403
LIG_SH2_CRK 483 487 PF00017 0.408
LIG_SH2_GRB2like 287 290 PF00017 0.388
LIG_SH2_SRC 179 182 PF00017 0.434
LIG_SH2_SRC 98 101 PF00017 0.430
LIG_SH2_STAP1 128 132 PF00017 0.434
LIG_SH2_STAP1 60 64 PF00017 0.463
LIG_SH2_STAT3 133 136 PF00017 0.492
LIG_SH2_STAT5 128 131 PF00017 0.388
LIG_SH2_STAT5 169 172 PF00017 0.399
LIG_SH2_STAT5 237 240 PF00017 0.388
LIG_SH2_STAT5 60 63 PF00017 0.495
LIG_SH2_STAT5 98 101 PF00017 0.437
LIG_SH3_3 228 234 PF00018 0.394
LIG_SH3_3 386 392 PF00018 0.412
LIG_SUMO_SIM_par_1 306 313 PF11976 0.497
LIG_TRAF2_1 17 20 PF00917 0.479
MOD_CK1_1 351 357 PF00069 0.388
MOD_CK2_1 109 115 PF00069 0.409
MOD_CK2_1 14 20 PF00069 0.294
MOD_CK2_1 255 261 PF00069 0.516
MOD_Cter_Amidation 209 212 PF01082 0.203
MOD_GlcNHglycan 188 192 PF01048 0.199
MOD_GlcNHglycan 255 258 PF01048 0.506
MOD_GlcNHglycan 328 331 PF01048 0.286
MOD_GlcNHglycan 350 353 PF01048 0.193
MOD_GlcNHglycan 38 41 PF01048 0.267
MOD_GlcNHglycan 400 403 PF01048 0.229
MOD_GlcNHglycan 46 49 PF01048 0.279
MOD_GlcNHglycan 62 65 PF01048 0.292
MOD_GSK3_1 128 135 PF00069 0.391
MOD_GSK3_1 23 30 PF00069 0.434
MOD_GSK3_1 251 258 PF00069 0.417
MOD_GSK3_1 422 429 PF00069 0.455
MOD_GSK3_1 432 439 PF00069 0.455
MOD_N-GLC_1 363 368 PF02516 0.239
MOD_NEK2_1 171 176 PF00069 0.544
MOD_NEK2_1 195 200 PF00069 0.388
MOD_NEK2_1 36 41 PF00069 0.416
MOD_NEK2_1 363 368 PF00069 0.425
MOD_NEK2_1 371 376 PF00069 0.401
MOD_NEK2_1 398 403 PF00069 0.391
MOD_NEK2_1 74 79 PF00069 0.438
MOD_NEK2_1 83 88 PF00069 0.409
MOD_PIKK_1 132 138 PF00454 0.492
MOD_PKA_1 466 472 PF00069 0.420
MOD_PKA_2 136 142 PF00069 0.479
MOD_PKA_2 195 201 PF00069 0.388
MOD_PKA_2 422 428 PF00069 0.492
MOD_Plk_1 171 177 PF00069 0.409
MOD_Plk_1 363 369 PF00069 0.388
MOD_Plk_2-3 458 464 PF00069 0.388
MOD_Plk_4 363 369 PF00069 0.412
MOD_Plk_4 83 89 PF00069 0.395
MOD_SUMO_rev_2 156 161 PF00179 0.452
TRG_DiLeu_BaLyEn_6 70 75 PF01217 0.492
TRG_ENDOCYTIC_2 179 182 PF00928 0.492
TRG_ENDOCYTIC_2 287 290 PF00928 0.421
TRG_ER_diArg_1 2 4 PF00400 0.416
TRG_ER_diArg_1 211 213 PF00400 0.403
TRG_ER_diArg_1 80 82 PF00400 0.492
TRG_ER_diArg_1 96 98 PF00400 0.492
TRG_NLS_Bipartite_1 81 99 PF00514 0.434
TRG_NLS_MonoExtC_3 94 100 PF00514 0.434
TRG_NLS_MonoExtN_4 92 99 PF00514 0.434
TRG_Pf-PMV_PEXEL_1 212 216 PF00026 0.203
TRG_Pf-PMV_PEXEL_1 436 440 PF00026 0.199
TRG_Pf-PMV_PEXEL_1 97 102 PF00026 0.292

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P584 Leptomonas seymouri 41% 100%
A0A0N1I0F3 Leptomonas seymouri 84% 100%
A0A0S4JH09 Bodo saltans 62% 99%
A0A1X0NIU4 Trypanosomatidae 42% 98%
A0A1X0P425 Trypanosomatidae 64% 99%
A0A3Q8IC07 Leishmania donovani 45% 98%
A0A3Q8IMK1 Leishmania donovani 100% 100%
A0A3R7LBN6 Trypanosoma rangeli 64% 99%
A0A3S7X3G0 Leishmania donovani 46% 98%
A4HLU7 Leishmania braziliensis 89% 100%
A4I5L8 Leishmania infantum 45% 100%
A4I5L9 Leishmania infantum 46% 100%
B2GV06 Rattus norvegicus 53% 94%
D0A680 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 67% 99%
E9B0W3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 47% 100%
E9B0W4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 48% 100%
E9B473 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
F1CYZ5 Acetobacterium woodii 25% 93%
P37766 Escherichia coli (strain K12) 25% 92%
P55809 Homo sapiens 53% 94%
Q09450 Caenorhabditis elegans 53% 94%
Q29551 Sus scrofa 55% 94%
Q4Q3V3 Leishmania major 98% 100%
Q4Q7A2 Leishmania major 47% 100%
Q4Q7A3 Leishmania major 45% 99%
Q54JD9 Dictyostelium discoideum 52% 96%
Q5XIJ9 Rattus norvegicus 52% 94%
Q8X5X6 Escherichia coli O157:H7 25% 92%
Q9BYC2 Homo sapiens 54% 95%
Q9D0K2 Mus musculus 53% 94%
Q9ESL0 Mus musculus 53% 94%
Q9JJN4 Mus musculus 53% 94%
Q9W058 Drosophila melanogaster 50% 95%
V5DQB8 Trypanosoma cruzi 64% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS