RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

E9AHP4_LEIIN

TriTrypDb:

LINF_330031500

Length:

455

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AHP4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHP4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	395	399	PF00656	0.718
CLV_C14_Caspase3-7	428	432	PF00656	0.699
CLV_NRD_NRD_1	127	129	PF00675	0.546
CLV_NRD_NRD_1	307	309	PF00675	0.695
CLV_NRD_NRD_1	319	321	PF00675	0.565
CLV_PCSK_KEX2_1	118	120	PF00082	0.592
CLV_PCSK_KEX2_1	309	311	PF00082	0.709
CLV_PCSK_KEX2_1	319	321	PF00082	0.681
CLV_PCSK_KEX2_1	323	325	PF00082	0.665
CLV_PCSK_KEX2_1	443	445	PF00082	0.552
CLV_PCSK_PC1ET2_1	118	120	PF00082	0.675
CLV_PCSK_PC1ET2_1	309	311	PF00082	0.709
CLV_PCSK_PC1ET2_1	323	325	PF00082	0.665
CLV_PCSK_PC1ET2_1	443	445	PF00082	0.603
CLV_PCSK_PC7_1	319	325	PF00082	0.719
CLV_PCSK_SKI1_1	138	142	PF00082	0.621
CLV_PCSK_SKI1_1	19	23	PF00082	0.554
CLV_PCSK_SKI1_1	232	236	PF00082	0.424
CLV_PCSK_SKI1_1	312	316	PF00082	0.721
CLV_PCSK_SKI1_1	410	414	PF00082	0.593
DEG_APCC_DBOX_1	231	239	PF00400	0.438
DEG_Nend_UBRbox_2	1	3	PF02207	0.545
DEG_SPOP_SBC_1	371	375	PF00917	0.620
DOC_PP2B_LxvP_1	430	433	PF13499	0.637
DOC_PP2B_LxvP_1	72	75	PF13499	0.670
DOC_SPAK_OSR1_1	250	254	PF12202	0.499
DOC_USP7_MATH_1	14	18	PF00917	0.481
DOC_USP7_MATH_1	172	176	PF00917	0.803
DOC_USP7_MATH_1	184	188	PF00917	0.675
DOC_USP7_MATH_1	205	209	PF00917	0.634
DOC_USP7_MATH_1	259	263	PF00917	0.504
DOC_USP7_MATH_1	344	348	PF00917	0.800
DOC_USP7_MATH_1	367	371	PF00917	0.716
DOC_USP7_MATH_1	377	381	PF00917	0.604
DOC_USP7_MATH_1	75	79	PF00917	0.803
DOC_WW_Pin1_4	166	171	PF00397	0.698
DOC_WW_Pin1_4	186	191	PF00397	0.443
DOC_WW_Pin1_4	403	408	PF00397	0.764
LIG_14-3-3_CanoR_1	111	117	PF00244	0.514
LIG_14-3-3_CanoR_1	176	186	PF00244	0.771
LIG_14-3-3_CanoR_1	19	24	PF00244	0.502
LIG_14-3-3_CanoR_1	237	245	PF00244	0.590
LIG_14-3-3_CanoR_1	335	340	PF00244	0.734
LIG_14-3-3_CanoR_1	382	386	PF00244	0.623
LIG_14-3-3_CanoR_1	418	427	PF00244	0.647
LIG_14-3-3_CanoR_1	44	52	PF00244	0.539
LIG_BRCT_BRCA1_1	207	211	PF00533	0.683
LIG_FHA_1	111	117	PF00498	0.514
LIG_FHA_1	287	293	PF00498	0.797
LIG_FHA_1	30	36	PF00498	0.500
LIG_FHA_1	334	340	PF00498	0.599
LIG_FHA_1	356	362	PF00498	0.704
LIG_FHA_2	28	34	PF00498	0.545
LIG_FHA_2	382	388	PF00498	0.724
LIG_LIR_Gen_1	108	116	PF02991	0.462
LIG_LIR_Gen_1	17	26	PF02991	0.497
LIG_LIR_Nem_3	108	112	PF02991	0.490
LIG_LIR_Nem_3	151	157	PF02991	0.532
LIG_LIR_Nem_3	17	23	PF02991	0.492
LIG_MYND_1	70	74	PF01753	0.704
LIG_SH2_CRK	109	113	PF00017	0.470
LIG_SH2_CRK	7	11	PF00017	0.454
LIG_SH2_NCK_1	258	262	PF00017	0.547
LIG_SH2_STAT5	20	23	PF00017	0.507
LIG_SH3_2	171	176	PF14604	0.671
LIG_SH3_3	165	171	PF00018	0.721
LIG_SH3_3	187	193	PF00018	0.641
LIG_SH3_3	20	26	PF00018	0.623
LIG_SH3_3	326	332	PF00018	0.690
LIG_SH3_3	67	73	PF00018	0.713
LIG_SUMO_SIM_par_1	112	117	PF11976	0.508
LIG_TRAF2_1	240	243	PF00917	0.532
LIG_TYR_ITIM	5	10	PF00017	0.445
LIG_UBA3_1	210	215	PF00899	0.720
LIG_WW_3	170	174	PF00397	0.668
MOD_CDK_SPxxK_3	166	173	PF00069	0.708
MOD_CDK_SPxxK_3	403	410	PF00069	0.669
MOD_CK1_1	149	155	PF00069	0.715
MOD_CK1_1	175	181	PF00069	0.735
MOD_CK1_1	218	224	PF00069	0.629
MOD_CK1_1	279	285	PF00069	0.621
MOD_CK1_1	370	376	PF00069	0.768
MOD_CK1_1	77	83	PF00069	0.739
MOD_CK2_1	124	130	PF00069	0.563
MOD_CK2_1	236	242	PF00069	0.504
MOD_CK2_1	257	263	PF00069	0.528
MOD_GlcNHglycan	148	151	PF01048	0.693
MOD_GlcNHglycan	16	19	PF01048	0.457
MOD_GlcNHglycan	179	182	PF01048	0.660
MOD_GlcNHglycan	218	221	PF01048	0.713
MOD_GlcNHglycan	238	241	PF01048	0.432
MOD_GlcNHglycan	259	262	PF01048	0.525
MOD_GlcNHglycan	279	282	PF01048	0.652
MOD_GlcNHglycan	346	349	PF01048	0.794
MOD_GlcNHglycan	369	372	PF01048	0.740
MOD_GlcNHglycan	377	380	PF01048	0.774
MOD_GlcNHglycan	394	397	PF01048	0.608
MOD_GlcNHglycan	436	439	PF01048	0.641
MOD_GlcNHglycan	65	68	PF01048	0.674
MOD_GlcNHglycan	76	80	PF01048	0.756
MOD_GlcNHglycan	84	87	PF01048	0.596
MOD_GSK3_1	110	117	PF00069	0.472
MOD_GSK3_1	253	260	PF00069	0.439
MOD_GSK3_1	279	286	PF00069	0.644
MOD_GSK3_1	367	374	PF00069	0.685
MOD_GSK3_1	377	384	PF00069	0.735
MOD_GSK3_1	388	395	PF00069	0.788
MOD_N-GLC_1	45	50	PF02516	0.478
MOD_NEK2_1	112	117	PF00069	0.463
MOD_NEK2_1	148	153	PF00069	0.627
MOD_NEK2_1	177	182	PF00069	0.606
MOD_NEK2_1	241	246	PF00069	0.402
MOD_NEK2_1	333	338	PF00069	0.637
MOD_NEK2_1	82	87	PF00069	0.774
MOD_OFUCOSY	252	257	PF10250	0.469
MOD_PIKK_1	205	211	PF00454	0.591
MOD_PK_1	335	341	PF00069	0.695
MOD_PKA_2	110	116	PF00069	0.507
MOD_PKA_2	172	178	PF00069	0.781
MOD_PKA_2	236	242	PF00069	0.511
MOD_PKA_2	334	340	PF00069	0.696
MOD_PKA_2	381	387	PF00069	0.637
MOD_Plk_1	241	247	PF00069	0.408
MOD_Plk_1	302	308	PF00069	0.738
MOD_Plk_1	45	51	PF00069	0.536
MOD_Plk_4	425	431	PF00069	0.616
MOD_ProDKin_1	166	172	PF00069	0.698
MOD_ProDKin_1	186	192	PF00069	0.440
MOD_ProDKin_1	403	409	PF00069	0.754
MOD_SUMO_for_1	314	317	PF00179	0.746
TRG_DiLeu_BaEn_1	53	58	PF01217	0.525
TRG_DiLeu_BaLyEn_6	5	10	PF01217	0.445
TRG_ENDOCYTIC_2	109	112	PF00928	0.466
TRG_ENDOCYTIC_2	20	23	PF00928	0.495
TRG_ENDOCYTIC_2	7	10	PF00928	0.446
TRG_ER_diArg_1	307	310	PF00400	0.693
TRG_ER_diArg_1	319	321	PF00400	0.565
TRG_NES_CRM1_1	417	431	PF08389	0.606
TRG_Pf-PMV_PEXEL_1	119	123	PF00026	0.632
TRG_Pf-PMV_PEXEL_1	138	142	PF00026	0.601

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILE8	Leptomonas seymouri	48%	100%
A0A3Q8IH00	Leishmania donovani	99%	100%
A4HLT8	Leishmania braziliensis	73%	98%
D0A688	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9B464	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	99%
Q4Q3W2	Leishmania major	92%	99%