LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
E9AHP3_LEIIN
TriTrypDb:
LINF_330031400
Length:
311

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AHP3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHP3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 136 138 PF00675 0.723
CLV_NRD_NRD_1 181 183 PF00675 0.569
CLV_NRD_NRD_1 204 206 PF00675 0.617
CLV_NRD_NRD_1 4 6 PF00675 0.620
CLV_NRD_NRD_1 55 57 PF00675 0.401
CLV_PCSK_KEX2_1 136 138 PF00082 0.638
CLV_PCSK_KEX2_1 181 183 PF00082 0.541
CLV_PCSK_KEX2_1 204 206 PF00082 0.700
CLV_PCSK_KEX2_1 4 6 PF00082 0.650
CLV_PCSK_KEX2_1 55 57 PF00082 0.401
CLV_PCSK_PC7_1 51 57 PF00082 0.396
CLV_PCSK_SKI1_1 124 128 PF00082 0.428
CLV_PCSK_SKI1_1 51 55 PF00082 0.407
CLV_PCSK_SKI1_1 87 91 PF00082 0.403
DEG_APCC_DBOX_1 188 196 PF00400 0.547
DEG_Nend_UBRbox_3 1 3 PF02207 0.626
DEG_SCF_FBW7_1 66 72 PF00400 0.511
DOC_ANK_TNKS_1 204 211 PF00023 0.589
DOC_CKS1_1 66 71 PF01111 0.519
DOC_MAPK_gen_1 103 110 PF00069 0.350
DOC_MAPK_gen_1 169 177 PF00069 0.586
DOC_PP1_RVXF_1 159 166 PF00149 0.584
DOC_USP7_MATH_1 281 285 PF00917 0.726
DOC_WW_Pin1_4 65 70 PF00397 0.598
LIG_14-3-3_CanoR_1 136 140 PF00244 0.646
LIG_14-3-3_CanoR_1 265 269 PF00244 0.503
LIG_APCC_ABBAyCdc20_2 137 143 PF00400 0.650
LIG_BRCT_BRCA1_1 230 234 PF00533 0.558
LIG_FHA_1 301 307 PF00498 0.656
LIG_FHA_1 70 76 PF00498 0.524
LIG_FHA_1 78 84 PF00498 0.423
LIG_FHA_2 130 136 PF00498 0.582
LIG_FHA_2 196 202 PF00498 0.524
LIG_KLC1_Yacidic_2 257 262 PF13176 0.573
LIG_LIR_Apic_2 143 147 PF02991 0.519
LIG_LIR_Gen_1 16 27 PF02991 0.454
LIG_LIR_Gen_1 162 173 PF02991 0.543
LIG_LIR_Nem_3 122 126 PF02991 0.398
LIG_LIR_Nem_3 162 168 PF02991 0.596
LIG_LIR_Nem_3 231 237 PF02991 0.566
LIG_LIR_Nem_3 24 30 PF02991 0.398
LIG_LIR_Nem_3 255 261 PF02991 0.528
LIG_LIR_Nem_3 52 57 PF02991 0.400
LIG_LYPXL_S_1 26 30 PF13949 0.496
LIG_PDZ_Class_1 306 311 PF00595 0.665
LIG_Pex14_2 123 127 PF04695 0.387
LIG_Pex14_2 26 30 PF04695 0.473
LIG_Pex14_2 73 77 PF04695 0.523
LIG_PTB_Apo_2 20 27 PF02174 0.428
LIG_PTB_Apo_2 56 63 PF02174 0.422
LIG_PTB_Phospho_1 56 62 PF10480 0.413
LIG_SH2_CRK 93 97 PF00017 0.390
LIG_SH2_NCK_1 42 46 PF00017 0.425
LIG_SH2_PTP2 144 147 PF00017 0.589
LIG_SH2_STAT5 144 147 PF00017 0.570
LIG_SH2_STAT5 260 263 PF00017 0.481
LIG_SH3_1 63 69 PF00018 0.463
LIG_SH3_3 63 69 PF00018 0.530
LIG_SH3_3 9 15 PF00018 0.607
LIG_SH3_3 98 104 PF00018 0.526
LIG_SH3_4 218 225 PF00018 0.559
LIG_SUMO_SIM_par_1 78 84 PF11976 0.552
LIG_TRAF2_1 238 241 PF00917 0.540
MOD_CK1_1 125 131 PF00069 0.522
MOD_CK1_1 167 173 PF00069 0.559
MOD_CK1_1 296 302 PF00069 0.650
MOD_CK2_1 129 135 PF00069 0.537
MOD_GlcNHglycan 115 118 PF01048 0.466
MOD_GSK3_1 125 132 PF00069 0.413
MOD_GSK3_1 159 166 PF00069 0.501
MOD_GSK3_1 296 303 PF00069 0.629
MOD_GSK3_1 65 72 PF00069 0.438
MOD_N-GLC_1 306 311 PF02516 0.665
MOD_NEK2_1 195 200 PF00069 0.686
MOD_NEK2_1 213 218 PF00069 0.475
MOD_NEK2_1 44 49 PF00069 0.535
MOD_PIKK_1 187 193 PF00454 0.614
MOD_PKA_2 135 141 PF00069 0.627
MOD_PKA_2 214 220 PF00069 0.600
MOD_PKA_2 264 270 PF00069 0.654
MOD_Plk_1 154 160 PF00069 0.602
MOD_Plk_1 163 169 PF00069 0.543
MOD_Plk_1 263 269 PF00069 0.429
MOD_Plk_2-3 148 154 PF00069 0.637
MOD_Plk_4 264 270 PF00069 0.490
MOD_ProDKin_1 65 71 PF00069 0.593
MOD_SUMO_for_1 175 178 PF00179 0.470
TRG_DiLeu_BaEn_1 84 89 PF01217 0.495
TRG_DiLeu_LyEn_5 84 89 PF01217 0.462
TRG_ENDOCYTIC_2 27 30 PF00928 0.382
TRG_ENDOCYTIC_2 93 96 PF00928 0.375
TRG_ER_diArg_1 204 206 PF00400 0.625
TRG_ER_diArg_1 54 56 PF00400 0.383

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PE06 Leptomonas seymouri 64% 100%
A0A0S4JDA2 Bodo saltans 24% 97%
A0A1X0P3S3 Trypanosomatidae 43% 100%
A0A3S7X717 Leishmania donovani 99% 100%
A0A422NI03 Trypanosoma rangeli 41% 100%
A4HLT7 Leishmania braziliensis 79% 97%
D0A689 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 36% 100%
E9B463 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
Q4Q3W3 Leishmania major 95% 100%
V5DQC4 Trypanosoma cruzi 39% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS