LeishMANIAdb
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Cilia- and flagella-associated protein 91

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Cilia- and flagella-associated protein 91
Gene product:
Solute carrier (proton/amino acid symporter) - TRAMD3 or PAT1 - putative
Species:
Leishmania infantum
UniProt:
E9AHP1_LEIIN
TriTrypDb:
LINF_330031200
Length:
755

Annotations

Annotations by Jardim et al.

Transporters, Solute carrier (proton/amino acid symporter

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 12
GO:0005856 cytoskeleton 5 11
GO:0042995 cell projection 2 11
GO:0043226 organelle 2 11
GO:0043228 non-membrane-bounded organelle 3 11
GO:0043229 intracellular organelle 3 11
GO:0043232 intracellular non-membrane-bounded organelle 4 11
GO:0110165 cellular anatomical entity 1 12
GO:0005930 axoneme 2 1

Expansion

Sequence features

E9AHP1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHP1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 135 139 PF00656 0.578
CLV_C14_Caspase3-7 226 230 PF00656 0.523
CLV_C14_Caspase3-7 389 393 PF00656 0.503
CLV_C14_Caspase3-7 418 422 PF00656 0.484
CLV_C14_Caspase3-7 51 55 PF00656 0.557
CLV_C14_Caspase3-7 516 520 PF00656 0.415
CLV_C14_Caspase3-7 709 713 PF00656 0.406
CLV_NRD_NRD_1 117 119 PF00675 0.730
CLV_NRD_NRD_1 217 219 PF00675 0.218
CLV_NRD_NRD_1 261 263 PF00675 0.252
CLV_NRD_NRD_1 283 285 PF00675 0.258
CLV_NRD_NRD_1 30 32 PF00675 0.554
CLV_NRD_NRD_1 306 308 PF00675 0.247
CLV_NRD_NRD_1 453 455 PF00675 0.473
CLV_NRD_NRD_1 567 569 PF00675 0.581
CLV_NRD_NRD_1 614 616 PF00675 0.413
CLV_NRD_NRD_1 634 636 PF00675 0.469
CLV_PCSK_FUR_1 213 217 PF00082 0.219
CLV_PCSK_FUR_1 632 636 PF00082 0.454
CLV_PCSK_KEX2_1 117 119 PF00082 0.730
CLV_PCSK_KEX2_1 215 217 PF00082 0.218
CLV_PCSK_KEX2_1 261 263 PF00082 0.224
CLV_PCSK_KEX2_1 282 284 PF00082 0.285
CLV_PCSK_KEX2_1 30 32 PF00082 0.536
CLV_PCSK_KEX2_1 306 308 PF00082 0.232
CLV_PCSK_KEX2_1 312 314 PF00082 0.441
CLV_PCSK_KEX2_1 350 352 PF00082 0.691
CLV_PCSK_KEX2_1 453 455 PF00082 0.397
CLV_PCSK_KEX2_1 567 569 PF00082 0.507
CLV_PCSK_KEX2_1 614 616 PF00082 0.435
CLV_PCSK_KEX2_1 634 636 PF00082 0.425
CLV_PCSK_PC1ET2_1 312 314 PF00082 0.466
CLV_PCSK_PC1ET2_1 350 352 PF00082 0.678
CLV_PCSK_PC1ET2_1 567 569 PF00082 0.507
CLV_PCSK_PC7_1 213 219 PF00082 0.228
CLV_PCSK_SKI1_1 124 128 PF00082 0.727
CLV_PCSK_SKI1_1 399 403 PF00082 0.633
CLV_Separin_Metazoa 621 625 PF03568 0.618
DEG_APCC_DBOX_1 281 289 PF00400 0.458
DEG_Nend_Nbox_1 1 3 PF02207 0.543
DEG_SPOP_SBC_1 104 108 PF00917 0.699
DOC_CKS1_1 502 507 PF01111 0.508
DOC_CYCLIN_RxL_1 485 496 PF00134 0.545
DOC_MAPK_MEF2A_6 501 509 PF00069 0.512
DOC_PP1_RVXF_1 23 29 PF00149 0.624
DOC_PP2B_LxvP_1 340 343 PF13499 0.563
DOC_PP4_FxxP_1 29 32 PF00568 0.526
DOC_PP4_FxxP_1 436 439 PF00568 0.494
DOC_PP4_FxxP_1 67 70 PF00568 0.634
DOC_PP4_FxxP_1 714 717 PF00568 0.382
DOC_USP7_MATH_1 104 108 PF00917 0.651
DOC_USP7_MATH_1 142 146 PF00917 0.608
DOC_USP7_MATH_1 155 159 PF00917 0.677
DOC_USP7_MATH_1 361 365 PF00917 0.496
DOC_USP7_MATH_1 75 79 PF00917 0.658
DOC_WW_Pin1_4 171 176 PF00397 0.418
DOC_WW_Pin1_4 182 187 PF00397 0.418
DOC_WW_Pin1_4 429 434 PF00397 0.568
DOC_WW_Pin1_4 493 498 PF00397 0.469
DOC_WW_Pin1_4 501 506 PF00397 0.500
DOC_WW_Pin1_4 690 695 PF00397 0.573
LIG_14-3-3_CanoR_1 154 160 PF00244 0.686
LIG_14-3-3_CanoR_1 236 243 PF00244 0.462
LIG_14-3-3_CanoR_1 458 464 PF00244 0.547
LIG_14-3-3_CanoR_1 654 660 PF00244 0.495
LIG_14-3-3_CanoR_1 92 101 PF00244 0.683
LIG_BIR_III_4 475 479 PF00653 0.515
LIG_BIR_III_4 721 725 PF00653 0.396
LIG_CaM_IQ_9 156 171 PF13499 0.363
LIG_CaM_IQ_9 521 536 PF13499 0.362
LIG_FHA_1 183 189 PF00498 0.523
LIG_FHA_1 337 343 PF00498 0.580
LIG_FHA_1 415 421 PF00498 0.502
LIG_FHA_1 433 439 PF00498 0.508
LIG_FHA_1 494 500 PF00498 0.503
LIG_FHA_1 502 508 PF00498 0.507
LIG_FHA_2 224 230 PF00498 0.476
LIG_FHA_2 299 305 PF00498 0.509
LIG_FHA_2 49 55 PF00498 0.649
LIG_FHA_2 697 703 PF00498 0.594
LIG_Integrin_RGD_1 136 138 PF01839 0.543
LIG_LIR_Apic_2 174 180 PF02991 0.428
LIG_LIR_Apic_2 435 439 PF02991 0.537
LIG_LIR_Apic_2 66 70 PF02991 0.628
LIG_LIR_Apic_2 712 717 PF02991 0.385
LIG_LIR_Gen_1 234 243 PF02991 0.526
LIG_LIR_Gen_1 464 472 PF02991 0.473
LIG_LIR_Nem_3 234 240 PF02991 0.485
LIG_LIR_Nem_3 367 371 PF02991 0.495
LIG_LIR_Nem_3 464 470 PF02991 0.466
LIG_LIR_Nem_3 646 652 PF02991 0.475
LIG_MYND_3 131 135 PF01753 0.549
LIG_NRBOX 523 529 PF00104 0.365
LIG_PTB_Apo_2 532 539 PF02174 0.363
LIG_REV1ctd_RIR_1 26 31 PF16727 0.585
LIG_REV1ctd_RIR_1 535 545 PF16727 0.387
LIG_SH2_CRK 237 241 PF00017 0.467
LIG_SH2_CRK 467 471 PF00017 0.480
LIG_SH2_GRB2like 196 199 PF00017 0.448
LIG_SH2_PTP2 177 180 PF00017 0.424
LIG_SH2_SRC 177 180 PF00017 0.424
LIG_SH2_SRC 196 199 PF00017 0.345
LIG_SH2_SRC 292 295 PF00017 0.523
LIG_SH2_STAP1 649 653 PF00017 0.373
LIG_SH2_STAT3 2 5 PF00017 0.599
LIG_SH2_STAT5 177 180 PF00017 0.428
LIG_SH2_STAT5 237 240 PF00017 0.448
LIG_SH2_STAT5 292 295 PF00017 0.523
LIG_SH3_3 169 175 PF00018 0.418
LIG_SH3_3 29 35 PF00018 0.613
LIG_SH3_3 499 505 PF00018 0.497
LIG_SH3_3 691 697 PF00018 0.582
LIG_SUMO_SIM_anti_2 206 212 PF11976 0.425
LIG_TRAF2_1 276 279 PF00917 0.393
LIG_TRAF2_1 671 674 PF00917 0.402
LIG_TRAF2_1 698 701 PF00917 0.517
MOD_CDK_SPK_2 429 434 PF00069 0.494
MOD_CDK_SPK_2 493 498 PF00069 0.473
MOD_CDK_SPK_2 690 695 PF00069 0.661
MOD_CDK_SPxxK_3 501 508 PF00069 0.536
MOD_CK1_1 158 164 PF00069 0.284
MOD_CK1_1 223 229 PF00069 0.290
MOD_CK1_1 352 358 PF00069 0.752
MOD_CK1_1 364 370 PF00069 0.656
MOD_CK1_1 383 389 PF00069 0.450
MOD_CK1_1 432 438 PF00069 0.592
MOD_CK1_1 63 69 PF00069 0.641
MOD_CK2_1 142 148 PF00069 0.735
MOD_CK2_1 200 206 PF00069 0.256
MOD_CK2_1 298 304 PF00069 0.374
MOD_CK2_1 667 673 PF00069 0.371
MOD_CK2_1 696 702 PF00069 0.520
MOD_DYRK1A_RPxSP_1 501 505 PF00069 0.493
MOD_GlcNHglycan 144 147 PF01048 0.677
MOD_GlcNHglycan 202 205 PF01048 0.256
MOD_GlcNHglycan 357 360 PF01048 0.740
MOD_GlcNHglycan 586 589 PF01048 0.412
MOD_GlcNHglycan 669 672 PF01048 0.432
MOD_GlcNHglycan 94 97 PF01048 0.768
MOD_GSK3_1 167 174 PF00069 0.250
MOD_GSK3_1 225 232 PF00069 0.279
MOD_GSK3_1 308 315 PF00069 0.313
MOD_GSK3_1 341 348 PF00069 0.713
MOD_GSK3_1 349 356 PF00069 0.777
MOD_GSK3_1 366 373 PF00069 0.402
MOD_GSK3_1 383 390 PF00069 0.443
MOD_GSK3_1 87 94 PF00069 0.621
MOD_NEK2_1 266 271 PF00069 0.358
MOD_NEK2_1 308 313 PF00069 0.392
MOD_NEK2_1 349 354 PF00069 0.669
MOD_NEK2_1 60 65 PF00069 0.574
MOD_NEK2_1 76 81 PF00069 0.630
MOD_PIKK_1 287 293 PF00454 0.290
MOD_PIKK_1 598 604 PF00454 0.484
MOD_PIKK_1 87 93 PF00454 0.686
MOD_PKA_1 312 318 PF00069 0.506
MOD_PKA_1 350 356 PF00069 0.509
MOD_PKA_2 235 241 PF00069 0.196
MOD_PKA_2 266 272 PF00069 0.395
MOD_PKA_2 312 318 PF00069 0.462
MOD_PKA_2 350 356 PF00069 0.509
MOD_PKA_2 623 629 PF00069 0.454
MOD_PKA_2 653 659 PF00069 0.546
MOD_PKA_2 87 93 PF00069 0.665
MOD_Plk_1 220 226 PF00069 0.279
MOD_Plk_1 656 662 PF00069 0.441
MOD_Plk_1 672 678 PF00069 0.409
MOD_Plk_2-3 229 235 PF00069 0.290
MOD_Plk_4 158 164 PF00069 0.261
MOD_Plk_4 266 272 PF00069 0.395
MOD_Plk_4 432 438 PF00069 0.532
MOD_Plk_4 446 452 PF00069 0.389
MOD_ProDKin_1 171 177 PF00069 0.248
MOD_ProDKin_1 182 188 PF00069 0.248
MOD_ProDKin_1 429 435 PF00069 0.566
MOD_ProDKin_1 493 499 PF00069 0.474
MOD_ProDKin_1 501 507 PF00069 0.505
MOD_ProDKin_1 690 696 PF00069 0.575
MOD_SUMO_rev_2 729 735 PF00179 0.474
TRG_DiLeu_BaEn_1 206 211 PF01217 0.261
TRG_DiLeu_BaLyEn_6 523 528 PF01217 0.367
TRG_ENDOCYTIC_2 237 240 PF00928 0.339
TRG_ENDOCYTIC_2 467 470 PF00928 0.477
TRG_ER_diArg_1 116 118 PF00400 0.661
TRG_ER_diArg_1 213 216 PF00400 0.249
TRG_ER_diArg_1 261 263 PF00400 0.262
TRG_ER_diArg_1 282 284 PF00400 0.264
TRG_ER_diArg_1 29 31 PF00400 0.556
TRG_ER_diArg_1 305 307 PF00400 0.388
TRG_ER_diArg_1 528 531 PF00400 0.370
TRG_ER_diArg_1 613 615 PF00400 0.446
TRG_ER_diArg_1 632 635 PF00400 0.520
TRG_ER_diArg_1 99 102 PF00400 0.741
TRG_Pf-PMV_PEXEL_1 283 287 PF00026 0.387
TRG_Pf-PMV_PEXEL_1 545 549 PF00026 0.390
TRG_Pf-PMV_PEXEL_1 614 618 PF00026 0.482

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I8T7 Leptomonas seymouri 64% 99%
A0A0S4J7Y8 Bodo saltans 34% 100%
A0A1X0P3Q9 Trypanosomatidae 40% 100%
A0A3Q8IGQ6 Leishmania donovani 99% 100%
A0A422NI23 Trypanosoma rangeli 40% 100%
A4HLT5 Leishmania braziliensis 81% 100%
D0A691 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 39% 100%
E9B461 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
Q386N1 Trypanosoma brucei brucei (strain 927/4 GUTat10.1) 39% 100%
Q4Q3W5 Leishmania major 94% 100%
V5BP91 Trypanosoma cruzi 41% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS