LeishMANIAdb
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Mitochondrial carrier protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Mitochondrial carrier protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
E9AHN9_LEIIN
TriTrypDb:
LINF_330031000
Length:
308

Annotations

LeishMANIAdb annotations

A divergent protein family loosely similar in structure to the FAM210 family of poorly-known mitochondrial proteins.. Localization: Mitochondrial (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Cellular components
Term Name Level Count
GO:0016020 membrane 2 4
GO:0110165 cellular anatomical entity 1 4

Expansion

Sequence features

E9AHN9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHN9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 181 183 PF00675 0.369
CLV_NRD_NRD_1 218 220 PF00675 0.639
CLV_NRD_NRD_1 294 296 PF00675 0.380
CLV_NRD_NRD_1 31 33 PF00675 0.501
CLV_NRD_NRD_1 67 69 PF00675 0.497
CLV_NRD_NRD_1 89 91 PF00675 0.514
CLV_PCSK_KEX2_1 181 183 PF00082 0.369
CLV_PCSK_KEX2_1 294 296 PF00082 0.355
CLV_PCSK_KEX2_1 31 33 PF00082 0.501
CLV_PCSK_KEX2_1 42 44 PF00082 0.440
CLV_PCSK_KEX2_1 67 69 PF00082 0.497
CLV_PCSK_KEX2_1 89 91 PF00082 0.514
CLV_PCSK_PC1ET2_1 42 44 PF00082 0.503
CLV_PCSK_SKI1_1 132 136 PF00082 0.456
CLV_PCSK_SKI1_1 185 189 PF00082 0.354
CLV_PCSK_SKI1_1 68 72 PF00082 0.526
DEG_Nend_Nbox_1 1 3 PF02207 0.697
DOC_CKS1_1 170 175 PF01111 0.565
DOC_PP4_FxxP_1 197 200 PF00568 0.302
DOC_USP7_MATH_1 144 148 PF00917 0.717
DOC_USP7_MATH_1 158 162 PF00917 0.632
DOC_USP7_MATH_1 20 24 PF00917 0.675
DOC_USP7_MATH_1 246 250 PF00917 0.428
DOC_USP7_MATH_1 45 49 PF00917 0.654
DOC_USP7_MATH_1 95 99 PF00917 0.796
DOC_WW_Pin1_4 169 174 PF00397 0.580
DOC_WW_Pin1_4 41 46 PF00397 0.701
DOC_WW_Pin1_4 55 60 PF00397 0.632
LIG_14-3-3_CanoR_1 185 194 PF00244 0.548
LIG_14-3-3_CanoR_1 298 308 PF00244 0.687
LIG_14-3-3_CanoR_1 43 52 PF00244 0.696
LIG_14-3-3_CanoR_1 89 93 PF00244 0.720
LIG_BIR_III_4 151 155 PF00653 0.687
LIG_BRCT_BRCA1_1 281 285 PF00533 0.556
LIG_FHA_1 107 113 PF00498 0.812
LIG_FHA_2 69 75 PF00498 0.697
LIG_GBD_Chelix_1 270 278 PF00786 0.340
LIG_LIR_Apic_2 195 200 PF02991 0.302
LIG_LIR_Gen_1 192 202 PF02991 0.473
LIG_LIR_Gen_1 205 214 PF02991 0.328
LIG_LIR_Gen_1 249 258 PF02991 0.339
LIG_LIR_Nem_3 15 19 PF02991 0.635
LIG_LIR_Nem_3 192 197 PF02991 0.478
LIG_LIR_Nem_3 205 211 PF02991 0.393
LIG_LIR_Nem_3 249 253 PF02991 0.369
LIG_LIR_Nem_3 47 52 PF02991 0.690
LIG_MYND_1 84 88 PF01753 0.663
LIG_Pex14_2 197 201 PF04695 0.302
LIG_Pex14_2 209 213 PF04695 0.302
LIG_SH2_STAT5 198 201 PF00017 0.347
LIG_SH2_STAT5 210 213 PF00017 0.347
LIG_SH2_STAT5 226 229 PF00017 0.341
LIG_SH2_STAT5 276 279 PF00017 0.418
LIG_SH3_3 167 173 PF00018 0.598
LIG_SH3_3 274 280 PF00018 0.340
LIG_WRC_WIRS_1 13 18 PF05994 0.635
MOD_CK1_1 116 122 PF00069 0.773
MOD_CK1_1 147 153 PF00069 0.697
MOD_CK1_1 15 21 PF00069 0.632
MOD_CK1_1 159 165 PF00069 0.668
MOD_CK1_1 189 195 PF00069 0.577
MOD_CK1_1 41 47 PF00069 0.687
MOD_CK2_1 68 74 PF00069 0.694
MOD_CMANNOS 247 250 PF00535 0.582
MOD_Cter_Amidation 65 68 PF01082 0.497
MOD_GlcNHglycan 115 118 PF01048 0.556
MOD_GlcNHglycan 127 130 PF01048 0.509
MOD_GlcNHglycan 22 25 PF01048 0.378
MOD_GlcNHglycan 3 6 PF01048 0.481
MOD_GlcNHglycan 49 52 PF01048 0.464
MOD_GlcNHglycan 93 96 PF01048 0.537
MOD_GlcNHglycan 97 100 PF01048 0.571
MOD_GSK3_1 111 118 PF00069 0.730
MOD_GSK3_1 132 139 PF00069 0.673
MOD_GSK3_1 15 22 PF00069 0.775
MOD_GSK3_1 156 163 PF00069 0.677
MOD_GSK3_1 41 48 PF00069 0.685
MOD_GSK3_1 68 75 PF00069 0.736
MOD_GSK3_1 91 98 PF00069 0.700
MOD_NEK2_1 1 6 PF00069 0.689
MOD_NEK2_1 12 17 PF00069 0.625
MOD_NEK2_1 52 57 PF00069 0.697
MOD_NEK2_2 88 93 PF00069 0.659
MOD_PIKK_1 144 150 PF00454 0.739
MOD_PKA_2 52 58 PF00069 0.696
MOD_PKA_2 7 13 PF00069 0.630
MOD_PKA_2 88 94 PF00069 0.736
MOD_Plk_1 106 112 PF00069 0.655
MOD_Plk_1 192 198 PF00069 0.467
MOD_Plk_4 175 181 PF00069 0.586
MOD_Plk_4 202 208 PF00069 0.302
MOD_Plk_4 226 232 PF00069 0.371
MOD_ProDKin_1 169 175 PF00069 0.572
MOD_ProDKin_1 41 47 PF00069 0.698
MOD_ProDKin_1 55 61 PF00069 0.647
MOD_SUMO_for_1 187 190 PF00179 0.543
TRG_DiLeu_BaLyEn_6 8 13 PF01217 0.683
TRG_ENDOCYTIC_2 198 201 PF00928 0.339
TRG_ENDOCYTIC_2 210 213 PF00928 0.363
TRG_ENDOCYTIC_2 275 278 PF00928 0.388
TRG_ER_diArg_1 180 182 PF00400 0.571
TRG_ER_diArg_1 294 296 PF00400 0.589
TRG_ER_diArg_1 67 69 PF00400 0.681
TRG_ER_diArg_1 88 90 PF00400 0.690

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I0G0 Leptomonas seymouri 41% 100%
A0A3Q8IMI4 Leishmania donovani 99% 100%
E9AEH3 Leishmania major 82% 100%
E9B459 Leishmania mexicana (strain MHOM/GT/2001/U1103) 78% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS